A novel glycogene-related signature for prognostic prediction and immune microenvironment assessment in kidney renal clear cell carcinoma by Xuyan Zhao, Hanxiao Cui, Mingjing Zhou, Xueting Ren, Zihao Li, Peinan Liu, Danni Zhao, Shuai Lin, Huafeng Kang

“…Consensus clustering, Cox regression, and LASSO regression analyses were conducted to develop an optimal glycogene-related signature. The prognostic relevance of this molecular signature was rigorously analyzed, along with its connections to tumour microenvironment (TME), tumour mutation burden, immune checkpoint activity, cancer-immunity cycle regulation, immunomodulatory gene expression patterns, and therapeutic response profiles. …”
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Adaption of the Memorial Sloan Kettering Cancer Center Nomograms for the Prediction of Prostate Cancer–specific Death in Sweden: A Population-based Cohort Study by Renata Zelic, Marcus Westerberg, Pär Stattin, Hans Garmo, Lorenzo Richiardi, Olof Akre, Andreas Pettersson

“…Both the preoperative and the postoperative model showed high discrimination for prostate cancer–specific death (optimism-corrected C-index: 0.81 and 0.87, respectively), but not for other-cause mortality (0.67, both models). …”
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Potential of Natural Sheep Casings Waste as a Sole Nitrogen Source for the Marine Microalga <i>Scenedesmus rubescens</i> MDP19 Growth and Lipid Production by Sanaa Ouzakar, Nadia Skali Senhaji, Francesca Rigano, Cinzia Cafarella, Francesco Cacciola, Luigi Mondello, Jamal Abrini

“…This approach not only offers a sustainable and economical alternative for optimizing microalgae cultivation but also contributes to the valorization of organic waste, thus supporting more ecological and responsible practices.…”
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Insights in biomarkers complexity and routine clinical practice for the diagnosis of thyroid nodules and cancer by Maria de Lurdes Godinho de Matos, Mafalda Pinto, Ana Gonçalves, Sule Canberk, Maria João Martins Bugalho, Paula Soares

“…Conclusions The knowledge of genetic and molecular biomarkers has achieved a high level of complexity, and the difficulties related to its applicability determine that their implementation in clinical practice is not yet a reality. More studies with larger series are needed to optimize their use in routine practice. …”
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Detection of mpox and other orthopoxviruses using a lateral flow device as a point-of-care diagnostic by Stephen M. Laidlaw, David Ulaeto, Steve Lonsdale, Graeme Clark, Rebecca Sumner, Thomas Edwards, Emily Adams, Anne-Sophie Logist, Bram Van Holm, Carlos Maluquer de Motes, Peter Horby, Piet Maes, Miles W. Carroll

“…As MPXV clade II remains circulating worldwide, a new outbreak of the more fatal clade I disease has been declared in Central and East Africa, and remains uncontrolled in part due to the lack of point-of-care (POC) diagnostics for rapid decisions on treatment and self-isolation. …”
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Optimising AVATAR therapy for people who hear distressing voices: study protocol for the AVATAR2 multi-centre randomised controlled trial by Philippa Garety, Clementine J. Edwards, Thomas Ward, Richard Emsley, Mark Huckvale, Paul McCrone, Mar Rus-Calafell, Miriam Fornells-Ambrojo, Andrew Gumley, Gillian Haddock, Sandra Bucci, Hamish McLeod, Amy Hardy, Emmanuelle Peters, Inez Myin-Germeys, Thomas Craig

“…Discussion This study will clarify optimal therapy delivery, test efficacy in a multi-site study and enable the testing of the AVATAR software platform, therapy training and provision in NHS settings. …”
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Association Between Fentanyl Use and Post-Intubation Mean Arterial Pressure During Rapid Sequence Intubation: Prospective Observational Study by Abdullah Bakhsh, Ahmad Bakhribah, Raghad Alshehri, Nada Alghazzawi, Jehan Alsubhi, Ebtesam Redwan, Yasmin Nour, Ahmed Nashar, Elmoiz Babekir, Mohamed Azzam

“…Medication choice for RSI may either optimize or deoptimize hemodynamic parameters, thereby impacting patient outcomes. …”
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Association between Alzheimer's disease pathologic products and age and a pathologic product-based diagnostic model for Alzheimer's disease by Weizhe Zhen, Yu Wang, Hongjun Zhen, Weihe Zhang, Wen Shao, Yu Sun, Yanan Qiao, Shuhong Jia, Zhi Zhou, Yuye Wang, Leian Chen, Jiali Zhang, Dantao Peng, Dantao Peng

“…BackgroundAlzheimer's disease (AD) has a major negative impact on people's quality of life, life, and health. More research is needed to determine the relationship between age and the pathologic products associated with AD. …”
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Improvement of accuracy and diagnostic significance of breast tumor fine-needle aspiration biopsy by miRNA analysis of material isolated from cytological smears by N. N. Kolesnikov, S. E. Titov, Yu. A. Veryaskina, A. V. Vladimirova, R. B. Samsonov, A. S. Artem’eva, V. I. Novik, L. M. Bershteyn, I. F. Zhimulev, A. V. Malek

“…A possibility to use biopsy material for farther analysis of tumor-markers would open a perspective to obtain more information and to improve objectivity of traditional diagnostic approaches, including FNAB. …”
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Distinct infectivity and neutralization antibody responses in the highly homologous AAV Go.1 and AAV5 by Mei Li, Haixiao Ma, Yang Wu, Yunling Gao, Jie Wang, Jie Wang, Hanbing Wang

“…A study involving 20 healthy volunteers revealed that high-titer neutralizing antibodies had a more pronounced inhibitory effect on rAAV5 compared to rAAV Go.1. …”
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Incidence and risk factors of post-transplant diabetes mellitus among kidney transplant recipients: a retrospective study from a tertiary center in Saudi Arabia by Mutlaq Alotaibi, Najlaa Almalki, Manal E. Alotaibi, Majed Alosaimi, Monther Alazwari, Mohamed Hussein, Faisal Alhomayani, Abdulmajeed Alotaibi, Ameerah Bajaber, Fahad Bhutto, Abdulmajeed Algethami, Bassem A. Almalki

“…PTDM patients were significantly older (53.1 ± 12.9 vs. 45.4 ± 14.6 years, p < 0.001) and had higher BMI (27.0 ± 4.7 vs. 25.2 ± 5.4 kg/m², p = 0.023). Hypertension was a more frequent cause of ESRD in the PTDM group (24.1% vs. 6.3%, p = 0.006). …”
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Genome-Wide Association Study for Weight-Related Traits in <i>Scylla paramamosain</i> Using Whole-Genome Resequencing by Lin Chen, Yaodong Zhang, Peitan Jia, Siyi Zhou, Qionghui Qin, Weiren Zhang, Kewei Huang, Xiaopeng Wang, Haihui Ye

“…Body-related traits exhibited more unique GO terms and KEGG pathways associated with metabolism and immunity, whereas appendage-related traits showed some unique GO terms and KEGG pathways involved in development and morphogenesis. …”
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Effects and mechanisms of supramaximal high-intensity interval training on extrapulmonary manifestations in people with and without chronic obstructive pulmonary disease (COPD-HIIT... by Johan Jakobsson, Chris Burtin, Mattias Hedlund, Carl-Johan Boraxbekk, Jonas Westman, Nina Karalija, Per Stål, Thomas Sandström, David Ruttens, Harry R. Gosker, Jana De Brandt, André Nyberg

“…In people with COPD, short-duration high-intensity interval training (HIIT) holds the potential to induce a more optimal stimulus for training adaptations while circumventing the ventilatory burden often associated with MICT in people with COPD. …”
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Ultrasound Assessment in Polycystic Ovary Syndrome Diagnosis: From Origins to Future Perspectives—A Comprehensive Review by Stefano Di Michele, Anna Maria Fulghesu, Elena Pittui, Martina Cordella, Gilda Sicilia, Giuseppina Mandurino, Maurizio Nicola D’Alterio, Salvatore Giovanni Vitale, Stefano Angioni

“…Future directions should focus on robust AI training datasets, multicenter validation, and age-/BMI-specific cut-offs to optimize the balance between sensitivity and specificity, ultimately facilitating earlier and more precise PCOS diagnoses.…”
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Physics-informed modeling of splitting tensile strength of recycled aggregate concrete using advanced machine learning by Kennedy C. Onyelowe, Viroon Kamchoom, Shadi Hanandeh, S. Anandha Kumar, Rolando Fabián Zabala Vizuete, Rodney Orlando Santillán Murillo, Susana Monserrat Zurita Polo, Rolando Marcel Torres Castillo, Ahmed M. Ebid, Paul Awoyera, Krishna Prakash Arunachalam

“…The collected 257 records were partitioned into training set of 200 records (80%) and validation set of 57 records (20%) in line with a more reliable partitioning of database. Five advanced machine learning techniques created using the “Weka Data Mining” software version 3.8.6 were applied to predict the Fsp and the Hoffman & Gardener method and performance metrics were also used to evaluate the sensitivity and performance of the variables and ML models, respectively. …”
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Association of dietary cholesterol intake with the risk of fatal cardiovascular events in individuals with type 2 diabetes by A. K. Kuntsevich, O. D. Rymar, S. V. Mustafina, G. I. Simonova, L. V. Shcherbakova, E. G. Verevkin, A. O. Shchetinina, S. K. Malyutina

“…The results of this study may suggest a possible association of high-cholesterol foods with an increased risk of death in people with type 2 diabetes, pointing to the need for people with diabetes to control their dietary cholesterol levels and more optimal type of diet for this population.…”
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Management and impact of obesity in Canada: A real-world survey of people with obesity and their physicians by Jennifer Glass, Sophie Carter, Esther Artime, Victoria Higgins, Lewis Harrison, Andrea Leith, David CW. Lau, Ian Patton, Jennifer L. Kuk

“…Results: Overall, 50 physicians (35 general practitioners, 15 endocrinologists) and 199 PwO were analyzed. More than 85 % of PwO had ≥1 ORC. The most common ORCs were hypertension, dyslipidemia, depression, and type 2 diabetes, and one-quarter to one-half of ORCs were not optimally controlled. …”
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Mass Media Exposure and Cervical Cancer Screening in Rural Sub‐Saharan Africa: A Multi‐Country Cross‐Sectional Analysis by Alex Bawuah, Vicky Q. Wang, Khadijat Adeleye, Edward Kwabena Ameyaw, Sanni Yaya

“…Women with exposure to mass media were significantly more likely to undergo screening. Specifically, women who watched television less than once a week (AOR = 1.22, 95% CI: 1.07–1.38) or at least once a week (AOR = 1.39, 95% CI: 1.26–1.53) had higher odds of being screened compared to those with no exposure to television. …”
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Associations between exercise and university students’ depression during the COVID-19 pandemic and lockdown: the mediating role of relative deprivation and subjective exercise expe... by Chao Chen, Jie Ma, Jinzhuang Song, Chuang Yan, Minghao Yan

“…Furthermore, as a well-established determinant of depression, relative deprivation (RD) warrants further investigation to determine whether it is associated with exercise, which requires more conclusive evidence. Currently, the available evidence is insufficient to draw firm conclusions on the relationships between student exercise and depression, RD and subjective exercise experience (SEE). …”
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Biochar Co-Applied with Lime Enhances Soil Phosphorus Availability via Microbial and Enzymatic Modulation of Paddy Soil by Yang Zhang, Caidi Yang, Jun Wang, Shenggao Lu

“…Biochar co-applied with lime increased the available P (Olsen-P by 169–209%) and inorganic P (Al-P by 53.4–161%, Fe-P by 96.3–198%, and Ca-P by 59.0–154%) more than biochar alone, compared to the control (CK). …”
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