Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model. by Jun-Yi Zhu, Natalia Vereshchagina, Vrinda Sreekumar, Lena F Burbulla, Ana C Costa, Katharina J Daub, Dirk Woitalla, L Miguel Martins, Rejko Krüger, Tobias M Rasse

“…We generated the first loss-of-Hsc70-5/mortalin-function Drosophila model. …”
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Identification of Ecological Security Pattern and Ecological Restoration Zoning Strategy in the Shandong Section of the Beijing-Hangzhou Grand Canal by Chizhou Xu, Yande Jing, Yiwen Zhang, Yingchun Liu, Wenyang Yin, Shiping Zhao

“…Additionally, 40 ecological corridors, 48 ecological pinch points, and 75 ecological barrier points were generated, densely distributed in the east. The area was divided into five core functional zones. (4) Conclusions: Establishing ecological function zones and considering landscape changes from high-frequency human activities in spatial planning can lead to a more reasonable division of ecological restoration areas. …”
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TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres by Tomáš Janovič, Gloria I. Perez, Greta Boelting, Jens C. Schmidt

“…To quantitatively analyze shelterin function, we generated a panel of human cancer cell lines expressing HaloTagged shelterin proteins from their endogenous loci. …”
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Advances in the study of the role of high-frequency mutant subunits of the SWI/SNF complex in tumors by Jiumei Zhao, Jing Zhu, Yu Tang, Kepu Zheng, Ziwei Li

“…As a catalytic subunit of the SWI/SNF complex, SMARCA4 has ATPase activity that catalyzes the hydrolysis of ATP to produce energy and power the chromatin remodeling complex, which is critical to the function of the SWI/SNF complex. The study data indicate that approximately 25% of cancers have one or more SWI/SNF subunit genetic abnormalities, and at least nine different SWI/SNF subunits have been identified as having repeated mutations multiple times in various cancers, suggesting that mutations affecting SWI/SNF subunits may introduce vulnerabilities to these cancers. …”
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Public security patrol path planning recommendation method based on wolf-pack optimization algorithm using DAF and BRS by Dongxing Wang, Gaomin Zhang, Fangbo Wu, Zhiyang Huang, Yiping Chen

“…Firstly, an optimization objective function regarding the public security patrol path planning (S3P-Function) was abstracted from the actual situation; Moreover, this paper proposed an improved wolf-pack optimization algorithm named DAF-BRS-CWOA using Dynamic-Adjustment-Factor(DAF) and Balanced-Raid-Strategy (BRS), and DAF devoted to adjust the overall wolf-pack running strategy by dynamically adjusting the number of airdropped wolves during the stage of Summon-Raid while BRS with symmetric property was to improve both the algorithm’s global exploration as well as the local development capabilities by increasing the number of checking locations, that means not only checking the reverse position of the current wolf, but also the positions generated according to certain rules between the reverse position of the current wolf and the current optimal wolf during the stage of Summon-Raid; Finally, DAF-BRS-CWOA was adopted to optimize S3P-Function, forming a public security patrol path planning recommendation method based on DAF-BRS-CWOA (S3PRM-DAF-BRS-CWOA). 30 independent numerical experiments were conducted on 20 public classical datasets by DAF-BRS-CWOA compared with GA, PSO, WDX-WPOA. …”
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Large Language Model-Guided SARSA Algorithm for Dynamic Task Scheduling in Cloud Computing by Bhargavi Krishnamurthy, Sajjan G. Shiva

“…Nowadays, more enterprises are rapidly transitioning to cloud computing as it has become an ideal platform to perform the development and deployment of software systems. …”
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Sucla2 Knock‐Out in Skeletal Muscle Yields Mouse Model of Mitochondrial Myopathy With Muscle Type–Specific Phenotypes by Makayla S. Lancaster, Paul Hafen, Andrew S. Law, Catalina Matias, Timothy Meyer, Kathryn Fischer, Marcus Miller, Chunhai Hao, Patrick Gillespie, David McKinzie, Jeffrey J. Brault, Brett H. Graham

“…Physiological and morphological analyses of hindlimb muscles showed remarkable differences in ex vivo function and cellular consequences between the EDL and SOL muscles, with SOL muscles significantly more impacted by Sucla2 inactivation. …”
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Analyse d'une formation plurilingue à distance : actions et interactions by Jean-Jacques Quintin, Monica Masperi

“…Galanet" learning schemes assemble large groups of students (from one to two hundred in general) who are geographically located in different universities and committed to completing common tasks the final objective of which is to create a quadrilingual press file publication online.The present study will be developed along two complementary axes:1. a quantitative analysis of the messages posted on the forum page of the platform for each session.2. a qualitative analysis of sample interventions generated in one of these sessions.On the one hand, the quantitative approach will allow for the highlighting of certain salient features of the e-learning experience as a whole, including how sessions function and their impact on both students and tutors.On the other hand, the qualitative approach will allow to examine and understand more fully the discursive practices elicited by the learning scenario and the plurilinguistic dimension of the forum exchanges.…”
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Neural Mechanisms of Circadian Regulation of Natural and Drug Reward by Lauren M. DePoy, Colleen A. McClung, Ryan W. Logan

“…Circadian rhythms are endogenously generated near 24-hour variations of physiological and behavioral functions. …”
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Optimization design on process parameters of copper wire bonding for power modules by HU Biao, CHENG Lanxian, LI Zhenling, DAI Xiaoping

“…Secondly, a prediction model of copper wire bonding performance was constructed using the BP neural network, and the optimal values of process parameters were generated by solving the BP neural network fitness function with GA. …”
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Optimization and Analysis of Double-circular-arc Harmonic Gear based on Genetic Algorithm by Zhonglong Luo, Xiaochuan Peng

“…The results show that this optimization method can optimize more parameters contemporary and reduce the calculation time. …”
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How a lack of haptic feedback affects eye-hand coordination and embodiment in virtual reality by Ewen Lavoie, Jacqueline S. Hebert, Craig S. Chapman

“…Returning haptic feedback in VR generated eye-hand coordination more similar to real-world interactions. …”
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Method to Correct the Velocity Variation Information of an Automatic Crash Notification System in Vehicle-to-Rigid Barrier Frontal Collisions by Ying Lu, Xiaojie Ji, Yu Shu

“…Third, an automatic crash notification algorithm involving a velocity variation correction function (VVCF) was proposed based on the correlation model. …”
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Impact of temperature on tyre hardness by David Jelínek, Marek Semela

“… This article deals with the dependence of tyre hardness on temperature. In this study, more than 1 800 temperature-dependent hardness values were measured for 5 samples of summer tyres from different manufacturers and different ages. …”
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China’s Fiscal and Monetary Policies During the Global Financial Crisis and the Covid-19 Pandemic: Lessons and Policy Implications by Trương Quang Thông

“…The study generated the following major findings: First, the transition from loosening monetary policy to tightening monetary policy at the time of 2008 GFC is one notable approach and a valuable lesson learned; Second, prioritization of lifesaving and enhancing economic resiliency should be at the core in addressing the economic challenges, particularly during the Covid-19 epidemic; and Third, the importance of the central bank to function as a transmission belt for government to flood the country with liquidity through commercial bank lending.…”
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Upper-Bound Analysis of Slope Reliability Considering Anisotropic Spatial Variability and Reinforcement with Anti-slide Piles by ZHAO Zi-hao, WANG Jia-rui, FU Tao-tao, ZHU En-lin

“…MethodsFirstly, the random field was generated adopting the Cholesky decomposition method. …”
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ROLE OF FLUID ON THE CONTACT DEFORMATION RESPONSE OF BIOLOGICAL TISSUE by Michael V. Swain

“…All natural biological materials contain fluid and function in a fluidic environment, which plays a critical role in responding to loading events as well as tissue nutrition. …”
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Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum. by S John Curnow, Marianne Fairclough, Caroline Schmutz, Steve Kissane, Alastair K O Denniston, Kate Nash, Christopher D Buckley, Janet M Lord, Mike Salmon

“…The differentiation of fibrocytes remains poorly characterised and this has limited understanding of their biology and function. In particular two methods are used to generate fibrocytes in vitro that differ fundamentally by the presence or absence of serum.…”
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AFMF: adaptive fusion of multi-hop neighborhood features in graph convolutional network by Kang Liu, Xinyu Li, Lian Liu, Zhihao Xv, Aohang Pei, Runshi Ji

“…The cross entropy loss function drives the network to preserve critical information. …”
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A modification of Jacobson et al.'s (1997) individual branch‐antlered male method for censusing white‐tailed deer by Mark Weckel, Robert F. Rockwell, Frank Secret

“…For each sex–age group, we evaluated RPO as a function of TS using linear regression to generate photographic counts standardized by TS (standardized photographic occurrences [SPO]). …”
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