Deciphering the roles of non-coding RNAs in liposarcoma development: Challenges and opportunities for translational therapeutic advances by Zhi Xiong Chong, Wan Yong Ho, Swee Keong Yeap

“…Liposarcoma is one of the most prevalent forms of soft tissue sarcoma, and its prognosis is highly dependent on its molecular subtypes. …”
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PCOS and Inositols – Advances and Lessons We are Learning. A Narrative Review by Lentini G, Querqui A, Monti N, Bizzarri M

“…Clinical studies demonstrated myo-Ins efficacy, suggesting that an appropriate ratio in between myo-Ins/DCI (40:1) improves the reproductive function in PCOS women, even in absence of insulin resistance.Expert Opinion: Inositol-based treatments in PCOS are gaining momentum, demonstrating safety and efficacy greater than those obtained with other pharmacological agents. The efficacy depends not only on the modulation of insulin sensitivity but also on the direct, steroidogenic effects upon the ovaries. …”
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CORRECTION OF IMMUNE STATUS IN CHILDREN WITH FREQUENTLY RECURRENT INFECTIONS WITH COMPLEX PERORAL VACCINE by V.V. Chernikov

“…The market of drugs proposes some new medicines which are labeled by manufacturers as immunomodulating agents. Most of them are not licensed and they have no any evidence of their efficacy. …”
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Uncovering the connection between tunicamycin-induced respiratory deficiency and reduced fluconazole tolerance in Candida glabrata by Lijun Zheng, Yubo Dong, Jing Wang, Maoji Zhang, Yi Xu, Linfeng Ma, Liangsheng Guo

“…IntroductionCandida glabrata is a prevalent opportunistic fungal pathogen in humans, and fluconazole (FLC) is one of the most commonly used antifungal agents. However, the molecular mechanisms underlying FLC tolerance in C. glabrata remain largely unexplored.ObjectiveThis study aims to identify novel mechanisms regulating FLC tolerance, with a particular focus on tunicamycin (TUN)-induced respiratory deficiency.MethodsWe employed three distinct experimental approaches to investigate the impact of TUN on FLC tolerance: (1) co-treatment with TUN and FLC, (2) exclusive exposure to TUN, and (3) induction of petite formation through alternative methods. …”
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Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood–brain barrier permeability by Suyi Liu, Xingyue Jin, Yuanyuan Ge, Junlin Dong, Xinyue Liu, Xiao Pei, Ping Wang, Bing Wang, Yanxu Chang, Xie-an Yu

“…Abstract The blood–brain barrier (BBB) represents a formidable challenge in the treatment of neurological disorders, as it restricts the passage of most therapeutic agents into the central nervous system (CNS). …”
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Predicting immunotherapy efficacy in endometrial cancer: focus on the tumor microenvironment by Liubov A. Tashireva, Irina V. Larionova, Irina V. Larionova, Nikita A. Ermak, Anastasia A. Maltseva, Ekaterina I. Livanos, Anna Yu. Kalinchuk, Marina N. Stakheyeva, Larisa A. Kolomiets

“…Major question we raise here – which group of patients is the most favorable to achieve durable immunotherapy response in endometrial cancer?…”
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The liver-specific long noncoding RNA FAM99B inhibits ribosome biogenesis and cancer progression through cleavage of dead-box Helicase 21 by Yifei He, Hongquan Li, Qili Shi, Yanfang Liu, Qiaochu Pan, Xianghuo He

“…Abstract Emerging evidence has demonstrated that long noncoding RNAs (lncRNAs) are promising targets or agents for the treatment of human cancers. Most liver-specific lncRNAs exhibit loss of expression and act as tumor suppressors in liver cancer. …”
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Cannabis for Chronic Pain: Mechanistic Insights and Therapeutic Challenges by Carla Matos, Ana Teresa Pereira, Maria João Dias, Carla Sousa, Ana Ferreira Vinha, Carla Moutinho, Márcia Carvalho

“…<i>Cannabis sativa</i> contains several pharmacologically active compounds, the most prominent of which are delta-9-tetrahydrocannabinol (∆⁹-THC) and cannabidiol (CBD), which interact with the body’s endocannabinoid system, thereby modulating the pain response. …”
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Angiogenesis in Atrial Fibrillation: A Literature Review by Jie Lin, Haihuan Lin, Zhijun Xu, Zhihui Yang, Chenglv Hong, Ying Wang, Haocheng Lu

“…Atrial fibrillation (AF), the most prevalent clinically significant cardiac arrhythmia, is characterized by chaotic atrial electrical activity and currently affects an estimated 2.5–3.5% of the global population. …”
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Emerging mechanisms and implications of m6A in CVDs: potential applications of natural products by Hui Wang, Yun Zhang, Xiao Jiang, Guichun Liu, Shujian Xu, Jinbiao He, Xudong He, Ting Xiao, Lijuan Wang, LiJing Xiao, Xinhui Li

“…N6-methyladenosine (m6A) RNA methylation is the most common, abundant, and reversible epigenetic modification of RNAs, and it directs many essential processes in RNAs post-transcriptionally. …”
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Sea buckthorn flavonoids and their derivatives: potential natural compounds for the treatment of diabetic cardiomyopathy by Quan Zhang, Quan Zhang, Jiahong Zhang, Jiahong Zhang, Yujie Ouyang, Yujie Ouyang, Hongyan Liu, Hongyan Liu, Chunguang Xie, Chunguang Xie, Chunguang Xie, Xiaoxu Fu, Xiaoxu Fu, Xiaoxu Fu

“…Diabetic cardiomyopathy (DCM) is one of the most common complications of diabetes, characterized by high morbidity and disability rates, and can lead to heart failure. …”
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USP7 promotes temozolomide resistance by stabilizing MGMT in glioblastoma by Jiabing Li, Xiaorong Feng, Zhaohui Liu, Yunfang Deng, Zhiming Sun, Bei Chen, Lihui Wu, Xiaolong Wang, Lin Miao, Liyuan Zeng, Lei Hu, Yuming He, Ying Sheng, Yue Liu, Yu Zhao

“…Targeting USP7 provides mechanistic insights into regulating diverse alkylation repair pathways and offers a strategy to enhance the efficacy of combination chemotherapies, including TMZ and other alkylating agents, by modulating distinct repair mechanisms in GBM.…”
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Alternative splicing fine-tunes prey shift of Coccinellini lady beetles to non-target insect by Xuefei Tang, Xinhui Xia, Yuqi Liu, Xiyao Hong, Yuhao Huang, Guannan Li, Yuansen Liang, Xueqing Wang, Hong Pang, Yuchen Yang

“…Conclusion These findings unraveled the functional significance of AS reprogramming in modulating acclimation of Coccinellini lady beetles to prey shift from aphids to non-target insects and provided new genetic clues for evaluating their ecological safety as biological control agents.…”
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Therapeutic Potentials of MiRNA for Colorectal Cancer Liver Metastasis Treatment: A Narrative Review by Amir Hossein Barjasteh, Rawa Jaseb Mazhar AleKassar, Abdulridha Mohammed Al-Asady, Hanieh Latifi, Amir Avan, Majid Khazaei, Mikhail Ryzhikov, Seyed Mahdi Hassanian

“…Colorectal cancer (CRC) ranks among the most prevalent cancers worldwide and is the fourth leading cause of cancer-related deaths. …”
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The role of the mTOR pathway in breast cancer stem cells (BCSCs): mechanisms and therapeutic potentials by Chen Zhang, Shu Xu, Chuanzheng Yin, Shaobo Hu, Pian Liu

“…Abstract Breast cancer remains the most frequently diagnosed cancer globally, exerting a profound impact on women’s health and healthcare systems. …”
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Enhanced immunotherapeutic profile of oncolytic virus-based cancer vaccination using cyclophosphamide preconditioning by Guido Kroemer, AJ Robert McGray, Brian D Lichty, Byram W Bridle, Samuel T Workenhe, Jonathan G Pol, Yonghong Wan, Matthew J Atherton, Kyle B Stephenson, Natasha Kazdhan

“…Despite doubling the median survival in comparison to untreated controls, most vaccinated mice ultimately succumbed to cancer progression. …”
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Astrocyte heterogeneity in ischemic stroke: Molecular mechanisms and therapeutic targets by Daxing Li, Xinchen Huo, Ling Shen, Minjie Qian, Jindou Wang, Shijie Mao, Wenjing Chen, Runheng Li, Tianhao Zhu, Beicheng Zhang, Kunxuan Liu, Feifei Wu, Ying Bai

“…Here we systematically review current advancements in astrocyte heterogeneity following ischemic stroke, elucidate the molecular mechanisms underlying their activation, and further summarize promising therapeutic agents and molecular targets capable of modulating astrocyte heterogeneity.…”
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Dye-based fluorescent organic nanoparticles made from polar and polarizable chromophores for bioimaging purposes: a bottom-up approach by Daniel, Jonathan, Dal Pra, Ophélie, Kurek, Eleonore, Grazon, Chloé, Blanchard-Desce, Mireille

“…Among them luminescent metal-, semiconductor- or oxide-based “hard” nanoparticles have been the most widely used. Yet, they raise concern with respect to toxicity and degradability issues. …”
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Pancreatic cancer is feeling the heat by Elizabeth M Jaffee, Saumya Y Maru

“…Recent advances in genomic and proteomic technology advances are finally uncovering the complex inflammatory cellular and intercellular signals that require modulation and reprogramming. The goal is to ‘turn up the heat’ on PDACs with combination immunotherapies that incorporate T cell activating agents and immune modulatory agents, and successfully eradicate tumors. …”
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Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD by Feng Zhang, Kairui Yue, Simin Sun, Shengyuan Lu, Geng Jia, Yang Zha, Shuang Zhang, C. James Chou, Chenzhong Liao, Xiaoyang Li, Yajun Duan

“…Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents the most prevalent chronic liver disorder globally. Due to its intricate pathogenesis and the current lack of efficacious pharmacological interventions, there is a pressing need to discover novel therapeutic targets and agents for MASLD treatment. …”
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