Glycopattern comparison of sperm and exosomes from conventional in vitro fertilization and rescue intracytoplasmic sperm injection: Enhancing sperm motility through exosome‐mediate... by Muhammad Anas Ramzan, Zhedong Yang, Li Cao, Jinyuan Zhang, Fei Wu, Miaomiao Xin, Bo Guo, Lumin Wang, Lingyu Zhao, Yannan Qin, Chengcheng Liu

“…DBA is primarily bound to the neck, acrosomal region, plasma membrane, and tail of IVF sperm, but its binding was significantly reduced in RICSI sperm. Functionally, IVF exosomes enhanced RICSI sperm motility in a dose‐dependent manner by upregulating DBA‐recognized glycans. …”
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Effect of Ultrasound/Ultra-high Pressure Combined with Sous-vide Cooking on the Quality of Spiced Beef by Zhenhua SHI, Daobang TANG, Huaigu YANG, Xueming LIU, Xuping WANG, Yaosheng LIN, Jinhao ZOU, Jingrong CHENG, Mingjun ZHU

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Evaluation of mechanical properties and determination of the optimal concentration of a new carbonyl-rich graphene oxide in cementitious composites by Aldo Ribeiro de Carvalho, Marcela Martins Carrara, Gabriela dos Santos Pacífico, Natany Pinho Rosa, Letícia Lopardi Leal, Marina Costa Totti, Nayton Claudinei Vicentini, Alessandro Henrique de Lima, Welber Gianini Quirino, Thaís Mayra de Oliveira

“…Subsequently, microstructural properties were evaluated using scanning electron microscopy, X-ray diffraction, and thermal conductivity analysis. After 365 days, the durability of carbonation was also assessed using a computational model developed in MATLAB to more accurately calculate the carbonated area. …”
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Size-dependent effects of oxo-degradable plastic contamination on soil quality and the growth of Zea mays by Do Thi Kim THANH, Robert W. BROWN, Martine GRAF, Michaela K. REAY, Charlotte E. M. LLOYD, Gupeng LI, David R. CHADWICK, Davey L. JONES

“…Oxo-degradable plastics (ODPs) have emerged as a potentially more sustainable alternative to current plastic mulch films, however, uncertainty remains around the degradation rate of ODPs in soil and their impacts on soil quality and crop health. …”
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Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer by Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti

“…A p53‐specific target gene array revealed an uncommon p53 signature, with Pep3S leading to p53‐mediated repression of a subset of p53 targets. Comparative analysis indicated that this repression is driven by p53‐mediated activation of miR‐34a, which is functional in Pep3S‐induced cell death. …”
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How did New Zealand’s regional District Health Board groupings work to improve service integration and health outcomes: a realist evaluation by Robin Gauld, Rosalina Richards, Tim Stokes, Trudy Sullivan, Fiona Doolan-Noble, Andrew R Gray, Carol Atmore, Erin Penno, Lauralie Richard, Emma Wyeth, Brett Maclennan

“…This research explores how this initiative functioned, examining how, for whom and in what circumstances regional DHB groupings worked to deliver improvements in system integration and health outcomes and equity.Design We used a realist-informed evaluation study design. …”
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Amplification of Higher-Order Salivary Gland Volume Effects from External Beam Radiotherapy in Normal Tissue Complication Probability Modeling of Radiopharmaceutical Therapy by Chunming Gu, Robert F. Hobbs, Ana P. Kiess, Junghoon Lee, Todd McNutt, Harry Quon, Zhuoyao Xin, Tahir I. Yusufaly

“…In EBRT, salivary glands are usually assumed to be parallel organs, with QUANTEC guidelines based on <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>D</mi><mrow><mi>m</mi><mi>e</mi><mi>a</mi><mi>n</mi></mrow></msub></semantics></math></inline-formula>, but this is known to be a gross over-simplification of the full complexity of the underlying functional organization. The goal of this work is to combine machine learning of EBRT dose–outcome data with stylized small-scale RPT dosimetry to discover more reliable normal tissue complication probability (NTCP) models of xerostomia across both modalities. …”
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Exploiting <i>Brassica rapa</i> L. subsp. <i>pekinensis</i> Genome Research by Faujiah Nurhasanah Ritonga, Zeyu Gong, Yihui Zhang, Fengde Wang, Jianwei Gao, Cheng Li, Jingjuan Li

“…However, challenges exist in integrating multi-omics for the functional analysis of genes and for developing potential traits for Chinese cabbage improvement. …”
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Genome‐wide identification of bZIP transcription factors in 12 Rosaceae species and modeling of novel mechanisms of EjbZIPs response to salt stress by Ling Zhu, Mengjie Zhang, Xiuyao Yang, Yinqiang Zi, Tuo Yin, Xulin Li, Ke Wen, Ke Zhao, Jiaqiong Wan, Huiyun Zhang, Xinping Luo, Hanyao Zhang

“…These results can provide a theoretical basis for exploring the characteristics and functions of the bZIP TF family in more species and breeding salt‐tolerant E. japonica varieties. …”
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Comparison of the inflammatory biomarkers IL- 6, TNF-α, and CRP to predict the effect of nutritional therapy on mortality in medical patients at risk of malnutrition by Carla Wunderle, Elisabeth Martin, Alma Wittig, Pascal Tribolet, Thomas A. Lutz, Christina Köster-Hegmann, Zeno Stanga, Beat Mueller, Philipp Schuetz

“…Methods This is a secondary analysis of the Swiss-wide, multicenter, randomized controlled Effect of early nutritional therapy on Frailty, Functional Outcomes, and Recovery of malnourished medical inpatients Trial (EFFORT) trial comparing individualized nutritional support with usual care nutrition in medical inpatients. …”
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Prognostic importance of the Controlling Nutritional Status (CONUT) score in patients undergoing cardiac resynchronisation therapy by Yasuo Okumura, Yukitoshi Ikeya, Yuki Saito, Toshiko Nakai, Rikitake Kogawa, Naoto Otsuka, Yuji Wakamatsu, Sayaka Kurokawa, Kimie Ohkubo, Koichi Nagashima

“…The primary endpoint was all-cause mortality.Results The moderate or severe malnutrition group had a lower body mass index, more advanced New York Heart Association functional class, higher Clinical Frailty Scale score, lower levels of haemoglobin and higher levels of N-terminal probrain natriuretic peptide (all p&lt;0.05). …”
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AlphaMissense Predictions and ClinVar Annotations: A Deep Learning Approach to Uveal Melanoma by David J. Taylor Gonzalez, MD, Mak B. Djulbegovic, MD, MSc, Meghan Sharma, MD, MPH, Michael Antonietti, BS, Colin K. Kim, BS, Vladimir N. Uversky, PhD, DSc, Carol L. Karp, MD, Carol L. Shields, MD, Matthew W. Wilson, MD

“…We explore the use of a novel deep learning tool to assess the functional impact of genetic mutations in UM. Design: A cross-sectional bioinformatics exploratory data analysis of genetic mutations from UM cases. …”
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Immunological effects of CD19.CAR-T cell therapy in systemic sclerosis: an extended case study by Maren Claus, Merle Freitag, Meike Ewald, Lea Rodon, Franca Deicher, Carsten Watzl, Philipp Kolb, Hanns-Martin Lorenz, Michael Schmitt, Wolfgang Merkt

“…Decreasing autoantibody levels associated with a reduced ability to form functional immune complexes, the latter appearing to contribute to pathology in SSc via activation of Fcγ receptor IIIA + cells such as NK cells. …”
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Acceptability of veggie bread among Lebanese adults by Asma Chanbour, Hussein F. Hassan, Dima Kreidieh, Salma Khazaal, Tareq Osaili, Tareq Osaili, Khaled El Omari, Khaled El Omari, Nada El Darra

“…The study found that 51.2% valued fiber addition in bread, 37.5% considered veggie bread healthier, and 52.8% would switch to veggie bread if it offered more nutrients. Statistical analysis revealed significant associations between sociodemographic factors and participants' willingness to switch to veggie bread. …”
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Mild and reversible nephrotoxicity following repeated administration of damnacanthal in nude mice by Noppanan Kotsaouppara, Thunyatorn Yimsoo, Worapapar Treesuppharat, Jeeraphong Thanongsaksrikul, Potjanee Srimanote

“…However, further large-scale investigations are warranted to gain a more comprehensive understanding of damnacanthal toxicity profile and to ensure its safe use in potential therapeutic applications.…”
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Establishing a Staging System for Adjacent Segment Disease and Exploring Its Significance in Guiding Surgical Decisions: A Retrospective Study by Changpeng Qu, Jianwei Guo, Hao Tao, Chuanli Zhou, Kai Zhu, Yihao Sun, Lei Li, Zhiming Liu, Hao Zhang, Xuexiao Ma

“…Specifically, Groups B, C, and D showed earlier functional recovery compared to Group A, with Groups B and C experiencing more rapid relief from low back pain. …”
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Intratracheal Administration of Itraconazole-Loaded Hyaluronated Glycerosomes as a Promising Nanoplatform for the Treatment of Lung Cancer: Formulation, Physiochemical, and In Vivo... by Sultan Aati, Hanan O. Farouk, Marwa H. Elkarmalawy, Hanan Y. Aati, Nahla Sameh Tolba, Hossam M. Hassan, Mostafa E. Rateb, Doaa S. Hamad

“…Methods: The glycerosomes were functionalized with hyaluronic acid (HA-GLY) to potentiate the anticancer efficacy of ITZ and extend its local bio-fate. …”
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Exploring the relationship between vitamin B12, methylmalonic acid levels and all-cause mortality in heart failure populations: insights from the NHANES database by Wei Yu, Yao Wang, Yao Wang, Yao Wang, Yulu Zhou, Danyu Wu, Danyu Wu, Danyu Wu

“…Although a minor statistically significant association was observed in serum B12 levels and mortality (p = 0.045), it disappeared after multivariate regression analysis. Moreover, the correlation between MMA and mortality risk was more prominent in HF populations with poorer health status, such as advanced age, current smokers, hypertension, diabetes, overweight, or low estimated glomerular filtration rate (eGFR).ConclusionOur study indicated that a higher MMA level is associated with an increased all-cause mortality risk in HF populations, particularly in those aged 65 and above, current smokers, those with hypertension, diabetes, overweight, insufficient physical activity, or lower eGFR (&lt;60 mL/min/1.73 m2).…”
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Edaphic and climatic effects on soil water dynamics and infiltration patterns in tropical rainforests by Xin Zou, Ankit Shekhar, Yuxuan Mo, Ashutosh Kumar Singh, Xiaojin Jiang, Wenjie Liu

“…The preservation of forests’ hydrological functions is pivotal for alleviating land degradation and enhancing ecosystem services. …”
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The association of internet use and cognition among older adults: mediating roles of social networks and depressive symptoms by Xiuyuan Zhu, Zihan Ni, Xiaoying Zhu, Xiaoying Zhu, Yi Yang, Shiyu Xie, Xinguo Wang, Xiaoguang Yang

“…Additionally, propensity score matching (PSM) was applied to further validate the robustness of the results by reducing potential selection bias and ensuring a more comparable distribution of observed covariates between internet users and non-users.ResultsOur analysis found that the use of the internet by older adults was positively correlated with their social networks (β=0.090, p&lt;0.01). …”
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