Crosstalk between metabolism and epigenetics during macrophage polarization by Kangling Zhang, Chinnaswamy Jagannath

“…These epigenetic modifications control gene expression by regulating chromatin accessibility, thereby modulating macrophage function and polarization. Histone acetylation generally promotes a more open chromatin structure conducive to gene activation, while histone methylation can either activate or repress gene expression depending on the specific residue and its methylation state. …”
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Valency-affinity mapping of multivalent liposomes for tunable target cell discrimination by Victor A. Garcia, Paulina M. Eberts, Brenda M. Ogle, Casim A. Sarkar

“…BPI generally tracks with traditional binding selectivity, but BPI is more sensitive to off-target effects or poor on-target binding and thus may better assess particle performance. …”
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Joint ancestry and association testing in admixed individuals. by Daniel Shriner, Adebowale Adeyemo, Charles N Rotimi

“…In both stages, we use generalized linear models, providing the advantage that the joint test can be used with any phenotype distribution with an appropriate link function. …”
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A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein. by Oliver E Farrance, Eleanore Hann, Renata Kaminska, Nicholas G Housden, Sasha R Derrington, Colin Kleanthous, Sheena E Radford, David J Brockwell

“…More generally, the observation of two force phenotypes for the E9:Im9 complex demonstrates that force can re-sculpt the underlying energy landscape, providing new opportunities to modulate biological reactions in vivo; this rationalises the commonly observed discrepancy between off-rates measured by dynamic force spectroscopy and ensemble methods.…”
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Estradiol level on day two and day of trigger: A potential predictor of the invitro fertilization success by Alaa Ahmed Mohammed, Chiman Khudhur Mawlood

“…It is generally known that a particular quantity of estradiol per follicle is necessary for pregnancy to occur. …”
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Arrhythmia detection with transfer learning architecture integrating the developed optimization algorithm and regularization method by Fatma Akalın, Pınar Dervişoğlu Çavdaroğlu, Mehmet Fatih Orhan

“…The results obtained show that generalizations can be made for comprehensive, highly diverse and rich datasets.…”
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The effects of smoking, alcohol consumption, obesity, and physical inactivity on healthcare costs: a longitudinal cohort study by Younhee Kim

“…Cumulative healthcare costs during 2010–2019 were analyzed using a generalized linear model with log-link function and gamma distribution, adjusted for other health behaviors and sociodemographic factors. …”
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Dietary diversity and associated factors among people with tuberculosis in Kampala, Uganda: A cross-sectional study by Jonathan Izudi, Simon Kyazze, Francis Bajunirwe

“…Independent variables included sociodemographic, clinical, and behavioral factors. We used a Generalized Estimating Equation with a Poisson distribution, log link function, and robust standard errors, with health facility as a cluster and several variables to identify the factors associated with adequate DD. …”
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FEATURES OF IMPLEMENTATION OF MANAGEMENT INNOVATIONS BY IT ENTREPRENEURS by Stanislav A. Horbachenko

“….), innovations in internal structural subtypes of general management, financial innovation, marketing), innovations in the basics of science and practice of classical management (innovations in the principles, methods, management functions and elements of regulatory information and staffing). …”
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Patient routing and process approach implementation for regional oncology service by R. A. Murashko, S. N. Alekseenko, A. A. Koshkarov, L. G. Teslenko, M. A. Korogod, I. T. Rubtsova

“…We perceive prospects of the integrated information platform in the extension and improvement of its subsystems’ functionality and content, sourcing more data providers and the circuit expansion to the federal and regional levels.…”
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Association between medication adherence and health-related quality of life among type 2 diabetic adults in Mexico by Sara I. Olvera-Cruz, Araceli Cano-Estrada, José Á. Hernández-Mariano, Ana C. Castañeda-Márquez, Yaneth C. O. Orihuela, María A. Mejía-Blanquel

“…After adjusting for confounders, we observed that non-adherent adults were more likely to have poor HRQoL in six domains of SF-36: physical functioning (adjusted odds ratio [ORa] =2.02; 95% confidence interval [95% CI] =1.06, 3.80); physical role (ORa = 2.37; 95% CI = 1.13, 4.96); bodily pain (ORa = 2.71; 95% CI = 1.45, 5.06); general health (ORa = 2.57; 95% CI = 1.37, 4.80); vitality (ORa = 3.30; 95% CI = 1.70, 6.39); social functioning (ORa = 2.97; 95% CI = 1.56, 5.65); and mental health (ORa = 2.66; 95% CI = 1.42, 4.98). …”
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Reverse Engineering Segment Routing Policies and Link Costs With Inverse Reinforcement Learning and EM by Kai Wang, Chee Wei Tan

“…Network routing is a core functionality in computer networks that holds significant potential for integrating newly developed techniques with minimal software effort through the use of Software-Defined Networking (SDN). …”
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Local communities in cities as a subject of control over solving local issues by Alexander A. Larichev

“…This article is devoted to exploring the possibilities of formalizing the institution of local communities of citizens in urban areas, with the goal to more extensively involve local population in solving local issues, including controlling the organization of relevant processes.The purpose of the article to refute or confirm the hypothesis that local communities may exercise local control functions effectively to improve the quality of local services and reduce the number of local government officials.The methodology of the study includes methods of theoretical analysis, as well as legal methods, including the formal legal method.The main results and scope of their application. …”
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Pattern and severity of multimorbidity among patients attending primary care settings in Odisha, India. by Sanghamitra Pati, Subhashisa Swain, Job Metsemakers, J André Knottnerus, Marjan van den Akker

“…Multimorbidity patterns (dyad and triad) were identified for 21 chronic conditions, functional limitation was assessed as a proxy measure of severity and the mean severity score for each pattern, was determined after adjusting for age. …”
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The role of community health workers in the reengineering of primary health care in rural Eastern Cape by Karl le Roux, Ingrid M. le Roux, Nokwanele Mbewu, Emily Davis

“…From hospitals to clinics, in the community and in the home, health care will focus more on prevention, health promotion, and advocacy for healthy lifestyles and well-being, in addition to clinical services. …”
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Cofilin1 controls transcolumnar plasticity in dendritic spines in adult barrel cortex. by Tadashi Tsubota, Reiko Okubo-Suzuki, Yohei Ohashi, Keita Tamura, Koshin Ogata, Masae Yaguchi, Makoto Matsuyama, Kaoru Inokuchi, Yasushi Miyashita

“…These new mechanistic insights into transcolumnar plasticity in adult rats may have a general significance for understanding reorganization of neocortical circuits that have more sophisticated columnar organization than the rodent neocortex, such as the primate neocortex.…”
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NMDA receptor inhibition increases, synchronizes, and stabilizes the collective pancreatic beta cell activity: Insights through multilayer network analysis. by Marko Šterk, Lidija Križančić Bombek, Maša Skelin Klemen, Marjan Slak Rupnik, Marko Marhl, Andraž Stožer, Marko Gosak

“…Since a disrupted collective activity is an important and possibly early contributor to impaired insulin secretion and glucose intolerance, it is of utmost importance to understand possible effects of NMDA receptor inhibition on beta cell functional connectivity. To address this issue, we combined confocal functional multicellular calcium imaging in mouse tissue slices with network science approaches. …”
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The parental non-equivalence of imprinting control regions during mammalian development and evolution. by Reiner Schulz, Charlotte Proudhon, Timothy H Bestor, Kathryn Woodfine, Chyuan-Sheng Lin, Shau-Ping Lin, Marine Prissette, Rebecca J Oakey, Déborah Bourc'his

“…Using comparative genomics of 17 extant mammalian species, we show here that, while ICRs in general have been constrained to maintain more CpGs than non-imprinted sequences, the rate of CpG loss at paternal ICRs has indeed been higher than at maternal ICRs during evolution. …”
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The genus Entomophthora: bringing the insect destroyers into the twenty-first century by Carolyn Elya, Henrik H. De Fine Licht

“…However, we are only starting to understand the functions of unusual molecular and genomic characteristics, such as having large > 1 Gb genomes full of repetitive elements and potential functional diploidy. …”
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Boosting GWAS using biological networks: A study on susceptibility to familial breast cancer. by Héctor Climente-González, Christine Lonjou, Fabienne Lesueur, GENESIS study group, Dominique Stoppa-Lyonnet, Nadine Andrieu, Chloé-Agathe Azencott

“…To address this shortcoming, one can use biological networks, which model functional relationships, to search for functionally related susceptibility loci. …”
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