Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma by Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian

“…Therefore, this study aimed to identify the optimal scFv and investigate its biological functions to further optimize the therapeutic potential of CAR-T cells targeting CEA-positive carcinoma.MethodsWe screened four reported humanized or fully human anti-CEA antibodies (M5A, hMN-14, BW431/26, and C2-45), and inserted them into a 3rd-generation CAR structure. …”
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Microstructural transformation for robust and high-efficiency Zintl thermoelectrics by Meng Jiang, Qinghua Zhang, Siyuan Zhang, Ming Liu, Yuntian Fu, Zhiyuan Zhang, Xin Ai, Bohayra Mortazavi, Lianjun Wang, Qihao Zhang, Denys Makarov, Wan Jiang

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Computational modelling of immunological mechanisms: From statistical approaches to interpretable machine learning by María Rodríguez Martínez, Matteo Barberis, Anna Niarakis

“…To conclude the workshop, a round table was organized to foster discussions on the existing challenges and chart a roadmap for the development of the next generation of computational models dedicated to investigating the cellular and molecular functions that underlie the immune system.…”
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Novel In Vitro Selection of <i>Trans</i>-Acting <i>BCL-2</i> mRNA-Cleaving Deoxyribozymes for Cancer Therapy by Veera Vijaya Basamshetty, Vijay Kumar Gangipangi, Uppulapu Shravan Kumar, Santhosh Shanthi Bhupathi, Sridhar Reddy Kaulagari, Prashant Giri, Swapnil Sinha, Utpal Mohan, Konstantinos Sdrimas

“…Additionally, investigating the underlying molecular mechanisms in more complex cancer models will further validate the observed effects.…”
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Microstructural transition from ZrO₂ to Zr–Al intermetallics and property evolution in AA5051 composites by G. Anbuchezhiyan, G. Ananth, Vignesh M, K. Logesh, Nabisab Mujawar Mubarak, Elango Natarajan

“…AA5051 is lightweight and has excellent corrosion resistance, but it loses strength at higher temperatures as magnesium atoms diffuse more readily within the aluminium matrix, reducing the uniformity of the solid solution and weakening the alloy's strengthening mechanism. …”
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Increasing the capacity of electric grids based on the integration of meteorological data by M. Ya. Kletsel, E. V. Petrova, S. S. Girshin, V. A. Krivolapov, V. N. Goryunov, V. M. Trotsenko

“…The efficient and sustainable functioning of energy systems is a critical element for supplying of electricity necessary to maintain the vital functions of modern society. …”
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A data-mining analysis of host solute carrier family proteins in SARS-CoV-2 infection with reference to brain endothelial cells and the blood-brain barrier in COVID-19 by Talia Fradkin, Rainald Schmidt-Kastner

“…Literature searches for host SLCs revealed involvement of a subset of SLCs in infection mechanisms for SARS-CoV-2 and more broadly for other viruses. N = 17 host ABCs were found in brain endothelial cells where they may serve as efflux transporters.DiscussionThis hypothesis-generating work proposes a set of N = 80 host SLCs expressed in endothelial cells as contributors to BBB impairment after SARS-CoV-2 infection. …”
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In‐Sensor Computing‐Based Smart Sensing Architecture Implemented Using a Dual‐Gate Metal‐Oxide Thin‐Film Transistor Technology by Tengteng Lei, Yushen Hu, Xinying Xie, Runxiao Shi, Man Wong

“…Compatibility of the proposed architecture with functionally distinct elements for sensing, memory, and computing removes the restrictive demand for a single element simultaneously capable of all, thus making this architecture more generally applicable to a wider range of sensors and usage scenarios. …”
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Spatial-Spectral Linear Extrapolation for Cross-Scene Hyperspectral Image Classification by Lianlei Lin, Hanqing Zhao, Sheng Gao, Junkai Wang, Zongwei Zhang

“…Therefore, a model needs to be trained on one or more source domains (SD) and achieve robust domain generalization (DG) performance on an unknown target domain (TD). …”
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Management approach matters: meeting seagrass recovery and carbon mitigation goals by Melissa Ward, Connor Dibble, Maddie Millington-Drake, John Lynch, Karen McGlathery, Richard J. Lilley, Aaron L. Strong, Lisa M. Wedding

“…Abstract Seagrass habitats support biodiversity, improve water quality, protect coastlines, and sequester carbon, among other essential ecosystem functions, yet they are declining worldwide due to human activity. …”
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Use ATCCfinder to identify commercially available American Type Culture Collection strains based on sequence queries by Samuel I. Koehler, Earl A. Middlebrook, Blake T. Hovde, Erik R. Hanschen

“…The algorithm generates databases of the four ATCC data types: strain-specific genome assembly sequence data (sequence), information about how each strain was collected (metadata, catalogue), and structural/functional information about genome assemblies (annotation). …”
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The Actualisation of Regional Capacity Educational Space Based on Cluster Interaction: The Aspect of Formation of Training Health Culture by V. A. Fedorov, K. V. Chedov

“…The system component of the approach involves the consideration of the object (organisation, pedagogical system, educational space, etc.) not as a simple sum of any separate components, but as a single functional whole that has its own qualities distinguishable from the qualities of its individual parts. …”
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Mutational Spectrum Analysis of Seven Genes Associated with Thyroid Dyshormonogenesis by Xi Chen, Xiaohong Kong, Jie Zhu, Tingting Zhang, Yanwei Li, Guifeng Ding, Huijuan Wang

“…Fifteen (71%) patients carried 2 or more DUOX2 (14) or DUOXA2 (1) variants. The genetic basis of DH in nine (43%) patients harboring biallelic or triallelic pathogenic variants was resolved. …”
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Competitive Roles of DNRA and Denitrification on Organic Nitrogen Dynamics in Partially Saturated Soil‐Water Systems by Lecheng Liu, Tianyuan Zheng, Yingying Qiu, Yujie Hao, Haoran Ma, Xilai Zheng, Alberto Guadagnini

“…The rate of DNRA is documented to be (a) significantly faster in loam than in sandy loam, due to dissolved carbon release from loam aggregates, and (b) more effective in the presence of amino acid than urea in the natural soil, due to the role of amino acid as carbon source. …”
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Innovation Ecosystem of Iran's Tourism Industry with Emphasis on Supply Chain by Azizolah Jafari, mahdi alaei kerahrudi

“…Today’s tourism products target more specific markets, with customers seeking authentic experiences. …”
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Cembranoid Diterpenes from South China Sea Soft Coral <i>Sarcophyton crassocaule</i> by Hanyang Peng, Yanbo Zeng, Rui Zhang, Li Yang, Fei Wu, Cuijuan Gai, Jingzhe Yuan, Wenjun Chang, Haofu Dai, Xiachang Wang

“…Overall, our research results have enriched the library of secondary metabolites from soft corals, providing more molecular entities for subsequent research and development of related compounds.…”
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Massively parallel sequencing and analysis of the Necator americanus transcriptome. by Cinzia Cantacessi, Makedonka Mitreva, Aaron R Jex, Neil D Young, Bronwyn E Campbell, Ross S Hall, Maria A Doyle, Stuart A Ralph, Elida M Rabelo, Shoba Ranganathan, Paul W Sternberg, Alex Loukas, Robin B Gasser

“…In N. americanus, essential molecules were predicted using a combination of orthology mapping and functional data available for C. elegans. Further analyses allowed the prioritization of 18 predicted drug targets which did not have homologues in the human host. …”
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Rad6 Regulates Conidiation by Affecting the Biotin Metabolism in <i>Beauveria bassiana</i> by Yuhan Guo, Haomin He, Yi Guan, Longbin Zhang

“…Additionally, mutant strains exhibited a more pronounced decline in both conidial generation and hyphal development when cultured in nutrient-rich conditions. …”
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A non-sub-sampled shearlet transform-based deep learning sub band enhancement and fusion method for multi-modal images by Sudhakar Sengan, Praveen Gugulothu, Roobaea Alroobaea, Julian L. Webber, Abolfazl Mehbodniya, Amr Yousef

“…Abstract Multi-Modal Medical Image Fusion (MMMIF) has become increasingly important in clinical applications, as it enables the integration of complementary information from different imaging modalities to support more accurate diagnosis and treatment planning. The primary objective of Medical Image Fusion (MIF) is to generate a fused image that retains the most informative features from the Source Images (SI), thereby enhancing the reliability of clinical decision-making systems. …”
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Ultrastructural and developmental anatomy of the peripheral olfactory organs of Dicentrarchus labrax inhabiting Egyptian Mediterranean water by Sheren A. Al-Zahaby, Al-Ahmady S. Al-Zahaby, Radwa A. Mohamed, Eman H. Elsheikh

“…Results: Both placodes thickened and invaginated, generating simple olfactory pits with undifferentiated cells. …”
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