Clinical significance of primary tumor progression in metastatic hormone-sensitive prostate cancer by Yasutaka Yamada, Shinichi Sakamoto, Takuya Tsujino, Sinpei Saito, Kodai Sato, Kazuki Nishimura, Tatsuo Fukushima, Ko Nakamura, Yuki Yoshikawa, Tomohisa Matsunaga, Ryoichi Maenosono, Manato Kanesaka, Takayuki Arai, Tomokazu Sazuka, Yusuke Imamura, Kazumasa Komura, Kazuo Mikami, Kazuyoshi Nakamura, Satoshi Fukasawa, Kazuto Chiba, Yukio Naya, Maki Nagata, Atsushi Komaru, Hiroomi Nakatsu, Haruhito Azuma, Tomohiko Ichikawa

“…Results: The median age and initial prostate-specific antigen (iPSA) values were 74 and 221 ng/ml, respectively. 632 (64%) and 355 (36%) patients had clinical T stage ≤3 and 4 at diagnosis, respectively. mHSPC patients with clinical T stage 4 were more likely to have a higher grade group (GG), higher frequency of lymph node metastasis, lower hemoglobin (Hb), and more high-volume/risk disease in comparison with those with clinical T stage ≤3. …”
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Strategies for Construction and Optimization of the Ecological Security Pattern for Human Settlements in the Wuding River Basin by Xiaomeng WANG, Anrong DANG, Biao TONG, Xinyi LIU

“…In contrast, the southwestern region exhibits a more fragmented distribution of ecological sources, highlighting the need for targeted restoration efforts to improve connectivity. …”
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Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma by Yang Peng, Jing Yang, Jixing Ao, Yilin Li, Jia Shen, Xiang He, Dihong Tang, Chaonan Chu, Congrong Liu, Liang Weng

“…Background: Cervical adenocarcinoma (ADC) is more aggressive compared to other types of cervical cancer (CC), such as squamous cell carcinoma (SCC). …”
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Factors associated with health-related quality of life in women with paid work at breast cancer diagnosis: a German repeated cross-sectional study over the first five years after p... by Batoul Safieddine, Siegfried Geyer, Stefanie Sperlich, Johannes Beller, Dorothee Noeres

“…However, its significant effect was no more apparent at 5 years after primary surgery. At that stage, income was mostly associated with physical (ß=0.002; CI:0.0002, 0.003) and mental wellbeing (ß=0.002; CI:0.0005, 0.003) with higher summary scores for higher income especially in women aged ≤ 61 years. …”
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Diagnosis of tuberculosis in buffaloes in Argentina: intradermoreaction, compatible lesions and bacteriological culture by Emilia Irina Martínez, Fabiana Cipolini Galarza, Nolly María Monzón, Ana Gabriela Espasandin, José Luis Konrad, Elvira Falzoni, Soledad Barandiaran, Jimena Marfil, Marcela Martínez Vivot, Diana Elina Martínez

“…Of the 8 buffaloes with positive cultures, only 2 presented macroscopic tuberculosis-compatible lesions, one in the mediastinal lymph node and lung; and the other in the retropharyngeal ganglion. …”
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ALKBH5, an m6A demethylase, attenuates tumor growth and inhibits metastasis in papillary thyroid carcinoma by Yong Zhuang, Qingyan Cai, Xin Hu, Huibin Huang

“…Additionally, compared to the ALKBH5 overexpression group, cell proliferation and invasion were significantly more decreased in the mut-ALKBH5 overexpression group (P < 0.05). …”
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Modeling Study on Cascading Failures of Critical Infrastructure in Urban Flooding: A Case Study of the Maozhou River Basin by Ge Xinyu, Fan Dongli, Tian Zhan, Liu Qiaodan, Lyu Jiajie, Wang Yanlong

“…The results revealed the following. 1) Within the system's topological structure, the degree value of substation nodes is significantly higher than that of other facilities, making them a critical node for cascading failures triggered by floods. …”
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Mechanisms underlying the promotion of papillary thyroid carcinoma occurrence and progression by Hashimoto’s thyroiditis by Xiaohui Xue, Xiaohui Xue, Xiaohui Xue, Deqi Wu, Hangyu Yao, Kainan Wang, Kainan Wang, Kainan Wang, Zhengtao Liu, Zhengtao Liu, Zhengtao Liu, Zhengtao Liu, Haijiang Qu, Haijiang Qu

“…Future research should further elucidate the complex interplay between these two diseases to prevent the transformation of HT into PTC and offer more personalized treatment plans for PTC patients, including considerations for preoperative thyroidectomy and lymph node dissection strategies, as well as postoperative TSH suppression therapy risk assessment. …”
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Comparison of the clinical effects of robot-assisted total mesorectal excision and transanal total mesorectal excision by Zhang Cheng, Duan Fuxiao, Li Da, Gao Guangrong, Ma Rui

“…No significant differences were observed between the two groups in terms of maximum tumor diameter, number of lymph nodes dissected, and pathological tumor node metastasis stage (P>0.05). …”
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Medullary thyroid cancer in MEN2 pediatric/adolescent carriers of RET mutation: genotype/phenotype correlation and outcome in a retrospective series of 23 patients by Guenda Di Benedetto, Ignazio Barca, Laura De Gregorio, Claudia Scollo, Fiorenza Gianì, Federica Martorana, Marco Russo, Francesco Frasca, Gabriella Pellegriti, Gabriella Pellegriti, Giulia Sapuppo

“…Ten patients (52.6%) had a disease event during the follow-up: 2/19 (10.5%) showed biochemical disease, 6/19 (31.6%) lymph node recurrences, and 2/19 (10.5%) distant metastases (50% liver, 50% bone). …”
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Comorbidity in patients with lobular panniculitis-lipodermatosclerosis by O. N. Egorova, B. S. Belov, E. G. Sazhina

“…The intensity of pain on palpation of the node was assessed using a visual analogue scale (VAS). …”
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Features of the mobile pool of fatty acids (lipoproteins and free fatty acids) in adolescents with different body weights by Iuliia G. Samoilova, Oksana A. Oleynik, Daria V. Podchinenova, Mariia V. Matveeva, Irina N. Vorozhtsova, Margarita A. Kovarenko, Lyudmila M. Shuliko, Tamara D. Vachadze

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A Proposed Diagnostic and Treatment Algorithm for the Management of Lumbar Discogenic Pain by Lorio MP, Beall DP, Myers TJ, Naidu RK, McRoberts WP, Davis TT, Gage EG, Calodney AK, Verrills P, De Palma MJ, Amirdelfan K, Block JE

“…A decision tree approach was utilized with “either/or” choices at each branch or node in the algorithm. Clinical activities in this algorithm were divided into examination procedures and corresponding treatment interventions. …”
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Development and validation of a deep learning-based pathomics signature for prognosis and chemotherapy benefits in colorectal cancer: a retrospective multicenter cohort study by Shenghan Lou, Yanming Huang, Fenqi Du, Jingmin Xue, Genshen Mo, Hao Li, Zhanjiang Yu, Yuanchun Li, Hang Wang, Yuze Huang, Haonan Xie, Wenjie Song, Xinyue Zhang, Huiying Li, Chun Lou, Peng Han, Peng Han, Peng Han

“…IntroductionThe conventional tumor-node-metastasis (TNM) classification system remains limited in accurately forecasting prognosis and guiding adjuvant chemotherapy decisions for patients with colorectal cancer (CRC). …”
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Preoperative Briganti Nomogram Score and Risk of Prostate Cancer Progression After Robotic Surgery Beyond EAU Risk Categories by Antonio Benito Porcaro, Rossella Orlando, Andrea Panunzio, Alessandro Tafuri, Alberto Baielli, Francesco Artoni, Claudio Brancelli, Luca Roggero, Sonia Costantino, Andrea Franceschini, Michele Boldini, Lorenzo Pierangelo Treccani, Francesca Montanaro, Sebastian Gallina, Alberto Bianchi, Emanuele Serafin, Giovanni Mazzucato, Francesco Ditonno, Mariana Finocchiaro, Alessandro Veccia, Riccardo Rizzetto, Matteo Brunelli, Vincenzo De Marco, Salvatore Siracusano, Maria Angela Cerruto, Riccardo Bertolo, Alessandro Antonelli

“…The 2012 version of the Briganti nomogram assessing the risk of pelvic lymph node invasion was used. Here, the nomogram score was evaluated both as a continuous and a categorical variable. …”
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RARE CASE! SECOND PRIMARY MALIGNANCY IN LANGERHANS CELL HISTIOCYTOSIS, A JAK2+ CASE by Engin Yola, Aslı Odabaşı Giden, Caner Çulha, Düzgün Özatlı

“…Physical examination revealed remnants of old skin lesions (Figure 1), and there were no palpable lymph nodes or masses. Imaging showed a significant mass in the spleen and involvement in the frontal bone, liver, lungs, stomach, and neck lymph nodes, similar to previous findings. …”
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Lack of IFN-γ response of human uterine myometrium-derived MSCs significantly improve multiple IBD parameters compared to bone marrow MSCs: Implications for anti-TNFα-refractory pa... by Li-Tzu Wang, Hsiu-Huan Wang, Shih-Sheng Jiang, Chia-Chih Chang, Pei-Ju Hsu, Ko-Jiunn Liu, Huey-Kang Sytwu, B. Linju Yen, Men-Luh Yen

“…Overall, UtMSCs outperformed BMMSCs in improving microbiota, avoiding IFN-γ responses, and modulating overall Th responses, suggesting this MSC source may offer more significant effectiveness for IBD and Th1/Th17-mediated conditions. …”
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Autologous Tolerogenic Dendritic Cells for Rheumatoid Arthritis-2 (AuToDeCRA-2) study: protocol for a single-centre, experimental medicine study investigating the route of delivery... by Ema-Louise Long, James Stanway, Michael White, Nicola Goudie, Julia Phillipson, Miranda Morton, Asma Abdul Malek, Philip Brown, Geoff Hide, Ralph Jackson, Colin Nice, John Tuckett, Julie Diboll, Amy Anderson, Arthur Pratt, Catharien M. U. Hilkens, John Isaacs

“…Participants will be followed up with immune state monitoring performed on peripheral blood samples at baseline, 1, 3 and 6 weeks and lymph node aspirates at baseline and 1 week, alongside clinical assessment performed throughout and additionally at 12 weeks. …”
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HPV-negative oropharyngeal carcinoma as a separate prognostkally unfavorable form of cancer, requiring new approaches to treatment (case report) by A. R. Gevorkov, A. V. Boyko, A. P. Polyakov, L. V. Bolotina, N. N. Volchenko, I. V. Rebrikova, A. М. Lemeshko, S. V. Shashkov

“…Three months after completing the course of CRT, the patient underwent modified radical right-sided lymph node dissection. Histological examination revealed metastases from poorly differentiated squamous cell carcinoma in 3 lymph nodes (LNs) with an invasion into adjacent adipose tissue. …”
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Changes of brain structure and structural covariance networks in Parkinson’s disease with different sides of onset by Tianqi Xu, Zhihuai Deng, Yinhui Yu, Wenchao Duan, Zeyu Ma, Haoran Liu, Lianling Li, Moxuan Zhang, Siyu Zhou, Pengda Yang, Xueyan Qin, Zhenyu Zhang, Fangang Meng, Fangang Meng, Fangang Meng, Yuchen Ji

“…BackgroundParkinson’s disease (PD) typically presents with unilateral symptoms in early stages, starting on one side and progressing, with the onset side showing more severe motor symptoms even after bilateralization. …”
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