A novel founder variant in BEST1 gene causing autosomal recessive bestrophinopathy by Nagham Maher Elbagoury, Caroline Atef Tawfik, Asmaa Fawzy Abdel-Aleem, Heba Mahmoud Fathy, Dina Nabil Baddar, Mona Lotfi Essawi

“…The pathogenicity of the variants was tested using different in silico functional analysis tools. Results The clinical examination and investigations confirmed the ARB phenotype. …”
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Generative spatial artificial intelligence for sustainable smart cities: A pioneering large flow model for urban digital twin by Jeffrey Huang, Simon Elias Bibri, Paul Keel

“…The model enhances decision-making processes, supports evidence-based planning and design, fosters integrated development strategies, and enables the development of more efficient, resilient, and sustainable urban environments. …”
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Immunophenotyping of Blood Cell Subpopulations from Experimental Animals Infected by Yersinia Pestis with Different Plasmid Composition by V. V. Voitkova, V. I. Dubrovina, K. M. Korytov, G. B. Mukhturgin, S. A. Vityazeva, S. V. Balakhonov

“…Species-specific plasmid pYP determines synthesis bacteriocine (pesticin 1) and plasminogen activator, and plasmid pYT - murine toxin and a capsular antigen F1. Loss of one or more plasmids leads to a change of the pathogenic properties and a reduction or even total loss of the virulence of the pathogen, as well as affect the functional state organs of the immune system. …”
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Vegetation Monitoring of Palm Trees in an Oasis Environment (Boudenib, Morocco) Using Automatic Processing of Medium-Resolution Remotely Sensed Data by Kaoutar Badioui, Ann Van Griensven, Boud Verbeiren

“…Oases are part of the natural wealth and heritage of Morocco and contribute to the social, economic, and touristic environment. Morocco has lost more than 2/3 of its oases during the past century due to water scarcity, succession of drought periods, climate change and over-exploitation of groundwater resources. …”
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Effect of caffeine on heart rate variability parameters in female rats with doxorubicin-induced cardiomyopathy by V. V. Mukvych, O. V. Severynovska

“…One of the modern, non-invasive, and informative methods for assessing the functional state of the cardiovascular system is heart rate variability (HRV) analysis. …”
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Differentiation of glioma and radiation injury in rats using in vitro produce magnetically labeled cytotoxic T-cells and MRI. by Ali S Arbab, Branislava Janic, Kourosh Jafari-Khouzani, A S M Iskander, Sanath Kumar, Nadimpalli R S Varma, Robert A Knight, Hamid Soltanian-Zadeh, Stephen L Brown, Joseph A Frank

“…Our method produced functional, sensitized CTLs that specifically induced U251 cell death in vitro. …”
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Health effects and mediating mechanisms of smart wearable devices on older people: evidence from China by Enkai Guo, Enkai Guo, Enkai Guo, Shiyi He, Shiyi He, Shiyi He, Lan Zheng, Lan Zheng, Lan Zheng

“…The effect was more significant in those aged 70 years or older (β = 0.385, p < 0.001), those without chronic diseases (β = 0.590, p < 0.001), and those living with their children (β = 0.452, p < 0.001). …”
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Post stroke fall and associated factors among stroke survivors at hospitals in Jimma town, oromia regional state, Southwest Ethiopia, 2025: a cross sectional study by Yohannes Girma Legese, Foad Akmel, Keiru Abajebal, Dechasa Imiru Wayessa, Sisay Deme, Yazachew Mekonnen, Tesfalem Yitbarek

“…It significantly influences their well-being, increasing morbidity and reducing functional independence. It also leads to limiting activity and participation, increasing dependence and developing a fear of movements. …”
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Laboratory predictors of clinical outcomes in patients with atrial fibrillation by A. A. Sokolova, I. V. Goncharova, A. A. Vedernikov, N. S. Morozova, D. A. Napalkov

“…However, ABC scale, including hs-cTnT and NT- pro BNP, hasn't given more accurate result in stroke predicting than CHA2DS2-VASc scale. …”
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Effectiveness of digital health applications on the quality of life in patients with overweight or obesity: a systematic review by Melanie Mäder, Tonio Schönfelder, Ria Heinrich, Carsta Militzer-Horstmann, Patrick Timpel

“…Abstract Background Globally, more than half of the adult population is overweight, including those who are obese, which increases the risk of premature death and reduces quality of life (QoL). …”
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Depot-specific metabolic and inflammatory profiles in perirenal and renal sinus adipose tissue by Maria J. Pereira, Argyri Mathioudaki, Susanne Hetty, Amir Sedigh, Jan W. Eriksson, Maria K. Svensson

“…Conclusions The different kidney-associated adipose tissue depots exhibit distinct gene expression and functional profiles. PRAT displays higher expression of thermogenic markers and less inflammatory profile compared to RSAT and also OAT. …”
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Decision-making behavior in patients with depressive disorder and its relationship with depressive and anxiety symptoms by Wang Yuxiang, Zhang Luoya, Zhang Maomao, Deng Juan, Peng Yanjie, Cheng Xiaotong, Liu Kezhi, Lei Wei, Chen Jing

“…In depression group， BDI and BAI scores were positively correlated with the win-stay rate（r=0.450， 0.398， P<0.01）.ConclusionPatients with depressive disorder are more likely to change their decision-making strategies following negative outcomes. …”
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Summarizing Online Patient Conversations Using Generative Language Models: Experimental and Comparative Study by Rakhi Asokkumar Subjagouri Nair, Matthias Hartung, Philipp Heinisch, Janik Jaskolski, Cornelius Starke-Knäusel, Susana Veríssimo, David Maria Schmidt, Philipp Cimiano

“…ConclusionsTaken together, our results suggest that state-of-the-art pretrained language models are a valuable tool to provide qualitative insights about the patient experience to better understand unmet needs, patient priorities, and how a disease impacts daily functioning and quality of life to inform processes aimed at improving health care delivery and ensure that drug development focuses more on the actual priorities and unmet needs of patients. …”
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Evaluation Methods for the Human–Land Coupling Coordination Relationship in a Metro Station Area: A Case Study of Chengdu Metro Line 1 by Zhiyue Qiu, Shirui Wen, Hong Yuan, Ziyi Liu, Yao Wei, Siqi Yanling, Runlong Dai, Xiang Li, Yuxin Gu

“…At present, more than 200 cities in the world have developed metro systems. …”
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Spatial relationships between macrophyte assemblages, water and sediment features in deep lakes by Alice Dalla Vecchia, Rossano Bolpagni, Alex Laini, Daniele Nizzoli, Mariano Bresciani, Mattia Martin Azzella, Martin Wilkes

“…Beyond light availability, sediment features (TP and organic matter content) emerged as significant in determining the arrangement of macrophytes in relation to depth, offering a more informed view of macrophyte spatial processes and their functional implications in deep lakes.…”
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Sleep-Disordered Breathing and Central Respiratory Control in Children: A Comprehensive Review by Marco Zaffanello, Angelo Pietrobelli, Luana Nosetti, Giuliana Ferrante, Erika Rigotti, Stefania Ganzarolli, Giorgio Piacentini

“…Over time, these effects could lead to functional changes (e.g., disrupted chemical signalling) and physical damage in critical brain regions, creating a cycle of unstable breathing. …”
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Optimizing Energy and Spectral Efficiency in Mobile Networks: A Comprehensive Energy Sustainability Framework for Network Operators by Luis Mata, Marco Sousa, Pedro Vieira, Maria Paula Queluz, Antonio Rodrigues

“…Notably, the implemented ML and XAI model achieved an F1-Score of 0.78 for 5G scenarios and 0.83 for 4G scenarios in predicting the Energy Sustainability Class, relying on a reduced set of indicators encompassing the most influential factors. An additional analysis, based on domain expertise, provided evidence of potential causal relationships between the class and observed variables involving channel quality, Multiple Input Multiple Output (MIMO) utilisation, network topology and energy-saving functionalities. …”
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Genome-Wide Identification of the HSP Gene Family in Penaeus japonicus and Their Expression Characteristics During Development Stages by Xueqiong BIAN, Xianyun REN, Junxia WANG, Shaoting JIA, Jianjun GUO, Kuangcheng ZHAO, Ping LIU, Jian LI, Jitao LI

“…A few HSP family members were clustered first with HSP family members from Eriocheir sinensis, D. melanogaster, and other insects, and then with HSP family members from other species. Motif analysis showed that the hsp gene family was highly conserved; however, the functions of different families were quite different. …”
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Understanding the Educational and Social Difficulties in Children with Hemifacial Microsomia – A Literature Review by Michał Pniak, Paweł Miklis, Maciej Mawlichanów, Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej, Zofia Czaplińska-Paszek, Alicja Kot, Marta Wojtczak, Natalia Myśliwiec, Adrian Róźycki

“…Studies on emotional functioning demonstrated a similar level of behavioral adjustment compared to control groups. …”
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Patient Reported Outcome Measures in cancer care: a hybrid effectiveness-Implementation trial to optimise Symptom control and health service Experience (PROMISE)–protocol for a ran... by David Wyld, Afaf Girgis, Elizabeth Miller, Penelope M Webb, Gunter Hartel, Karen Martin, Rahul Ladwa, Melissa Eastgate, Suzanne O’Brien, Sabe Sabesan, Raymond J Chan, Amy Brown, Robert Mason, Mark B Pinkham, Bena Brown, Louisa G Collins, Fiona Crawford Williams, Kerrie Doupain, Vicki Fennelly, Peter McGuire, Rebecca Packer, Jasotha Sanmugarajah, Georgia Slapp, Doreen Tapsall, Jeanie White, Laurelie R Wishart

“…PROM scores can be tracked over time allowing more timely identification of problems and more appropriate intervention. …”
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