ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis by Hui Zhang, Fei Yu, Xinxin Chen, Haiyan Ye, Tao Zeng, Lixue Cao, Haojie Peng, Yanzhen Chen, Baijin Xia, Jialing Guo

“…We developed ICOS-enhanced B7H3-CAR-T cells (ICOS-B7H3-CAR) using the third-generation CAR-T cell technology, which featured magnified ICOS expression and targeted the B7H3 antigen. …”
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UFO: A tool for unifying biomedical ontology-based semantic similarity calculation, enrichment analysis and visualization. by Duc-Hau Le

“…Also, more functions would facilitate their task with ontology.…”
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Multi-Robot Navigation System Design Based on Proximal Policy Optimization Algorithm by Ching-Chang Wong, Kun-Duo Weng, Bo-Yun Yu

“…The system consists of a localization unit, an environment map unit, a path planning unit, and an environment monitoring unit, which provides functions for calculating robot coordinates, generating preselected paths, selecting optimal path combinations, robot navigation, and environment monitoring. …”
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Preliminary evaluation of a mindfulness intervention program in women with long COVID dysautonomia symptoms by Elizabeth Vandenbogaart, Matthew Figueroa, Diana Winston, Steve Cole, Julienne Bower, Jeffrey J. Hsu

“…Nonetheless, the symptom burden in this population is very high, and more attention is needed to provide effective multi-modal clinical therapies to this population.…”
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The role of mitochondria in the ischemic-reperfusion damage of the brain in operations on aortal arch in conditions of experiment by S. M. Gramatiuk, Yu. V. Ivanova, V. I. Kravchenko, O. O. Lohvinenko

“…In environment of ischemia/reperfusion of the brain in its cells a significant disorders of mitochondrial function occur, which are demonstrated by raising of generation of the oxygen active forms, and by lowering of transmembranous mitochondrial potential and velocity of mitochondrial respiration by 40%, what is accompanied by development of lactate-acidosis. …”
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Advancing offline magnetic resonance-guided prostate radiotherapy through dedicated imaging and deep learning-based automatic contouring of targets and neurovascular structures by Philipp Schubert, Matthias May, Daniel Höfler, Hans-Peter Fautz, Jana Hutter, Ricarda Merten, Sina Mansoorian, Thomas Weissmann, Lisa Deloch, Miriam Schonath, Nathalia Belmas, Felix Grabenbauer, Benjamin Frey, Udo Gaipl, Bernd-Niklas Axer, Juliane Szkitsak, Michael Uder, Christoph Bert, Rainer Fietkau, Florian Putz

“…An expert uro-radiation oncologist contoured erectile function-related anatomy (neurovascular bundles [NVB], pudendal arteries [IPA], penile bulb [PB], corpora cavernosa [CC]) and target structures (prostate [PR], seminal vesicles [SV]). …”
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Advances on whole genome sequencing in Triticeae by KUANG Liuhui, LI Qi, ZHANG Guoping

“…With the rapid development of third-generation long read sequencing technologies and assembly algorithms designed for complex genomes, and also the falling cost of genome sequencing in recent years, more and more Triticeae species have been successfully sequenced. …”
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Fosab, but not fosaa, plays important role in learning and memory in fish—insights from zebrafish gene knockout study by Qiuling Wang, Qiuling Wang, Qiuling Wang, Lixin Zhang, Lixin Zhang, Lixin Zhang, Chenyuan Zhu, Chenyuan Zhu, Chenyuan Zhu, Ke Lu, Ke Lu, Ke Lu, Jiaqi Wu, Jiaqi Wu, Jiaqi Wu, Xu-Fang Liang, Xu-Fang Liang, Xu-Fang Liang

“…In the T-maze behavioral assay, the fosab−/− zebrafish took significantly more than the average time to complete the assigned trial as the increase in the days compared to WT zebrafish, while the fosaa−/− zebrafish did not show a notable variance. …”
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Weighted single-step genome-wide association study identified genomic regions and candidate genes for growth and reproductive traits in Wenchang chicken by Ranran Zhu, Yu Zhang, Yuxiang Jiang, Zihan Xu, Yurong Tai, Ziyi Lian, Zhandeng Li, Xiuping Wang, Na Luo, Guiping Zhao, Xuemei Deng

“…LDB2 was proposed as a strong candidate gene due to its significant function and high consistency with other studies regarding various carcass traits in chickens. …”
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A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children by Joana Llauradó-Pont, Nikos Stratakis, Giovanni Fiorito, Evangelos Handakas, Alexander Neumann, Henrique Barros, Anne Lise Brantsæter, Kiara Chang, Leda Chatzi, Janine F. Felix, Regina Grazuleviciene, Vincent W. V. Jaddoe, Marianna Karachaliou, Marion Lecorguillé, Carla Lopes, Christopher Millett, Rosemary R. C. McEachan, Eleni Papadopoulou, Remy Slama, Eszter P. Vamos, Paolo Vineis, Martine Vrijheid, John Wright, Trudy Voortman, Mariona Bustamante, Oliver Robinson, Camille Lassale

“…Methods We conducted a meta-analysis of epigenome-wide association studies (EWAS) from a total of 3152 children aged 5–11 years from four European studies (HELIX, Generation XXI, ALSPAC, and Generation R). UPF consumption was defined applying the Nova food classification system (group 4), and DNA methylation was measured in blood with Illumina Infinium Methylation arrays. …”
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CONTINGENCY FACTORS AND MANAGEMENT ACCOUNTING PRACTICES OF LISTED MANUFACTURING FIRMS IN LAGOS STATE by Mustapha Abdulrasaq, Abdullahi Adio Babatunde, Isaac Biodun Ogunshola

“…Given this conclusion, the study recommends that as level of uncertainty in environment increase firms should generate more accounting information to monitor the environment. …”
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Intranasal application of a bifunctional pertactin-RTX fusion antigen elicits protection of mouse airway mucosa against Bordetella pertussis colonization by Carlos Espinosa-Vinals, Jana Holubova, Ondrej Stanek, Radim Osicka, Jiri Masin, Fresia Esther Arellano Herencia, Peter Sebo

“…Fusion to the N-terminus of an RTX908 antigen derived from CyaA enabled an accelerated folding of the pertactin passenger domain (rPrn) in function of calcium loading of the RTX908 moiety and conferred on the rPrn-RTX908 fusion antigen a superior capacity to induce functional anti-Prn IgG antibodies. …”
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ON POTENTIAL REPRESENTATIONS OF THE DISTRIBUTION LAW OF RARE STRONGEST EARTHQUAKES by M. V. Rodkin, V. F. Pisarenko, Ngo Thi Lu, T. A. Rukavishnikova

“…Moreover they testify also that the 'bend-down' is described by the finite distribution law, i.e. the bend-down occurs more efficiently than it is envisaged in the commonly used model developed by Y. …”
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Reflections and trajectories for interdisciplinary research on the energy transition by Cesare Sposito, Francesca Scalisi

“…The goals of climate neutrality by 2050 and the reduction of CO2 emissions by 55% (compared to the 1990 level) by 2030 (European Commission, 2019, 2021) pose the European Union, and even more so the rest of the world, with several complex issues, including a significant increase in ‘clean’ energy production from alternative and renewable sources, the reduction of energy poverty, greater security of energy supply and a drastic decrease in dependence on energy imports; at the same time, the aim is to foster modern economic growth decoupled from the use of non-renewable resources, the creation of new jobs, and to generate environmental and health benefits, objectives with inevitable cultural, political, economic, production, technological and social implications to be addressed both within one’s borders and in foreign policy. …”
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Quantifying the Effect of Land Use and Land Cover Changes on Spatial-Temporal Dynamics of Water in Hanjiang River Basin by Hao Xi, Yanbin Yuan, Heng Dong, Xiaopan Zhang

“…Built-up land provides more water supply compared to other land types, while forest land has the lowest average water supply. …”
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Comparative the efficacy and safety of Gosuranemab, Semorinemab, Tilavonemab, and Zagotenemab in patients with Alzheimer’s disease: a systematic review and network meta-analysis of... by Wenting Cai, Wenting Cai, Hui Zhang, Hui Zhang, Yan Wu, Yan Wu, Yao Yao, Jinping Zhang

“…Mean differences (MD) and 95% confidence interval (95%CI) as effect sizes to analyze continuous variables.ResultsThis study encompassed six RCTs involving 2,193 patients. Semorinemab were more effective than placebo in MMSE and ADAS-Cog scores (MDs ranging between 0.52 and 3.21; MDs ranging between 0.17 and 3.30). …”
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Calibrated muscle models improve tracking simulations without enhancing gait predictions. by Filippo Maceratesi, Míriam Febrer-Nafría, Josep M Font-Llagunes

“…<h4>Objectives</h4>This study presents two main aims: (i) to assess functionally-calibrated musculoskeletal models (FCMs) in both tracking and predictive simulations of human motion, against non-linearly scaled models (NSMs), and (ii) to examine the effects of three different variations of our baseline functional calibration approach on the results of tracking and predictive simulations.…”
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Providing context: Extracting non-linear and dynamic temporal motifs from brain activity. by Eloy Geenjaar, Donghyun Kim, Vince Calhoun

“…Interestingly, patients appear to spend more time in three clusters, one closer to controls which shows increased visual-sensorimotor, cerebellar-subcortical, and reduced cerebellar-visual functional network connectivity (FNC), an intermediate station showing increased subcortical-sensorimotor FNC, and one that shows decreased visual-sensorimotor, decreased subcortical-sensorimotor, and increased visual-subcortical domains. …”
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Modern approaches to the therapy of schizophrenia with atypical neuroleptics (based on clinical observations) by D. D. Samoylov, J. B. Barylnik

“…Cariprazine is one of the more effective antipsychotics, both in relation to positive symptoms and in relation to negative and cognitive symptoms.This paper presents a number of clinical observations that demonstrate the efficacy of the third-generation neuroleptic cariprazine as a potent antipsychotic drug with a favorable safety profile, providing high adherence to therapy and successfully used both in patients with the first psychotic episode and in patients with a disorder duration of more than five years. …”
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Total Drell–Yan in the flavorful SMEFT by Gudrun Hiller, Lara Nollen, Daniel Wendler

“…We also find that limits have only mild dependence on lepton flavor patterns; hierarchies in quark flavors are driven by the parton distribution functions. The strongest constraints are on couplings involving the first and second generation quarks, exceeding 10 TeV. …”
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