Methylation and gene expression patterns in adamantinomatous craniopharyngioma highlight a panel of genes associated with disease progression-free survival by Junier Marrero-Gutiérrez, Ana Carolina Bueno, Ana Carolina Bueno, Clarissa Silva Martins, Rui Milton Patrício Silva-Júnior, Antônio Carlos dos Santos, Marcelo Volpon Santos, Luiz Eduardo Wildemberg, Ximene Lima da Silva Antunes, Monica R. Gadelha, Ayrton Custodio Moreira, Ricardo Zorzetto Nicoliello Vêncio, Sonir Roberto R. Antonini, Margaret de Castro

“…Clustering analyses based on the methylation levels of probes and expression levels of the stringently filtered 212- and 37-gene sets further confirmed these two distinct ACP subgroups. Functional enrichment analysis highlighted key roles in synaptic modulation, nervous system development, cell adhesion, as well as pathways linked to RAS signaling, GTPase activity, and membrane potential regulation.ConclusionAlthough clinical characteristics were largely comparable between the clusters, ACP-B patients exhibited shorter median progression-free survival, suggesting a more aggressive phenotype. …”
Get full text

NRF2 maintains redox balance via ME1 and NRF2 inhibitor synergizes with venetoclax in NPM1-mutated acute myeloid leukemia by Jiayuan Hu, Zihao Yuan, Yan Shu, Jun Ren, Jing Yang, Lisha Tang, Xingyu Wei, Yongcan Liu, Fangfang Jin, Qiaoling Xiao, Xinyi Chen, Nan Wu, Wen Zhao, Ziwei Li, Ling Zhang

“…Additionally, the downstream target gene of NRF2 was identified by bioinformatics analysis and chromatin immunoprecipitation (ChIP) assays. …”
Get full text

Mechanism-based modular psychotherapy versus cognitive behavioural therapy for adolescents and young adults with childhood trauma experiences: study protocol for a feasibility tria... by Till Bärnighausen, Hanna Zimmermann, Christian Schmahl, Stephanie Bauer, Beate Ditzen, Hans-Christoph Friederich, Markus W Haun, Astrid Berner-Rodoreda, Elisabeth Schramm, Svenja Taubner, Corina Aguilar-Raab, Sabine C Herpertz, Manuel Feisst, Frank Enning, Katja I Seitz, Niklas Schouler, Jan Hundertmark, Maximilian Wilhelm, Svea Franz, Christoph W Korn, Ruben Vonderlin, Eva Vonderlin, Josef Bailer, Elias Bopp, Sophia von Stockert, Laura Tabea Kristalis, Claudia Calvano

“…They represent a patient group which requires more personalised interventions targeting the transdiagnostic mechanisms related to early trauma and its functional consequences. …”
Get full text

Longitudinal recovery trajectories and ventilatory modalities in COVID-19 acute respiratory distress syndrome survivors by Jessica González, Iván D. Benítez, Sally Santisteve, Anna Vila, Maria Aguilà, Gerard Torres, Anna Sánchez-Cucó, Mar Malla-Bañeres, Anna Moncusí-Moix, Jordi de Batlle, Esther Gracia-Lavedan, Adrián Ceccato, Ricard Ferrer, Anna Motos, Jordi Riera, Laia Fernández, Rosario Menéndez, José Ángel Lorente, Oscar Peñuelas, Dario García, Oriol Roca, Yhivian Peñasco, Pilar Ricart, Maria Cruz Martin Delgado, Luciano Aguilera, Alejandro Rodríguez, Maria Victoria Boado Varela, Felipe Pérez-García, Juan Carlos Pozo-Laderas, Jordi Solé-Violan, Berta Adell-Serrano, Mariana Andrea Novo, José Barberán, Rosario Amaya Villar, David de Gonzalo-Calvo, Antoni Torres, Ferran Barbé, Ferran Roche-Campo, José Garnacho-Montero, Jose M. Gómez, Aaron Blandino Ortiz, Luis Tamayo Lomas, Alejandro Úbeda, Mercedes Catalán-González, Angel Sánchez-Miralles, Ignacio Martinez Varela, Ruth Noemí Jorge García, Nieves Franco, Victor D. Gumucio-Sanguino, Elena Bustamante-Munguira, Luis Jorge Valdivia, Jesús Caballero, Elena Gallego, Amalia Martínez de la Gándara, Alvaro Castellanos-Ortega, Josep Trenado, Judith Marin-Corral, Guillermo M. Albaiceta, Maria del Carmen de la Torre, Ana Loza-Vázquez, Pablo Vidal, Jose M. Añón, Cristina Carbajales Pérez, Victor Sagredo, Nieves Carbonell, Lorenzo Socias, Carme Barberà, Angel Estella, Emili Diaz, Fatty Seck, Adriano D.S. Targa, Inmaculada Salvador-Adell, Luis Urrelo-Cerrón, Mireia Serra-Fortuny, Esther Sauras-Colón

“…Matched and sensitivity analysis showed results consistent with those reported. …”
Get full text

Speech and Music Acoustics, Rhythms of the Brain and their Impact on the Ability to Accept Information by I. V. Pavlov, V. M. Tsaplev

“…These scientists are studying the phenomena that accompany clinical death, and argue that at these moments the brain functions to the greatest extent as a receiving “antenna”. …”
Get full text

Factors that influence the provision of enteral feeding for critically ill children: a qualitative evidence synthesis by Elisabeth Søiland, Claire Glenton, Susan Munabi-Babigumira, Lena Victoria Nordheim, Suzgika Lakudzala, Idriss Ibrahim Kallon, Celeste Naude, Amanda Brand, Simon Lewin, Nyanyiwe Masingi Mbeye

Get full text

Structure-guided design of partial agonists at an opioid receptor by Balazs R. Varga, Sarah M. Bernhard, Amal El Daibani, Saheem A. Zaidi, Jordy H. Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina L. Nazarova, Alexa Kouvelis, Ryosuke Shinouchi, Haylee R. Hammond, Shainnel O. Eans, Violetta Weinreb, Elyssa B. Margolis, Jonathan F. Fay, Xi-Ping Huang, Amynah Pradhan, Vsevolod Katritch, Jay P. McLaughlin, Susruta Majumdar, Tao Che

“…Here we show that C6-Quino, a bitopic ligand developed through structure-based design, acts as a selective δOR partial agonist. Functional studies reveal that C6-Quino shows differential activity at G-protein and arrestin pathways and interacts with the sodium binding pocket, confirmed through cryo-EM analysis. …”
Get full text

Orthrus: a Pumilio-family gene involved in fruiting body and dark stipe development in Coprinopsis cinerea by Benedek Szathmári, Balázs Bálint, Botond Hegedüs, Máté Virágh, Zhihao Hou, Zhihao Hou, Xiao-Bin Liu, Hongli Wu, Csenge Földi, Julien Gagneur, Julien Gagneur, Johann Promeuschel, Árpád Csernetics, László G. Nagy, László G. Nagy

“…Our findings reveal fruiting-related functions for ort2, a novel conserved RNA-binding protein, and may serve as a novel entry point for understanding the molecular basis of dark stipe development.…”
Get full text

TROP2 is highly expressed in triple-negative breast cancer CTCs and is a potential marker for epithelial mesenchymal CTCs by Qingyu Liao, Ruiming Zhang, Zuli Ou, Yan Ye, Qian Zeng, Yange Wang, Anqi Wang, Tingmei Chen, Chengsen Chai, Bianqin Guo

“…Real-time dynamic molecular and functional typing of CTCs is necessary to precisely guide personalized treatment. …”
Get full text

Comparison of intravitreal anti-VEGF agents and oral carbonic anhydrase inhibitors in the treatment of cystoid macular edema secondary to retinitis pigmentosa by Jia Liang, Xueping Wu, Lu Chen, Lujia Feng, Xiangqing Hei, Yingying Diao, Yuke Ji, Huiyan Zheng, Zhenhua Zou, Dong Fang, Shaochong Zhang

“…No significant differences were found between the two groups in BCVA and CMT at 12 months or in IOP at any time point (all p > 0.05). Subgroup analysis indicated that oral acetazolamide was more effective than methazolamide in reducing CMT and improving BCVA at 3 and 6 months (p = 0.005 for BCVA at 3 months, p = 0.015 for BCVA at 6 months; p = 0.037 for CMT at 3 months, p < 0.001 for CMT at 6 months). …”
Get full text

Synthesis and analgesic activity of new pyrazole-containing derivatives of 1,2,4-triazole-3-thiol by S. O. Fedotov, A. S. Hotsulia, Yu. V. Karpenko

“…However, several existing analgesics may carry unwanted side effects, such as ulcers, blood clotting issues, drowsiness, and more. The development of new analgesics is focused on creating drugs that are both effective and associated with fewer adverse effects. …”
Get full text

Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. by Ying Wu, Lindsay L Waite, Anne U Jackson, Wayne H-H Sheu, Steven Buyske, Devin Absher, Donna K Arnett, Eric Boerwinkle, Lori L Bonnycastle, Cara L Carty, Iona Cheng, Barbara Cochran, Damien C Croteau-Chonka, Logan Dumitrescu, Charles B Eaton, Nora Franceschini, Xiuqing Guo, Brian E Henderson, Lucia A Hindorff, Eric Kim, Leena Kinnunen, Pirjo Komulainen, Wen-Jane Lee, Loic Le Marchand, Yi Lin, Jaana Lindström, Oddgeir Lingaas-Holmen, Sabrina L Mitchell, Narisu Narisu, Jennifer G Robinson, Fred Schumacher, Alena Stančáková, Jouko Sundvall, Yun-Ju Sung, Amy J Swift, Wen-Chang Wang, Lynne Wilkens, Tom Wilsgaard, Alicia M Young, Linda S Adair, Christie M Ballantyne, Petra Bůžková, Aravinda Chakravarti, Francis S Collins, David Duggan, Alan B Feranil, Low-Tone Ho, Yi-Jen Hung, Steven C Hunt, Kristian Hveem, Jyh-Ming J Juang, Antero Y Kesäniemi, Johanna Kuusisto, Markku Laakso, Timo A Lakka, I-Te Lee, Mark F Leppert, Tara C Matise, Leena Moilanen, Inger Njølstad, Ulrike Peters, Thomas Quertermous, Rainer Rauramaa, Jerome I Rotter, Jouko Saramies, Jaakko Tuomilehto, Matti Uusitupa, Tzung-Dau Wang, Michael Boehnke, Christopher A Haiman, Yii-Der I Chen, Charles Kooperberg, Themistocles L Assimes, Dana C Crawford, Chao A Hsiung, Kari E North, Karen L Mohlke

“…In conclusion, trans-ethnic high-density genotyping and analysis confirm the presence of allelic heterogeneity, allow the identification of population-specific variants, and limit the number of candidate SNPs for functional studies.…”
Get full text

48-Hour and 24-Hour Time-lapse Single-nucleus Transcriptomics Reveal Cell-type specific Circadian Rhythms in Arabidopsis by Yuwei Qin, Zhijian Liu, Shiqi Gao, Carlos Martínez-Vasallo, Yanping Long, Xinlong Zhu, Bin Liu, Ya Gao, Xiaodong Xu, Maria A. Nohales, Qiguang Xie, Jixian Zhai

“…Here, we find that four cell clusters in the shoot share a coherent rhythm, while around 3000 genes display cell-type specific rhythmic expression. Our analysis indicates that genes encoding circadian regulators oscillate in multiple cell types, and the majority of them are well-documented core clock genes, suggesting the snRNA-seq circadian data could be used to identify more clock components oscillating in a cell-autonomous way. …”
Get full text

A Conformationally Driven Mechanism in n‐Type Doping of Naphthalene Diimide‐Bithiophene Copolymer by 1H‐Benzimidazoles by Simone Cimò, Ilaria Denti, Lorenzo Rossi, Marco Cassinelli, Martina Rossi, Rossella Castagna, Garrett LeCroy, Alberto Salleo, Mario Caironi, Antonino Famulari, Chiara Castiglioni, Chiara Bertarelli

“…The study interestingly demonstrates that a relevant change in conductivity, with an increase of more than three orders of magnitude with respect to pristine P(NDI2OD‐T2), occurs before the annealing process takes place, thus revealing that benzimidazole‐derived dopants are already active at room temperature. …”
Get full text

The Assessment of the Effects of Implementing Special Improvement Plan on Rural Housing Development (Case Study: Abrisham Rural District) by Farhad Azizpour, Zohreh Sadeghi

“…There are a variety of theories in this regard, including theoretical approach of structuralism, functionalism approach, structural-functional approach, construction approach, phenomenological approach, critical realism, and structural-functional dynamics. …”
Get full text

Finely Designing Dicarboxylic Acid-Based Protic Ionic Liquids System for Tailoring Lignin Structure via Demethylation Strategy by Cheng Li, Xinyu Xiao, Qizhen Luo, Wanting Zhao, Wenzhe Xiao, Ling-Ping Xiao, Yao Tong, Shangru Zhai, Jian Sun

“…Lignin can endure demethylation modification to improve its activation by releasing more active functional groups. However, the process suffers from expensive, corrosive, and toxic issues by employing halogen-containing reagents, which has become an obstacle to industrial applications. …”
Get full text

Enhanced and selective photocatalytic reduction of CO2 to CH4 using a Pt-loaded CuPc/g-C3N4 Z-scheme heterojunction catalyst by Jinshan Chen, Jiangfeng Lu, Ran Lang, Chi Wang, Shuangyou Bao, Yuan Li, Kai Li, Maohong Fan

“…In comparison with other commonly studied photocatalysts, such as g–C3N4–based catalysts, the PtCuCN composite exhibited superior CH4 yield and product selectivity, demonstrating its potential as a more efficient photocatalyst for CO2 reduction. X-ray photoelectron spectroscopy (XPS), density functional theory (DFT) calculations, and in-situ infrared (IR) analysis revealed that the Pt0 species effectively lower the activation energy for CH4 formation, while CuPc extends the light absorption range and enhances charge separation. …”
Get full text

Recent advances in metal-organic frameworks for electrochemical sensing applications by Magesh Kumar Muthukumaran, Muthukumar Govindaraj, Sakthivel Kogularasu, Balasubramanian Sriram, Bharathi Kannan Raja, Sea-Fue Wang, Guo-Ping Chang-Chien, Arockia Selvi J

“…Reviewing recent advancements in MOF synthesis and functionality, this article provides a comprehensive overview of how MOFs can be developed as next-generation electrochemical sensing platforms. …”
Get full text

Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT by Jenni Murray, Ruth Baxter, Jane O’Hara, Laura Sheard, Catherine Hewitt, Natasha Hardicre, Charles Vincent, Eirini Oikonomou, Gerry Richardson, Rosie Shannon, Kalpita Baird, Stephen Brealey, Robbie Foy, Laura Mandefield, Sarah Hampton, Ed Breckin, Lubena Mirza, Alfredo Palacios, Sally Moore, Jayne Marran, Jacqui Elliot, Jane Schofield, Alison Cracknell, Beth Woods, Sarah Cockayne, Thomas Mills, Yvonne Birks, Olivia Joseph, Rebecca Lawton

“…Work package 4: Development and refinement of a care transitions intervention Intervention development Functional resonance analysis method was used to model the transition process. …”
Get full text

Monosaccharide coating modulate the intracellular trafficking of gold nanoparticles in dendritic cellsKey findings by Meshal A. Alobaid, Sarah-Jane Richards, Morgan R. Alexander, Matthew I. Gibson, Amir M. Ghaemmaghami

“…These findings highlight the utility of carbohydrate coatings to enable more targeted delivery of nanoparticles and their payload to distinct intracellular compartments in immune cells with potential applications in drug delivery and immunotherapy.…”
Get full text