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Reviewing the Etiologic Agents, Microbe-Host Relationship, Immune Response, Diagnosis, and Treatment in Chromoblastomycosis
Published 2021-01-01“…Few advances in treatment have been made so far, but one of the most promising ones is based on the use of immunomodulators, such as imiquimod. …”
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Molecular monitoring of short- and long-term transcriptional effects of hair growth stimulating agents.
Published 2024-01-01“…Differential expression analyses identified 52 differentially expressed genes and 17 modulated pathways following treatment with the three hair growth stimulating agents. …”
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Repurposed Antipsychotics as Potential Anticancer Agents: Clozapine Efficacy and Dopaminergic Pathways in Neuroblastoma and Glioblastoma
Published 2025-07-01“…These findings support further investigation into dopamine-targeting drugs as potential therapeutic agents in neuro-oncology.…”
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Phytochemicals as Chemo-Preventive and Therapeutic Agents Against Bladder Cancer: A Comprehensive Review
Published 2025-03-01Get full text
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GOLD(I)-BASED COMPLEX AUDMAP: A PROMISING ANTIPROLIFERATIVE AGENT FOR MELANOMA TREATMENT
Published 2025-05-01“…Introduction/Justification: Melanoma is the most aggressive type of skin cancer, with increasing global incidence. …”
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MMAgentRec, a personalized multi-modal recommendation agent with large language model
Published 2025-04-01Get full text
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Cystic fibrosis treatment; small molecule modulators vs genetic therapy
Published 2022-10-01“…Since the early 2010’s, the development of an actual therapy has reached great milestones including small molecule modulators and genetic therapy. Small molecule therapy depends on the development of small pharmacological agents that can bind to the mutated CFTR protein restoring its function. …”
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Computational discovery of novel aryl hydrocarbon receptor modulators for psoriasis therapy
Published 2025-06-01“…Among these, immune system modulation, as well as regulation of skin homeostasis and inflammation, make it a promising target for psoriasis therapy. …”
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How culture modulates anthropomorphism in Human-Robot Interaction: A review
Published 2025-05-01“…Anthropomorphism is the tendency to attribute human-like characteristics to nonhuman agents, including robots. In the context of Human-Robot Interaction (HRI) research, it is relevant to understand what factors are at play in modulating individuals' anthropomorphism towards robots. …”
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Cardioprotective effects of the estrogen receptors modulators in the conditions of experimental acute myocardial infarction
Published 2017-12-01“…All the drugs statistically significantly reduced oxidative stress marker products. The most marked effects were displayed by the selective estrogen receptors modulators toremifene and tamoxifen, which decreased in ST2 blood plasma level (by more than 46 %) providing realization of IL 33 cardioprotective properties. …”
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Gold and Silver Nanoparticles Efficiently Modulate the Crosstalk Between Macrophages and Cancer Cells
Published 2025-04-01“…Since it is fairly unknown how the promising anticancer agents, silver (AgNPs) and gold nanoparticles (AuNPs) affect the bidirectional communication and reprogramming in the tumor stroma, we examined the behavior, the tumor-supporting functions, and the expression of polarization and functional marker genes of TAMs to reveal how these are modulated upon interaction with nanoparticle-exposed cancer cells.Methods: We established co-cultures of murine immortalized J774 or primary bone marrow-derived macrophages with 4T1 breast cancer cells treated with AuNPs or AgNPs or with none of the nanoparticles. …”
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Novel pyran-based anti-inflammatory agents: design, synthesis, and mechanistic studies in LPS-stimulated macrophages
Published 2025-08-01“…Our results demonstrate that compound 19 is a promising candidate for the development of novel anti-inflammatory agents.…”
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Adaptation of Mycoplasmas to Fluoroquinolones: Modulation of Proteome and Genotoxicity of Extracellular Vesicles of Acholeplasma laidlawii
Published 2017-06-01“…It has been shown that a significant part of vesicular proteome of A. laidlawii strains with differential sensitivity to ciprofloxacin represents the bacterial virulence factors, as well as that the vesicles of all strains exhibit genotoxicity to lymphocytes of human peripheral blood in vitro. The most important of these results is the fact that the development of resistance of A. laidlawii to ciprofloxacin is accompanied by a significant modulation of vesicular proteome and the increase of mitotoxicity to eukaryotic cells. …”
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SCMAS: an IMU-based 6-DOF closed-loop permanent magnet actuation system for magnet agent
Published 2025-05-01Get full text
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Black Mulberry (Morus nigra L.): A Review of Attributes as an Anticancer Agent to Encourage Pharmaceutical Development
Published 2024-01-01“…Ethanol and methanol extraction methods appear to be the most effective in cancer management, offering compounds that facilitate the integration of apoptosis induction, cell growth inhibition, and cytotoxicity modulation. …”
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