Structure-dependent degradation of milk oligosaccharides by newly isolated intestinal commensal bacterial strains from suckling piglets and rabbits by Mathilde Rumeau, Sead Chadi, Frederic Pepke, Martin Beaumont, Cláudia M. Vicente, Agathe Juppeau, Céline Vandecasteele, Laurent Cauquil, Géraldine Pascal, Philippe Langella, Christelle Knudsen, Sylvie Combes, Rebeca Martín

“…Milk oligosaccharide fermentation generated a more diverse metabolome compared to glucose. …”
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Amniotic fluid-derived stem cells: potential factories of natural and mimetic strategies for congenital malformations by Cristiane S. R. Fonteles, Julia Enterria-Rosales, Ying Lin, John W. Steele, Ramiro A. Villarreal-Leal, Jing Xiao, Daniel I. Idowu, Beck Burgelin, Bogdan J. Wlodarczyk, Richard H. Finnell, Bruna Corradetti

“…The possibility to exploit both formulations as mRNA-therapeutics was explored by evaluating cell uptake in two different cell types(fibroblasts, and macrophages) and mRNA functionality overtime in an in vitro experimental setting as well as in an ex vivo, whole embryo culture using pregnant C57BL6 dams. …”
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Acridocarpus smeathmannii root extracts inhibit human prostate and bladder smooth muscle contraction, porcine arterial vasoconstriction, and cytotoxicity of prostate stromal cells by Oluwafemi Ezekiel Kale, Sheng Hu, Claudia Huber, Felix Schierholz, Anna Ciotkowska, Alexander Tamalunas, Christian G. Stief, Wolfgang Eisenreich, Martin Hennenberg

“…In addition, assays were conducted to evaluate cell proliferation and viability, providing complementary insights into functional and cellular-level effects. The bioactive compounds in the extract were characterized using gas chromatography–mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy and were subsequently evaluated in silico for their interaction with the α1-adrenergic receptor.ResultsProstate tissue contractions induced by α1-adrenergic agonists (0.1–100 µM) were reduced by 50% or more with A. smeathmannii at concentrations of 0.25 and 0.50 mg/mL. …”
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Deficiency of T cell CD40L has minor beneficial effects on obesity-induced metabolic dysfunction by Lisa Willemsen, Myrthe den Toom, Myrthe E Reiche, Marion J J Gijbels, Esther Lutgens, Bram van Os, Norbert Gerdes, Suzanne A B M Aarts

“…Our data indicate that other CD40L-expressing cell types are more relevant in the pathogenesis of obesity-associated metabolic dysfunction.…”
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Capturing sexual orientation and gender identity information in electronic medical records to inform the person-centred care of sexual and gender minority people by Simone Schmidt, Timothy Fazio, Aruska N. D’Souza, Stephen Muhi, Kath Feely, Benita Butler, Adam Boulton

“…In November 2022, The Royal Melbourne Hospital (RMH) enabled the SOGI capture EMR functionality. The purpose of this study is to understand how SOGI capture can inform the person-centred care of SGM people by way of interviews with SGM patients and RMH staff. …”
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Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy by Philip D Greenberg, Kristin G Anderson, Shannon K Oda, Breanna M Bates, Madison G Burnett, Magdalia Rodgers Suarez, Susan L Ruskin

“…Background In the USA, more than 50% of patients with ovarian cancer die within 5 years of diagnosis, highlighting the need for therapeutic innovations. …”
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Strong Hsp90α/β Protein Expression in Advanced Primary CRC Indicates Short Survival and Predicts Response to the Hsp90α/β-Specific Inhibitor Pimitespib by Sebastian B. M. Schmitz, Jakob Gülden, Marlene Niederreiter, Cassandra Eichner, Jens Werner, Barbara Mayer

“…The anti-cancer effect and chemosensitization of Pim-based therapy were prospectively confirmed in PDCS directly generated from Hsp90α/β > 40% pCRCs. Protein profiling combined with functional drug testing stratifies Hsp90α/β > 40% pCRC patients diagnosed with UICC IIb-IV for effective Pim-based therapy.…”
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A Monocyte-Driven Prognostic Model for Multiple Myeloma: Multi-Omics and Machine Learning Insights by Xie L, Gao M, Tan S, Zhou Y, Liu J, Wang L, Li X

“…Results indicated that low-risk patients are more likely to benefit from immunotherapy, while a high MGPS score reflects cellular functional impairment.Conclusion: Our findings reveal a complex interplay between immune cells and MM. …”
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Construction and characterization of chimeric FcγR T cells for universal T cell therapy by Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu

“…Methods Chimeric FcγR (CFR) constructs were generated using three distinct forms of FcγR, namely CD16A, CD32A, and CD64. …”
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The sensor histidine kinase PhcS participates in the regulation of quorum sensing-dependent virulence genes in Ralstonia pseudosolanacearum strain OE1-1 by Wakana Senuma, Masayuki Tsuzuki, Chika Takemura, Yuki Terazawa, Akinori Kiba, Kouhei Ohnishi, Kenji Kai, Yasufumi Hikichi

“…It is thus thought that PhcS participates in not only the 3-OH MAME sensing-independently PhcK-mediated regulation of phcA but also the PhcA activation following 3-OH MAME sensing. Both functions of PhcS are significantly influenced by the autophosphorylation of H230-PhcS.IMPORTANCEThe soil-borne Ralstonia solanacearum species complex (RSSC) infects more than 300 plant species in over 50 families, including solanaceous plants, causing the devastating wilt disease that substantially decreases agricultural production worldwide. …”
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Reconstruction of U.S. Regional-Scale Soybean SIF Based on MODIS Data and BP Neural Network by YAO Jianen, LIU Haiqiu, YANG Man, FENG Jinying, CHEN Xiu, ZHANG Peipei

“…The increased correlation suggests that BPSIF could more accurately reflect the dynamic changes in GPP during the soybean growing season, making it more reliable compared to the original SIF data. …”
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Patient-specific 3D tibial model: transforming meniscal allograft transplantation and surgical planning by Paula Andrea Sarmiento Riveros, Alejandro Jaramillo Quiceno, Rubén Darío Arias Pérez

“…Abstract Background Meniscal allograft transplantation (MAT) restores knee function by replacing a damaged or absent meniscus with a healthy allograft, helping to preserve joint stability, distribute the load, and reduce cartilage degeneration. …”
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RMixDA: A Random Compound Data Augmentation Operation Framework for Neural Machine Translation by Huijun Wang, Xiaojing Du, Xinkun Hao

“…We further incorporate contrastive learning, identifying augmented data as positive or negative samples to evaluate similarity more effectively. Additionally, a novel evaluation method for augmented data quality is introduced, which is regularized by the NMT model’s loss function to improve the positive correlation between augmented data quality and model training. …”
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Innovative Strategies For Social-Economic Development Financial Strategies In The Development Country by Chukwu Anthony Ogochukwu, Karina Kasztelnik

“…The research study highlighted the need for both the government and financing institutions to support small businesses to function effectively to remain relevant, continue to generate more employment, improve the living standard of the owners of small business, and ultimately impact development country at large. …”
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Assessment of nanoparticles and algae as mediators with Trifolium sp. for the assembly of biosolar cells by Ayesha Alam, Arifa Tahir, Faiza Anum, Labeeb Ali, Kanza Butt, Ihsan Ali

“…The optimum size of the solar panel is still a debatable question, and more research experiments with the integration of green biomass and nanotechnology are suggested. …”
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Comparative Salt-Stress Responses in Salt-Tolerant (Vikinga) and Salt-Sensitive (Regalona) Quinoa Varieties. Physiological, Anatomical and Biochemical Perspectives by Xavier Serrat, Antony Quello, Brigen Manikan, Gladys Lino, Salvador Nogués

“…The capacity of Vikinga to generate higher dry weight is a function of the capacity to generate greater amounts of leaves and roots in any condition. …”
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Drugs of abuse drive neurotransmitter plasticity that alters behavior: implications for mental health by Marta Pratelli, Marta Pratelli, Nicholas C. Spitzer, Nicholas C. Spitzer

“…Changes in the transmitter neurons express can generate changes in animal behavior. The ability of neurons to express multiple transmitters and/or switch them in response to environmental stimuli likely evolved to provide flexibility and complexity to neuronal circuit function in an ever-changing environment. …”
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Revolutionizing RPAS logistics and reducing CO2 emissions with advanced RPAS technology for delivery systems by Armin Mahmoodi, Leila Hashemi, Jeremy Laliberte, Richard C. Millar, Robert Walter Meyer

“…Also, it make RPAS logistics more practical and effective in real-world applications. …”
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Harnessing greylag goose optimization for efficient MPPT and seven-level inverter in renewable energy systems by K. Rajaram, R. Kannan

“…This load may exhibit an imbalance; hence, a more robust optimization approach must be used to address this problem. …”
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High‐Energy LiNiO2 Li Metal Batteries Enabled by Hybrid Electrolyte Consisting of Ionic Liquid and Weakly Solvating Fluorinated Ether by Qian Liu, Jiayi Xu, Wei Jiang, Jihyeon Gim, Adam P. Tornheim, Rajesh Pathak, Qijia Zhu, Peng Zuo, Zhenzhen Yang, Krzysztof Z. Pupek, Eungje Lee, Chongmin Wang, Cong Liu, Jason R. Croy, Kang Xu, Zhengcheng Zhang

“…Extensive characterization assisted by molecular dynamic simulation and density functional theory calculations reveals the function of the fluorinated ether to be far more profound than simple dilution and viscosity reduction. …”
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