First trimester circulating miR-208b-3p and miR-26a-1-3p are relevant to the prediction of gestational hypertension by Andrée-Anne Clément, Cécilia LÉGARÉ, Véronique Desgagné, Kathrine Thibeault, Frédérique White, Michelle S. Scott, Pierre-Étienne Jacques, William D Fraser, Patrice Perron, Renée Guérin, Marie-France Hivert, Anne-Marie Côté, Luigi Bouchard

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Epigenome profiling reveals distinctive regulatory features and cis-regulatory elements in pepper by Hongji Yang, Guorong Yu, Zhidong Lv, Tonghui Li, Xi Wang, Ying Fu, Zhangsheng Zhu, Guangjun Guo, Hang He, Ming Wang, Guochen Qin, Feng Liu, Zhenhui Zhong, Yan Xue

“…While the large and complex genome of pepper severely hampered the understanding of its functional genome, it also indicates a rich yet unexplored reservoir of regulatory elements (REs). …”
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Cell-Free DNA (cfDNA) Regulates Metabolic Remodeling in the ES-2 Ovarian Carcinoma Cell Line, Influencing Cell Proliferation, Quiescence, and Chemoresistance in a Cell-of-Origin-Sp... by Isabel Lemos, Catarina Freitas-Dias, Ana Hipólito, José Ramalho, Fabrizio Carteni, Luís G. Gonçalves, Stefano Mazzoleni, Jacinta Serpa

“…We observed instant reactions of adopting the metabolic profile that brings back the cell functioning of more favorable culture conditions supporting proliferation and resembling the cell of origin of the cfDNA variant, as observed in unselected ES-2 cells. …”
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Prevalence of Extended-Spectrum β-Lactamase-Producing <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i> and <i>Enterobacter cloacae</i> in Wastewater Effluent in Blantyre, Mala... by Edna Ibrahim, Charity Mkwanda, Edward Masoambeta, Luigia Scudeller, Tomislav Kostyanev, Hussein H. Twabi, Yohane K. Diness, Jobiba Chinkhumba, Janelisa Musaya, Rajhab S. Mkakosya, Surbhi Malhotra-Kumar, Chantal M. Morel, Save Kumwenda, Chisomo L. Msefula

“…<b>Results</b>: A total of 288 samples were collected between April 2023 and March 2024, and 97.6% (281/288) yielded one or more presumptive ESBL isolates. Bacterial growth was confirmed as 48.9% <i>Ec</i> (255/522), 33.0% <i>Kp</i> (172/522), and 10.0% <i>Enc</i> (52/522). …”
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Development and validation of a disulfidptosis-related genes signature for predicting outcomes and immunotherapy in acute myeloid leukemia by Han Gong, Han Gong, Ying Zhang, Xusheng Wu, Yiming Pan, Yiming Pan, Mingwei Wang, Mingwei Wang, Xiaofeng He, Jing Liu, Zhong Liu, Zhong Liu, Ling Li

“…Moreover, experiments validated the functions of PTPN6 and CSK in OCI-AML2 cells.ResultsWe identified 10 prognostic DRGs and revealed two disulfidptosis subtypes. …”
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A splice donor variant in SLAMF1 is associated with canine atopic dermatitis by Oliver P. Forman, Jamie Freyer, Abigail Kerr, Julia D. Labadie, Michael Denyer, Debbie J. Gow, Janet Alexander, Michelle Daya, Yaindrys Rodriguez Olivera, Cecilia Lozoya, Christian Leutenegger, Christian Savard, Jason T. Huff, Rebecca Chodroff Foran

“…Whole-genome resequencing revealed a compelling splice donor variant in the signaling lymphocytic activation molecule 1 (SLAMF1), a transmembrane receptor with important functions in immune cells. Further analysis of additional genome sequences and RNA samples from the MARS PETCARE BIOBANK confirmed that the SLAMF1 splice variant is a strong potential contributor to an increased risk of atopic dermatitis.DiscussionThe discovery represents the first compelling genetic variant associated with CAD to be validated in more than one breed of dog. …”
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Proteomic profiling improves prognostic risk stratification of the Sarculator nomogram in soft tissue sarcomas of the extremities and trunk wall by Madhumeeta Chadha, Sara Iadecola, Andrew Jenks, Valeriya Pankova, Yuen Bun Tam, Jessica Burns, Amani Arthur, Christopher P. Wilding, Liang Chen, Priya Chudasama, Dario Callegaro, Dirk C. Strauss, Khin Thway, Alessandro Gronchi, Robin L. Jones, Rosalba Miceli, Sandro Pasquali, Paul H. Huang

“…Abstract Background High‐risk soft tissue sarcomas of the extremities and trunk wall (eSTS), as defined by the Sarculator nomogram, are more likely to benefit from (neo)adjuvant anthracycline‐based therapy compared to low/intermediate‐risk patients. …”
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Construction of mitochondrial signature (MS) for the prognosis of ovarian cancer by Miao Ao, You Wu, Kunyu Wang, Haixia Luo, Wei Mao, Anqi Zhao, Xiaomeng Su, Yan Song, Bin Li

“…GO and KEGG analysis confirmed these genes were enriched in the generation of precursor metabolites and energy. It illustrated more lymphocyte infiltration in the high MS group than low MS group. …”
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Repurposed clindamycin suppresses pyroptosis in tumor-associated macrophages through Inhibition of caspase-1 by Adrian Weich, Johannes Berges, Cindy Flamann, Katrin Bitterer, Krishna Pal Singh, David Chambers, Christopher Lischer, Xin Lai, Olaf Wolkenhauer, Carola Berking, Gerhard Krönke, Shailendra Gupta, Heiko Bruns, Julio Vera, Research Group Macrophages

“…The method generates a ranking of drug-target interactions, the most promising of which are channeled towards experimental validation. …”
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Illumina complete long read assay yields contiguous bacterial genomes from human gut metagenomes by Dylan G. Maghini, Yuya Kiguchi, Aaron E. Darling, Leigh G. Monahan, Aaron L. Halpern, Catherine M. Burke, Erich Jaeger, Aaron Statham, Tiffany Truong, Kevin Ying, Stephen P. Bruinsma, Gary P. Schroth, Ami S. Bhatt

“…ABSTRACT Metagenomics enables direct investigation of the gene content and potential functions of gut bacteria without isolation and culture. …”
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Sol–gel auto-combustion synthesis of a novel ternary magnetic-recyclable ZnFe2O4/ZnO/CeO2 nano-photocatalyst for highly efficient visible-light-induced degradation of organic conta... by Saba Roostaei, Hanieh Ansarinejad, Elmuez A. Dawi, Forat H. Alsultany, Salman Khalaf Issa, Mina Ahmadi-Kashani, Masoud Salavati-Niasari

“…Furthermore, insights into the photocatalytic reaction mechanism and the •OH generation process on the ternary photocatalyst were provided. …”
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Educational Technologies in Modern Higher Education Institutions (Analysis of Russian and Foreign Research and Practice) by N. V. Bordovskaia, E. A. Koshkina, N. A. Bochkina

“…Statistically significant differences were identified for all considered functional characteristics of educational technology in Russian and foreign publications, with the exception of “Student Attitude to Educational Technology”. …”
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Integrating genome and transcriptome analysis to decipher balanced structural variants in unsolved cases of neurodevelopmental disorders by Simona Mellone, Alice Spano, Denise Vurchio, Giulia Borgonovi, Giulia Borgonovi, Alessandro Ugonotti, Giulia Paglino, Alba Bianco, Sara Ronzani, Maurizio Sciancalepore, Flavia Prodam, Flavia Prodam, Amanda Papa, Maurizio Viri, Umberto Dianzani, Umberto Dianzani, Mara Giordano, Mara Giordano

“…Transcriptomic analysis demonstrated the monoallelic and significantly reduced expression of EP300.ConclusionThese findings highlight the crucial role of WGS in identifying disease-associated BCAs and underscore the complementary value of RNA-Seq in assessing their functional consequences. This integrated approach enhanced diagnostic accuracy and clinical management, paving the way for more comprehensive and personalized care in these two patients.…”
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Low-frequency rTMS modulates small-world network properties in an AVH-related brain network in schizophrenia by Lin Zhang, Li Guo, Xiaohui Liu, Jing Han, Yuanqiang Zhu, Chaozong Ma, Ye Li, Weiliang Ye

“…Furthermore, most previous studies have analyzed whole-brain networks, lacking specificity regarding disease-relevant circuits.ObjectiveThis study aimed to investigate how low-frequency rTMS modulates the small-world network properties of a refined AVH-related network composed of 35 brain regions specifically implicated in hallucination generation and rTMS treatment effects, thereby providing a more targeted perspective on network reorganization. …”
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Transcriptional regulatory network reveals key transcription factors for regulating agronomic traits in soybean by Wu Jiao, Mangmang Wang, Yijian Guan, Wei Guo, Chang Zhang, Yuanchun Wei, Zhenwei Zhao, Hongyu Ma, Longfei Wang, Xinyu Jiang, Wenxue Ye, Dong Cao, Qingxin Song

“…We find TF binding sites (TFBSs) exhibit elevated chromatin accessibility and contain more rare alleles than other genomic regions. Intriguingly, the methylation variations at TFBSs partially contribute to expression bias among whole genome duplication paralogs. …”
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IMDM-20 enhances neutrophilic features during 1.3 % DMSO-mediated differentiation of HL-60 cells by Jorge Andrés Cázares-Preciado, José Antonio Cruz-Cárdenas, Alejandra López-Arredondo, Marco V. Gallardo-Camarena, Marion E.G. Brunck

“…Multiple differentiation protocols have been reported to generate neutrophil-like HL-60 cells, with limited consideration of how methodological variations might influence cell identity and functions. …”
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Immunological and biochemical changes in young children with recurrent course of respiratory infections and cytomegaloviral infection by L. N. Boyarskaya, T. S. Herasimchuk, Yu. V. Kotlova, L. N. Boyarskaya, A. H. Davydova

“…In the early convalescence period after respiratory infection process in children with CMV and RRI the immune response is characterized by a decreasing of the functional and metabolic activity of neutrophile granulocytes (р<0,05) and imbalance of humoral immunity consisting in decreased antibody generation (IgА (р<0,05), IgМ (р<0,05), tendency to IgG decreasing). …”
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Expectation Confirmation and Technology Acceptance: A Study of the Public's Attention to Accept the Government's Digital Human Avatar by Jinghao CHEN, Feng JIA, Qianxi LIU

“…[Purpose/Significance] In the digital age, government digital avatars represent a significant innovative application of the integration of generative artificial intelligence and digital government. …”
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Paper and cardboard as sustainable materials by Jerzy F. Latka

“…With regard to operating energy, materials can be rendered more sustainable by ensuring they have a higher thermal insulation value or greater thermal mass. …”
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Development and Analysis of a Non-Resonant Wide-Band Tri-Axial Electromagnetic Energy Harvester by Hamid Khan, Farid Ullah Khan

“…Additionally, experimental results show that the developed harvester can generate much more power than single-coil energy harvesters. …”
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