The Unpaved Road of Non-Coding RNA Structure–Function Relationships: Current Knowledge, Available Methodologies, and Future Trends by Ana Lúcia Leitão, Francisco J. Enguita

“…Non-coding RNA action is predominantly driven by sequence and structural motifs that interact with specific functional partners. Despite the exponential growth in primary RNA sequence data facilitated by next-generation sequencing studies, the availability of tridimensional RNA data is comparatively more limited. …”
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CTLA4Ig Improves Murine iTreg Induction via TGFβ and Suppressor Function In Vitro by Nina Pilat, Benedikt Mahr, Martina Gattringer, Ulrike Baranyi, Thomas Wekerle

“…However, since the CD28 pathway is more complex than initially thought, the question arose whether blocking CD80/86 would inadvertently impact immunological tolerance by interfering with Treg generation and function. …”
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A novel spectral transformation technique based on special functions for improved chest X-ray image classification. by Abeer Aljohani

“…We developed a mechanism which converts a given medical image to a spectral space which have a base set composed of special functions. In this study, we propose a chest X-ray image classification method based on spectral coefficients. …”
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Adaptive genetics reveals constraints on protein structure/function by evolving E. coli under constant nutrient limitation by Katja Schwartz, Margie Kinnersley, Charles Ross Lindsey, Gavin Sherlock, Frank Rosenzweig

“…Whole-genome whole-population sequencing makes it possible to identify mutations arising in such populations, to use them to discern functional modules where adaptation occurs, and then map gene structure–function relationships. …”
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Telomerase activity in T-cells as a functional test for pathogenicity assessment of novel genetic variants in telomere biology disorders by Olivia Carlund, Anna Norberg, Pia Osterman, Ida Andersson, Alva Eriksson, Sofie Degerman, Magnus Hultdin

“…We have developed a functional TA assay in patient-derived T-cells based on the Telomeric Repeat Amplification Protocol (TRAP) combined with qPCR. …”
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Role of AI and 3D quantitative computed tomography in obstructive airway diseases in correlation with pulmonary function tests by Amira Abdalla saad, Ahmed M. Osman, Hossam M. Abdelhamid, Mai Mohammad Sedik

“…Results A direct relation was discovered between wall thickness (WT), wall area (WA), and luminal area (LA) of the 3rd-generation bronchus of the right lower lung lobe and forced vital capacity (FVC), while no strong relation was found in the 4th and 5th generations. …”
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Novel Flavin Mononucleotide-Functionalized Cerium Fluoride Nanoparticles for Selective Enhanced X-Ray-Induced Photodynamic Therapy by Anastasia I. Kornienko, Maria A. Teplonogova, Marina P. Shevelyova, Matvei A. Popkov, Anton L. Popov, Vladimir E. Ivanov, Nelli R. Popova

“…In the context of normal cells, these nanoparticles serve the function of antioxidants, maintaining a high level of clonogenic activity. …”
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AGREE: an upper limb motorized exoskeleton for restoring arm functions: a single-blinded randomized controlled trial by Marta Gandolla, Beatrice Luciani, Valeria Longatelli, Peppino Tropea, Agnese Seregni, Massimo Corbo, Francesco Braghin, Alessandra Pedrocchi

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Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells by Yoon Kyung Jeon, Aram Lee, Haesun Park, Soyoung Lim, Jihyun Lim, Jaemoon Koh, Young Yang, Myeong-Sok Lee, Jong-Seok Lim

“…Furthermore, IHC staining of human tumor tissues revealed that MITF+ MO-MDSCs are more frequently observed in tumor tissues than in tumor-free draining lymph nodes obtained from patients with cancer.Conclusions Our results indicate that MITF regulates the differentiation and function of MDSCs and can be a novel therapeutic target for modulating MDSC activity in immunosuppressive TMEs.…”
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FEATURES OF WRITTEN LANGUAGE COMMUNICATION BY MEANS OF THE UKRAINIAN LANGUAGE (on the example of official-business, epistolary and conversational-functional styles) by Catherine S. Bondarchuk, Olha A. Chumachenko

“…The article analyzes the main types of oral and written communication on the material of different functional styles of the Ukrainian language. The research methodology consists of both the main methods of functional stylistics and its partial and concrete-practical methods, namely: functional, complex, semantic, comparative methods, multifaceted analysis and the method of direct observation. …”
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Influence of environmental exposures on T follicular helper cell function and implications on immunity: a comparison of Bangladeshi and American children by Dana M. Van Fossen, Hyunjae Cho, Lisa E. Wagar, Jennie Z. Ma, Julie Parsonnet, Rashidul Haque, Mark M. Davis, William A. Petri

“…ABSTRACT T follicular helper (Tfh) cells are crucial for B cell activation and subsequent antibody production. This functionality is influenced by surface markers such as CD40L, a costimulatory factor which promotes B cell activation, and CD57, which is a well-known marker of senescence. …”
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Multimodal Fusion Framework for Urban functional zone change detection using Remote Sensing and Social Sensing Data by B. Fang, B. Fang, B. Fang, B. Fang, X. Chen, X. Chen, X. Chen, X. Chen, H. Chen, H. Chen, Z. Xiang, Z. Xiang, B. Hu, B. Hu, Z. Hu, Z. Hu, Z. Hu, Z. Hu, W. Tu, W. Tu, W. Tu, W. Tu

“…For the RS-branch, RS imagery provides detailed spatial information about urban transformations; for the MP-branch, MP data as a typical social sensing data captures temporal patterns in human mobility, offering insights into functional shifts in urban spaces. By fusing these two complementary modalities, our approach allows for a more nuanced detection of urban functional zone changes. …”
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Development of Human Mast Cells from Hematopoietic Stem Cells within a 3D Collagen Matrix: Effect of Stem Cell Media on Mast Cell Generation by Tahereh Derakhshan, Rudra Bhowmick, Jerry W. Ritchey, Heather Gappa-Fahlenkamp

“…This work demonstrates the development of functional MCs within a 3D collagen matrix using a stem cell media that supports fibroblast and ECs.…”
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Isoliensinine Induces Ferroptosis in Urothelial Carcinoma Cells via the PI3K/AKT/HIF-1α Axis: Molecular Evidence from Next-Generation Sequencing by Yun-Chen Li, Hsuan-En Huang, Chia-Ying Yu, Ya-Chuan Chang, Shu-Yu Lin, Shao-Chuan Wang, Wen-Wei Sung

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Above-mJ optical parametric chirped pulse amplifier at 3 μm for laser-driven coherent soft x-ray generation beyond the water window by Pritha Dey, Lutz Ehrentraut, Johannes Tümmler, Matthias Schnürer, Stefan Eisebitt

“…Optical parametric chirped pulse amplification (OPCPA) provides an excellent platform to generate ultrashort mid-infrared pulses in the spectral window beyond the scope of traditional mode-locked lasers. …”
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Functional Approaches to Discover New Compounds via Enzymatic Modification: Predicted Data Mining Approach and Biotransformation-Guided Purification by Te-Sheng Chang

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Behavioral interventions to benefit cognition (Intervenciones cognitivas para beneficiar la cognición) by Jennifer L. Etnier, Chia-Hao Shih, Aaron Piepmeier

“…In addition, given the likelihood that multiple underlying mechanisms support cognitive function, research is currently focusing on how to combine lifestyle factors into multi-component interventions to generate greater and more meaningful effects. …”
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The association between gestational selective serotonin reuptake inhibitor (SSRI) treatment and newborn thyroid screen: a large-scale cohort study by Orian Raviv, Yael Lebenthal, Michal Yackobovitch-Gavan, Eyal Cohen-Sela, Shlomo Almashanu, Ronella Marom, Jacky Herzlich, Liran Hiersch, Avivit Brener

“…However, the impact of gestational SSRI treatment on newborn thyroid function is lacking. We explored the impact of gestational SSRI treatment on newborn thyroid function as measured by the National Newborn Screening (NBS) Program and identified contributory factors. …”
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Effects of Cacna1d D307G Mutation on Blood Pressure and Kidney Function in Rats with Salt Loading by Lan Cheng, Hui Chen, R. Nfornah Maboh, Huan Wang

“…Methods: We used the CRISPR/Cas9 technique to generate the Cacna1d D307G mutation rat model and investigated the effects of Cacna1d D307G mutation on blood pressure (BP) and renal function. …”
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Structure–function relationships in unspecific peroxygenases revealed by a comparative study of their action on the phenolic lignin monomer 4-propylguaiacol by Marta Barros-Reguera, Esteban Lopez-Tavera, Gabriela C. Schröder, Greta Nardini, Kenneth A. Kristoffersen, Iván Ayuso-Fernández, Vincent G. H. Eijsink, Morten Sørlie

“…Our study provides valuable insights into the structure–function relationships underpinning enhanced peroxygenase activity of UPOs and provides a functional mapping of a broad UPO-sequence space for 4-PG, highlighting these enzymes as promising catalysts for the selective oxyfunctionalization of a phenolic lignin monomer.…”
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