Investigating the causal pathways among psychopathological variables, cognitive impairment, and real-life functioning in people with schizophrenia by Luigi Giuliani, Francesco Sanmarchi, Armida Mucci, Paola Rucci, Edoardo Caporusso, Paola Bucci, Giulia M. Giordano, Mario Amore, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Silvana Galderisi, Mario Maj

“…State-of-the-art instruments were used to assess the study variables. Two PAGs were generated at baseline and after 4 years of follow-up to model the nature of the causal relationships linking psychopathology, cognition, and functioning. …”
Get full text

Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice by Jie Li, Yuanjie Guo, Liyuan Ma, Yixiang Liu, Chao Zou, Huiying Kuang, Bing Han, Yingliang Xiao, Yanbo Wang

Get full text

Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs) by Emma Keltsch, Jennifer Greiner, Lena Wahl, Ingrid Knape, Daniel Tews, Michael Denkinger, Klaus-Michael Debatin, Gudrun Strauss

“…Myeloid-derived suppressor cells (MDSCs) are potent inhibitors of T cell activation and function, whose induction requires chronic inflammation. …”
Get full text

Functional properties and toxicological analysis of nanocellulose-based aerogels loaded with polyphenols from Hyeronima macrocarpa berries by Andrés Felipe Alzate-Arbeláez, Farid B. Cortés, Benjamín A. Rojano

“…The differences found in samples for the different functional assays can be explained by the various types of interactions generated between the antioxidant molecules and aerogels, in the various media where the analyses are carried out. …”
Get full text

FUNCTIONAL ACTIVITY OF IFNα- AND IL-4-INDUCED HUMAN DENDRITIC CELLS: A COMPARATIVE STUDY by O. Yu. Leplina, M. A. Tikhonova, T. V. Tyrinova, E. A. Alyamkina, S. S. Bogachev, A. A, Ostanin, E. R. Chernykh

“…It was shown that IL-4-DCs and IFN-DCs didnot differ in their key functional characteristics, i.e., in their ability to stimulate proliferation of T-cells inresponse to alloantigens, and to induce generation of T-regulatory cells in mixed leukocyte culture. …”
Get full text

Electrogeneration of non-electroactive and non-conducting materials: a counterintuitive concept for the functionalization and nanostructuration of electrode surfaces by Walcarius, Alain

“…It is mainly based on electrochemically induced redox reactions involving electroactive precursors, which are intended to form solid deposits onto the electrode surface. More recently, a rather counterintuitive approach has emerged by exploiting electrochemistry to generate non-electroactive and non-conductive thin films (e.g., sol–gel derived materials), based on the electrogeneration of a catalyst that is likely to induce indirectly the formation of a thin film (i.e., without direct electron transfer with the precursors). …”
Get full text

Recent advances on biogenesis, functions and therapeutic potential of long noncoding RNAs in T cell acute lymphoblastic leukemia by Parminder Kaur, Pankaj Sharma, Prateek Bhatia, Minu Singh

Get full text

Reference Function Based Spatiotemporal Fuzzy Logic Control Design Using Support Vector Regression Learning by Xian-Xia Zhang, Ye Jiang, Shiwei Ma, Bing Wang

“…The concept of reference function is introduced to 3D FLC for the generation of 3D membership functions (MF), which enhance the capability of the 3D FLC to cope with more kinds of MFs. …”
Get full text

Effects of Mesenchymal Stem Cells on Functions of Chimeric Antigen Receptor-Expressing T Lymphocytes and Natural Killer Cells by Vladislav Volarevic, Carl Randall Harrell, Aleksandar Arsenijevic, Valentin Djonov, Ana Volarevic

“…Additionally, MSCs may serve as vehicles for targeted delivery of immunomodulatory agents, and should be considered as active components in the design of next-generation CAR-based immunotherapies. Accordingly, in this review article we emphasize molecular and cellular mechanisms involved in MSC-dependent modulation of CAR-expressing immune cells, paving the way for more efficient CAR-based immunotherapy for malignant diseases.…”
Get full text

Increased functional potency of multi-edited CAR-T cells manufactured by a non-viral transfection system by Aine O’Sullivan, Sarah Case, Aisling McCrudden, Emer Hackett, Louise Gallagher, Darren Martin, Gillian P. Johnson, Kirti Mahadik, Thomas Kienzle, Jude Kevin Lim, Aya Nashat, Kartik Srinivasan, Mark W. Lowdell, Lisa O’Flynn, Jamie Frankish

“…Improving manufacturing processes to preserve cell health and function of edited T cells is equally critical. Here, we report that Solupore, a Good Manufacturing Practice-aligned, non-viral physicochemical transfection system, can be used to manufacture multi-edited CAR-T cells using CRISPR-Cas9 ribonucleoproteins while maintaining robust cell functionality. …”
Get full text

Metagenomic and physicochemical profiling reveal microbial functions in pit mud for Jiang-Nong Jianxiang Baijiu fermentation by Lianbin Cao, Hongmei Sun, Ziyi Xu, Xiaoxiao Xu, Guangchuan Shi, Jianqiang Zhang, Changli Liang, Tongbiao Li, Chaoying Liu, Mingcheng Wang, Shilin Tian, Enzhong Li

Get full text

Transplantation of decellularized porcine kidney grafts repopulated with primary human cells demonstrates filtration function in pigs by David Y. Lo, Boyukkhanim Ahmadzada, MacKenna A. Stachel, Melia Schaefer, Usman Ashraf, John I. Wagner, Ethan J. Vanderslice, Madie Tornquist, Kendra Mariakis, Peggy Halsten, Christopher D. Lindsay, Emily C. Beck, Scott L. Nyberg, Jeffrey J. Ross

“…Conclusions Our results showcase a human-scale, transplantable bioengineered kidney capable of performing requisite filtration function. This study reinforces the possibility for the bioengineering of transplantable human kidneys, which could someday provide increased and more equitable access to kidney grafts for the treatment of end-stage renal disease.…”
Get full text

PhyloFunc: phylogeny-informed functional distance as a new ecological metric for metaproteomic data analysis by Luman Wang, Caitlin M. A. Simopoulos, Joeselle M. Serrana, Zhibin Ning, Yutong Li, Boyan Sun, Jinhui Yuan, Daniel Figeys, Leyuan Li

“…A more informative functional distance metric that incorporates evolutionary relatedness is needed to better understand microbiome functional dissimilarities. …”
Get full text

Precipitation–fire functional interactions control biomass stocks and carbon exchanges across the world's largest savanna by M. Williams, M. Williams, D. T. Milodowski, D. T. Milodowski, T. L. Smallman, T. L. Smallman, K. G. Dexter, G. C. Hegerl, I. M. McNicol, M. O'Sullivan, C. M. Roesch, C. M. Ryan, C. M. Ryan, S. Sitch, A. Valade

“…Compared to this analysis, LSMs showed marked differences in spatial distributions and magnitudes of C stocks and fire emissions. The current generation of LSMs represents savanna as a single plant functional type, missing important spatial functional variations identified here. …”
Get full text

An efficient spectrum sensing of mixed kernel SVM based on sampling covariance matrix by Jianyuan NIE, Jianrong BAO, Bin JIANG, Chao LIU, Fang ZHU, Jianhai HE

“…In recent years,with the blind detection algorithms were proposed,more and more blind algorithms based on sampling covariance matrix were applied to spectrum sensing.The detection threshold was an approximation,and the detection performance would be affected for this algorithms.Thus,the mixed kernel function support vector machine (SVM) efficient spectrum sensing based on sampling covariance matrix was proposed.The statistics which were maximum minimum eigenvalue (MME) and covariance absolute value (CAV) of sensing signal sampling covariance matrices were used as the feature vectors of SVM and were trained to generate a spectrum sensing classifier.The advantage of this algorithm was that it needn’t calculate the detection threshold and the extraction of features reduces size of the sample set.The genetic algorithm (GA) was used to optimize the parameters of mixed kernel function SVM algorithm.The experimental results show that the proposed method has higher detection probability than MME and CAV algorithms,and has less sensing time than SVM,which has good practicability.…”
Get full text

Estimation of Copula Density Using the Wavelet Transform by Fatimah Hashim Falhi, Munaf Yousif Hmood

“… This paper proposes a new method to estimate the copula density function using wavelet decomposition as a nonparametric method, to obtain more accurate results and address the issue of boundary effects that nonparametric estimation methods suffer from. …”
Get full text

Space Debris Sky Survey Observation Strategy Based on HEALPix and Greedy Algorithm by Shuqi Liu, Shaoming Hu, Junju Du, Hai Cao, Bo Zhang, Yuchen Jiang, Shuai Feng

“…The characteristics of the telescope and dynamic changes in the movement and position of space debris are considered in this strategy. An objective function was designed based on these factors. Using the pixelated sphere method to finely divide the celestial area, applying the summation filtering method, and using a greedy algorithm, the benefit of the objective function can be maximized, thus generating the optimal sky survey observation strategy. …”
Get full text

Effects of pneumatic tube systems on viscoelastic coagulation tests in septic patients and healthy individuals: protocol of the randomized controlled VETaPT-trial by Martin Mirus, Erik Buehrer, Lars Heubner, Christian Schnabel, Thea Koch, Peter Markus Spieth

“…However, the effect of PTS transport on VET results remains unclear, especially with newer VET technologies and in critically ill patients, who may be more vulnerable to acceleration forces.ObjectiveThe VETaPT (Viscoelastic Testing after Pneumatic Tube Transport) trial investigates whether PTS transport influences results of three next generation VET and platelet function testing in healthy volunteers and critically ill septic patients. …”
Get full text

Amplifying the Voices of South Korean Youths as a Generational Minority Against Conventional Paths of Success Through Hip Hop Music: A Text Analysis of Lyrics by James Jungho An, Yoona Kim, Wonjae Choi, Myunggu Jung

“…These findings suggest that, just as hip hop has historically functioned as a tool for empowering racial minorities, hip hop can provide a platform for younger or less dominant generations to challenge and potentially redefine the conventional measures of success imposed by previous or more dominant generations in South Korea.…”
Get full text

Thrombomodulin is a stronger indicator of combined oral contraceptives-induced activated protein C pathway resistance in the thrombin generation test than activated protein C by Marisa Ninivaggi, Lily Sokolova, Lily Sokolova, Demy Donkervoort, Bas de Laat, Bas de Laat, Romy de Laat-Kremers

Get full text