Vancomycin levels for Bayesian dose-optimization in critical care: a prospective cohort study by Natalia Dreyse, Natalia Dreyse, Nicole Salazar, Jose M. Munita, Jordi Rello, Jordi Rello, Jordi Rello, René López, René López

“…Bland–Altman analysis indicated better agreement between AUC-3 and AUC-2 with AUCRef.ConclusionBayesian software using two vancomycin levels provides a more accurate and less biased AUC/MIC estimation in critically ill patients.…”
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Optimizing canopy-spacing configuration increases soybean yield under high planting density by Ruidong Li, Cailong Xu, Zongsheng Wu, Yifan Xu, Shi Sun, Wenwen Song, Cunxiang Wu

“…In practice, a 20–60 cm row spacing configuration could be employed for high-density soybean planting to achieve a more substantial yield gain.…”
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Enhancing Port Energy Autonomy Through Hybrid Renewables and Optimized Energy Storage Management by Dimitrios Cholidis, Nikolaos Sifakis, Nikolaos Savvakis, George Tsinarakis, Avraam Kartalidis, George Arampatzis

“…The unique proposed EMS takes it a step further, optimizing not just the energy flow but also the cost, making the overall system more efficient—and less costly—for the user. …”
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Optimizing Nitrogen Input Increased Yield and Efficiency in Maize-Soybean Strip Intercropping System by Yuwen Liang, Qiannan Liu, Jinghan Zeng, Fei Xiong, Jian Guo, Guanghao Li, Dalei Lu

“…Optimizing nitrogen (N) fertilizer combination is a crucial measure to maximize yield and production efficiency in a maize-soybean strip intercropping system (MSSI). …”
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Generic multidimensional economic environmental operation of power systems using equilibrium optimization algorithm by Mohamed T. Mouwafi, Adel A. Abou El-Ela, Amany A. El-Hamoly, Ragab A. El-Sehiemy

“…The numerical results obtained by the proposed EOA are compared with other optimization techniques such as grey wolf optimization, particle swarm optimization (PSO), differential evolution algorithm, and other optimization techniques in the literature. …”
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Post-Processing Optimization of the Global 30 m Land Cover Dynamic Monitoring Product by Zhehua Li, Xiao Zhang, Wendi Liu, Tingting Zhao, Weitao Ai, Jinqing Wang, Liangyun Liu

“…Erroneous changes in GLC_FCS30D were considerably mitigated with the post-processing optimization method, providing more reliable insights into GLC changes from 1985 to 2022 at a 30 m resolution.…”
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Optimal Treatment of Magnetic Seizure Therapy (MST) in Patients with Clozapine-Resistant Schizophrenia (CRS) by Xiang Q, Xu P, Zhai Z, Jia Y, Li C, Liu D

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Optimization design of an acoustic cover layer for a cylindrical cavity based on porous materials by Bohan ZHANG, Jili RONG, Xiuyan CHENG

“…In this study, a comprehensive investigation into the parameter fitting and acoustic performance optimization of porous materials is conducted, utilizing advanced physical models, multifluid impedance transfer theory, and particle swarm optimization algorithms. …”
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End-to-End Detector Optimization with Diffusion Models: A Case Study in Sampling Calorimeters by Kylian Schmidt, Krishna Nikhil Kota, Jan Kieseler, Andrea De Vita, Markus Klute, Abhishek, Max Aehle, Muhammad Awais, Alessandro Breccia, Riccardo Carroccio, Long Chen, Tommaso Dorigo, Nicolas R. Gauger, Enrico Lupi, Federico Nardi, Xuan Tung Nguyen, Fredrik Sandin, Joseph Willmore, Pietro Vischia

“…The success of this proof-of-concept study provides a foundation for the future applications of end-to-end optimization to more complex detector systems, offering a promising path toward systematically exploring the vast design space in next-generation experiments.…”
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Using multiple machine learning algorithms to optimize the water quality index model and their applicability by Fei Ding, Shilong Hao, Wenjie Zhang, Mingcen Jiang, Liangyao Chen, Haobin Yuan, Nan Wang, Wenpan Li, Xin Xie

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Optimizing Lidocaine Dosing in Hepatectomy Patients: A Population Pharmacokinetic Study of Active Metabolites by He C, Qi X, Liu Y, Jin Y, Zhang M, Zhang Y, Fu L, Zheng L, Tu F, Wang Z

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Optimizing Small Cell Performance: A New MIMO Paradigm With Distributed ASTAR-RISs by Shakil Ahmed, Ahmed E. Kamal, Mohamed Y. Selim, Md Akbar Hossain, Saifur Rahman Sabuj

“…As the demand for high-speed data transmission grows with the expected emergence of 6G networks and the proliferation of wireless devices, more than traditional wireless infrastructure may be required. …”
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Optimizing transcutaneous spinal stimulation: excitability of evoked spinal reflexes is dependent on electrode montage by Kelly Lynn Thatcher, Karen Emily Nielsen, Evan Blake Sandler, Oliver John Daliet, Jennifer Ann Iddings, Edelle Carmen Field-Fote

“…DV-I and DV-U montages therefore have the potential for lower and more tolerable interventional stimulation intensities. …”
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Integrating multi-omics data to optimize immunotherapy in endometrial cancer: a comprehensive study by Xin Guan, Rongchuan Cao, Longbi Liu, Lin Ma, Ning Gao, Yanfei Yang, Mingyue Xiao, Rui Du, Yuzhe Su, Zhen Wang, Xiaofeng Liu, Lu Han

“…Moreover, the incidence of mutations was more prevalent among patients in the R group. In independent cohorts, the Scissor algorithm suggests that macrophages may exert a substantial impact on immunotherapy response in patients with EC. …”
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Optimization and Machine Learning in Modeling Approaches to Hybrid Energy Balance to Improve Ports’ Efficiency by Helena M. Ramos, João S. T. Coelho, Eyup Bekci, Toni X. Adrover, Oscar E. Coronado-Hernández, Modesto Perez-Sanchez, Kemal Koca, Aonghus McNabola, R. Espina-Valdés

“…This research provides a comprehensive review of hybrid energy solutions and optimization models for ports and marine environments. …”
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Industrial data-driven machine learning soft sensing for optimal operation of etching tools by Feiyang Ou, Henrik Wang, Chao Zhang, Matthew Tom, Sthitie Bom, James F. Davis, Panagiotis D. Christofides

“…For large datasets with high quality data that enable model training for more complex tasks, regression models that predict the oxide thickness of the product are also developed. …”
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Improved Lyrebird optimization for multi microgrid sectionalizing and cost efficient scheduling of distributed generation by Karthik Nagarajan, Arul Rajagopalan, Mohit Bajaj, Valliappan Raju, Vojtech Blazek, Lukas Prokop

“…Unlike conventional local search strategies that rely on fixed step sizes, Levy Flight prevents premature convergence by allowing the algorithm to escape local optima and explore the solution space more effectively. Additionally, a chaotic sine map is integrated to enhance global search capability, ensuring better diversity and superior optimization performance compared to traditional algorithms. …”
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Integrating optimal terrain representations from public DEMs using spaceborne LiDAR by Xingang Zhang, Shanchuan Guo, Haowei Mu, Bo Yuan, Zilong Xia, Xiaoquan Pan, Hong Fang, Pengfei Tang, Peijun Du

“…The proposed method provides a scalable and adaptable approach for DEM optimization for various regions and datasets. It allows for the incorporation of new DEMs without requiring degradation assumptions or extensive training processes, enhancing terrain representation as more LiDAR observation data becomes available.…”
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Recognition mechanism and sequence optimization of organophosphorus pesticides aptamers for better monitoring contaminations in food by Pengfei Chen, Chaoqiong Hu, Xuan Tao, Zheng Zhou, Lijun Wang, Xiao Yang, Zhenming Che, Xianggui Chen, Yukun Huang

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An optimized integrin α6-targeted peptide capable of delivering toxins for melanoma treatment by Zheng Zhao, Zi-Qian Li, Ying-Bin Huang, Meng-meng Liu, Fei Cao, Guo-Long Bu, Peng-Fei Xu, Qi Fang, Zhu-Long Hu, Di Wu, Guo-Kai Feng, Xue-Kui Liu

“…The multimerized 4S5 peptide coupled with an intracellular delivery peptide (N) and endosomal escape peptide (G) was separated by a GGS spacer. This optimized peptide was called 4S5NG. The 4S5NG, EGFP or PE24 peptide-protein conjugates were purified via a C-terminal His-tag. …”
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