Thymoquinone Enhances Doxorubicin Efficacy via RAS/RAF Pathway Modulation in Ovarian Adenocarcinoma by Veysel Toprak, İlhan Özdemir, Şamil Öztürk, Orhan Yanar, Yusuf Ziya Kizildemir, Mehmet Cudi Tuncer

“…These findings suggest that thymoquinone exerts an-ti-proliferative and pro-apoptotic effects by modulating the RAS/RAF signaling cascade. Furthermore, the co-administration of thymoquinone with doxorubicin potentiated these effects, suggesting a synergistic interaction between the two agents. …”
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Lumateperone tosylate, A Selective and Concurrent Modulator of Serotonin, Dopamine, and Glutamate, in the Treatment of Schizophrenia by Kunal Maini, Janice W. Hollier, Haley Gould, Victoria Bollich, John LaForge, Elyse M. Cornett, Amber N. Edinoff, Adam M. Kaye, Alan D. Kaye

“…Lumateperone is a selective and concurrent modulator of serotonin, dopamine, and glutamate, which all mediate or modulate serious mental illness…”
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Simultaneous TGF-β and GITR pathway modulation promotes anti-tumor immunity in glioma by Daniela Lorizio, Manuela Silginer, Julia Friesen, Alan L. Epstein, Michael Weller, Patrick Roth

“…Combining GITR modulation with TGF-β inhibition amplified these effects, resulting in significantly stronger immune cell-mediated tumor cell killing compared to single-agent treatments. …”
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Evaluation of Dietary Bioactive Agents Against Aflatoxin B1 and Ochratoxin A-Induced Duodenal Toxicity in Rats by Sarra Rafai, Alessandra Cimbalo, Lara Manyes

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Synthesis and Antimicrobial Resistant Modulatory Activity of 2,4-Dinitrophenylhydrazone Derivatives as Agents against Some ESKAPE Human Pathogens by Alberta Ade, Cedric D. K. Amengor, Abena Brobbey, Isaac Ayensu, Benjamin K. Harley, Yaw Duah Boakye

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Modulation of Wnt/Beta-Catenin Pathway by Major Dietary Phytochemicals Against Breast Cancer Development by Noah Lieb, Annalisa Tran, Martha Torres, Ajay Bommareddy

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Modern ideas about the consequences of sympathoadrenal hyperactivation in hypertensive patients with metabolic disorders: modulation possibilities by Yu. V. Zhernakova

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Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR2 by Joanna Kosinska, Julian C Assmann, Julica Inderhees, Helge Müller-Fielitz, Kristian Händler, Sven Geisler, Axel Künstner, Hauke Busch, Anna Worthmann, Joerg Heeren, Christian D Sadik, Matthias Gunzer, Vincent Prévot, Ruben Nogueiras, Misa Hirose, Malte Spielmann, Stefan Offermanns, Nina Wettschureck, Markus Schwaninger

“…Monomethyl fumarate (MMF) and its prodrug dimethyl fumarate (DMF) are currently the most widely used agents for the treatment of multiple sclerosis (MS). …”
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Effectiveness of anabolic and anti-resorptive agents for preventing postmenopausal osteoporosis fractures: a systematic review and network meta-analysis by Peng Su, Maofu Li, Jian Xiao, Longbin Bai

“…Conclusions This study identified anti-sclerostin antibody as the most effective anabolic agent for rapid BMD gains and early fracture prevention, followed by anti-RANKL antibody as the most effective anti-resorptive agent for long-term maintenance. …”
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Timing of gene expression alters susceptibility to aflatoxicosis: a heterogeneous spectrum of disease in response to a single universal agent by Magd Ahmed Kotb, Nabil Mohamed Amr Lotfi, Ahmed Khaled Elhatw

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Tirzepatide mitigates Stroke-Induced Blood-Brain barrier disruption by modulating Claudin-1 and C/EBP-α pathways by Duozi Wang, Jianhong Wang, Binghu Li, Shu Yang, Fuqiang Guo, Bo Zheng, Jian Wang

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The pleiotropic effects of statins: a comprehensive exploration of neurovascular unit modulation and blood–brain barrier protection by Jia-Cheng Liu, Shuang-Yin Lei, Dian-Hui Zhang, Qian-Yan He, Ying-Ying Sun, Hong-Jing Zhu, Yang Qu, Sheng-Yu Zhou, Yi Yang, Chao Li, Zhen-Ni Guo

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HSP₇₀ Modulators for the Correction of Cognitive, Mnemonic, and Behavioral Disorders After Prenatal Hypoxia by Olena Aliyeva, Igor F. Belenichev, Ivan Bilai, Iryna Duiun, Lyudmyla Makyeyeva, Valentyn Oksenych, Oleksandr Kamyshnyi

“…Based on the results of this study, we identified the pharmacological agents Angiolin and Cerebrocurin as promising neuroprotective agents after perinatal hypoxia.…”
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ERBB3 influences the ferroptosis pathway via modulation of lipid peroxidation and GSH synthesis in gastric cancer by Robert Jenke, Theresa Heinrich, Florian Lordick, Achim Aigner

“…Abstract Gastric cancer remains one of the most lethal malignancies worldwide, with high relapse rates and limited survival for patients with advanced disease. …”
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Carrier-Free Silibinin/Sorafenib Microparticles Alleviate Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating Fatty Acid Metabolism by Han F, Wang H, Wang L, Fan L, Peng S, Hou X, Shu X, Sun B, Liu Y

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Controlled Modulation of Serum Protein Binding and Biodistribution of Asymmetric Cyanine Dyes by Variation of the Number of Sulfonate Groups by Franziska M. Hamann, Robert Brehm, Jutta Pauli, Markus Grabolle, Wilhelm Frank, Werner A. Kaiser, Dagmar Fischer, Ute Resch-Genger, Ingrid Hilger

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In vitro and in vivo characterization of oridonin analogs as anti-inflammatory agents that regulate the NF-κB and NLRP3 inflammasome axis by Huiping Ou, Huiping Ou, Zhanpan Wu, Jinhua Ning, Qiufeng Huang, Wancun Wang, Guochun Yang, Yingxun Zhou, Anguo Hou, Peng Li, Lingyun Chen, Wen Bin Jin

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Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial‐mesenchymal transition and modulating SIRT1/β‐catenin signaling pathway in breast cancer by Xiaoxia Jin, Yingze Wei, Yushan Liu, Xiaoyun Lu, Fei Ding, Jiatai Wang, Shuyun Yang

“…Doxorubicin (DOX) is one of the most commonly used chemotherapeutic agents against breast cancer, but acquired resistance to DOX can seriously impede the efficacy of chemotherapy, leading to poor prognosis and recurrences of cancer. …”
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Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways by Hnin Ei Ei Khine, Utid Suriya, Thanyada Rungrotmongkol, Supakarn Chamni, Yanxi Lu, Alan Bénard, Bin Lan, Debabrata Mukhopadhyay, David Chang, Andrew Biankin, Regine Schneider-Stock, Robert Grützmann, Rungroch Sungthong, Christian Pilarsky, Chatchai Chaotham

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Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways. by Ketaki Ganti, Paola Massimi, Joaquin Manzo-Merino, Vjekoslav Tomaić, David Pim, Martin P Playford, Marcela Lizano, Sally Roberts, Christian Kranjec, John Doorbar, Lawrence Banks

“…A subset of high-risk Human Papillomaviruses (HPVs) are the causative agents of a large number of human cancers, of which cervical is the most common. …”
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