Novel Approach to Proficiency Testing Reveals Significant Variations in Biomarker Practice Leading to Critical Differences in Lung Cancer Management by Kassandra R. Bisson, MHSc, Andrea Beharry, MLT, Normand Blais, MD, Michael D. Carter, MD, PhD, Parneet K. Cheema, MD, Patrice Desmeules, MD, John G. Garratt, RT, Barbara Melosky, MD, Bryan Lo, PhD, Stephanie Snow, MD, Basile Tessier-Cloutier, MD, Edwin Tio, MD, Stephen Yip, MD, PhD, Jennifer R. Won, PhD, Brandon S. Sheffield, MD

“…Four laboratories (31%) reported the results of their biomarkers after more than 30 days.Only three laboratories received optimal status (23%). …”
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International Consensus on Evidence Gaps and Research Opportunities in Extracorporeal Cardiopulmonary Resuscitation for Refractory Out‐of‐Hospital Cardiac Arrest: A Report From the... by Laurie J. Morrison, Elizabeth A. Hunt, Brian Grunau, Thomas P. Aufderheide, Clifton Callaway, Joseph E. Tonna, Comilla Sasson, Audrey Blewer, Bryan F. McNally, Demetris Yannopoulos, Jan Belohlavek, Jason Bartos, Alain Combes, Ahamed Idris, Raina M. Merchant, Leith States, Emily Tinsley, Renee Wong, Scott T. Youngquist, George Sopko, Karl B. Kern

“…The increased accessibility of extracorporeal membrane oxygenation following the COVID‐19 pandemic and the publication of the first randomized trial of extracorporeal cardiopulmonary resuscitation (ECPR) prompted the National Heart, Lung, and Blood Institute to sponsor a workshop on ECPR. Two more randomized trials have since been published in 2022 and 2023. …”
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Efficient removal of cadmium (II) and arsenic (III) from water by nano-zero-valent iron modified biochar-zeolite composite by Mengyuan Wu, Lijuan Wu, Wen Zhang, Xianbao Zhong, Runfeng Guo, Ziying Cui, Yajun Yang, Jialong Lv

“…The influence of pH on removal efficiency was more pronounced than that of temperature, with nZVI-BCZo exhibiting a higher affinity for As(III) compared to Cd(II). …”
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The sensitivity of aerosol data assimilation to vertical profiles: case study of dust storm assimilation with LOTOS-EUROS v2.2 by M. Pang, M. Pang, J. Jin, T. Yang, X. Chen, A. Segers, B. Buyantogtokh, Y. Gu, J. Li, H. X. Lin, H. X. Lin, H. Liao, W. Han

“…Our findings reveal that the assimilation of ground observations would optimize the dust field at the ground in general. However, the vertical structure presents a more complex challenge. …”
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Development and validation of a genetic probability for venous thromboembolism by Zhuqing Shi, Ashley J. Mulford, Huy Tran, Michal Filipczak, Song Gao, Stevie Xie, Jason Lobel, Jun Wei, Andrew S. Rifkin, Annabelle Ashworth, Siqun Lilly Zheng, Clay Wiske, David Duggan, Brian T. Helfand, Arman Qamar, Alan R. Sanders, Alfonso J. Tafur, Jianfeng Xu

“…Objectives: This study aimed to develop an optimized risk-assessment tool combining mutations and PGS for diverse ancestry populations. …”
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Comparative and synergistic impacts of lime and biochar on soil properties, nitrogen transformation, and microbial function in acidic soils under tobacco cropping by Bianhong Zhang, Lina Tang, Zhicheng Chen, Xiaoyan Chen, Lindong You, Ruixin Pan, Ting Chen, Yifei Liu, Wenxiong Lin, Wenxiong Lin, Jinwen Huang

“…This study offers valuable insights into the synergistic use of lime and biochar for mitigating soil acidification and optimizing nitrogen management in agricultural systems.…”
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Lack of IFN-γ response of human uterine myometrium-derived MSCs significantly improve multiple IBD parameters compared to bone marrow MSCs: Implications for anti-TNFα-refractory pa... by Li-Tzu Wang, Hsiu-Huan Wang, Shih-Sheng Jiang, Chia-Chih Chang, Pei-Ju Hsu, Ko-Jiunn Liu, Huey-Kang Sytwu, B. Linju Yen, Men-Luh Yen

“…Our findings also highlight that understanding MSC source-specific therapeutic mechanisms is crucial for optimizing clinical therapies.…”
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Empirical Models for Estimating Draught and Vertical Reaction Forces of a Duckfoot Tool in Compacted Soil: Effects of Moisture Content, Depth, Width, and Speed by Aleksander Lisowski, Daniel Lauryn, Tomasz Nowakowski, Jacek Klonowski, Adam Świętochowski, Michał Sypuła, Jarosław Chlebowski, Jan Kamiński, Krzysztof Kostyra, Magdalena Dąbrowska, Adam Strużyk, Leszek Mieszkalski, Mateusz Stasiak

“…The developed models have a generalisable value in the analysed ranges, and further research should focus on creating more universal, theoretical models of soil–tool interactions.…”
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Antioxidant functionalized double-net/TA dynamic hydrogel promotes cartilage regeneration through stabilization of chondrocyte phenotype by Xu Wu, Honglei Wang, Chenlong Li, Yaying Zhu, Qixuan Wang, Tianyu Zhang, Yaoyao Fu, Aijuan He

“…These findings offer novel insights for optimizing cartilage tissue engineering strategies through metabolic modulation.…”
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Early Forest Fire Detection With UAV Image Fusion: A Novel Deep Learning Method Using Visible and Infrared Sensors by Kunlong Niu, Chongyang Wang, Jianhui Xu, Jianrong Liang, Xia Zhou, Kaixiang Wen, Minjian Lu, Chuanxun Yang

“…This research contributes to multisource image fusion for forest fire detection, providing a more accurate and reliable early warning tool and laying the foundation for future work in this field.…”
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Standardization and validation of a novel reverse transcriptase polymerase chain reaction method for detecting virulent strains of the infectious bursal disease virus by Vladimir Longa-Bobadilla, Phillip Ormeño-Vásquez, Manuel Criollo-Orozco, Luis Tataje-Lavanda, Katherine Huamán-Gutierrez, Ángela Montalván, Mirko Zimic, Manolo Fernández-Sanchez, Manolo Fernández-Díaz

“…Results: After determining the optimal RT-PCR conditions, the newly designed primers successfully amplified a 402-bp consensus sequence of the VP5 gene. …”
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Insights from metagenomics on microbial biosynthesis of vitamins B and K2 in chicken gut microbiota by Hai-Long Yu, Hai-Long Yu, Xin-Wen Hou, Ji-Xin Zhao, Guo-Hua Liu, Jin-Xin Meng, Jin-Xin Meng, Yong-Jie Wei, Yanan Cai, Jian Liu, Kai-Meng Shang, Hong-Bo Ni, Rui Liu, He Ma, Fu-Long Nan, Xiao-Xuan Zhang, Bei-Ni Chen, Xing Yang

“…Genomic analysis revealed that a mere 8.2% of genomes were capable of producing five or more vitamins, while almost half were limited to synthesizing just one. …”
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Comparison of two genetic strategies for diagnostic work-up of hypertrophic cardiomyopathy: impact on the diagnosis of Fabry disease or transthyretin amyloidosis by Aurélien Palmyre, Fairouz Koraichi, Flavie Ader, Erwan Donal, Céline Bordet, Pascal de Groote, Laurence Faivre, Patricia Reant, Annick Toutain, Karine Nguyen, Bertrand Isidor, Anne-Claire Brehin, Lise Legrand, Estelle Gandjbakhch, Julie Proukhnitzky, Richard Isnard, Nicolas Mansencal, Jean-François Pruny, Jean-Pierre Rabes, Bruno Francou, Catherine Caillaud, Pascale Richard, Philippe Charron

“…Abstract Background Diagnostic work-up of patients with hypertrophic cardiomyopathy is crucial for appropriate management. However, the optimal genetic strategy remains debatable. We compared two strategies: targeted testing based on careful examination of clinical red flags versus large multigene panel analysis without gene prioritization. …”
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Spatiotemporal evolution of time-lagged vegetation responses to moisture conditions and the influencing factors in a highly human-impacted area in China by Yuxing Yan, Guoqiang Wang, Yinglan A, Xiaojing Zhang, Baolin Xue, Jin Wu, Yuntao Wang

“…The results revealed that TSd significantly increased in the study area between 1982 and 2021 (0.338 months yr−1), suggesting that vegetation was more susceptible to prolonged moisture conditions. …”
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Prevalence and correlates of depression and anxiety in caregivers of children with attention-deficit/hyperactivity disorder during the fifth wave of COVID-19 and school closure in... by Samson Chun Hung, Anson Kai Chun Chau, Janet Hiu-Ching Lei, Eric Tsz-Him Lai, Gabbie Hou-Sem Wong, Iris Ka-Yan Leung, Wing-Chung Chang, Chung Ho, Brian Man-Ho Leung, Wilfred Shone-Horn Wong, Joe Kwun-Nam Chan, Krystal Chi-Kei Lee, Calvin Pak-Wing Cheng, Wai-Chi Chan, Corine Sau-Man Wong, Gloria Hoi-Kei Chan, Patrick Wing-Leung Leung, Zoe Hoi-Shuen Yu

“…Multivariate regression analyses revealed that caregivers’ pre-existing mental disorder, greater COVID-19 stressor burden, and more severe emotional symptoms and insomnia of ADHD children were independently associated with both caregivers’ depression and anxiety status. …”
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A glyco-engineering approach for site-specific conjugation to Fab glycans by Maria L. Jaramillo, Traian Sulea, Yves Durocher, Mauro Acchione, Melissa J. Schur, Anna Robotham, John F. Kelly, Marie-France Goneau, Alma Robert, Yuneivy Cepero-Donates, Michel Gilbert

“…Effective processes for synthesizing antibody-drug conjugates (ADCs) require: 1) site-specific incorporation of the payload to avoid interference with binding to the target epitope, 2) optimal drug/antibody ratio to achieve sufficient potency while avoiding aggregation or solubility problems, and 3) a homogeneous product to facilitate approval by regulatory agencies. …”
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Impact of Long-Acting Somatostatin Analogues on Glucose Metabolism in Acromegaly: A Hospital-Based Study by Ming Shen, Meng Wang, Wenqiang He, Min He, Nidan Qiao, Zengyi Ma, Zhao Ye, Qilin Zhang, Yichao Zhang, Yeping Yang, Yanjiao Cai, Yakupujiang ABuDuoReYiMu, Yun Lu, Bin Lu, Xuefei Shou, Yongfei Wang, Hongying Ye, Yiming Li, Shiqi Li, Yao Zhao, Xiaoyun Cao, Zhaoyun Zhang

“…Receiver-operating characteristic (ROC) curves were generated to determine the optimal cutoffs to predict the impact of SSA on glucose metabolism. …”
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How sustainable are hypocaloric and balanced diets for weight loss? by Ramona De Amicis, Andrea Foppiani, Alessandro Leone, Federica Sileo, Francesca Menichetti, Sara Paola Mambrini, Marta Pellizzari, Massimiliano Tucci, Daniela Martini, Cristian Del Bo, Patrizia Riso, Simona Bertoli, Alberto Battezzati

“…Complex carbohydrates-rich foods (13% bread, 12% pasta/cereals) and vegetables (21%) were prescribed in higher quantities in hypocaloric diets, being more aligned with the EAT-IT pattern. Conclusions Protein sources, being less sustainable, pose challenges in hypocaloric diets. …”
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MRI guided online adaptive radiotherapy and the dosimetric impact of inter- and intrafractional motion in patients with cervical cancer by Shouliang Ding, Zun Piao, Meining Chen, Fanghua Li, Yongbao Li, Biaoshui Liu, Hongdong Liu, Xiaoyan Huang, Junyun Li

“…The non-ART plans and online adaptive plans were obtained by recalculating or re-optimizing from reference plans on daily MRI, respectively. …”
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Comparing PET/MRI with PET/CT for Pretreatment Staging of Gastric Cancer by Yi Liu, Dong Zheng, Jia-jin Liu, Jian-xin Cui, Hong-qing Xi, Ke-cheng Zhang, Xiao-hui Huang, Bo Wei, Xin-xin Wang, Bai-xuan Xu, Ke Li, Yun-he Gao, Wen-quan Liang, Jia-he Tian, Lin Chen

“…SUVmax/ADC positively correlated with tumor volume and Ki-67. PET/MRI performs more accurately in TNM staging compared with PET/CT and is optimal for accurate N staging. …”
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