Specific overexpression of contactin-associated protein-like 2 and its effects on pain-related behaviour in mice by Mandy Tseng, Steven J. Middleton, Adham Farah, Sarosh R. Irani, John M. Dawes, David L. Bennett

“…The aim of this study was to assess whether overexpressing CASPR2 could be a potential approach to treat pain. Methods:. We generated a Cre-dependent mouse line to express human CASPR2 (R26LSL:hCNTNAP2(+/+) (CASPR2OE)) and crossed this with either Hoxb8Cre or Nav1.8Cre mice for CASPR2 overexpression in either all DRG neurons or to target nociceptors more selectively. …”
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Bidirectional seismic response of assembled monolithic subway station-aboveground structure system under artificial bedrock ground motions by Yu Miao, Han-Wen Ji, Yang Shi

“…In this study, we firstly performed the statistical analysis on bidirectional bedrock ground motion parameters (response spectrum, duration and envelope function) using KiK-net data, and obtained some suggested values of the above parameters. …”
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Intercomparison and Validation of MIRS, MSPPS, and IMS Snow Cover Products by Jessica Chiu, Stephany Paredes-Mesa, Tarendra Lakhankar, Peter Romanov, Nir Krakauer, Reza Khanbilvardi, Ralph Ferraro

“…We analyze this disagreement rate as a function of terrain and land cover type, finding that, relative to IMS, MIRS shows fewer false positives but more false negatives than MSPPS over high elevation and grassland areas.…”
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Elaborating Strategies of Sustainable Development at Industrial Enterprises by T. A. Shipilova

“…This strategy is a key element of successful running of business in current circumstances, where requirements to sustainability and responsibility to the environment are becoming more and more important. The research found the link between the rate of industry sustainability and provision of sustainable development of enterprises in different industries. …”
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Investigation of Knee Torque Dynamics in Single-Leg Transfemoral Prosthetic during Walking Using Mathematical Modeling by Peguy Kameni Nteutse, Abebe Geletu

“…These findings highlight the importance of optimizing the design and performance of transfemoral prosthetic devices to improve the knee torque dynamics and overall functionality of amputees. Our mathematical model provides a useful tool for future research in this field, which could help develop more effective prosthetic devices for transfemoral amputees.…”
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A novel ubiquitin-related genes-based signature demonstrated values in prognostic prediction, immune landscape sculpture and therapeutic options in laryngeal cancer by Lu Liu, Lu Liu, Lu Liu, Lu Liu, Bing Wang, Xiaoya Ma, Xiaoya Ma, Lei Tan, Lei Tan, Lei Tan, Xudong Wei, Xudong Wei

“…As evaluated, the low-risk group had a more activated immune function, higher infiltration of anti-cancer immune cells and stronger expression of immune-promoting cytokines than the high-risk group. …”
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A comparative analysis of syntactic complexity in argumentative essays from rhetorical perspective: ChatGPT vs. English native speakers. by Wenlong Liu, Xianming Liu

“…Additionally, ChatGPT's syntactic complexity was characterized by lower variability across multiple measures, indicating a more uniform and formulaic output. These findings underscore the differences between ChatGPT and native speakers in syntactic complexity and rhetorical functions in argumentative essays, therefore contributing to our understanding of ChatGPT's argumentative writing performance and providing valuable insights for ChatGPT integration into writing instruction.…”
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GROG Facilitated Compressed Sensing for Radial MRI by Yumna Bilal, Ibtisam Aslam, Muhammad Faisal Siddiqui, Omair Inam, Kashif Amjad, Jawad Hasan Alkhateeb, Hammad Omer

“…Addressing these challenges typically involves the use of a GeneRalized Autocalibrating Partially Parallel Acquisitions (GRAPPA) operator generated Bunched Phase Encoding data together with a conjugate gradient (CG) reconstruction algorithm, that mimics the functionality of the oscillating gradients required for bunched phase encoding sampling. …”
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Constructing Real-Life Benchmarks for Community Detection by Rewiring Edges by Jing Xiao, Hong-Fei Ren, Xiao-Ke Xu

“…In order to make the performance evaluation of community detection algorithms more accurate and deepen our analysis of community structures and functional characteristics of real-life networks, a new benchmark constructing method is designed from the perspective of directly rewiring edges in a real-life network instead of building a model. …”
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Piloting a minimum data set (MDS) in english care homes: a qualitative study of professional perspectives on implementation and data use by Rachael E. Carroll, Nick Smith, Sinead ER Palmer, Jennifer Kirsty Burton, Adam Lee Gordon, Ann-Marie Towers, Stacey E. Rand, Freya Tracey, Anne Killett, Lucy Webster, Barbara Hanratty, Karen Spilsbury, Gizdem Akdur, Kaat De Corte, Julienne E. Meyer, Liz Jones, Claire Goodman

“…Abstract Background Digitalisation within English care homes offers potential to make more effective use of substantial data collected by staff during care planning and recording. …”
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A High-Throughput, Three-Dimensional Multiple Myeloma Model Recapitulating Tumor-Stroma Interactions for CAR-Immune Cell-Mediated Cytotoxicity Assay by Luanpitpong S, Janan M, Poohadsuan J, Rodboon N, Samart P, Rungarunlert S, Issaragrisil S

“…Through this assay, we demonstrated that CAF-like stromal cells impaired NK cell effector function in 2D culture and 3D spheroids, likely via paracrine signaling and physical barrier function. …”
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Autophagic flux-lipid droplet biogenesis cascade sustains mitochondrial fitness in colorectal cancer cells adapted to acidosis by Xiaojie Liu, Xue Sun, Wenqing Mu, Yanan Li, Wenqing Bu, Tingting Yang, Jia Zhang, Rui Liu, Jiayu Ren, Jin Zhou, Peishan Li, Yufang Shi, Changshun Shao

“…Here, we show that colorectal cancer cells adapted to acidic microenvironment (CRC-AA) are more reliant on oxidative phosphorylation than their parental cells, and the acetyl-CoA in CRC-AA cells are generated from fatty acids and glutamine, but not from glucose. …”
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Using Evolutionary Computation on GPS Position Correction by Jung Yi Lin

“…In this paper, we proposed an evolutionary computation based technique to generate a correction function by two GPS receivers and a known reference location. …”
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Carbon Footprint Assessment on the Viability of Utilizing Brewer’s Spent Grain to Produce Biochar by Emily Newman, Nitin Nitin, Edward Spang, Glen Fox

“…The study employed a carbon footprint assessment approach to quantify the greenhouse gas (GHG) emissions associated with each disposal method, using one unprocessed kg of BSG as the functional unit. The results indicated that landfilling BSG generated approximately 3 kg CO₂ equivalent (CO₂e) per kg of unprocessed BSG, whereas biochar production reduced emissions to 1.18 kg CO₂e per kg of BSG. …”
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Prediction and Mapping of Soil Total Nitrogen Using GF-5 Image Based on Machine Learning Optimization Modeling by LIU Liqi, WEI Guangyuan, ZHOU Ping

“…The results revealed that 86.1% of the land in the Jian Sanjiang study area had a total nitrogen content of more than 2.0 g/kg, primarily concentrated in first and second-grade plots, while third and fourth-grade plots accounted for only 11.83% of the total area. …”
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Adenoviral-vectored neoantigen vaccine augments hyperexpanded CD8+ T cell control of tumor challenge in mice by David Li, Gabriel Dagotto, Alessandro Colarusso, Robert C Patio, Tochi Anioke, Victoria Giffin, Ruoran Guan, Trisha Anand, Esther Mbiwan, Malika Aid, Dan Barouch

“…However, Ad26.VP22.7Epi induced CD8+ T cells showed more upregulation of T cell maturation, activation, and Th1 pathways compared with peptide vaccine induced CD8+ T cells, suggesting improved functional T cell quality. …”
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Choice of activation protocol impacts the yield and quality of CAR T cell product, particularly with older individuals by Palak H Mehta, Gemma S Trollope, Patrick Leung, Shivali Savita Chinni, Anna Iasinskaia, Aaron J Harrison, Hannah Hughes‐Parry, Misty R Jenkins, Michael H Kershaw, Anthony Jaworowski, Clare Y Slaney, Rachel M Koldej, David S Ritchie, Kylie M Quinn

“…Results Older samples generated fewer, more differentiated CAR T cells than young samples, and the αCD3/CD28 mAb protocol exacerbated this, further reducing yield and quality. …”
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Just the Kitchen. On Food Preparation in the Late Middle Ages and Early Modern Period by Anna Marciniak-Kajzer

“…These are usually separate buildings, functioning as back-of-house facilities. The former were located separately, most probably because of the fire hazard, and the latter perhaps because of the odours that were generated by the brewing process and the maturation or drying of the cheeses. …”
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Praticare l’intersezionalità nei centri antiviolenza: l’accoglienza delle donne migranti, richiedenti asilo e rifugiate by Chiara Carbone

“…Structural violence is identified through the recognition of language and cultural barriers (Crenshaw 1991), institutional-bureaucratic barriers and legal barriers, obstacles that contribute to making women in different ways and to different degrees more vulnerable and subject to forms of violence on the basis of specific dynamics, which are generated by the intersection of some axes, for example gender, ethnicity and social class membership.  …”
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Detour-Straddle 3D-like path planning of unmanned mining truck in open pit mines based on optimized ant colony algorithm by Mingyu GAO, Jiusheng BAO, Yan YIN, Deping HU, Kekun ZHANG, Chenzhong ZHU, Maosen WANG, Kai WANG

“…The simulation results show that: After optimization, the path length of the ant colony algorithm is shortened by 16.53% and 16.79% respectively in the scenario with fewer and more obstacles. Moreover, the path quality is effectively improved by reducing the path inflection point, making the path generated by the algorithm more in line with the actual demand. …”
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