Transcriptomic and proteomic analysis reveals wall-associated and glucan-degrading proteins with potential roles in Phytophthora infestans sexual spore development. by Xiaofan Niu, Audrey M V Ah-Fong, Lilianna A Lopez, Howard S Judelson

“…Despite being dormant, oospores contained a mostly normal complement of proteins required for core cellular functions. The RNA-seq data generated here and in prior studies were used to identify new housekeeping controls for gene expression studies that are more stable than existing normalization standards. …”
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Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury by Pihu Mehrotra, James Jablonski, John Toftegaard, Yali Zhang, Shahryar Shahini, Jianmin Wang, Carey W. Hung, Reilly Ellis, Gabriella Kayal, Nika Rajabian, Song Liu, Kelly C. S. Roballo, Susan B. Udin, Stelios T. Andreadis, Kirkwood E. Personius

“…Abstract Peripheral Nerve Injuries (PNI) affect more than 20 million Americans and severely impact quality of life by causing long-term disability. …”
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Trustworthy Analytics in ETSI ZSM: A 5G Security Case Study by Panagiotis Radoglou-Grammatikis, Efklidis Katsaros, Evangelos Syrmos, Georgios P. Katsikas, Dimitrios Klonidis, Vasileios Argyriou, Thomas Lagkas, Panagiotis Sarigiannidis

“…For this purpose, we take into account a particular case study which focuses on the orchestration of security services within the 5G core. More specifically, the deployment of a new User Plane Function (UPF) equipped with intrusion detection services that leverage Artificial Intelligence (AI) is investigated. …”
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Quantitative SISCOM assessment for epileptogenic zone localization: insights from a multicenter study comparing two software platforms in temporal lobe epilepsy by Carla Oliveira Young, Brunno Machado de Campos, Edna Marina de Souza, Sergio Querino Brunetto, Maria Julia de Oliveira Santos Gualberto, Leonardo Alexandre-Santos, Marcos Geraldo Merichelo de Oliveira, Marina Koutsodontis Machado Alvim, Fernando Cendes, Elba Etchebehere, Lauro Wichert-Ana, Bárbara Juarez Amorim

“…Both SPM and Analyze were concordant with the EZ reference standard in 14 cases (70%), showing no difference in sensitivity between the methods. However, SPM generated smaller, more localized clusters, while Analyze produced larger clusters with broader spatial coverage. …”
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HpFBH3 transactivates HpCO7 via binding to the E-boxes in the promoter and may accelerate flower formation in pitaya by Xiaowei Cai, Ling Xiao, Xiangmei Nie, Qiandong Hou, Sulin Wen, Kun Yang, Xiaopeng Wen

“…In practice, accelerating flower formation and inducing more flowers usually result in higher yield. However, the genes for this purpose have not been well characterized in pitaya. …”
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Intentional heterogeneity in autologous cell-based gene therapies: strategic considerations for first-in-human trials by Antoni Ribas, Carl H June, Philip D Greenberg, Crystal L Mackall, Marcela V Maus, John E Connolly, Christopher R Cabanski, Ute Dugan, Mark D Stewart, Jeff D Allen, EnJun Yang, Alexander Marson

“…Recent advances in genome editing technologies have identified hundreds of gene edits that improve T-cell functionality in preclinical models. However, the limited direct translatability of these findings and the impracticality of testing each of the individual edits in a traditional clinical trial highlight the need for more efficient strategies.This article provides an overview of genome-wide screens that identify gene knockouts and knock-ins to enhance T-cell function and the limitations with translating these results to human trials. …”
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Optimized enrichment of murine blood–brain barrier vessels with a critical focus on network hierarchy in post-collection analysis by Hanaa Abdelazim, Audra Barnes, James Stupin, Ranah Hasson, Carmen Muñoz-Ballester, Kenneth L. Young, Stefanie Robel, James W. Smyth, Samy Lamouille, John C. Chappell

“…This vital role in neurological health and function has garnered significant attention from the scientific community and inspired methodology for enriching BBB capillaries. …”
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Uncertainty management in multiobjective electric vehicle integrated optimal power flow based hydrothermal scheduling of renewable power system for environmental sustainability by Susanta Dutta, Siddhartha Ghosh, Tushnik Sarkar, Provas Kumar Roy, Chandan Paul, Ruba Abu Khurma, Mohd Asif Shah, Saurav Mallik

“…Moreover, an analysis of variance (ANOVA) test and box plot are used to thoroughly investigate this data to provide a more precise assessment of QOSCA’s robustness. After integrating wind-solar and EV, the numerical analysis for IEEE 57 bus and IEEE 118-bus utilizing QOSCA for single objective over generation cost is reduced by 21%, emission is reduced by 17.5%, APL is reduced by 0.17% and 2.59%. …”
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Crude Radix Aconiti Lateralis Preparata (Fuzi) with Glycyrrhiza Reduces Inflammation and Ventricular Remodeling in Mice through the TLR4/NF-κB Pathway by Ping Yan, Wen Mao, Lushuai Jin, Mingsun Fang, Xia Liu, Jiali Lang, Lu Jin, Beibei Cao, Qiyang Shou, Huiying Fu

“…CFZ+GC was more effective than CFZ and PFZ, whereas CFZ had higher toxicity than CFZ+GC and PFZ. …”
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Deep sequencing reveals distinct microRNA-mRNA signatures that differentiate pancreatic neuroendocrine tumor from non-diseased pancreas tissue by N Matyasovska, N Valkova, M Gala, S Bendikova, A Abdulhamed, V. Palicka, Neil Renwick, Pavol Čekan, Evan Paul

“…Then we crossed a list of differentially expressed mRNAs with a list of in silico predicted mRNA targets of the most and least abundant miRs to generate high probability miR-mRNA interaction networks. …”
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Neocarzilin A induces apoptosis and mitochondrial disturbance by targeting reticulon 4-mediated endoplasmic reticulum stress by A. T. Jauch, J. Sailer, J. Braun, E. Czeslik, J. Geyer, C. Eberhagen, A. M. Vollmar, H. Zischka, S. A. Sieber, S. Zahler

“…We here additionally demonstrate the perturbation of mitochondrial functions (fragmentation of mitochondrial networks, ultrastructural changes, increased Opa1 splicing, loss of mitochondrial membrane potential, and excessive ROS generation) upon treatment with NCA. …”
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Developments and Applications of Liver-on-a-Chip Technology—Current Status and Future Prospects by Joseph Mugaanyi, Jing Huang, Jiongze Fang, Arthur Musinguzi, Caide Lu, Zaozao Chen

“…While challenges remain, such as vascularization and long-term function, ongoing advancements are paving the way toward clinical and pharmaceutical integration. …”
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Effect of cutting parameters and tool coating on residual stress and cutting temperature in dry hard turning of AISI 52100 steel using finite element method by Sandip Mane, Rajkumar Bhimgonda Patil, Md Irfanul Haque Siddiqui, Choon Kit Chan, Yong Xu

“…The thermal performance of coated carbide tools; more specifically, the performance of titanium nitride (TiN), titanium carbonitride (TiCN), and aluminum oxide (Al2O3) coating layers were examined. …”
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Mental health and well-being of older adults living with HIV in sub-Saharan Africa: a systematic review by Charles R J C Newton, Amina A Abubakar, Patrick Nzivo Mwangala, Adam Mabrouk, Ryan Wagner

“…Future work should have sufficiently large samples of PLWH50+, engage appropriate comparison groups, harmonise the measurement of these outcomes using a standardised methodology to generate more robust prevalence estimates and confirm predictors.PROSPERO registration number CRD42020145791.…”
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Disinfection Performance Improvement of UV Reactor by Baffle Design by Nakwon Jo, Woochul Hwang

“…This method was implemented as a user-defined function and integrated into the commercial CFD software ANSYS CFX 2023R1. …”
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An Overview of Heavy Metal Contamination of Water and Its Effect on Human Health by Danjuma, M.S., Abdulkadir, B.

“…The continuous industrial activities that generate metals have led to their wide distribution in the environment which raised a concern over the effects of such metals on human health and the environment itself. …”
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A Novel Multi-Image Encryption Scheme Using Generalized Rectangular Transform and Advanced 5-D Hyperchaotic Map by Yu-Chi Lan, Chung-Ming Wang

“…In the pixel diffusion phase, a bit-level random permutation (BLRP) technique is employed alongside a Penta-Hyperchaotic Map (PHM), an advanced 5-D discrete memristor and meminductor-based hyperchaotic map, integrated with the SHA-512 hashing function. Unlike traditional pixel-based diffusion methods, BLRP shuffles bits, achieving finer confusion and making structural inference significantly more difficult for attackers. …”
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THE MUNICIPAL LEGAL AWARENESS: STRUCTURAL ANALYSIS by Denis O. Bobrovnyk

“…The author considers that, unlike municipal legal psychology, which is formed mainly spontaneously, depending on subjective events in municipal life and the experience of past generations, municipal legal ideology is formed in a systemic way as a result of: a) scientific (doctrinal), theoretical reflection of the municipal legal reality, b) based on the generalization and development of the most famous and significant municipal legal theories of the past and present; c) study of the main regularities of the formation, development and functioning of municipalism and its regulatory support and maintenance; d) study of the fundamental principles of municipalism, which are enshrined in international legal standards of local democracy; e) study of the basic principles of the state municipal policy. …”
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A Refined Terrace Extraction Method Based on a Local Optimization Model Using GF-2 Images by Guobin Kan, Jie Gong, Bao Wang, Xia Li, Jing Shi, Yutao Ma, Wei Wei, Jun Zhang

“…The model structure and loss function were adjusted accordingly to achieve high-quality terrace mapping results. …”
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Muscarinic acetylcholine receptor activated effectors in principal neurons of the rat basolateral amygdala by Todd J. Sahagian, Scott W. Harden, Jennifer L. Bizon, Jennifer L. Bizon, Barry Setlow, Barry Setlow, Charles J. Frazier, Charles J. Frazier

“…Improved understanding of these effectors will provide potentially valuable new insights on the wide range of mechanisms through which cholinergic system dysfunction can lead to impaired executive function.…”
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