Frequency, intensity and duration of physical activity is associated with frailty in older adults with cardiac aging by Laureen Y. T. Wang, Wee Shiong Lim, Ru-San Tan, Louis L. Y. Teo, Shu Yun Tan, Chun How Ooi, Alvin Cong Wei Ong, Jean-Paul Kovalik, Jorming Goh, Fei Gao, Angela S. Koh

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Prosthetic valve thrombosis in a patient secondary to COVID-19: a case report by L. V. Rasputina, D. V. Didenko

“…At the same time, concomitant cardiac pathology is associated with a more severe course of COVID-19 and higher risks of complications and mortality. …”
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Changes and Risk Factors of Skeletal Muscle Mass and Strength in Patients with Type 2 Diabetes over 60 Years Old: A Cross-Sectional Study from China by Liming Hou, Yan Liu, Xing Li, Cong Huo, Xin Jia, Jie Yang, Yunzhen Lei, Rong Xu, Chao Sun, Xiaoming Wang

“…The accelerate loss of skeletal muscle mass, strength, and function, named sarcopenia, is a progressive and generalised skeletal muscle disorder, and it is always associated with increased outcomes including falls, frailty, and disability. …”
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Responses to checkpoint inhibition in metastatic triple negative breast cancer driven by divergent myeloid phenotypes by Avia D. Wilkerson, Ivan Juric, Salendra Singh, Patricia A. Rayman, Paul G. Pavicic, Jennifer Powers, Prerana Bangalore Parthasarathy, Zahraa Al-Hilli, Jennifer S. Ko, Timothy Chan, Tyler Alban, Alberto J. Montero, C. Marcela Diaz-Montero

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Investigating the mutual effects of autophagy and apoptosis in heart tissue of type 2 diabetic rats in interaction with aerobic exercise training and vitamin D3 injection by Hadi Golpasandi, Mohammad Rahman Rahimi, Slahadin Ahmadi

“…The results also showed that fasting glucose levels and insulin resistance index decreased significantly in DAT, DVD and DVDAT groups (P<0.001), and this decrease was more in DVDAT group (P<0.001).Conclusion: In general, it could be concluded that type 2 diabetes causes disturbances in cellular and metabolic homeostasis, including insulin resistance, through increased autophagy and apoptosis in heart tissue, which can be reversed through aerobic training and vitamin D3, and improve glucose metabolism and insulin resistance.…”
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Concurrent validity of the Single Assessment Numerical Evaluation and hip-specific patient-reported outcome measures: a cross-sectional retrospective database analysis by Elizabeth M. Bergman, Edward P. Mulligan, Rupal M. Patel, Joel Wells

“…The SANE may be a pragmatic alternative for clinical benchmarking in a general population of patients with hip pain. The construct validity of the SANE should be questioned compared to legacy measures whose content validity has been more rigorously investigated. …”
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Can machine-learning algorithms improve upon classical palaeoenvironmental reconstruction models? by P. Sun, P. B. Holden, H. J. B. Birks, H. J. B. Birks

“…We found that the classical approaches are generally more robust, although they could also generate reconstructions which have modest statistical significance and therefore may be unreliable. …”
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Prospective Study of Ultrasound Markers of Organ Congestion in Critically Ill Patients With Acute Kidney Injury by William Beaubien-Souligny, Laura Galarza, Brian Buchannan, Vincent I. Lau, Neill K.J. Adhikari, Jean Deschamps, Emmanuel Charbonney, André Denault, Ron Wald

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Investigation and analysis of exercise behavior stage in non-dialysis patients with chronic kidney disease by Chen Jia, Hu Jie-qiong, Wang Jing

“…There were significant differences in the GLTEQ scores among different ages ［18-35 years old （21.60 ± 3.35） points； &gt;35-50 years old （17.24 ± 3.14） points； &gt;50-65 years old （12.38 ± 2.79） points］， genders ［male （18.53 ± 3.85） points； female （12.84 ± 3.00） points］， CKD course ［&lt;3 years （21.37 ± 3.48） points； 3-5 years （17.28 ± 3.32） points； &gt;5 years （12.86 ± 3.01） points］， primary incidence of CKD［glomerulonephritis （12.18 ± 2.73） points； hypertensive renal damage （15.80 ± 2.50） points； diabetic renal disease （20.91 ± 4.08） points； chronic pyelonephritis （17.93 ± 0.68） points； others （20.05 ± 0.23） points］， education level［junior high school or below （20.85 ± 3.91） points； High school or technical secondary school （16.69 ± 2.40） points； junior college or above （12.37 ± 2.78） points］ and residence status ［urban residents （13.79 ± 2.92） points； suburban or rural residents （21.31 ± 2.76） points］ （<italic>P</italic>&lt;0.05）.ConclusionsThe overall exercise activity of non-dialysis CKD patients is insufficient， and the worse the renal function indicates a more obvious exercise deficiency. …”
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Evaluation of vascular cognitive impairment and identification of imaging markers using machine learning: a multimodal MRI study by Haoying He, Dongwei Lu, Sisi Peng, Jiu Jiang, Fan Fan, Dong Sun, Tianqi Sun, Zhipeng Xu, Ping Zhang, Xiaoxiang Peng, Ming Lei, Junjian Zhang

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A genotype-first approach identifies high incidence of NF1 pathogenic variants with distinct disease associations by Anton Safonov, Tomoki T. Nomakuchi, Elizabeth Chao, Carrie Horton, Jill S. Dolinsky, Amal Yussuf, Marcy Richardson, Virginia Speare, Shuwei Li, Zoe C. Bogus, Maria Bonanni, Anna Raper, Trust Odia, Bradley S. Wubbenhorst, Elsa Faulders, Elisabeth M. Schuth, Kate Loranger, Jingwen Zhang, Carly Bess Scalise, Adam ElNaggar, Youbao Sha, Stephanie A. Felker, Jeffrey Weitzel, Staci Kallish, Marylyn D. Ritchie, Penn Medicine BioBank, Katherine L. Nathanson, Theodore G. Drivas

“…Our findings suggest that NF1 pathogenic variants are substantially more common than previously thought, often characterized by somatic mosaicism and reduced penetrance, and are important contributors to cancer risk in the general population.…”
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Glucagon-like peptide-1 receptor agonists in neurodegenerative diseases: Promises and challenges by Zhi Dong Zhou, Lingxiao Yi, Karolina Popławska-Domaszewicz, Kallol Ray Chaudhuri, Joseph Jankovic, Eng King Tan

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Prognostic value of the modified multiple myeloma comorbidity index in real clinical practice by N. V. Skvortsova, I. B. Kovynev, A. B. Loginova, K. V. Halzov, T. I. Pospelova

“…Cox multivariate analysis showed that the most significant predictors of reduced overall survival of patients with MM are impaired renal function (glomerular filtration rate &lt;30 ml / min / 1.73 m2 (according to the CKD-EPI formula), general condition according to the Karnowski scale ≤70 %, chronic obstructive pulmonary disease with moderate (50 % ≤ forced expiratory volume in 1 second &lt;80 %) and severe (30 % ≤ forced expiratory volume in 1 second &lt;50 %) severity of bronchial obstruction and the ratio κ / λ free light chains &lt;0.04 or &gt;65. …”
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Artifacts of Previous Eras, as Objects of Reverence by Ancient Populations (based on the materials of the archaeological places of Bukovyna) by Віталій Калініченко, Сергій Пивоваров

“…Artifacts of previous eras received the general name «arrows of thunder» in the scientific literature. …”
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VeloFHE: GPU Acceleration for FHEW and TFHE Bootstrapping by Shiyu Shen, Hao Yang, Zhe Liu, Ying Liu, Xianhui Lu, Wangchen Dai, Lu Zhou, Yunlei Zhao, Ray C. C. Cheung

“… Bit-wise Fully Homomorphic Encryption schemes like FHEW and TFHE offer efficient functional bootstrapping, enabling concurrent function evaluation and noise reduction. …”
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Metabolic Syndrome Spectrum in Children with Classic Congenital Adrenal Hyperplasia—A Comprehensive Review by Sanja Panic Zaric, Tatjana Milenkovic, Sladjana Todorovic, Katarina Mitrovic, Dimitrije Cvetkovic, Maja Cehic, Jelena Vekic, Katja Dumic, Rade Vukovic

“…Subclinical atherosclerosis was indicated by increased carotid intima–media thickness, elevated hs-CRP, and impaired endothelial function. Other findings suggested changes in lipid profiles, particularly decreased HDL-c and increased triglycerides, although the findings were less consistent; Conclusions: Compared with the general pediatric population, children with CCAH were found to have an increase in multiple cardiometabolic risk factors. …”
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RETRACTED: COL10A1-DDR2 axis promotes the progression of pancreatic cancer by regulating MEK/ERK signal transduction by Zhihui Wen, Zhihui Wen, Zhihui Wen, Jingbo Sun, Junjie Luo, Yun Fu, Yue Qiu, Yanyan Li, Yangwei Xu, Hongmei Wu, Qingling Zhang, Qingling Zhang

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Validation of the EKFC equation for glomerular filtration rate estimation and comparison with the Asian-modified CKD-EPI equation in Chinese chronic kidney disease patients in an e... by Li Zhao, Huan-li Li, Hui-jing Liu, Jin Ma, Wei Liu, Jian-min Huang, Ling-ge Wei, Peng Xie

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Stereoselective Synthesis and Antimicrobial Studies of <i>Allo</i>-Gibberic Acid-Based 2,4-Diaminopyrimidine Chimeras by Dima Depp, Noémi Regina Sebők, András Szekeres, Zsolt Szakonyi

“…While the 4-monoamino-substituted derivatives exhibited only weak antibacterial activity, they demonstrated significant antifungal effectiveness against <i>C. krusei</i>. In general, 5-chloro-substituted pyrimidine derivatives displayed more consistent biological activities compared to their 5-fluoro counterparts, with the exception of one derivative, which showed acceptable activity against both <i>C. krusei</i> and <i>C. albicans</i>. …”
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CladeDate: Calibration information generator for divergence time estimation by Santiago Claramunt

“…CladeDate is particularly suited for groups with limited fossil information or when assumptions of more complex methods are not met, and provides a general and practical solution to the problem of generating calibration information for divergence time estimation.…”
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