Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer by Giulia Casari, Brenda Romaldi, Andrea Scirè, Cristina Minnelli, Daniela Marzioni, Gianna Ferretti, Tatiana Armeni

“…These changes play a critical role in modulating cell function in both healthy and pathological conditions. …”
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Cuproptosis: a novel therapeutic mechanism in lung cancer by Cheng Luo, Xinhui Wu, Shipeng Zhang, Junwen Tan, Yuzhi Huo, Xinyue Zhang, Bo Ning, Yuanhang Ye, Fei Wang

“…Abstract Background Lung cancer, one of the most prevalent and deadly malignant tumors, is increasingly common globally in terms of both morbidity and mortality rates. …”
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Mechanisms of beneficial effects of DPP-4 inhibitors as a promising perspective for the prevention/treatment of the disruption of cardio-cerebrovascular homeostasis by Katarina Tomović Pavlović, Marko Anderluh, Andrija Šmelcerović

“…Notably, they are among the few hypoglycemic agents that are safe and effective in patients with impaired renal function—where the use of agents like metformin and SGLT-2 inhibitors is often contraindicated. …”
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Targeted and cytotoxic inhibitors used in the treatment of breast cancer by Robert Roskoski Jr.

“…Breast cancer is the most commonly diagnosed malignancy and the fifth leading cause of cancer deaths worldwide. …”
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CPI203, a BET inhibitor, down-regulates a consistent set of DNA synthesis genes across a wide array of glioblastoma lines. by Matthew C Garrett, Troy Carnwath, Rebecca Albano, Yonghua Zhuang, Catherine A Behrmann, Merissa Pemberton, Farah Barakat, Robert Lober, Mark Hoeprich, Anthony Paravati, Marilyn Reed, Hailey Spry, Daniel Woo, Eric O'Brien, Brett VanCauwenbergh, John Perentesis, Rani Nasser, Mario Medvedovic, David R Plas

“…However, CPI203 was the most consistently effective compound, and the BET inhibitor class was the most consistently effective class of compounds across the gliomasphere panel. …”
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Hydrophilic Regulator Hexapeptides as Inhibitors of Tumor Cell Multiple Drug Resistance by V. V. Lebedev, S. A. Novikov, E. YU. Rybalkina, T. N. Zabotina

“…Multiple drug resistance (MDR) of tumor cells to cytostatics is one of the most often and severe complications of chemotherapy in oncological patients. …”
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Probiotics in the comprehensive prevention of respiratory infections in children by S. V. Nikolaeva, D. V. Usenko, Yu. N. Khlypovka, A. V. Gorelov

“…Viral infections of the respiratory tract are the most common cause of infectious diseases, especially in children. …”
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Elucidating the role of PPARG inhibition in enhancing MERS virus immune response: A network pharmacology and computational drug discovery by Ahmed M. Hassan, Leena H. Bajrai, Azzah S. Alharbi, Meshari M. Alhamdan, Vivek Dhar Dwivedi, Esam I. Azhar

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The small RNA complement of adult Schistosoma haematobium. by Andreas J Stroehlein, Neil D Young, Pasi K Korhonen, Ross S Hall, Aaron R Jex, Bonnie L Webster, David Rollinson, Paul J Brindley, Robin B Gasser

“…Small non-coding RNAs (sncRNAs) have been explored in selected schistosome species and are suggested to play essential roles in the post-transcriptional regulation of genes, and in modulating flatworm-host interactions. However, genome-wide small RNA data are currently lacking for key schistosomes including Schistosoma haematobium-the causative agent of urogenital schistosomiasis of humans.…”
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Multifaceted Therapeutic Potential of Plant-Derived Exosomes: Immunomodulation, Anticancer, Anti-Aging, Anti-Melanogenesis, Detoxification, and Drug Delivery by Arzu Zeynep Karabay, Jaleh Barar, Yalda Hekmatshoar, Yalda Rahbar Saadat

“…This review provides an overview of EVs from plant sources with emphasis on their health-promoting potential and possible use as therapeutic agents. This review highlights the essential biological effects of plant-derived extracellular vesicles, including immune modulation, anticancer activities, protection against chemical toxicity and pathogens, as well as anti-aging, anti-melanogenesis, and anti-arthritic effects, along with ongoing clinical studies. …”
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The dual GLP-1 and GIP receptor agonist tirzapetide provides an unintended interaction with the β-adrenoceptors and plays a role in glucose metabolism in hyperglycemic or senescent... by Dunya Aydos, Zeynep Busra Aksoy, Mehmet Altay Unal, Kamil Can Akcali, Ceylan Verda Bitirim, Belma Turan

“…Furthermore, mechanistically, the cardioprotective effect of TZPD includes significant regulation of the cellular Ca2+, at most, modulating the proteins in β-ARs signaling pathways. …”
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Preclinical Trials of Cancer Stem Cells Targeted by Metal-Based Coordination Complexes: A Systematic Review by Ana Caroline Mafra Bezerra, Lucas Elohim Cardoso Viana Baptista, Maria Núbia Alencar Couto, Milton Masahiko Kanashiro

“…Breast cancer was the most frequently studied tumor type. Many studies reported modulation of CSC-related markers, including EPCAM, CD44, CD133, CD24, SOX2, KLF4, Oct4, NOTCH1, ALDH1, CXCR4, and HES1, suggesting effects on CSC maintenance pathways. …”
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Ginger and Its Constituents: Role in Prevention and Treatment of Gastrointestinal Cancer by Sahdeo Prasad, Amit K. Tyagi

“…Although a large variety of chemotherapeutic agents have been introduced since the last few decades to combat GI cancer, most of them are very expensive and have side effects. …”
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P32 | BLOCKING CANCER CELL MOVEMENT: THE ROLE OF PAXILLIN AND EZRIN IN CERVICAL TUMOR

“… Cervical cancer remains one of the most common malignancies affecting women worldwide, with metastasis being a key factor contributing to poor prognosis and treatment failure. …”
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SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export. by Ross Hall, Anabel Guedán, Melvyn W Yap, George R Young, Ruth Harvey, Jonathan P Stoye, Kate N Bishop

“…SARS-CoV-2 encodes 9 predicted accessory proteins, which are presumed to be dispensable for in vitro replication, most likely having a role in modulating the host cell environment to aid viral replication. …”
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The effect of plant mucilaginous gel polysaccharides on oxidative tolerance and fermentation of dietetic yoghurts by Tulay Ozcan, Lutfiye Yilmaz-Ersan, Raziye Asli Keser

“…The addition of stevia into yoghurt accelerated fermentation most probably by the potential stimulating effect of steviol glycosides on bacterial growth. …”
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Iron metabolism and ferroptosis in human health and disease by Meijuan Zhong, Yuandi Wang, Junxia Min, Fudi Wang

“…Abstract Iron is indispensable to most lifeforms, underpinning a myriad of physiological processes. …”
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Synthesis and antitumoral activity of novel biaryl hydroxy-triazole and fluorene-triazole hybrids by David Chafi Zeitune, Marcelo Folhadella Martins Faria Azevedo, Mariane Senna Rangel, Robert de Sousa Bastos, José de Brito Vieira Neto, Claudia do Ó Pessoa, Camilla Djenne Buarque

“…Aim: The development of selective and potent antitumor agents remains a significant challenge. This study aimed to synthesize and evaluate biaryl hydroxy-1,2,3-triazoles and 9H-fluorene-1,2,3-triazole hybrids, inspired by previously identified bioactive 1,2,3-triazoles, for their cytotoxic potential against human cancer cell lines. …”
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Repurposing ProTAME for Bladder Cancer: A Combined Therapeutic Approach Targeting Cell Migration and MMP Regulation by Ihsan Nalkiran, Hatice Sevim Nalkiran

“…Bladder cancer, the fourth most common cancer type among men, remains a therapeutic challenge due to its heterogeneity and frequent development of chemoresistance. …”
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Targeted Inhibition of CHD1L by OTI-611 Reprograms Chemotherapy and Targeted Therapy-Induced Cell Cycle Arrest and Suppresses Proliferation to Produce Synergistic Antitumor Effects... by Hector Esquer, Qiong Zhou, Daniel V. LaBarbera

“…As a result of this mechanism, OTI-611 can reprogram the cell cycle effects of other antitumor agents to modulate and arrest cells in G1 when used in combination, including agents commonly known to arrest cells in the G2/M phase. …”
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