Clinical implications, safety, efficacy of Recombinant Human Granulocyte Colony-Stimulating Factors and Pegylated Equivalent by Silvia Bolis, Emilia Cocorocchio, Consuelo Corti, Andrés J M Ferreri, Niccolò Frungillo, Giovanni Grillo, Emanuela Salè Omodeo, Lucilla Tedeschi, Vittorio Ruggero Zilioli

“…For instance, lenograstim binds to receptors in the same way of endogenous ligand, and neutrophils obtained from stimulation with this G-CSF have a physiological activity profile similar to neutrophils normally generated in humans. Conversely, the different interaction between filgrastim and G-CSF receptor is more frequently associated with morphological abnormalities, reduced motility and chemotaxis and a reduced response to bacterial stimuli in induced neutrophils.…”
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Possibilities of Physical Medicine in the Treatment of Median Nerve Paralysis – Case Report by Jarosław Pasek, Grzegorz Cieślar, Tomasz Pasek

“…The recent years this is the dynamic development of method from physical medicine which more and more often help led treatment. Case Report. …”
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Influence of Infotainment-System Audio Cues on the Sound Quality Perception Onboard Electric Vehicles in the Presence of Air-Conditioning Noise by Massimiliano Masullo, Katsuya Yamauchi, Minori Dan, Federico Cioffi, Luigi Maffei

“…The results indicate that introducing ISA cues in car cabins fosters improvements in the perceived aesthetic dimension of sound quality, making it more functioning, natural, and pleasant. For the Italian group, adding ISA cues also moderated the loudness dimension by reducing noise perception. …”
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Impact of carbon emission trading on urban electricity efficiency by SHI Yang, SONG Jia

“…[Results] (1) The pilot policy of carbon emission rights trading has significantly enhanced the urban electricity efficiency; (2) Its mechanism of action mainly lies in that, when the electricity price cannot fully regulate the situation, carbon emission rights trading can increase the supply constraints faced by thermal power enterprises and promote the transformation of their functions to improve the power supply flexibility of these enterprises; (3) When the proportion of thermal power generation in the city's electricity generation is higher, the number of thermal power enterprises participating in carbon emission rights trading is greater, and the total volume of carbon emission rights trading is larger, the effect of enhancing electricity consumption efficiency becomes stronger; (4) The carbon emission rights trading policy not only promotes the improvement of electricity efficiency but also boosts the economic growth of the city and reduces the air pollution level. …”
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Potential Applicability of Air-Cooled Ladle Furnace Slag Fine Aggregate in Concrete Production by Jeongmin Ra, Sunmi Choi, Sangchul Shin, Jinman Kim

“…Electric arc furnace oxidizing slag (EAFOS) represents 80% of the electric arc furnace slag generated. Recently, EAFOS has been utilized as high value-added functional aggregate in a growing number of cases for the construction of air-cooling technology that turns EAFOS into fine aggregate-sized particles by spraying it into the air using high-pressure compressed air. …”
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The extracellular loop 2 (ECL2) of the human histamine H4 receptor substantially contributes to ligand binding and constitutive activity. by David Wifling, Günther Bernhardt, Stefan Dove, Armin Buschauer

“…To study the role of the FF motif in ECL2, we generated the hH4R-F168A mutant. The receptor was co-expressed in Sf9 insect cells with the G-protein subunits Gαi2 and Gβ1γ2, and the membranes were studied in [3H]histamine binding and functional [35S]GTPγS assays. …”
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A comparative survey of the influence of small self-cleaving ribozymes on gene expression in human cell culture by Dennis Kläge, Elisabeth Müller, Jörg S. Hartig

“…We were able to identify functional structures suited for aptazyme design and generated highly efficient hammerhead ribozyme variants originating from the human genome. …”
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Robust models of disease heterogeneity and control, with application to the SARS-CoV-2 epidemic. by Kory D Johnson, Annemarie Grass, Daniel Toneian, Mathias Beiglböck, Jitka Polechová

“…This not only reduces the median total infections and peak quarantine cases, but also controls outbreaks much more reliably: such a controller entirely prevents rare but large outbreaks. …”
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In-silico study of bacterial keratinase and optimization of extraction procedure for keratin from Country chicken and Indian blue rock pigeon feathers by Sathvika Kamaraj, Suneetha Vuppu

“…This extraction procedure is significantly more cost-effective and yields more keratin than earlier approaches. …”
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Phenotypic mutation rates and the abundance of abnormal proteins in yeast. by Martin Willensdorfer, Reinhard Bürger, Martin A Nowak

“…In our model, genes are regulated to synthesize a certain number of functional proteins. During this process, depending on the phenotypic mutation rate, abnormal proteins are generated. …”
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Vibroacoustic monitoring of bearing points failures in the driving system of the mining main ventilation fans by T. ZAKRZEWSKI

“…As there is no access to them in the course of operation, diagnostic methods which can be applied without dismantling the machine, and particularly vibroacoustic methods based on the fact that there is a dependence between failure-free operation and the vibroacoustic condition of bearings become more and more essential. The evaluation of the technical condition of rolling and slide bearings, based on measures of a vibratory signal, made on the basis of amplitude values of discrete components occurring in the spectra of the recorded vibratory signals, has; been the subject of diagnostic examinations. …”
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Calorimetric Measurements of a High-Power RF Signal by R. V. Budaragin, Z. Ju. Salasenko, A. D. Serov, I. A. Tsvetkova

“…The parameters of the cooling system were determined based on minimizing the time to achieve thermal equilibrium (time to establish readings) and the set parameters (input temperature no more than 35 °С, temperature difference no more than 40 °С). …”
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Cultural Codes of Marriage Rituals in Anatolia: From Ritual to Word in the Context of Oral Culture by Atila Kartal

“…Consequently, an interdisciplinary approach that incorporates the study of transitional rituals and oral culture is necessary to achieve a more comprehensive understanding. By examining cultural elements from diverse perspectives, we can develop a more comprehensive and nuanced understanding of cultural diversity in Anatolia.…”
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Artificial Intelligence Teaching System and Data Processing Method Based on Big Data by Bo Xu

“…As the carrier of students’ autonomous learning, the artificial intelligence teaching system provides a wealth of learning resources and learning tools on the one hand, and on the other hand, it gradually accumulates more and more learning behaviors, learning status, and other large amounts of data, which is an in-depth study of online learning and provides valuable and generative dynamic resources. …”
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Modeling and optimization of renewable hydrogen systems: A systematic methodological review and machine learning integration by M.D. Mukelabai, E.R. Barbour, R.E. Blanchard

“…The practicability of socio-economic objective functions is also assessed, proposing that the more comprehensive Levelized Value Addition (LVA) is best suited for inclusion into models. …”
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Re-use of Building Products in the Netherlands by Loriane Icibaci

“… Over the years, the consumption of materials for construction exceeded more than half of the total materials consumed in the Netherlands, and construction waste exceeded the volume of solid waste produced by households. …”
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Bicarbonate Within: A Hidden Modulator of Antibiotic Susceptibility by Selvi C. Ersoy, Warren E. Rose, Richard A. Proctor

“…Mechanistically, bicarbonate appears to influence <i>mecA</i> expression and PBP2a production/localization, as well as key elements for PBP2a functionality, including the PBP2a chaperone PrsA, components of functional membrane microdomains (FMMs), and wall teichoic acid (WTA) synthesis. …”
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Logical gates recognition in a flat transistor circuit by D. I. Cheremisinov, L. D. Cheremisinova

“…Decompilation tools for transistor circuits can not only significantly reduce the time to perform VLSI topology check, but also provide the basis for generating test cases, logical reengineering of integrated circuits and reverse engineering to detect untrusted attachments.The objective of the work is to solve the problem of extracting the structure of the functional level from a flat circuit of the transistor level by recognizing in it subcircuits that implement logical elements.M e t h o d s. …”
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Colorectal cancer-infiltrating NK cell landscape analysis unravels tissue-resident PD-1+ NK cells in microsatellite instability tumors by Valentina Obino, Chiara Giordano, Simona Carlomagno, Chiara Setti, Marco Greppi, Matteo Bozzo, Silvia Pesce, Silvia Pesce, Elisa Ferretti, Elisa Ferretti, Simona Candiani, Simona Candiani, Letizia Muccio, Enrico Ciferri, Tania Buttiron Webber, Agnese Solari, Fulvia Ortolani, Laura Paleari, Matteo Clavarezza, Andrea Barberis, Marco Filauro, Nicoletta Provinciali, Nicoletta Provinciali, Mariangela Rutigliani, Emanuela Marcenaro, Emanuela Marcenaro, Andrea DeCensi, Andrea DeCensi, Mariella Della Chiesa, Mariella Della Chiesa, Simona Sivori, Simona Sivori

“…Since CRC microenvironment can induce NK cell dysfunction and hinder cancer control, understanding tumor-associated NK cell features is mandatory to fully unlock their immunotherapeutic potential.PurposeOur study aims at elucidating the molecular and functional characteristics of tumor-associated NK cells in CRC focusing on the expression of immune checkpoints that critically regulate NK cell function. …”
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Use of Technology to Support Health Care Providers Delivering Care in Low- and Lower-Middle-Income Countries: Systematic Umbrella Review by Adam Craig, Harriet Lawford, Maggie Miller, Liuyi Chen-Cao, Leanna Woods, Siaw-Teng Liaw, Myron Anthony Godinho

“…Digital health innovations (DHIs) promise more efficient and equitable health care delivery. …”
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