Clinical and morphological aspects of neoadjuvant chemotherapy efficacy in patients with aggressive luminal HER2-negative breast cancer by D.  A. Morozov, I. V. Kolyadina, I. V. Poddubnaya, I.  P. Ganshina, S. V. Khokhlova, V. V. Kometova, V. V. Rodionov

“…An increase in the size of the residual tumor and the number of affected lymph nodes were associated with an increase in the RCB class. …”
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Biodegradable Electrospun PLGA Nanofibers-Encapsulated Trichinella Spiralis Antigens Protect from Relapsing Experimental Autoimmune Encephalomyelitis and Related Gut Microbiota Dys... by Sabljić L, Radulović N, Đokić J, Stojanovic DB, Radojević D, Glamočlija S, Dinić M, Golić N, Vasilev S, Uskoković P, Sofronić-Milosavljević L, Gruden-Movsesijan A, Tomić S

“…Gut barrier function and microbiota composition were analyzed using qPCR, 16S rRNA sequencing, and metabolomic analyses.Results: ESL1 antigens, released from PLGA and drained via myeloid antigen-presenting cells through lymph nodes, protected the animals from developing EAE symptoms. …”
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Nasal mRNA Nanovaccine with Key Activators of Dendritic and MAIT Cells for Effective Against Lung Tumor Metastasis in Mice Model by Li A, Cai X, Li D, Yu Y, Liu C, Shen J, You J, Qiao J, Wang F

“…Intranasal immunization has emerged as a more effective method of inducing local immune responses against cancer cells in the lungs.Methods: An innovative layered double hydroxide- and 5-OP-RU–based mRNA nanovaccine (Mg/Al LDH-5-OP-RU/mRNA) was synthesized via coprecipitation. …”
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A secure end-to-end communication framework for cooperative IoT networks using hybrid blockchain system by Suresh Babu Erukala, Dimitar Tokmakov, Anoosha Perumalla, Rajesh Kaluri, Anna Bekyarova-Tokmakova, Nevena Mileva, Slavi Lubomirov

“…Additionally, lightweight authentication protects resource-constrained IoT nodes using an aggregate signature, ensuring security and performance in real-time scenarios. …”
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Morphological and immunohistochemical features of placenta in postpartum women with hyperprolactinemia history by T. D. Zadorozhna, E. V. Kolomiiets, L. Ye. Tumanova, S. M. Kylykhevych

“…Pregnant women with HP have a high incidence of perinatal complications; thus, the threat of self-abortion in these women is more than 48.4 %, and in 16.1 % of pregnant women it ends in premature birth. …”
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IMMUNOLOGICAL AND MORPHOLOGICAL PREDICTORS OF CLINICAL HETEROGENEITY OF PATIENTS WITH GRAVES' DISEASE (BASED ON RESEARCH OF THE THYROID GLAND OPERATIONAL MATERIAL) by T. V. Saprina, T. S. Prokhorenko, N. V. Ryazantseva, I. N. Vorozhtsova, S. Yu. Martynova, A. N. Dzyuman, A. P. Zima, O. S. Popov, I. A. Khlusov, K. T. Kasoyan, I. P. Shabalova

“…The first includes the formation of 1 and 2 histological options GD (minimally expressed monocytes infiltration, lack of oncocytic transformation of thyroid epithelium), with some clinical characteristics (persistent and pronounced hyperthyroidism, the large size of goiter, higher titer of receptor TSH-antibody and smaller TPO-antibody, diffuse nature of the lesion), and the second – is represented by 3d histological option with oncocytic restructuring of follicular epithelium, expressed the monocyte/macrophage infiltration with the TNF-RI expression and clinical patterns, including: the older age group of patients, the smaller size of goiter, the emergence of “pseudo nodes” ultrasound, reflecting the presence of lymphoid follicles-infiltrates, more lenient for hyperthyroidism. …”
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Clinical Implementation of Cone Beam Computed Tomography-Guided Online Adaptive Radiation Therapy in Whole Breast Irradiation by Koen J. Nelissen, MS, Wilko F.A.R. Verbakel, PhD, Judith G. Middelburg–van Rijn, MD, Barbara L.T. Rijksen, MD, Marjan A. Admiraal, PhD, Jorrit Visser, PhD, Jessica van der Himst, Karin N. Goudschaal, MS, Ewa Bucko, Ben J. Slotman, MD, Angelique R.W. van Vlaenderen, MS, Desiree H.J.G. van den Bongard, PhD, MD

“…Future work will focus on more complex breast indications, such as whole breast, including axillary nodes, to further investigate the benefits and challenges of oART in breast cancer.…”
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Efficacy and safety of cisplatin and paclitaxel (PlaTax regimen) in the neoadjuvant treatment of patients with stage II–III triple-negative breast cancer by O. O. Gordeeva, I. V. Kolyadina, L. G. Zhukova, I. P. Ganshina, G. V. Vyshinskaya, M. A. Kazantseva, M. V. Sukhova, O. E. Ryabishina, E. V. Lubennikova, D. A. Filonenko, E. I. Chichikov, I. N. Polushkina, E. I. Borisova, A. N. Lud, A. A. Meshcheryakov

“…Other important prognostic factors were size of the tumor, status of regional lymph nodes, grade. Delay in surgical treatment more than a month lead to decreased 3-year progression-free survival: 87.1 % vs. 62.5 % (p = 0.047).Conclusions. …”
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On Channel Transforms to Enhance Reciprocity and Quantization in Physical-Layer Secret Key Generation by Ghalib Hussain, Syed Junaid Nawaz, Shurjeel Wyne, Mohammad N. Patwary

“…First, average contiguous duration (ACD), a second-order fading statistics metric, is considered to select and bias the channel samples that are more likely to fall in the same quantization interval. …”
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The Modern View on the Problem of Respiratory Lesions in Patients with Liver Cirrhosis. Clinical Case Description by Abrahamovych M., Tolopko S.

“…The imbalance of vasoactive substances on the one hand, and diffuse fibrosis with formed regeneration nodes on the other, lead to the increased portal vascular resistance and portal hypertension (PH) with the following disorders of systemic hemodynamics and circulation of almost all organs, including the lungs, resulting in hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PPH). …”
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Sistema Distribuido de Detección de Sismos Usando una Red de Sensores Inalámbrica para Alerta Temprana. by Ana Zambrano Vizuete, Israel Pérez Llopis, Carlos Palau Salvador, Manuel Esteve Domingo

“…In this paper, we present a distributed, reliable, hierarchical and hard real-time system architecture of smartphones acting as opportunistic sensor nodes. Using a low energy-consumption application, we have used the smartphones inertial sensor as an accelerograph. …”
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Integrated genome mining and molecular networking uncover the biosynthetic potential of a novel mangrove-derived strain Streptomyces sp. B1866 by Liyuan Jiang, Wenjin Hu, Jinling Qin, Baorui Teng, Siwei Chen, Dan Zhang, Hui Lei, XinLi Pan

“…UPLC-MS/MS-based molecular networking further revealed the biosynthetic potential of strain B1866 since several nodes could not be assigned to the previously reported compounds. …”
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Analysis of microRNA expression reveals convergent evolution of the molecular control of diapause in annual killifishes by Emanuel Barth, Emanuel Barth, Mario Baumgart, Luca Dolfi, Rongfeng Cui, Marco Groth, Roberto Ripa, Aurora Savino, Dario Riccardo Valenzano, Dario Riccardo Valenzano, Matthias Platzer, Manja Marz, Alessandro Cellerino, Alessandro Cellerino

“…MicroRNAs are small RNAs that represent central nodes in the control of gene expression at the post-transcriptional level and are involved in many developmental processes. …”
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CRYPTO-RESISTANT METHODS AND RANDOM NUMBER GENERATORS IN INTERNET OF THINGS (IOT) DEVICES by Petro Klimushyn, Tetiana Solianyk, Oleksandr Mozhaiev, Yurii Gnusov, Oleksandr Manzhai, Vitaliy Svitlychny

“…The analysis of technologies and circuit solutions allowed to draw the following conclusions: protection of IoT solutions includes: security of IoT network nodes and their connection to the cloud using secure protocols, ensuring confidentiality, authenticity and integrity of IoT data by cryptographic methods, attack analysis and network cryptographic stability; the initial basis for the protection of IoT solutions is the true randomness of the formed RNG sequences and used in algorithms for cryptographic transformation of information to protect it; feature of IoT devices is their heterogeneity and geographical distribution, limited computing resources and power supply, small size; The most effective (reduce power consumption and increase the generation rate) for use in IoT devices are RNG exclusively on a digital basis, which implements a three-stage process: the initial digital circuit, normalizer and random number flow generator; Autonomous Boolean networks (ABN) allow to create RNG with unique characteristics: the received numbers are really random, high speed – the number can be received in one measure, the minimum power consumption, miniature, high (up to 3 GHz) throughput of Boolean chaos; a promising area of ABN development is the use of optical logic valves for the construction of optical ABN with a bandwidth of up to 14 GHz; the classification of known classes of RNG attacks includes: direct cryptanalytic attacks, attacks based on input data, attacks based on the disclosure of the internal state of RNG, correlation attacks and special attacks; statistical test packages to evaluate RNG sequences have some limitations or shortcomings and do not replace cryptanalysis; Comparison of cryptoaccelerators with cryptographic transformation software shows their significant advantages: for AES block encryption algorithm, speeds increase by 10-20 times in 8/16-bit cryptoaccelerators and 150 times in 32-bit, growth hashing of SHA-256 in 32-bit cryptoaccelerators more than 100 times, and for the NMAS algorithm - up to 500 times. …”
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U-Net-based VGG19 model for improved facial expression recognition by Xiaohu ZHAO, Jingyi ZHANG, Mingzhi JIAO, Lixun XIE, Lanfei WANG, Weiqing SUN, Di ZHANG

“…This change reduces the number of nodes in these layers from [4096, 4096, 1000] to just [7], effectively addressing the large parameter size in the VGG19 network. …”
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CXCR5 engineered human and murine Tregs for targeted suppression in secondary and tertiary lymphoid organs by Matteo Doglio, Jyoti Rana, Adriana Stucchi, Maite-Muñoz Melero, Alessia Ugolini, Tatiana Jofra, Cristiano Toma, Clara Bercher-Brayer, Pierluigi Carulli, Sandeep Kumar, Paolo Monti, Elisa Martini, Senthilkumar Thirumurugan, Moanaro Biswas, Chiara Bonini, Georgia Fousteri

“…Although antigen-specific regulatory T cells (Tregs), such as chimeric antigen receptor (CAR) Tregs, generally persist longer and localize to target tissues more effectively than polyclonal Tregs in animal models, their numbers still progressively decline over time. …”
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Engineering and Evaluation of a Live-Attenuated Vaccine Candidate with Enhanced Type 1 Fimbriae Expression to Optimize Protection Against <i>Salmonella</i> Typhimurium by Patricia García, Arianna Rodríguez-Coello, Andrea García-Pose, María Del Carmen Fernández-López, Andrea Muras, Miriam Moscoso, Alejandro Beceiro, Germán Bou

“…Fimbrial overexpression did not alter intestinal colonization or translocation to mesenteric lymph nodes (mLNs). Immunization elicited a mixed IgG1/IgG2a, significantly increased IgA and IgG against type 1 fimbriae-expressing <i>Salmonella</i>, and enhanced the ability of fecal extracts to inhibit the adherence of wild-type strains. …”
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Prognostic value of primary gross tumor volume and standardized uptake value of F-FDG in PET/CT for distant metastasis in locoregionally advanced nasopharyngeal carcinoma by Ya-Nan Jin, Ji-Jin Yao, Si-Yang Wang, Wang-Jian Zhang, Guan-Qun Zhou, Fan Zhang, Zhi-Bin Cheng, Jun Ma, Hao-Yuan Mo, Ying Sun

“…Combining SUVmax-N with clinical stage gives a more precise picture in predicting distant metastasis.…”
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Comparison of Yield and Quality of Forage in the Intercropping of Rye (Secale cereale L.) and Vetch (Vicia villosa Roth.) under Different Tillage Systems by T Salavati, Gh Heidari, M Majidi, Sh Khalesro

“…The studied traits included the number of nodes in the hairy vetch root, dry forage yield of hairy vetch and rye, land equivalent ratio, neutral and acid detergent insoluble fiber, digestible dry matter, and ash percentage. …”
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Metastatic neuroendocrine tumor with extensive bone marrow involvement at diagnosis: Evaluation of response and hematological toxicity profile of PRRT with 177Lu-DOTATATE by Sandip Basu, Rohit Ranade, Pradeep Thapa

“…Associated sites of metastases included the liver (n = 5), breast (n = 1), and aortocaval nodes (n = 1). On baseline diagnostic study [68Ga-DOTANOC/TATE or the technetium (99mTc)-hydrazinonicotinamide (HYNIC)-tektrotyd (TOC)], tracer uptake in the bone marrow in all patients was Grade III. …”
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