Epigenetic Therapy as a Putative Molecular Target to Modulate B Cell Biology and Behavior in the Context of Immunological Disorders by Thayse Pinheiro da Costa, Marcia Cury El-Cheikh, Katia Carneiro

“…In this review, we discuss a putative role of iHDACs in the modulation of peritoneal B cell subpopulation’s balance as well as their role as therapeutic agents in the context of chronic diseases mediated by peritoneal B cells.…”
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Huqi formula suppresses hepatocellular carcinoma growth by modulating the PI3K/AKT/mTOR pathway and promoting T cell infiltration by Donghao Yin, Xiang Li, Xuemeng Yang, Xiaofei Shang, Zhen Li, Jiahao Geng, Yanyu Xu, Zijing Xu, Zixuan Wang, Zimeng Shang, Zhiyun Yang, Linlan Hu, Quanwei Li, Jiabo Wang, Xinhua Song, Xiuhui Li, Xiaojun Wang

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The plant growth-promoting Burkholderia vietnamiensis produces acyl-homoserine lactones and modulates the quorum-sensing signaling in the rhizosphere by Selvaraj Poonguzhali, Selvaraj Poonguzhali, Kiyoon Kim, Munusamy Madhaiyan, Munusamy Madhaiyan, Munusamy Madhaiyan, Tongmin Sa, Tongmin Sa

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Dual modulation of amyloid beta and tau aggregation and dissociation in Alzheimer’s disease: a comprehensive review of the characteristics and therapeutic strategies by Yunkwon Nam, Soo Jung Shin, Vijay Kumar, Jihyeon Won, Sujin Kim, Minho Moon

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PDE Inhibitors and Autophagy Regulators Modulate CRE-Dependent Luciferase Activity in Neuronal Cells from the Mouse Suprachiasmatic Nucleus by Erik Maronde, Abdelhaq Rami

“…Results: In this study the different impacts of common PDE inhibitors and autophagy modulators on CRE-luciferase activity applied alone and in combination with known CRE-luciferase activating agents showed that (1) PDE3, 4 and 5 are present in SCNCRE cells, with (2) PDE3 being the most active and (3) the autophagy inhibitor 3-Methyladenin (3-MA) displaying PDE inhibitor-like behavior. …”
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Linking GERD and the Peptide Bombesin: A New Therapeutic Strategy to Modulate Inflammatory, Oxidative Stress and Clinical Biochemistry Parameters by Alessio Ardizzone, Sarah Adriana Scuderi, Lelio Crupi, Michela Campolo, Irene Paterniti, Anna Paola Capra, Emanuela Esposito

“…Gastroesophageal reflux disease (GERD) represents one of the most prevalent foregut illnesses, affecting a large portion of individuals worldwide. …”
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New Nitrogen-, Oxygen-, and Sulfur-Containing Heterocyclic Compounds as Anti-Colon Cancer Agents: Synthesis, Multitargeted Evaluations, Molecular Docking Simulations and ADMET Pred... by Nahed Nasser Eid El-Sayed, Najeh Krayem, Hamed Ahmed Derbala, Shimaa Kamal, Syde Nasir Abbas Bukhari, Mohamed K. El-Ashrey, Zainab M. Almarhoon, Seham Soliman Alterary, Abir Ben Bacha

“…The underlying anticancer mechanism of the most active compound was investigated through analysis of cell cycle distribution, apoptosis induction, intracellular reactive oxygen species levels, mitochondrial membrane potential disruption, and expression levels of apoptosis-related genes. …”
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Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562 by Nehad M. El-Dydamony, Rana M. Abdelnaby, Rasha Abdelhady, Omaima Ali, Mohamed I. Fahmy, Rasha R. Fakhr Eldeen, Amira A. Helwa

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A Graphene-Based Lipid Modulation Nanoplatform for Synergetic Lipid Starvation/Chemo/Photothermal Therapy of Oral Squamous Cell Carcinoma by Li R, Li Y, Song Z, Gu Y, Jiao X, Wan C, Liu T, Zhang R, Gao R, Wang X

“…In this study, we developed a graphene-based lipid modulation nanoplatform (NSD) that carries SB-204990, a small molecule inhibitor specific for ATP citrate lyase (ACLY), and doxorubicin (DOX), a chemotherapeutic agent, and the trio enables synergistic treatment of OSCC with lipid starvation, chemotherapy, and photothermal therapy.Methods: We first determined whether ACLY expression was upregulated in OSCC, and then assessed the growth inhibitory effects of SB-204990 on SCC-15 cells and changes in lipid (acetyl coenzyme A, free fatty acids, and cholesterol) levels. …”
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Integrated Network Analysis to Identify Key Modules and Potential Hub Genes Involved in Bovine Respiratory Disease: A Systems Biology Approach by Aliakbar Hasankhani, Abolfazl Bahrami, Abolfazl Bahrami, Negin Sheybani, Farhang Fatehi, Roxana Abadeh, Hamid Ghaem Maghami Farahani, Mohammad Reza Bahreini Behzadi, Ghazaleh Javanmard, Sadegh Isapour, Hosein Khadem, Herman W. Barkema

“…After aggregation of gene coexpression networks based on the hub genes with PPI networks, a total of 307 hub–hub genes were identified in the eight candidate modules. Interestingly, most of these hub–hub genes were reported to play an important role in the immune response and BRD pathogenesis. …”
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Unlocking the therapeutic potential of Pelargonium sidoides natural extract: A scoping review by Bárbara Donadon Reina, Samuel Santana Malheiros, Sâmmea Martins Vieira, Paula Ferreira de Andrade, Lívia Nordi Dovigo

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Improvement of Polyethylene Glycol, Sorbitol, Mannitol, and Sucrose-Induced Osmotic Stress Tolerance through Modulation of the Polyamines, Proteins, and Superoxide Dismutase Activi... by Zahoor Ahmad Sajid, Faheem Aftab

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Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways by Mohammad Abdel-Halim, Dalia S. El-Gamil, Mennatallah A. Hammam, Mohamed El-Shazly, Yi-Hsuan Wang, Po-Hsiung Kung, Yu-Cheng Chen, Michal Korinek, Ashraf H. Abadi, Matthias Engel, Tsong-Long Hwang

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The Connection between the Toxicity of Anthracyclines and Their Ability to Modulate the P-Glycoprotein-Mediated Transport in A549, HepG2, and MCF-7 Cells by Aneta Rogalska, Marzena Szwed, Błażej Rychlik

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Licochalcone A selectively modulates mTORC1‐TFEB to enhance autophagy and demonstrates neuroprotective effects in a mouse model of Parkinson's disease by Sisi Wang, Ziyang Ding, Zhou Zhu, Xiaoru Zhong, Ashok Iyaswamy, Yaping Niu, Wei Zhang, Jichao Sun, Yulin Feng, Chuanbin Yang, Jigang Wang

“…Therefore, small molecules that selectively modulate the mTORC1‐TFEB pathway represent a novel and promising approach for treating PD. …”
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Emerging frontiers in epigenetic-targeted therapeutics for pediatric neuroblastoma by Xiaokang Wang, Gengrui Xu, Hongyan Ma, Xiaoyan Deng, Guiping Ma

“…Neuroblastoma (NB), the most prevalent extracranial solid malignancy in children, poses significant therapeutic challenges, particularly concerning high-risk subtypes characterized by an immunologically “cold” phenotype. …”
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Anti-staphylococcal activity, antibiotic-resistance modulation effects and action of Harungana madagascariensis (Hypericaceae) fruit extracts on the antioxidant system of multidrug... by Brenda Ngueffo Tiwa, Aimé Gabriel Fankam, Céline Brinda Sonfack, Richard Mouozong, Michael Francis Kengne, Armelle Tsafack Mbaveng, Victor Kuete

“…Moreover, the extracts were evaluated for their antibiotic-resistance modulation effects against some multidrug-resistant Staphylococcus aureus. …”
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Toward Fairer and More Accurate Real-Time Pedestrian Attribute Recognition for Enhanced Women’s Safety: A Domain-Adversarial Multi-Head Model With Agent-Based Reporting by M. Balaji, G. Anitha

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Comparative Analysis of Freeze-Dried <i>Pleurotus ostreatus</i> Mushroom Powders on Probiotic and Harmful Bacteria and Its Bioactive Compounds by Gréta Törős, Áron Béni, Ferenc Peles, Gabriella Gulyás, József Prokisch

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Identification, Detection, and Management of Soft Rot Disease of Ginger in the Eastern Himalayan Region of India by Utpal Dey, Shatabhisa Sarkar, Durga Prasad Awasthi, Mukesh Sehgal, Ravinder Kumar, Biman De, Nayan K. Adhikary, Abhijit Debnath, Rahul Kumar Tiwari, Milan Kumar Lal, Subhash Chander, Ph. Ranjit Sharma, Amulya Kumar Mohanty

“…Rhizome rot, also called soft rot, is one of the most devastating diseases found in ginger that causes yield losses of up to 100% under favourable conditions. …”
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