Beyond nutritional immunity: immune-stressing challenges basic paradigms of immunometabolism and immunology by Edmund K. LeGrand

“…Pathogens have the well-known advantage of rapid evolution due to short generation times and large populations. However, pathogens have the rarely noted disadvantage of the vulnerability to stress involved in proliferation as well as being localized. …”
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Graph-enhanced implicit aspect-level sentiment analysis based on multi-prompt fusion by Xu Li, Xinlong Wang, Chunlong Yao, Yang Li

“…Additionally, they often use short texts with few available features, making the analysis more challenging. To this end, this paper proposes a generative model for graph-enhanced implicit aspect-level sentiment analysis based on multi-prompt fusion. …”
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CDK2 inhibition sensitizes anthracycline-induced immunogenic cell death and enhances the efficacy of anti-PD-1 therapy by Yu Chen, Wancheng Liu, Qiaomei Cai, Chaohu Pan, Zhenghao Yin, Yijiao Tang, Zhixu He, Genhong Cheng, Liping Shu, Liping Shu

“…IntroductionCDK2 (Cyclin-dependent kinase 2) is an oncogenic cyclin-dependent kinase with potent mitogenic and immunosuppressive functions. Despite extensive research on CDK2 inhibitors, the lack of selectivity has made it unclear whether CDK2 inhibition specifically facilitate immunogenic cell death.MethodsWe used CRISPR-Cas9 system to generate Cdk2-/- MCA205 cells. …”
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Patellar motion and dysfunction of its stabilizers in a biomechanical model of the knee joint by A. S. Yurova, A. I. Tyagunova, F. B.  Loginov, Yu. V. Vassilevski, A. V. Lychagin, E. B. Kalinsky, E. V. Larina, N.  V. Gorohova, K. A. Devyatyarov, O. N. Bogdanov, I. B. Kovalenko, K. V. Chesnokova, M. A.  Dergachev, E. Yu. Mychka, O. N. Kosukhin

“…Gmsh and Paraview were used to generate the contact surfaces. Simulations of knee passive flexion with consistent patellar stabilizers exclusion were carried out to identify their influence on patellar movement.Results. …”
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Mechanisms of γ-ray irradiation induced oxidation corrosion in SnBi eutectic solder joints: Insights from first-principles calculations by Qilong Guan, Shengli Li, Kai Li, Xuan Li, Ruiqi Wang, Xiaojiu Tang, Chunjin Hang

“…Bi incorporation lowers the work function of the Sn-based solid solution than Bi-based solid solution, making Sn more susceptible to oxidation. …”
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Adjacency List Algorithm for Traffic Light Control Systems in Urban Networks by Sergio Rojas-Blanco, Alberto Cerezo-Narváez, Manuel Otero-Mateo, Sol Sáez-Martínez

“…To address this challenge, this paper presents an algorithm and MATLAB function that generates an adjacency list of traffic signals to provide detailed information about the relationships between all signals within a network. …”
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A Novel Method for Preparing Uniform Micro-Sized Dry Powder Formulations, Including Aggregation-Controlled VHH by Tatsuru Moritani, Hidekazu Masaki, Ryo Yonehara, Takeru Suzuki, Hidenao Arai, Masayuki Tsuchiya, Naoto Nemoto

“…However, this process degraded VHHs or inactivated their function, and ultimately, only about 30% of the original VHHs were functional, whereas the remaining VHHs that were not degraded showed little loss of functionality, even after storage at room temperature for more than two years. …”
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Dissecting the genetic basis of fruiting efficiency for genetic enhancement of harvest index, grain number, and yield in wheat by Dipendra Shahi, Jia Guo, Md Ali Babar, Sumit Pradhan, Muhsin AVCI, Jordan McBreen, Zhao Liu, Guihua Bai, Paul St. Amand, Amy Bernardo, Matthew Reynolds, Gemma Molero, Sivakumar Sukumaran, John Foulkes, Jahangir Khan

“…Fruiting efficiency (FE) is a key trait for increasing GN by making more spike assimilates available to reproductive structures. …”
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Profiling of the Predicted Circular RNAs in Ductal In Situ and Invasive Breast Cancer: A Pilot Study by Marco Galasso, Giorgio Costantino, Lorenzo Pasquali, Linda Minotti, Federica Baldassari, Fabio Corrà, Chiara Agnoletto, Stefano Volinia

“…The recent advantage obtained by next generation sequencing allows a depth investigation of a new “old” kind of noncoding transcript, the circular RNAs. …”
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Case Report: Subcutaneous ofatumumab for patients with immunosuppressant-dependent or ineffective primary membranous nephropathy by Jie Chen, De-tian Li, Xin Feng, Bei-Ru Zhang

“…However, some patients either fail to respond to rituximab or experience adverse reactions, indicating that newer-generation CD20 mAbs may offer a more effective alternative. …”
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Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii by Francesca L. Short, Ram Maharjan, Liping Li, Nusrat Afrin, Natasha Delgado, Christine J. Boinett, Julian Parkhill, Amy K. Cain, Ian T. Paulsen

“…Bacteria with high mutation rates have a survival advantage in some stressful environments because they generate beneficial mutations more frequently. “Hypermutators” are bacterial strains that carry gene inactivations that increase general mutation rates. …”
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Sky cooling for LED streetlights by Saichao Dang, Hasan H. Almahfoudh, Abdulrahman M. Alajlan, Hussam Qasem, Jiake Wang, Yingkun Zhu, Osman M. Bakr, Boon S. Ooi, Qiaoqiang Gan

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Development of a hydrogel-based three-dimensional (3D) glioblastoma cell lines culture as a model system for CD73 inhibitor response study by Marjan Bahraminasab, Samira Asgharzade, Ali Doostmohamadi, Atefeh Satari, Farkhonde Hasannejad, Samaneh Arab

“…Conclusion Our current research demonstrates the great potential of CD73 inhibitor for clinical translation of cancer studies by analyzing the behavior and function of 3D tumor cells, and thus for more effective treatment protocols for GBM.…”
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Machine learning-based prediction of FeNi nanoparticle magnetization by Federico Williamson, Nadhir Naciff, Carlos Catania, Gonzalo dos Santos, Nicolás Amigo, Eduardo M. Bringa

“…More than 1600 NPs were created and split into training and testing sets (70%–30% split), with features including the number of Ni/Fe surface and core atoms, potential energy distributions, pair correlation functions, and coordination distributions. …”
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Carbon and water footprints within an environmental laboratory: Water, energy, and packaging management strategies by María F. Manobanda-Lisintuña, Cristina A. Villamar-Ayala

“…Results show that under normal conditions the laboratory generated a carbon footprint of 10.10 kg CO2-eq/sample (82 % energy used), and a water footprint of 11.76 m3/sample (97 % indirect water). …”
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The trials and errors of developing an experimental model to study the impact of maternal gut microbiome disruption on perinatal asphyxia by Mara Ioana Ionescu, Ana Maria Catrina, Ioana Alexandra Dogaru, Didina Catalina Barbalata, Cristian Ciotei, Cerasela Haidoiu, Vladimir Suhaianu, Gratiela Gradisteanu Pircalabioru, Siobhain M. O’Mahony, Ana-Maria Zagrean

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Smart Charging and V2G: Enhancing a Hybrid Energy Storage System with Intelligent and Bidirectional EV Charging by Thomas Franzelin, Sarah Schwarz, Stephan Rinderknecht

“…Managing electric vehicle charging enables the demand to align with fluctuating generation, while storage systems can enhance energy flexibility and reliability. …”
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Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion by Shufeng Xie, Shufeng Xie, Jinlan Long, Ruiheng Wang, Ruiheng Wang, Rufang Xiang, Rufang Xiang, Huajian Xian, Yixin Wang, Weiyu Dou, Wenjie Zhang, Dan Li, Ting Kang, Zhihong Chen, Zhihong Chen, Chunjun Zhao, Zhenshu Xu, Han Liu

“…In this study, we aim to enhance CAR-T cell function by focusing on the solely transmembrane domain design.MethodsUtilizing plasmid construction and lentivirus generation, we get two different transmembrane CAR-T cells [19CAR-T(1a) and 19CAR-T(8α)]. …”
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Effect of random terms on the shape of dendrites analyzed by the phase-field model. by Shinya Fujiwara, Kiyoshiro Okada, Katsuhiro Endo, Kenta Hirayama, Mayu Muramatsu

“…In terms of the probability distribution for generating random numbers, the uniform and Gaussian distributions are used for comparison. …”
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Utilizing small molecules to probe and harness the proteome by pooled protein tagging with ligandable domains by Katherine E. Larrimore, Yevgeniy V. Serebrenik

“…These libraries unlock opportunities to explore the proteome with a versatile toolbox of small molecule probes designed to interact with the fused tags, allowing researchers to visualize protein localization, induce protein misfolding, manipulate protein-protein interactions, modulate protein stability, and more in a scalable, systematic manner. This review explores recent studies employing multifunctional domains at proteome scale, delving into how the associated chemical probes have been employed to enable insights into endogenous protein function, cellular processes, and disease mechanisms. …”
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