Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage. by Joel A Dietz, Margaret E Maes, Shuang Huang, Brian S Yandell, Cassandra L Schlamp, Angela D Montgomery, R Rand Allingham, Michael A Hauser, Robert W Nickells

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Modulated electro-hyperthermia therapy combined with Korean mistletoe extract treatment exerts a strong anti-tumor activity by enhancing cellular and humoral immune responses in mi... by Yebeen Kim, Jinwoo Hur, Sung-Chul Hong, Jaewoon Jung, Choon-Ho Park, Joon Beom Park, Taek Joon Yoon, Jong Bae Kim, Seung-Hoon Yang

“…Electro-hyperthermia therapy (EHT) has been known to cause temperature-dependent cell death and enhance the effects of conventional antitumor treatments, such as chemotherapy and radiotherapy. Furthermore, EHT modulates the innate and adaptive immune systems. Mistletoe is one of the most broadly studied complementary and alternative therapeutic agents for cancer treatment due to its ability to stimulate the immune systems. …”
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Inflammatory links between epilepsy and depression: a review of mechanisms and therapeutic strategies by Yu-Qian Shi, He-Cai Yang, Cong He, Yu-Hao Wang, Jia Zheng, Xing-Yi Wang, Fang-Yi Hao, Chu-Wen Feng, Lin Ma, Yue-Hui Zhang, Zheng Liu

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Effect of prior and first-line immunotherapy on baseline immune biomarkers and modulation of the tumor microenvironment in response to nivolumab and relatlimab combination therapy... by James Larkin, Evan J Lipson, Charlie Garnett-Benson, Ignacio Melero, Reinhard Dummer, Paolo A Ascierto, Vanna Chiarion-Sileni, Marta Nyakas, Hao Tang, Inge Marie Svane, Margaret Callahan, Eva Muñoz-Couselo, Jean Jacques Grob, Katriina Peltola, Sonia Dolfi, Carlos Alberto Gomez-Roca, Patrick Djidel, Deepti Warad, Diane Reusser-Wolf

“…Further research is needed to identify patients who will most benefit from anti-LAG-3/PD-(L)1 agents, and to elucidate the mechanisms of action of, and resistance to, this combination therapy in patients with advanced melanoma.Trial registration number NCT01968109.…”
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SLFN11: a pan-cancer biomarker for DNA-targeted drugs sensitivity and therapeutic strategy guidance by Kunzhong Zhou, Yuewen Li, Weifang Wang, Yilin Chen, Bingyan Qian, Yiteng Liang, Hongmei Li, Ruiting Xu, Li Zhuang

“…Therapeutic responses to identical chemotherapy regimens often vary significantly among patients with the same type of cancer, underscoring the need for additional biomarkers to identify individuals most likely to benefit from specific treatments. …”
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Neuroprotective and anticonvulsant effect of trimetazidine in a PTZ-kindling model of mice through modulation of the IL-1β/IL-1R1 and HMGB-1/TLR-4 axis by Shahnawaz Ahmad, Mohammed Samim, Seema Jain, Divya Vohora, Nidhi

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<i>Gallic</i>, <i>Aconitic</i>, and <i>Crocetin</i> Acids as Potential TNF Modulators: An Integrated Study Combining Molecular Docking, Dynamics Simulations, ADMET Profiling, and G... by Adolat Manakbayeva, Andrey Bogoyavlenskiy, Timur Kerimov, Igor Yershov, Pavel Alexyuk, Madina Alexyuk, Vladimir Berezin, Vyacheslav Dushenkov

“…This research explores organic acids as potential TNF modulators, highlighting their complex interactions and providing a foundation for developing these compounds as anti-inflammatory agents targeting TNF-mediated diseases.…”
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MODERN OPPORTUNITIES IN UVEITIS TREATMENT by D. A. Krakhmaleva, E. A. Pivin, S. V. Trufanov, S. A. Malozhen

“…Depending on the activit y of the inflammatory process it may require  system or topical anti-inflammatory and/or immunosuppressive treatment with corticosteroids or immunomodulatory therapeutic agents. The main groups  of drugs are presented with the immunosuppressive alkylating agents,  corticosteroids, antimetabolites, T-cell inhibitors  and  biological modulators of the  immune  response. …”
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Marine-derived secondary metabolites in oncology: A comprehensive review by Samah S. Abuzahrah, Serag Eldin I. Elbehairi, Tahani Bakhsh, Ahmed Atwa, Nouf Juaid, Reham Hassan Mekky

“…Marine-derived secondary metabolites are emerging as promising anticancer agents due to their structural diversity and potent bioactivity. …”
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Preparation and pharmacological characterization of the enantiomers of the anticancer agent R/S-N-3-cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopy... by Michael Schnekenburger, Eric Goffin, Matthieu Schoumacher, Nikolay Tumanov, Ange Mouithys-Mickalad, Pascal de Tullio, Johan Wouters, Philippe Lebrun, Marc Diederich, Bernard Pirotte

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Self-Awareness Mechanism for Top-down Attention using Fuzzy Logic in Sustainable Business Intelligence by Muhammad Furqan Khan, Wasim Ahmad Khan, Muhammad Muzaffar Hameed, Arslan Ahmad Siddiqi

“…Utilizing a prioritization technique and fuzzy logic to identify the most important stimulus, this mechanism enhances the agent's self-awareness and self-control mechanisms. …”
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MANAGING THE ROAD NETWORK OF URBAN AGGLOMERATION: FORMATION OF THE INFORMATION MODELING by T. V. Bobrova, A. A. Andryushenkov

“…The structure of the system presented on the principles of multi-agent project management. The authors identified the types of mathematical models for solving key problems in the framework of design modules by creation of an agglomeration transport framework, ensuring the regulatory requirements of the transport and operational condition of roads and by creation of conditions for the continuous and safe movement of road transport.Results. …”
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Inflammatory bowel disease and multiple sclerosis by M. Dominguez-Gallego, V. Meca-Lallana, C. Ana Belén

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Structure of associative heterarchical memory by R. V. Dushkin, V. A. Lelekova, V. Y. Stepankov, S. Fadeeva

“…When working with AH-memory, a developer should select from a variety of possible module sets those AH-memory components that support the most successful and efficient functioning of the AI-agent.…”
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Unveiling prognostic value of JAK/STAT signaling pathway related genes in colorectal cancer: a study of Mendelian randomization analysis by Nan Zhang, Wenli Yue, Bihang Jiao, Duo Cheng, Jingjing Wang, Fang Liang, Yingnan Wang, Xiyue Liang, Kunkun Li, Junwei Liu, Yadong Li

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Mycobacterium ulcerans and Mycobacterium marinum: Pathogenesis, Diagnosis and Treatment by Loh Teng-Hern Tan, Pendru Raghunath, Long Chiau Ming, Jodi Woan-Fei Law

“…In term pathogenesis, prolonged cell exposure to exotoxin mycolactone produced by M. ulcerans could lead to Buruli ulcer. Meanwhile, like most pathogenic mycobacteria, M. marinum evades the host immune responses by invading and replicating inside host cells and it is capable of modulating host immune responses. …”
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Nanotechnology in Cancer Treatment: Innovative Approaches to Overcoming Drug Resistance in Tumors by Kirolos Eskandar

“…By penetrating biological barriers and modulating the tumor microenvironment, nanocarriers enhance the efficacy of anticancer agents while minimizing side effects. …”
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Repurposing Historic Drugs for Neutrophil-Mediated Inflammation in Skin Disorders by Ludovica Franceschin, Alessia Guidotti, Roberto Mazzetto, Jacopo Tartaglia, Christian Ciolfi, Mauro Alaibac, Alvise Sernicola

“…Some of these agents are approved for the management of specific dermatologic conditions, but most of their current uses are off-label and only supported by isolated reports or case series. …”
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Epigenetic regulation of histone modifications in glioblastoma: recent advances and therapeutic insights by Li Zhang, Yang Yang, Yanchu Li, Chenyu Wang, Chenbin Bian, Hongbin Wang, Feng Wang

“…Abstract Glioblastoma (GBM) is the most common primary malignant brain tumor, characterized by its aggressive behavior, limited treatment options, and poor prognosis. …”
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Boosting sustainable agriculture by arbuscular mycorrhizal fungi under abiotic stress condition by Noor Alam Chowdhary, L.S. Songachan

“…Arbuscular mycorrhizal fungi (AMF) which form symbiotic associations with the roots of most terrestrial plants, have emerged as key biological agents to enhance plant resilience under abiotic stress conditions by improving nutrient and water uptake, modulating hormonal signalling, enhancing antioxidant defense mechanisms, and maintaining osmotic homeostasis. …”
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