Improving the Anti-Tumor Effect of Indoleamine 2,3-Dioxygenase Inhibitor CY1-4 by CY1-4 Nano-Skeleton Drug Delivery System by Hui Li, Junwei Liu, Jingru Wang, Zhuoyue Li, Jianming Yu, Xu Huang, Bingchuan Wan, Xiangbao Meng, Xuan Zhang

“…In vivo studies showed that the oral bioavailability of CY1-4 in 20 mg/kg MSNM@CY1-4 was about 23.9-fold more than that in 50 mg/kg CY1-4 suspension. In B16F10 tumor-bearing mice, MSNM@CY1-4 significantly inhibited tumor growth, prolonged survival time, significantly inhibited IDO activity in blood and tumor tissues, and reduced Tregs in tumor tissues and tumor-draining lymph nodes to improve anti-tumor efficacy. …”
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Data-Driven Distributionally Robust Optimization for Solar-Powered EV Charging Under Spatiotemporal Uncertainty in Urban Distribution Networks by Tianhao Wang, Xuejiao Zhang, Xiaolin Zheng, Jian Wang, Shiqian Ma, Jian Chen, Mengyu Liu, Wei Wei

“…The model is evaluated on a modified IEEE 123-bus feeder with 52 EV-PV nodes, using 15 min resolution over a 24 h horizon and 12 months of real-world data. …”
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Evolution of treatment for children with esthesioneuroblastoma (1969–2019) by A. D. Rodina, A. S. Krylov, T. V. Gorbunova, V. A. Korolyov, O. A. Merkulov, N. V. Ivanova, V. G. Polyakov

“…The affected cervical lymph nodes were irradiated in 10 (35 %) patients (total focal dose 40 Gy). …”
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Apatia multimodal iatrogênica Multimodal apathy: a unique effect of antidepressant therapy at the neurological-psychiatric interface by Ricardo de Oliveira-Souza, Wagner Martignoni de Figueiredo

“…A sample of the relevant clinical evidence favoring the distinction of apathy confined to a single sensory domain ("unimodal apathy") from apathy confined to more than one sensory realm ("multimodal apathy") is reviewed. …”
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Role of Magnetic Resonance Imaging in the Low Back Pain in Young Adults at a Tertiary Care Hospital in Northeast India by R. Harshith, Jaybrata Ray

“…MRI findings were classified into disc degeneration, spinal canal narrowing, Modic changes, Schmorl’s nodes, spondylolisthesis and osteophytes. Statistical analysis was done using SPSS, with significance set at P < 0.05. …”
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Whole slide images as non-fungible tokens: A decentralized approach to secure, scalable data storage and access by Arlen Brickman, Yigit Baykara, Miguel Carabaño, Sean M. Hacking

“…Today, we need cheaper, more efficient, highly scalable, and transparent solutions for WSI data storage and access of medical records and medical imaging data. …”
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Analysis of Technologies for Applying High-Entropy Coatings by Physical Deposition Method by K. N. Polityko, I. V. Kolesnikov, D. S. Manturov

“…They can be operated in tribo-loaded nodes.…”
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Impact of the COVID-19 pandemic on the diagnosis, tumor characteristics, and survival outcomes of colorectal cancer: a retrospective cohort study by Enver Yarikkaya, Merve Cin, Sena Ecin-Demezoglu, Beste Noyan-Mod, Mert Mahsuni Sevinc, Yakup Bozkaya, Nevra Dursun-Kepkep

“…Patient demographics, tumor characteristics (diameter, location, histological type, grade, multifocality, invasion depth, lymphovascular and perineural invasion, number of metastatic lymph nodes, tumor budding, and deposits), and clinical factors (operability, presence of distant metastases, and survival status) were evaluated. …”
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Malignant cell-specific CXCL14 promotes tumor lymphocyte infiltration in oral cavity squamous cell carcinoma by John B Sunwoo, JuneHo Shin, Sidharth V Puram, Anuraag Parikh, William Faquin, Derrick T Lin, Itay Tirosh

“…Objectives To explore lymphocyte infiltration as a potential mechanism behind CXCL14-mediated tumor growth suppression in oral cavity squamous cell carcinoma (OSCC).Methods We analyzed single cell RNA-sequencing (scRNA-seq) data from OSCC to identify expression changes among malignant cells in lymph nodes (LN) versus primary tumors. CXCL14 expression in murine OSCC cell lines was quantified using qRT-PCR. …”
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Community structure and diversity of soil nematodes in different slope directions of wild cherry plum forests in Xinjiang, China by CAO Jing, CUI Dong, JIANG Zhicheng, YAN Jiangchao, WU Yunhao, LIU Junqi, GUO Jinfeng, HAN Yaxin, HAN Shutong

“…Among them, the number of nodes, edges, edge density, and connectivity of the nematode network in the semi shaded slope soil were the highest, indicating that in this habitat, the nematode collinear network was more complex and had a more stable food web structure inside. …”
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Multivalent fusion protein targeting VEGFR2 and DR5 receptors: assessing the antiangiogenic and antitumor effects via multimodal microangiography by Irina N. Druzhkova, Anna G. Orlova, Anastasiia S. Fedulova, Arina V. Avakiants, Alina A. Isakova, Ekaterina V. Kukovyakina, Yuan Zijian, Ekaterina A. Plotnikova, Galina V. Trunova, Andrey A. Pankratov, Anton A. Plekhanov, Alexey A. Kurnikov, Pavel V. Subochev, Alexey K. Shaytan, Marine E. Gasparian, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh, Daniel Razansky, Anne V. Yagolovich

“…OA imaging of the vessel network in xenograft tumor nodes of human glioblastoma and pancreatic adenocarcinoma displayed a decrease in the vessel fraction in DR5-B-treated xenograft tumors, with the effect being even more pronounced in SRH-DR5-B-iRGD-treated tumor nodes. …”
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Clinical characteristics of acquired anti-IFN-γ autoantibodies in patients infected with non-tuberculous mycobacteria: a prospective cohort study by Hanlin Liang, Siqiao Liang, Yan Ning, Xuemei Huang, Ruiling Ning, Ni Chen, Limei Hong, Xiaona Liang, Siyao Wu, Ping Yan, Hongyu Wei, Zengtao Luo, Qiangxiu Zeng, Dongming Qu, Zhiyi He

“…In the AIGAs-positive group, lymph nodes, bones, skin, and blood were the most frequently affected sites. …”
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Clinical case of COVID-19 in a patient with Hodgkin's lymphoma by D. A. Malashenko, Zh. B. Ponezheva, A. N. Turapova, E. P. Rodionov, A. A. Ploskireva, M. A. Magomedov, N. G. Burda, I. I. Tsvetaev, T. A. Trubina

“…The total number of cases of a new coronavirus infection in the Russian Federation exceeded 22 million, of which more than 398 thousand cases were fatal.All resources of the healthcare organizations around the world were thrown into the fight against the coronavirus pandemic, which affected the quality of medical care for patients with other diseases. …”
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Global consensus building and prioritisation of fundamental lupus challenges: the ALPHA project by Victoria P Werth, Brad Rovin, Susan Manzi, Ian Bruce, Karen Costenbader, Leslie Hanrahan, Sandra Raymond, Sang-Cheol Bae, Thomas Dörner, Karin Tse, Laura Eve Schanberg, Yaritza Peña, Annick Anderson, Kathleen Arntsen, Kenneth Getz, Amy Kao, Eric Morand, Joan M Von Feldt

“…Objective Lupus is a complex, heterogeneous autoimmune disease that has yet to see significant progress towards more timely diagnosis, improved treatment options for short-term and long-term outcomes, and appropriate access to care. …”
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Identification of anti-TIM-3 based checkpoint inhibitor combinations with activity in immunotherapy refractory melanoma models by Paulo C Rodriguez, Yian Ann Chen, Brian Ruffell, Jiannong Li, Manali S Phadke, Keiran S M Smalley, Vincent C Luca, Sathya Sriramareddy, Thuy T T Tran

“…Flow cytometry, tetramer binding assays, T-cell depletion and analysis of the tumor-draining lymph nodes were used to determine the mechanisms of action of the ICI combinations. …”
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THE ROLE OF PSMA PET/CT IN THE CHARACTERIZATION OF HEAD AND NECK SQUAMOUS CELL CARCINOMA by Hadila da Silva Veras Sousa, Victor Cabral Costa Ribeiro Heringer, Ligia Traldi Macedo, Najua Abou Arab, Simone Kuba, Celso Dario Ramos, Carmen Silvia Passos Lima

“…FDG uptake values were higher than PSMA uptake values in primary tumors (P < 0.001) and lymph nodes (P = 0.01). Conclusion: HNSCC lesions were more effectively detected by FDG PET/CT, highlighting its superior sensitivity for assessing tumor activity. …”
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Right-sided hemicolectomy in 90-year-old patient with cecum cancer by A. M. Sidorenko, T. A. Semenova, V. V. Varvarov

“…There were multiple metastatic regional lymph nodes up to 3 cm in diameter along a.ileocolica. …”
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Relationship between prenatal anxiety, depression, pregnancy stress and their social determinants by Weicui Meng, Sufeila Shalayiding, Xiaoting Wang, Bahedana Sailike, Ting Jiang

“…These findings provide a theoretical basis and practical guidance for developing more precise and effective perinatal mental health interventions in Urumqi.…”
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Physical Information Neural Network-Based Seepage Behavior Analysis of Earth and Rock Dams by XUE binghan, HUANG zhenhua, LEI Jianwei, FANG Hongyuan

“…Solving this fixed-boundary seepage field with the PINN yields the full field distribution, including hydraulic head values at free-surface nodes. The convergence error is computed based on hydraulic head values from two successive iterations at these nodes. …”
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Local-free recurrence survival after breast-conserving surgery and the breast cancer complex treatment by A. D. Zikiryahodjaev, M. V. Ermoshchenkova, A. R. Bosieva, J. F. Omarova, N. N. Volchenko, I. V. Reshetov

“…The incidence of cancer in situ was higher in the OBS group: 14.7% vs. 3.3% in the RBR group (p &lt; 0.001), metastases in regional lymph nodes were more frequent in the RBR group: 34.3% against 20.3% in OBS (p &lt; 0.001). …”
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