Adjuvant combination and antigen multimerization shape neutralizing antibody and T cell responses to a SARS-CoV-2 RBD subunit vaccine by João Pedro da Silva Nunes, Mariângela de Oliveira Silva, Juliana de Souza Apostolico, Isabela Pazotti Daher, Rodolfo Ferreira Marques, Marcio Massao Yamamoto, Alexia Adrianne Venceslau Brito Carvalho, Maria Fernanda de Castro-Amarante, Edison Luiz Durigon, Carsten Wrenger, Luiz Mario Ramos Janini, Edmarcia Elisa de Souza, Robert Andreata-Santos, Juliana Terzi Maricato, Edecio Cunha-Neto, Edecio Cunha-Neto, Edecio Cunha-Neto, Jorge Kalil, Jorge Kalil, Silvia Beatriz Boscardin, Silvia Beatriz Boscardin, Daniela Santoro Rosa, Daniela Santoro Rosa

“…Additionally, RBD-trimer immunization more efficiently inhibited viral replication in the lungs of mice challenged with the ancestral Wuhan strain compared to the monomer. …”
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Differences in risk factors between all-cause and pulmonary embolism-related death in acute pulmonary embolism: insights from the COMMAND VTE registry-2 by Soichiro Kobayashi, Yoshito Ogihara, Yugo Yamashita, Takeshi Morimoto, Ryuki Chatani, Kazuhisa Kaneda, Yuji Nishimoto, Nobutaka Ikeda, Yohei Kobayashi, Satoshi Ikeda, Kitae Kim, Moriaki Inoko, Toru Takase, Shuhei Tsuji, Maki Oi, Takuma Takada, Kazunori Otsui, Jiro Sakamoto, Takeshi Inoue, Shunsuke Usami, Po-Min Chen, Kiyonori Togi, Norimichi Koitabashi, Seiichi Hiramori, Kosuke Doi, Hiroshi Mabuchi, Yoshiaki Tsuyuki, Koichiro Murata, Kensuke Takabayashi, Hisato Nakai, Daisuke Sueta, Wataru Shioyama, Tomohiro Dohke, Toru Sato, Ryusuke Nishikawa, Takeshi Kimura, Kaoru Dohi

“…Background: Accurate risk prediction of early mortality, particularly pulmonary embolism (PE)-related death, in patients with acute PE has become more important for selecting optimal management strategies. …”
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Clinical performance evaluation of the SiJoy GS1 continuous glucose monitor during oral glucose tolerance testing in healthy adults by Wanyi Zhao, Wanyi Zhao, Wanyi Zhao, Wanyi Zhao, Wanyi Zhao, Dongmei Zheng, Dongmei Zheng, Dongmei Zheng, Dongmei Zheng, Dongmei Zheng, Xianbao Shi, Feng Xu, Feng Xu, Lin Chen, Lin Chen, Xingmei Liu, Xingmei Liu, Xingmei Liu, Xingmei Liu, Xiaolong Jin, Xiaolong Jin, Qingbo Guan, Qingbo Guan, Qingbo Guan, Qingbo Guan, Qingbo Guan, Chao Xu, Chao Xu, Chao Xu, Chao Xu, Chao Xu

“…The latter approach was more suitable due to the less variability in the timing of glucose peaks during the OGTT.ConclusionsIn the study, the SiJoy GS1 sensor exhibited consistent performance. …”
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The Journey to Advanced Clinical Pharmacy Practice: Global Collaboration Will Accelerate the Pace by Paul W. Bush

“…</p><p>It was defined as the direct, responsible provision of medication-related care for the purpose of achieving definite outcomes that improve a patient’s quality of life.  In 1993, more than 200 participants met in San Antonio at the ASHP Conference on Implementing Pharmaceutical Care. …”
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Dissecting the link between PD-1/PD-L1-based immunotherapy and cancer pain: mechanisms, research implications, and artificial intelligence perspectives by Marco Cascella, Brigida Miranda, Carmen Gagliardi, Lucia Santaniello, Milena Mottola, Alida Mancusi, Laura Ferrara, Federica Monaco, Francesca Gargano, Francesco Perri, Alessandro Ottaiano, Maurizio Capuozzo, Ornella Piazza, Stefano Pepe, Anna Crispo, Agostino Guida, Giovanni Salzano, Giustino Varrassi, Luigi Liguori, Francesco Sabbatino, The TRIAL Group

“…Cancer-related pain represents one of the most common complaints of cancer patients especially for those with advanced-stage of disease and/or bone metastases. More effective therapeutic strategies are needed not only to improve the survival of cancer patients but also to relieve cancer-related pain. …”
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Initial experience in implementing quantitative DCE-MRI to predict breast cancer therapy response in a multi-center and multi-vendor platform setting by Brendan Moloney, Xin Li, Michael Hirano, Assim Saad Eddin, Jeong Youn Lim, Debosmita Biswas, Anum S. Kazerouni, Alina Tudorica, Isabella Li, Mary Lynn Bryant, Courtney Wille, Chelsea Pyle, Habib Rahbar, Habib Rahbar, Su Kim Hsieh, Travis L. Rice-Stitt, Suzanne M. Dintzis, Suzanne M. Dintzis, Amani Bashir, Amani Bashir, Evthokia Hobbs, Alexandra Zimmer, Jennifer M. Specht, Jennifer M. Specht, Sneha Phadke, Sneha Phadke, Nicole Fleege, Nicole Fleege, James H. Holmes, James H. Holmes, Savannah C. Partridge, Savannah C. Partridge, Wei Huang

“…Voxel-based PK analysis using fixed R1,0 was deemed the optimal approach, which allowed the inclusion of data from one vendor platform where VFA measurements produced ≥100% overestimation of R1,0. …”
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Comprehensive analysis of culture-negative periprosthetic joint infection with metagenomic next-generation sequencing by Lan Lin, Lan Lin, Lan Lin, Jiayu Li, Jiayu Li, Jiayu Li, Canhong Zhang, Juncheng Li, Juncheng Li, Juncheng Li, Baijian Wu, Baijian Wu, Baijian Wu, Zida Huang, Zida Huang, Zida Huang, Jianhua Lv, Mingzhong Liu, Wenbo Li, Wenbo Li, Wenbo Li, Wenming Zhang, Wenming Zhang, Wenming Zhang, Xinyu Fang, Xinyu Fang, Xinyu Fang

“…With advancements in sample collection, optimized culture methods, molecular diagnostic tools, and early targeted therapies, CN PJI may achieve clinical outcomes comparable to CP PJI.…”
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Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular... by Louis Bherer, Louis Bherer, Louis Bherer, Tudor Vrinceanu, Emma Gabrielle Dupuy, Emma Gabrielle Dupuy, Mathieu Gayda, Thomas Vincent, Pierre-Olivier Magnan, Pierre-Olivier Magnan, Hanieh Mohammadi, Claudine Gauthier, Claudine Gauthier, Christine Gagnon, Simon Duchesne, Kirk I. Erickson, Daniel Gagnon, Frédéric Lesage, Sonia Lupien, Judes Poirier, Marie-Pierre Dubé, Éric Thorin, Martin Juneau, Juliana Breton, Sylvie Belleville, Sylvie Belleville, Guylaine Ferland, Guylaine Ferland, Flavie Gaudreau-Majeau, Flavie Gaudreau-Majeau, Caroll-Ann Blanchette, Caroll-Ann Blanchette, Paolo Vitali, Anil Nigam, Anil Nigam

“…Meta-analyses suggest that longer intervention studies of around 1 year are more likely to show cognitive improvements and changes in brain biomarkers. …”
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Canadian multidisciplinary expert consensus on the use of biologics in upper airways: a Delphi study by Andrew V. Thamboo, Melissa Lee, Mohit Bhutani, Charles Chan, Yvonne Chan, Ken R. Chapman, Christopher J. Chin, Lori Connors, Del Dorscheid, Anne K. Ellis, Richard M. Gall, Krystelle Godbout, Arif Janjua, Amin Javer, Shaun Kilty, Harold Kim, Gordon Kirkpatrick, John M. Lee, Richard Leigh, Catherine Lemiere, Eric Monteiro, Helen Neighbour, Paul K. Keith, George Philteos, Jaclyn Quirt, Brian Rotenberg, Juan C. Ruiz, John R. Scott, Doron D. Sommer, Leigh Sowerby, Marc Tewfik, Susan Waserman, Ian Witterick, Erin D. Wright, Cory Yamashita, Martin Desrosiers

“…With the overlap between upper and lower airway disease, optimal management of the upper airways is undertaken in conjunction with that of the lower airways. …”
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A study of the safety and immunogenicity of a new vaccine for the prevention of COVID-19 based on virus-like particles in phase I clinical trials by Tatiana V. Grebennikova, Olga N. Zaykova, Alexey A. Plotnikov, Lyudmila V. Kostina, Yana Yu. Chernoryzh, Olesia V. Eliseeva, Oleg E. Latyshev, Viktor F. Larichev, Irina T. Fedyakina, Milana A. Losich, Ilya M. Kirillov, Ilya E. Filatov, Marina V. Balandina, Valery V. Tsibezov, Kirill I. Yurlov, Ekaterina I. Lesnova, Valeria M. Kondratieva, Alina A. Kozlova, Marina S. Baranets, Aleksandr L. Gintsburg

“…Introduction. One of the more promising developments in preventing the spread of infections, including COVID-19, is the production of vaccines based on virus-like particles (VLP). …”
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Real-world practices of low-molecular-weight heparin for venous thromboembolism prophylaxis in patients hospitalized with COVID-19: a multicenter prospective study from China by Feiya Xu, Yuzhi Tao, Lijun Chen, Yunhui Zhang, Binliang Wang, Jing Han, Chaosheng Deng, Weijia Liu, Guohui Fan, Rui Liang, Zhaofei Chen, Yinong Chen, Kaiyuan Zhen, Yunxia Zhang, Zhu Zhang, Shuai Zhang, Jun Wan, Wanmu Xie, Peiran Yang, YuTing Kang, Dingyi Wang, Chen Wang, Zhenguo Zhai

“…Despite guidelines recommending prophylactic anticoagulation, particularly for those in intensive care, real-world adherence and optimal venous thromboembolism (VTE) prevention strategies remain challenging, particularly in populations with complex comorbidities. …”
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Mixed-methods, descriptive and observational cohort study examining feeding and growth patterns among low birthweight infants in India, Malawi and Tanzania: the LIFE study protocol by Christopher R Sudfeld, Karim Manji, Rodrick Kisenge, Tisungane Mvalo, Melda Phiri, Christopher Duggan, Lauren Spigel, Anne CC Lee, Bethany A Caruso, Laura Subramanian, Megan Marx Delaney, Shivaprasad S Goudar, Linda Vesel, Katherine EA Semrau, Irving F Hoffman, Melissa Young, Friday Saidi, Jnanindra Nath Behera, Roopa M Bellad, Leena Das, Sangappa Dhaded, Gowdar Guruprasad, Sujata Misra, Sanghamitra Panda, Latha G Shamanur, Sunil S Vernekar, Sarah Somji, Linda Adair, Kiersten Israel-Ballard, Stephanie L Martin, Kimberly L Mansen, Krysten North, Emily Benotti, Eliza Fishman, Katelyn Fleming, Natalie Henrich, Kate Miller, Danielle E Tuller

“…The majority of LBW infants are born in low- and middle-income countries (LMICs) and account for more than 60%–80% of newborn deaths. Feeding promotion tailored to meet the nutritional needs of LBW infants in LMICs may serve a crucial role in curbing newborn mortality rates and promoting growth. …”
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Clinical Presentation and Long‐Term Survival Outcomes of Patients With Monoclonal Gammopathy of Renal Significance (MGRS): A Multicenter Retrospective Study by K. Mancuso, R. Mina, S. Rocchi, E. Antonioli, M. T. Petrucci, F. Fazio, A. Gozzetti, M. Salvini, C. S. Cartia, G. Bertuglia, F. Patriarca, A. B. Dalla Palma, S. Barbato, G. De Cicco, F. Bigi, E. Favero, P. Tacchetti, L. Pantani, I. Rizzello, M. Puppi, M. Talarico, V. Solli, A. Kanapari, M. Cavo, E. Zamagni

“…ABSTRACT Introduction MGRS are new rare clinical entities, whose recognition and optimal management is evolving. Methods To implement real‐life data, we retrospectively analysed a multicentre cohort of 60 patients with renal biopsy‐proven MGRS receiving mainly novel treatments (between 2006 and 2021) in eight Italian centres. …”
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Outpatient Virtual Care Among People Living With and Beyond Cancer From Culturally and Linguistically Diverse Backgrounds in Australia: A Protocol for a Realist Evaluation by Prince Peprah, Sagda Osman, Rebecca Mitchell, Ashfaq Chauhan, Ramya Walsan, Maryam Sina, Bronwyn Newman, Nadine El‐Kabbout, Jan Mumford, Emilie Francis‐Auton, Elizabeth Manias, Virginia Mumford, Kate Churruca, Michelle Moscova, Natalie Taylor, Craig Nelson, Alexander Cardenas, Robyn Clay‐Williams, Jeffrey Braithwaite, Reema Harrison

“…Discussion Knowledge of the contexts and mechanisms that produce optimal outcomes from virtual care is essential to guide the design, adjustment and implementation of virtual care models that provide equitable care outcomes for all patients. …”
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Balancing the benefits and risks of colchicine use among patients with atherosclerotic cardiovascular disease: an umbrella review of meta-analyses of randomised controlled trialsRe... by Rui-Han Bao, Na Zhao, Xiao-Feng Jiang, Zi-Han Cong, Jun Liu, Long-Dan Kang, Yu-Han Chen, Jia-Nan Sun, Wei-Yi Xing, Jia-Xin Liu, Xue-Li Bai, Hai-Chen Lv, Jing-Ying Zhao, Qi-Peng Ma, Ting-Ting Gong, Qi-Jun Wu

“…Subgroup analyses indicated that optimal clinical application required consideration of patient age, geographic variance in pharmacogenomics, and protocol adjustments (recommended dose ≤0.5 mg/day for more than a month) to balance efficacy–risk profiles. …”
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The Influence of Edaphic and Climatic Factors on the Morphophysiological Behavior of Young Argan Plants Cultivated in Orchards: A Comparative Analysis of Three Regions in Southwest... by Fatima Ezzahra Tiouidji, Assma Oumasst, Salma Tabi, Naima Chabbi, Abdelaziz Mimouni, Meriyem Koufan, Naima Ait Aabd, Abdelghani Tahiri, Youssef Karra, Jamal Hallam, Redouan Qessaoui, Rachid Bouharroud, Fouad Elame, Nadya Wahid, Ahmed Wifaya

“…This contributes to the development of more effective domestication strategies and the restoration of agroecosystems. …”
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An integrated inventory of One Health tools: Mapping and analysis of globally available tools to advance One Health by Casey Barton Behravesh, Dominique F. Charron, Amanda Liew, Natalia Cediel Becerra, Catherine Machalaba, David T.S. Hayman, Janice R. Ciacci Zanella, Elmoubasher Farag, Abhishek Chaudhary, Hayley Belles, Wiku B. Adisasmito, Salama Almuhairi, Pépé Bilivogui, Salome A. Bukachi, Natalia Casas, Andrew A. Cunningham, Nitish Debnath, Osman Dar, Baptiste Dungu, George F. Gao, Margaret Khaitsa, Marion P.G. Koopmans, John S. Mackenzie, Serge Morand, Vyacheslav Smolenskiy, Lei Zhou, Wanda Markotter, Thomas C. Mettenleiter

“…Tools were available to support all three TOC outcome pathways, and many addressed more than one Action Track and TOC outcome pathway. …”
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Unveiling neurogenic biomarkers for the differentiation between sepsis patients with or without encephalopathy: an updated meta-analysis by Jiyun Hu, Wenchao Li, Shucai Xie, Ya Liao, Tao Chen, Xinrun Wang, Weiping Xia, Fang Huang, Zhaoxin Qian, Lina Zhang

“…Accurate diagnosis of SAE is crucial for the timely initiation of optimal treatment and appropriate patient management. …”
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Experience with the use of cladribine tablets in real-life clinical practice: independent analysis of data from 12 Russian clinical centres by A. N. Boyko, V. M. Alifirova, D. V. Pashkovskaya, E. I. Kuchina, S. A. Sivertseva, E. L. Turova, Z. A. Goncharova, O. Yu. Rudenko, Yu. Yu. Pogrebnova, F. A. Khabirov, T. I. Khaibullin, N. N. Babicheva, N. L. Khoroshilova, O. V. Dzundza, O. A. Soldatova, A. N. Belova, G. Е. Sheiko, A. Е. Makarova, N. G. Glavinskaya

“…In this respect, such a switch does not appear to be optimal, in contrast to cases where first-line drugs are switched to cladribine.…”
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Compartmentalization of High Infratemporal Fossa in Oral Cavity Squamous Cell Carcinomas and Its Impact on Clinical Outcome by Abhishek Mahajan, Ujjwal Agarwal, Renuka M. Ashtekar, Nivedita Chakrabarty, Richa Vaish, Vijay Maruti Patil, Vanita Noronha, Nandini Menon, Vasundhara Smriti, Jai Prakash Agarwal, Sarbani Ghosh-Laskar, Anil K. D’Cruz, Pankaj Chaturvedi, Prathamesh Pai, Asawari Patil, Munita Bal, Swapnil Rane, Neha Mittal, Kumar Prabhash

“…Notably, infranotch disease has a more favorable prognosis compared to supranotch disease. …”
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