Interventions to improve mental health and well-being in care-experienced children and young people aged less than 25: the CHIMES systematic review by Rhiannon Evans, Sarah MacDonald, Robert Trubey, Jane Noyes, Michael Robling, Simone Willis, Soo Vinnicombe, Maria Boffey, Charlotte Wooders, Asmaa El-Banna, GJ Melendez-Torres

“…Interventions were primarily evaluated in the United States and targeted young people’s competencies or carers’ parenting practices. Meta-analysis reported limited evidence that interventions effectively improved mental health in the shorter term (0–6 months): total social, emotional and behavioural problems (d = −0.15, 95% confidence interval −0.28 to −0.02); internalising problem behaviours (d = −0.35, 95% confidence interval −0.61 to −0.08); externalising problem behaviours (d = −0.30, 95% confidence interval −0.53 to −0.08); depression and anxiety (d = −0.26, 95% confidence interval −0.40 to −0.13) and social–emotional functioning difficulties (d = −0.18, 95% confidence interval −0.31 to −0.05), but these impacts were not observed in the longer term (> 6 months). …”
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A Senomorphlytic Three‐Drug Combination Discovered in Salsola collina for Delaying Aging Phenotypes and Extending Healthspan by Jiqun Wang, Wenwen Liu, Yunyuan Huang, Guangwei Wang, Xiaobo Guo, Donglei Shi, Tianyue Sun, Chaojiang Xiao, Chao Zhang, Bei Jiang, Yuan Guo, Jian Li

“…Notably, JM10101 exhibits a more sophisticated senomorphlytic role encompassing both senomorphic and senolytic functions than JM10001 in the modulation of senescent cells, offering a promising strategy for the discovery of combination drugs in the rational development of anti‐aging therapies.…”
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Abstract 215: A Sweet Indicator: HbA1C and Thrombectomy Outcomes in Hispanics by Zorain M. Khalil, Samantha D. Miller, Yazan D. Abualnadi, Sohum K. Desai, Kaiser O. Sadiq, Wondwossen G. Tekle, Ameer E. Hassan

“…We performed this retrospective cohort analysis to assess the impact of poorly controlled diabetes, defined as HbA1C of 9.0% or greater, on the functional and procedural outcomes of Hispanic patients with acute ischemic stroke undergoing mechanical thrombectomy. …”
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Epigenetic Drift Is Involved in the Efficacy of HBV Vaccination by Francesca Ferraresi, Simona Anticoli, Stefano Salvioli, Chiara Pirazzini, Luciano Calzari, Davide Gentilini, Christian Albano, Reparata Rosa Di Prinzio, Salvatore Zaffina, Rita Carsetti, Paolo Garagnani, Anna Ruggieri, Katarzyna Malgorzata Kwiatkowska

“…The literature search and pathway analysis indicate that such genes are involved in the correct functioning of the immune system. …”
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Targeted temperature management at 33 versus 36 degrees after out-of-hospital cardiac arrest: A follow-up study by Robert Doerning, Kyle R. Danielson, Jane Hall, Catherine R. Counts, Michael R. Sayre, Sarah Wahlster, James A. Town, Sue Scruggs, David J. Carlbom, Nicholas J. Johnson

“…Aim: Targeted temperature management (TTM) is commonly used in the setting of out-of-hospital cardiac arrest (OHCA) to improve survival and functional outcomes. However, real-world evidence of effects and optimal temperature are limited. …”
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Integrative spatial and single-cell transcriptomics elucidate programmed cell death-driven tumor microenvironment dynamics in hepatocellular carcinoma by Kai Lei, Kai Lei, Yutong Zhao, Shumin Li, Jiawei Liu, Wenhao Chen, Caihong Zhou, Yi Zhang, Jinmei Tan, Jian Wu, Qi Zhou, Qi Zhou, Jiehui Tan

“…T cells in high-PCD patients were more likely to be exhausted, with elevated expression of exhaustion markers. …”
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Relieving acute pain (RAP) study: a proof-of-concept protocol for a randomised, double-blind, placebo-controlled trial by Thomas Scalea, Luana Colloca, Se Eun Lee, Meghan Nichole Luhowy, Nathaniel Haycock, Chika Okusogu, Soojin Yim, Nandini Raghuraman, Robert Goodfellow, Robert Scott Murray, Patricia Casper, Myounghee Lee, Yvette Fouche, Sarah Murthi

“…This study hypothesises that dose-extending placebos can be an effective treatment in relieving clinical acute pain in trauma patients who take opioids.Methods and analysis The relieving acute pain is a proof-of-concept randomised, placebo-controlled, double-blinded, single-site study enrolling 159 participants aged from 18 to 65 years with one or more traumatic injuries treated with opioids. …”
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Right-restricting measures implemented by Public Health Surveillance services during the COVID-19 pandemic: a systematic review protocol by Tiago Correia, Marcelo Dayrell Vivas, Larissa Bragagnolo, Igor Antônio Lourenço da Silva, Fernando Tureck, Reinaldo Santos, Samara Kielmann, Debora do Carmo, Camila Avarca, Franciele da Silva, Mariana Paes, Luis Fernando Nogueira Tofani, Arthur Chioro

“…Considering the various measures that may have been adopted, the following categories of analysis will be used: (i) Public Health Surveillance as a field, (ii) the various specific areas of Health Surveillance, (iii) law enforcement, (iv) right-restricting measures and consent, (v) interactions between right-restricting measures and routine Public Health Surveillance functions, (vi) differences between countries and (vii) Health Surveillance lessons learnt from the COVID-19 pandemic. …”
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A splice donor variant in SLAMF1 is associated with canine atopic dermatitis by Oliver P. Forman, Jamie Freyer, Abigail Kerr, Julia D. Labadie, Michael Denyer, Debbie J. Gow, Janet Alexander, Michelle Daya, Yaindrys Rodriguez Olivera, Cecilia Lozoya, Christian Leutenegger, Christian Savard, Jason T. Huff, Rebecca Chodroff Foran

“…Whole-genome resequencing revealed a compelling splice donor variant in the signaling lymphocytic activation molecule 1 (SLAMF1), a transmembrane receptor with important functions in immune cells. Further analysis of additional genome sequences and RNA samples from the MARS PETCARE BIOBANK confirmed that the SLAMF1 splice variant is a strong potential contributor to an increased risk of atopic dermatitis.DiscussionThe discovery represents the first compelling genetic variant associated with CAD to be validated in more than one breed of dog. …”
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An Adiabatic-Expansion-Induced Perturbation Study on Gas–Aerosol Partitioning in Ambient Air—Formation of NH₄NO₃ and Microdroplet Nitrogen Fixation (2) by Yating Gao, Qinchu Fan, Yujiao Zhu, Hengqing Shen, Qi Yuan, Yang Gao, Huiwang Gao, Xiaohong Yao

“…These findings suggest that microdroplet redox reactions are more likely responsible for the generation of NH₃ + HNO₃ than conventional atmospheric NH₃ chemistry. …”
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Unveiling the Full Protein Effectorome of the Black Sigatoka Pathogen <i>Pseudocercospora fijiensis</i>—An In Silico Approach by Karla Gisel Carreón-Anguiano, Jewel Nicole Anna Todd, César De los Santos-Briones, Santy Peraza-Echeverría, Ignacio Islas-Flores, Blondy Canto-Canché

“…Protein families related to key functions of the hemibiotrophic lifestyle, such as Salicylate hydroxylase and Isochorismatase, are widely represented families of effectors in the <i>P. fijiensis</i> genome. …”
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Menstrual blood and ritual beliefs: a qualitative study on menstrual health and hygiene practices among senior high school girls in Volta Region, Ghana by Sitsofe Gbogbo, Israel Wuresah, Wisdom Axame, Priscilla Klutse, Emmanuel Gbogbo, Robert Kokou Dowou, Sarah Odi Mantey, Sarah Abena Yeome Ayitey, Ishmael Boateng, Paramount Eli Nelson, Nuworza Kugbey, Victor Christian Korley Doku, Julie Hennegan, Frank E. Baiden, Fred N. Binka

“…Improving menstrual hygiene in schools requires more than infrastructure – secure, private disposal options and culturally sensitive education are essential.…”
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Understanding facilitators and barriers to adherence in home-based pulmonary rehabilitation for chronic obstructive pulmonary disease patients using the Health Belief Model: a qual... by Qiuxuan Zeng, Wenli Chen, Siyi Xu, Xu Yang, Dandan Xue, Yuhang Peng, Xiaohong Lin, Yingwen Yu, Huixin Huang, Ping Huang, Min Dong, Jiaying Li

“…Deductive thematic analysis approach was used to analyze the data.ResultsEighteen patients were recruited through purposive sampling. …”
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Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies by Silke Pudewell, Julia Heuser, Inna Dorogobed, Britta Lipinski, Thi Hong Hue Tran, Pia Metzenmacher, Richard Kunze, Felix Geyer, Stefan Zielonka, Doreen M. Floss, Harald Kolmar, Jens M. Moll, Jürgen Scheller

“…Historically, direct inhibition of glycoprotein 130 (gp130)—the shared transmembrane receptor for IL-6-type cytokines—was avoided due to concerns that broad suppression might cause more harm than benefit. However, this view is being reconsidered in light of the clinical success of Janus kinase (JAK) inhibitors, which broadly disrupt cytokine signaling, including pathways mediated by gp130.MethodsHere we developed four single domain antibodies (sdAb), consisting out of a camelid-derived nanobody and a human Fc-fragment, and characterized them by direct protein interaction analysis, epitope binding, epitope binning, as well as inhibition of cytokine-induced stimulation and proliferation of appropriate Ba/F3 cell lines and trans-migration in HT-29 cells.ResultsThe four sdAb-Fc constructs GP01-, GP11- GP13- and GP20-Fc bind directly to gp130 in the cytokine binding module (CBM) and largely inhibit IL-6-type cytokine signaling by interfering with the high-affinity binding site of IL-6, IL-11, CLCF1, CT1, CNTF, OSM and LIF. …”
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Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype by Marianna Hellén, Isabelle Weert, Stephan A. Müller, Noora Räsänen, Pinja Kettunen, Šárka Lehtonen, Michael Peitz, Klaus Fließbach, Mari Takalo, Marja Koskuvi, Stefan F. Lichtenthaler, Ville Leinonen, Alfredo Ramirez, Olli Kärkkäinen, Mikko Hiltunen, Jari Koistinaho, Taisia Rõlova

“…The responses of iMGs to Aβ42, LPS and IFNγ were studied by metabolomics, proteomics, and functional assays. Results Here, we demonstrate that iMGs with the APOE4/4 genotype exhibit reduced basal pinocytosis levels compared to APOE3/3 iMGs. …”
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Proteomic profiling improves prognostic risk stratification of the Sarculator nomogram in soft tissue sarcomas of the extremities and trunk wall by Madhumeeta Chadha, Sara Iadecola, Andrew Jenks, Valeriya Pankova, Yuen Bun Tam, Jessica Burns, Amani Arthur, Christopher P. Wilding, Liang Chen, Priya Chudasama, Dario Callegaro, Dirk C. Strauss, Khin Thway, Alessandro Gronchi, Robin L. Jones, Rosalba Miceli, Sandro Pasquali, Paul H. Huang

“…Abstract Background High‐risk soft tissue sarcomas of the extremities and trunk wall (eSTS), as defined by the Sarculator nomogram, are more likely to benefit from (neo)adjuvant anthracycline‐based therapy compared to low/intermediate‐risk patients. …”
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Garlic Extracts Nanoliposome as an Enhancer of Bioavailability of ABA and Thiamine Content and as an Antifungal Agent Against <i>Fusarium oxysporum</i> f. sp. <i>pisi</i> Infecting... by Barbara Kutasy, Géza Hegedűs, Márta Kiniczky, József Péter Pallos, Ágnes Nagy, István Pócsi, Klaudia Pákozdi, Máté Kállai, Csaba Weingart, Katalin Andor, Bettina Kovács, Eszter Virág

“…Therefore, optimizing the formulation of biopesticides and plant conditioning agents is essential to improve the absorption and bioavailability of active ingredients, ensuring more effective disease management in <i>P. sativum</i> cultivation. …”
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Effects of Three Different Bee Pollen on Digestion, Immunity, Antioxidant Capacity, and Gut Microbes in <i>Apis mellifera</i> by Xin-Meng Li, Ying Wang, Li Lei, Ge Zhang, Bao-Hua Xu

“…Feeding assays demonstrated that honeybees consumed significantly more sunflower bee-collected pollen than maize bee-collected pollen or lotus bee-collected pollen. …”
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Older surgical patients’ preferences for follow-up care after hospital discharge: A multi-method qualitative study into their underlying needs by Aafke J de Groot, Marike E de Boer, Elizabeth M Wattel, Cees MPM Hertogh, Marja FIA Depla

“…Background: Almost 30 % of older patients suffer from functional decline during hospital stay which often makes follow-up care decisions necessary. …”
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Repurposed clindamycin suppresses pyroptosis in tumor-associated macrophages through Inhibition of caspase-1 by Adrian Weich, Johannes Berges, Cindy Flamann, Katrin Bitterer, Krishna Pal Singh, David Chambers, Christopher Lischer, Xin Lai, Olaf Wolkenhauer, Carola Berking, Gerhard Krönke, Shailendra Gupta, Heiko Bruns, Julio Vera, Research Group Macrophages

“…We hypothesize that the immunomodulation of TAMs can remodel the UM tumor microenvironment and make it more susceptible to therapeutic interventions. Methods In our work, we designed a novel computational pipeline that combines single-cell transcriptomics data, network analysis, multicriteria decision techniques, and pharmacophore-based docking simulations to select molecular targets and matching repurposable drugs for TAM immunomodulation. …”
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