Camellia sinensis phytochemical profiling, drug-likeness, and antibacterial activity against gram-positive and gram-negative bacteria: in vitro and in silico insights by Farouk Boudou, Amal Belakredar, Ahcene Keziz, Huda Alsaeedi, David Cornu, Mikhael Bechelany, Mikhael Bechelany, Ahmed Barhoum, Ahmed Barhoum

“…Drug-likeness modeling indicated favorable profiles for most compounds, although EGCG violated Lipinski’s rule due to its molecular weight (458.4 g/mol). Density Functional Theory analysis revealed significant variations in electronic properties among the selected compounds, with quercetin exhibiting the smallest HOMO-LUMO gap (2.31 eV), suggesting high reactivity. …”
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Repurposing of Some Nucleoside Analogs Targeting Some Key Proteins of the Avian H5N1 Clade 2.3.4.4b to Combat the Circulating HPAI in Birds: An In Silico Approach by Mohd Yasir Khan, Abid Ullah Shah, Nithyadevi Duraisamy, Mohammed Cherkaoui, Maged Gomaa Hemida

“…Among them, GS441524 exhibited superior interaction scores and a greater number of hydrogen bonds with key functional residues of NA and PB2/CBD. The MM-GBSA binding free energy calculations further supported these findings, as GS441524 displayed more favorable binding energies compared to several known standard inhibitors, including F0045S for HA, Zanamivir for NA, Rimantadine and Amantadine for M2, and PB2-39 for PB2/CBD. …”
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Abstract 022: Acute Kidney Injury in Subarachnoid Hemorrhage: Exploring its Clinical Significance and Prognostic Implications by Galadu Subah, Lee Hecht, Bridget Nolan, Aiden Lui, Anaz Uddin, Christina Ng, Nitesh Damodara, Chirag Gandhi, Fawaz Al‐Mufti

“…Specifically, the study highlights a strong correlation between AKI and heightened complication rates, poor functional outcome, extended hospital stays, and elevated mortality rates. …”
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DEFORMATION OF THE MELODRAMA GENRE IN UKRAINIAN POSTMODERN LITERATURE: IREN ROZDOBUDKO AND NATALIA HURNYTSKA by Olha O. Lilik, Olena V. Sazonova

“…The development of melodrama at the current stage is determined by postmodern trends in the literary process, as well as the existence of “women’s writing” as an artistic and aesthetic phenomenon, within which the specified genre functions. A comparative analysis of two examples of melodrama in modern Ukrainian literature (the novel “The Melody of Coffee in the Tonality of Cardamom” by Natalia Hurnytska and the novel “Once Upon a Time...” by Irene Rozdobudko) made it possible to conclude that the indicated signs of melodramatism are clearly presented in both works. …”
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Designing the outsourcing model in central government organizations by Mahnaz Moradi, Morteza Ghasemi, Maryam Majidi, Gholamreza Amjadi

“…Outsourcing is related to the transfer of a complete functional department of the business or some activities of a functional department and keeping the rest of the activities of that department internally. …”
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Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis by Emma Schuster, Nurmaa K. Dashzeveg, Fangjia Tong, Yuzhi Jia, Lamiaa El-Shennawy, Tong Zhang, Andrew D. Hoffman, Reta Birhanu Kitata, Golam Kibria, Youbin Zhang, Joshua R. Squires, Chunlei Zheng, Erika Ramos, Rokana Taftaf, David Scholten, Hannah F. Almubarak, Valery Adorno-Cruz, David P. Sullivan, Carolina Reduzzi, Allegra C. Minor, William Purev-Ochir, Sabina Spahija, Rong Xu, Kalliopi P. Siziopikou, Leonidas C. Platanias, Ami Shah, William A. Muller, William J. Gradishar, Massimo Cristofanilli, Chia-Feng Tsai, Tujin Shi, Huiping Liu

“…Abstract Multicellular circulating tumor cell (CTC) clusters can be up to 50 times more efficient than single CTCs in mediating viable metastasis. …”
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Serum proteomics of adults with acute liver failure provides mechanistic insights and attractive prognostic biomarkers by Katharina Remih, Franziska-Maria Hufnagel, Anna Sophie Karl, Valerie Durkalski-Mauldin, William Martens Lee, Constantine J. Karvellas, Zemin Su, Jody A. Rule, Petra Tomanová, Laura Krieg, Isabel Karkossa, Kristin Schubert, Martin von Bergen, Frank Tacke, Sonja Luckhardt, Nicole Ziegler, Aimo Kannt, Bastian Engel, Richard Taubert, Robert John Fontana, Pavel Strnad

“…Single-cell RNAseq data mapped biomarkers to cells of origin; functional enrichment analysis provided mechanistic insights. …”
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Label-Free Optical Transmission Tomography for Direct Mycological Examination and Monitoring of Intracellular Dynamics by Eliott Teston, Marc Sautour, Léa Boulnois, Nicolas Augey, Abdellah Dighab, Christophe Guillet, Dea Garcia-Hermoso, Fanny Lanternier, Marie-Elisabeth Bougnoux, Frédéric Dalle, Louise Basmaciyan, Mathieu Blot, Pierre-Emmanuel Charles, Jean-Pierre Quenot, Bianca Podac, Catherine Neuwirth, Claude Boccara, Martine Boccara, Olivier Thouvenin, Thomas Maldiney

“…While both the spatial resolution and technical set up of this technology are more likely designed for the histopathological analysis of tissue biopsies, there is to our knowledge no previous work reporting the use of a light interference-based optical technique for direct mycological examination and monitoring of intracellular processes. …”
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Youth co-production for sustainable engagement and empowerment in health (YiPEE): protocol for a cluster-randomised controlled trial of an intervention for mental health promotion... by Josefien van Olmen, Pilvikki Absetz, Mark Tomlinson, Carina King, Edwin Wouters, Josefien van Olmen, G J Melendez-Torres, Jeroen De Man, Stefan Swartling Peterson, Suresh Kumar, Mariam Claeson, Monika Martens, Frances Mathews, Christina A Laurenzi, Yoona Kim, Yeukai Chideya, Maria Niemi, Vijaya Raghavan, Jill Åhs, Anu Linnansaari, Fredric Azariah, Moitreyee Sinha, Upasana Sharma, Orlaith O’Sullivan, Yoo Na Kim, Akshaya Rajesh, Samyukta Saravanan, Nivetha Vasanthan, N P Haritha, Lander Willem, Jeroen de Man, Christina Laurenzi, GJ Melendez Torres, Matt Hughsam, Maureen Gikonyo, Joyce Arita

“…Character education-focused interventions are effective for improving adolescent psychosocial functioning and mental well-being. Therefore, an intervention that focuses on developing these strengths and is delivered within a school environment, through an adolescent-informed approach using creativity-focused components, has the potential to improve adolescent mental health and well-being.Methods and analysis This protocol describes the YiPEE cluster-randomised controlled trial with concurrent mixed-methods process evaluation and economic evaluation, which aims to determine the impact of a multilevel multicomponent intervention in schools in Chennai, Tamil Nadu, India. …”
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Developing a multivariate drought index to assess drought characteristics based on the SWAT-Copula method in the Poyang Lake basin, China by Liping Guo, Fusheng Chen, Bin Wang, De Li Liu, Xiulong Chen, Hongsheng Huang, Hua Bai, Kaitao Liao, Zhiming Xia, Keyu Xiang, Linchao Li, Taihui Zheng, Qiang Yu

“…A Multivariate Standardized Drought Index (MSDI) was then developed with simulated Standardized Soil Moisture Index (SSI) and Standardized Precipitation Index (SPI) based on copula functions. We found that (1) The SWAT can simulate monthly streamflow well with NS being 0.76–0.92 for validation data over the sub-basins in the PLB. (2) The MSDI index indicated that there were more drought events during 1960–1979 and 2000–2019, highlighting a cyclical pattern of drought events in the PLB. (3) The Xiushui River Basin encountered the most extreme drought conditions since 2000, indicating the basin faced a high risk of dry conditions. …”
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A Study on the Possibility of Molecular Communication between Honey Bees and Sunflower through the Interspecies Transfer of Small RNAs by Leila Gharehdaghi, Gholamhosein Tahmasbi, Taher Harkinezhad

“…In other words, miRNAs can be transferred not only between cells and tissues within an organism but also across different species while maintaining their regulatory functions. Given the vital role of honeybees in plant pollination, this insect may serve as a more suitable model for studying these interactions. …”
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Didgital-art цінних паперів by Oleh Kardash, Viktor Chelombitko

“…Analysis of recent research and publications in traditional techniques. …”
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Optimizing hybrid models for forest leaf and canopy trait mapping from EnMAP hyperspectral data with limited field samples by Nizom Farmonov, Susanne Walden, Eric Martinée, Christian Lampei, Mona Schreiber, Lars Opgenoorth, Anjaharinony Andry Ny Aina Rakotomalala, Tobias Müller, Nina Farwig, Stefan Pinkert, Lucy Saueressig, Annabell Rosemarie Wagner, Robert R. Junker, Jochem Verrelst, Jörg Bendix

“…Accurate estimation of functional vegetation traits is essential for understanding ecosystem dynamics and supporting environmental monitoring. …”
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Efficient removal of cadmium (II) and arsenic (III) from water by nano-zero-valent iron modified biochar-zeolite composite by Mengyuan Wu, Lijuan Wu, Wen Zhang, Xianbao Zhong, Runfeng Guo, Ziying Cui, Yajun Yang, Jialong Lv

“…The influence of pH on removal efficiency was more pronounced than that of temperature, with nZVI-BCZo exhibiting a higher affinity for As(III) compared to Cd(II). …”
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LRP1 involvement in FHIT-regulated HER2 signaling in non-small cell lung cancer by Théophile Ponchel, Emma Loeffler, Julien Ancel, Audrey Brisebarre, Nathalie Lalun, Véronique Dalstein, Anne Durlach, Gaëtan Deslée, Stéphane Dedieu, Myriam Polette, Béatrice Nawrocki-Raby

“…Dual targeting of HER2 and LRP1 might represent a therapeutic strategy to more efficiently inhibit HER2 signaling in FHIT-negative NSCLC.…”
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Expression Profile of Human Cytomegalovirus <i>UL111A</i> cmvIL-10 and LAcmvIL-10 Transcripts in Primary Cells and Cells from Renal Transplant Recipients by Giovana W. C. Almeida, Martha T. Oliveira, Isabella G. L. Martines, Giuliano C. Fiori, Michael M. Nevels, Ian J. Groves, John Sinclair, José Medina-Pestana, Rayra Sampaio da Silva, Monica Nakamura, Lucio Requião-Moura, Emma Poole, Maria C. Carlan da Silva

“…The cmvIL-10 (isoform A) has similar properties to cIL-10, while LAcmvIL-10 (isoform B) has more restricted biological properties. Other isoforms are produced (C to H) but have unknown functions. …”
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Cardiac MRI of differing ischemia and reperfusion times in a myocardial infarction pig model by David Boll, Simon Reiss, Heidi R. Cristina Schmitz, Christian Weber, Julien Thielmann, Felix Spreter, Kian Tadjalli Mehr, Diana Chiang, Markus Jäckel, Lukas Heger, Jonathan Rilinger, Dirk Westermann, Constantin von zur Mühlen, Timo Heidt, Michael Bock, Alexander Maier

“…CMR was performed at a clinical 3 T system including functional imaging, T1 and T2 mapping and late gadolinium enhancement (LGE) 2–5 h or three days post-reperfusion. …”
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Who gets referred for knee or hip replacement? A theoretical model of the potential impact of evidence-based referral thresholds using data from a retrospective review of clinic re... by Andrew J Price, Andrew Judge, Alastair Gray, Rachael Gooberman-Hill, David Beard, Adrian Sayers, Rob Middleton, Stephanie Smith, Karen L Barker, David Murray, Sujin Kang, Elena Benedetto, James Smith, Ray Fitzpatrick, Helen A Dakin, Peter Eibich, Nigel Arden, Andy Carr, Kristina Harris, Elizabeth Gibbons, Jill Dawson, Laura Miller, Elsa Marques, Ashley Blom

“…More research is required to explore other important patient characteristics currently influencing hub decisions.…”
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IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice by Tingwenyi Hu, Xiangrong Tang, Tiechao Ruan, Shunhua Long, Guicen Liu, Jing Ma, Xueqi Li, Ruoxuan Zhang, Guoning Huang, Ying Shen, Tingting Lin

“…To date, many components of RSs and their functions in human sperm flagella remain unclear. Methods We recruited a cohort of 323 infertile males with ASZ between August 2019 and June 2024. …”
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Ten sessions of hyperbaric oxygen versus sham treatment in patients with long covid (HOT-LoCO): a randomised, placebo-controlled, double-blind, phase II trial by Kenny A Rodriguez-Wallberg, Judith Bruchfeld, Michael Runold, Peter Lindholm, Anders Kjellberg, Jan H Kowalski, Adrian Hassler, Sara El Gharbi, Sarah Al-Ezerjawi, Emil Boström, Marcus Ståhlberg, Malin Nygren-Bonnier, Anna Schening, Katarina Fischer

“…The primary endpoint analysis included 79 subjects (40 in HBOT and 39 in control). …”
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