Autoinflammatory diseases: An immunologist’s view by A. Yu. Shcherbina

“…Moreover, it is important that the detection of a causative genetic defect frequently determines man-agement tactics for patients.For AIS treatment, there is a spectrum of agents modulating these or those inflammatory components. …”
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Exploring effector protein dynamics and natural fungicidal potential in rice blast pathogen Magnaporthe oryzae. by Jannatul Ferdousy, Tanjin Barketullah Robin, Mst Sanjida Nasrin, Istiak Ahmed, Tawsif Hossain, Md Mehedi Hasan, Mehrab Hassan Soaeb, Md Ahsanul Tamim, Nusrat Jahan Yeasmin, Ummay Habiba, Nadim Ahmed, Nurul Amin Rani, Md Shishir Bhuyian, Suvarna N Vakare, Abu Tayab Moin, Rajesh B Patil, Mohammad Shahadat Hossain

“…Rice blast, caused by Magnaporthe oryzae, is one of the most destructive fungal diseases in rice, resulting in major economic losses worldwide. …”
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Epigenetic Mechanisms of Cardioprotection: Focus is on Activation of Sirtuins by K. A. Aitbaev, I. T. Murkamilov, Zh. A. Murkamilova, I. O. Kudaibergenova, F. A. Yusupov

“…A deeper understanding of the epigenetic mechanisms through which SIRT1 and SIRT6 exert their cardioprotective effect will have widespread implications and will accelerate the development of selective and effective pharmacological agents for modulating sirtuins for the prevention and treatment of CVD.…”
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Targeting dysregulated molecular pathways in cancer cell lines using small molecule inhibitors as a promising therapeutic strategy by Hassan H Almasoudi, Shoaib Khan

“…Abstract Biologically active heterocycles hold considerable potential in modulating cellular pathways associated with cancer progression. …”
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The Effects of Probiotics, Prebiotics and Synbiotics on Glycemic Control in Diabetic Patients: A Narrative and Meta-Analysis Study by Dorsa Ghafouri

“…Recently, probiotics and prebiotics have emerged as complementary therapies in diabetes, aiming the composition and function of gut microbiota. These microbiome-modulating agents can improve metabolic health through an enhanced glucose homeostasis and the insulin sensitivity. …”
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Natural Compounds as Regulators of the Cancer Cell Metabolism by Claudia Cerella, Flavia Radogna, Mario Dicato, Marc Diederich

“…Nevertheless, a very poor number of compounds are under investigation as potential modulators of cell metabolism. Candidate agents should display selectivity of action towards cancer cells without side effects. …”
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The Use of Tricyclic Antidepressants for Postherpetic Neuralgia – A Case Series by Jamal Hasoon, Syed Mahmood

“…Postherpetic neuralgia (PHN) is one of the most debilitating forms of neuropathic pain that can occur after a herpes zoster infection. …”
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Intercellular adhesion disorders in tumorigenesis by Olga A. Bocharova, Regina V. Karpova, Evgeny V. Bocharov, Valerian G. Kucheryanu, Vyacheslav S. Kosorukov, Ivan S. Stilidi

“…Direct communication between brain DA and peripheral DA is crucial in modulating immune function. Peripheral DA mediates differentiation, binding to tumor cells, and cytotoxicity of CD8+ T cells. …”
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Ameliorative effects of Brassica oleracea var. viridis ethanol extract and fractions on cimetidine-induced reproductive toxicity in male Wistar rats by Emmanuel Orire Ikuomola, Daniel Udofia Owu, Victor Otu Oka, Olufunke Onaadepo, Felix Nnaemeka Ugwu, Patrick Maduabuchi Aja

“…The search for natural protective agents has highlighted Brassica oleracea var. viridis (collard greens) for its antioxidant and endocrine-modulating properties.ObjectivesThis study evaluated the protective effects of Brassica oleracea var. viridis (collard greens) ethanol extract and its solvent fractions on cimetidine-induced reproductive toxicity in male Wistar rats, focusing on body/organ weights, hormonal profiles, antioxidant enzyme activities, and testicular histoarchitecture.MethodsThirty-five rats were divided into seven groups: control, cimetidine (120 mg/kg), ethanol extract (200 mg/kg), and cimetidine + fractions (aqueous, butanol, and hexane). …”
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Gallic Acid Enhances Olaparib-Induced Cell Death and Attenuates Olaparib Resistance in Human Osteosarcoma U2OS Cell Line by Mehmet Kadir Erdogan, Ayse Busra Usca

“…Cancer remains one of the most formidable diseases globally and continues to be a leading cause of mortality. …”
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Epigenetic Therapies in Melanoma—Targeting DNA Methylation and Histone Modification by Adrian Bogdan Tigu, Andrei Ivancuta, Andrada Uhl, Alexandru Cristian Sabo, Madalina Nistor, Ximena-Maria Mureșan, Diana Cenariu, Tanase Timis, Doru Diculescu, Diana Gulei

“…This review aims to identify existing potential therapeutical approaches using therapeutic agents that can modulate DNA methylation and histone modification, which can lead to tumor inhibition, cell death initiation and reactivation of tumor suppressor genes.…”
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Insights into the lemon (Citrus limon) epiphytic microbiome: impact of the biocontrol yeast Clavispora lusitaniae 146 by Maria Cecilia Rasuk, José Matías Irazoqui, María Florencia Perez, Martina María Pereyra, Pedro Eugenio Sineli, Anja Poehlein, Rolf Daniel, Julian Rafael Dib

“…Although strain 146 has proven to be an effective agent, the influence of a microbial biological control agent on the postharvest lemon microbiome has not been studied until now. …”
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The role of microbiota in nonalcoholic fatty liver disease: mechanism of action and treatment strategy by Siwen Shen, Yao Liu, Nuoya Wang, Zhenhe Huang, Guifang Deng

“…Furthermore, we explore the role of prebiotics, plant-derived compounds, and synthetic agents in modulating gut microbiota and liver health. …”
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STAT signaling pathways in immune cells and their associated mechanisms in cancer pathogenesis by Sepideh Sohrabi, Shiva Alipour, Zahra Ghahramanipour, Javad Masoumi, Behzad Baradaran

“…Conclusion: The majority of immune cells use the Jak/STAT signaling pathway, which is one of the most important signaling pathways with a role in induction of proper immune responses. …”
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Anti-Cancer Stem Cell Properties of Square Planar Copper(II) Complexes with Vanillin Schiff Base Ligands by Yihan Wang, Kuldip Singh, Chunxin Lu, Kogularamanan Suntharalingam

“…Breast cancer relapse and metastasis, the leading cause of breast cancer-associated deaths, is linked to the existence of breast cancer stem cells (CSCs). Redox-modulating metal complexes have been used to perturb the redox balance in breast CSCs and effect cell death. …”
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Tools for regulating metabolic diseases: extracellular vesicles from adipose macrophages by Liang Zhang, Kecheng Lou, Yunmeng Zhang, Yuanjing Leng, Yuqing Huang, Xinxin Liao, Xiaoliang Liu, Shangzhi Feng, Guoqiang Feng

“…Metabolic diseases have gradually become one of the most significant global medical burdens. Diseases such as obesity, diabetes, and metabolic syndrome, along with their complications, are clinically categorized as metabolic diseases. …”
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Efficacy and safety of pharmacological treatments in inclusion body myositis: a systematic review by Pedro M Machado, Eduardo José Ferreira Santos, Nicholas Yapp, Pedro Sousa, Bayram Farisogullari, Hermaleigh Townsley

“…Treatments included various immunosuppressive and immunomodulatory agents, alongside interventions modulating muscle growth and protein homoeostasis. …”
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RECENT ADVANCES IN TARGETING PROTEINS AND ENZYMES ASSOCIATED WITH DIABETIC PATHOPHYSIOLOGY by Mubarak Muhammad Dahiru

“…Results: Some of the significant dysfunctions include insulin absence and resistance, glucose toxicity, dyslipidemia, nephropathy, retinopathy, neuropathy, and cardiovascular complications, which are mostly attributed to persistent hyperglycemia. Moreover, different proteins and enzymes are associated with diabetic pathophysiology, including 11β-hydroxysteroid dehydrogenase, glutamine: fructose-6-phosphate aminotransferase, alpha-glucosidase, glucokinase, glucose-6-phosphate dehydrogenase, protein tyrosine phosphatase 1B, renin-Angiotensin-aldosterone-system, mono-ADP ribosyltransferase-sirtuin-6, and pyruvate dehydrogenase complex which acts as modulative targets of antidiabetic agents to manage diabetes. …”
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Targeting programmed cell death in diabetic kidney disease: from molecular mechanisms to pharmacotherapy by Fengzhao Liu, Zhenyu Yang, Jixin Li, Tao Wu, Xiangyu Li, Lijuan Zhao, Wenru Wang, Wenfei Yu, Guangheng Zhang, Yunsheng Xu

“…Additionally, we explore the potential of natural products derived primarily from botanical sources as therapeutic agents, highlighting their multifaceted effects on modulating PCD crosstalk, thereby proposing novel strategies for DKD treatment.…”
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Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment by Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai

“…It further explores therapeutic opportunities arising from targeting TME interactions, including rational combinations of KRAS inhibitors with immune checkpoint blockade, metabolic agents, or microbiota‐modulating strategies.…”
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