Combined transcriptome and proteome profiling reveal cell-type-specific functions of Drosophila garland and pericardial nephrocytes by Heiko Meyer, Judith Bossen, Maren Janz, Xenia Müller, Sven Künzel, Thomas Roeder, Achim Paululat

“…Factor-specific comparisons identified novel candidate proteins either expressed and secreted by the nephrocytes or sequestered by them. The data generated in this study represent a valuable basis for a more specific application of the Drosophila model in analysing renal cell function in health and disease.…”
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Estimation of Copula Density Using the Wavelet Transform by Fatimah Hashim Falhi, Munaf Yousif Hmood

“… This paper proposes a new method to estimate the copula density function using wavelet decomposition as a nonparametric method, to obtain more accurate results and address the issue of boundary effects that nonparametric estimation methods suffer from. …”
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Large-scale urban building function mapping by integrating multi-source web-based geospatial data by Wei Chen, Yuyu Zhou, Eleanor C. Stokes, Xuesong Zhang

“…Due to the limited availability of socio-economic geospatial data, it is more challenging to map building functions than building morphological information, especially over large areas. …”
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Narrowing the gap between machine learning scoring functions and free energy perturbation using augmented data by Ísak Valsson, Matthew T. Warren, Charlotte M. Deane, Aniket Magarkar, Garrett M. Morris, Philip C. Biggin

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Effects of Mesenchymal Stem Cells on Functions of Chimeric Antigen Receptor-Expressing T Lymphocytes and Natural Killer Cells by Vladislav Volarevic, Carl Randall Harrell, Aleksandar Arsenijevic, Valentin Djonov, Ana Volarevic

“…Additionally, MSCs may serve as vehicles for targeted delivery of immunomodulatory agents, and should be considered as active components in the design of next-generation CAR-based immunotherapies. Accordingly, in this review article we emphasize molecular and cellular mechanisms involved in MSC-dependent modulation of CAR-expressing immune cells, paving the way for more efficient CAR-based immunotherapy for malignant diseases.…”
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Increased functional potency of multi-edited CAR-T cells manufactured by a non-viral transfection system by Aine O’Sullivan, Sarah Case, Aisling McCrudden, Emer Hackett, Louise Gallagher, Darren Martin, Gillian P. Johnson, Kirti Mahadik, Thomas Kienzle, Jude Kevin Lim, Aya Nashat, Kartik Srinivasan, Mark W. Lowdell, Lisa O’Flynn, Jamie Frankish

“…Improving manufacturing processes to preserve cell health and function of edited T cells is equally critical. Here, we report that Solupore, a Good Manufacturing Practice-aligned, non-viral physicochemical transfection system, can be used to manufacture multi-edited CAR-T cells using CRISPR-Cas9 ribonucleoproteins while maintaining robust cell functionality. …”
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Investigating the causal pathways among psychopathological variables, cognitive impairment, and real-life functioning in people with schizophrenia by Luigi Giuliani, Francesco Sanmarchi, Armida Mucci, Paola Rucci, Edoardo Caporusso, Paola Bucci, Giulia M. Giordano, Mario Amore, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Silvana Galderisi, Mario Maj

“…State-of-the-art instruments were used to assess the study variables. Two PAGs were generated at baseline and after 4 years of follow-up to model the nature of the causal relationships linking psychopathology, cognition, and functioning. …”
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Metagenomic and physicochemical profiling reveal microbial functions in pit mud for Jiang-Nong Jianxiang Baijiu fermentation by Lianbin Cao, Hongmei Sun, Ziyi Xu, Xiaoxiao Xu, Guangchuan Shi, Jianqiang Zhang, Changli Liang, Tongbiao Li, Chaoying Liu, Mingcheng Wang, Shilin Tian, Enzhong Li

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Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs) by Emma Keltsch, Jennifer Greiner, Lena Wahl, Ingrid Knape, Daniel Tews, Michael Denkinger, Klaus-Michael Debatin, Gudrun Strauss

“…Myeloid-derived suppressor cells (MDSCs) are potent inhibitors of T cell activation and function, whose induction requires chronic inflammation. …”
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Functional properties and toxicological analysis of nanocellulose-based aerogels loaded with polyphenols from Hyeronima macrocarpa berries by Andrés Felipe Alzate-Arbeláez, Farid B. Cortés, Benjamín A. Rojano

“…The differences found in samples for the different functional assays can be explained by the various types of interactions generated between the antioxidant molecules and aerogels, in the various media where the analyses are carried out. …”
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PhyloFunc: phylogeny-informed functional distance as a new ecological metric for metaproteomic data analysis by Luman Wang, Caitlin M. A. Simopoulos, Joeselle M. Serrana, Zhibin Ning, Yutong Li, Boyan Sun, Jinhui Yuan, Daniel Figeys, Leyuan Li

“…A more informative functional distance metric that incorporates evolutionary relatedness is needed to better understand microbiome functional dissimilarities. …”
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Precipitation–fire functional interactions control biomass stocks and carbon exchanges across the world's largest savanna by M. Williams, M. Williams, D. T. Milodowski, D. T. Milodowski, T. L. Smallman, T. L. Smallman, K. G. Dexter, G. C. Hegerl, I. M. McNicol, M. O'Sullivan, C. M. Roesch, C. M. Ryan, C. M. Ryan, S. Sitch, A. Valade

“…Compared to this analysis, LSMs showed marked differences in spatial distributions and magnitudes of C stocks and fire emissions. The current generation of LSMs represents savanna as a single plant functional type, missing important spatial functional variations identified here. …”
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Fast-track analysis of beetroot using the liquid generated during the cooking processOpen Data is available at under the name “UBU-Polymers Research Group 02062025″. by María Gaona-Ruiz, Saúl Vallejos, Ana Rodríguez, Miriam Trigo-López, Celia Carrillo

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Space Debris Sky Survey Observation Strategy Based on HEALPix and Greedy Algorithm by Shuqi Liu, Shaoming Hu, Junju Du, Hai Cao, Bo Zhang, Yuchen Jiang, Shuai Feng

“…The characteristics of the telescope and dynamic changes in the movement and position of space debris are considered in this strategy. An objective function was designed based on these factors. Using the pixelated sphere method to finely divide the celestial area, applying the summation filtering method, and using a greedy algorithm, the benefit of the objective function can be maximized, thus generating the optimal sky survey observation strategy. …”
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Effects of pneumatic tube systems on viscoelastic coagulation tests in septic patients and healthy individuals: protocol of the randomized controlled VETaPT-trial by Martin Mirus, Erik Buehrer, Lars Heubner, Christian Schnabel, Thea Koch, Peter Markus Spieth

“…However, the effect of PTS transport on VET results remains unclear, especially with newer VET technologies and in critically ill patients, who may be more vulnerable to acceleration forces.ObjectiveThe VETaPT (Viscoelastic Testing after Pneumatic Tube Transport) trial investigates whether PTS transport influences results of three next generation VET and platelet function testing in healthy volunteers and critically ill septic patients. …”
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Amplifying the Voices of South Korean Youths as a Generational Minority Against Conventional Paths of Success Through Hip Hop Music: A Text Analysis of Lyrics by James Jungho An, Yoona Kim, Wonjae Choi, Myunggu Jung

“…These findings suggest that, just as hip hop has historically functioned as a tool for empowering racial minorities, hip hop can provide a platform for younger or less dominant generations to challenge and potentially redefine the conventional measures of success imposed by previous or more dominant generations in South Korea.…”
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Thrombomodulin is a stronger indicator of combined oral contraceptives-induced activated protein C pathway resistance in the thrombin generation test than activated protein C by Marisa Ninivaggi, Lily Sokolova, Lily Sokolova, Demy Donkervoort, Bas de Laat, Bas de Laat, Romy de Laat-Kremers

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A fusion analytic framework for investigating functional brain connectivity differences using resting-state fMRI by Yeseul Jeon, Jeong-Jae Kim, SuMin Yu, Junggu Choi, Sanghoon Han, Sanghoon Han

“…The framework involves three steps: first, constructing ROI-based Functional Connectivity Networks (FCNs) to manage resting-state fMRI data; second, employing a Self-Attention Deep Learning Model (Self-Attn) for binary classification to generate attention distributions encoding group-level differences; and third, utilizing a Latent Space Item-Response Model (LSIRM) to extract group-representative ROI features, visualized on group summary FCNs.ResultsWe applied our framework to analyze four types of cognitive impairments, demonstrating their effectiveness in identifying significant ROIs that contribute to the differences between the two disease groups. …”
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Enhancing bioactive profiles of elderberry juice through yeast fermentation: a pathway to low-sugar functional beverages by Amir Shazad, Ali Zein Alabiden Tlais, Davide Gottardi, Pasquale Filannino, Francesca Patrignani, Rosalba Lanciotti, Marco Gobbetti, Raffaella Di Cagno

“…In response to the growing need for functional beverages, this study aimed to harness yeast metabolism to optimize elderberry juice fermentation, targeting sugar reduction and enrichment of bioactive compounds with enhanced functional properties. …”
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Enhancement of the operating time of the overcurrent relay of the distribution network with high-level penetration of renewable energy sources by Mahmoud Aref, Mahmoud A. Mossa, Emad Abdelkarim, Khairy Sayed, Mishari Metab Almalki, Alaa F.M. Ali

“…The calculation of the output current of distribution generation (DG) units interfaced with an inverter during the fault is a major issue for isolated and grid-connected distributed networks. …”
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