Functional Approaches to Discover New Compounds via Enzymatic Modification: Predicted Data Mining Approach and Biotransformation-Guided Purification by Te-Sheng Chang

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Behavioral interventions to benefit cognition (Intervenciones cognitivas para beneficiar la cognición) by Jennifer L. Etnier, Chia-Hao Shih, Aaron Piepmeier

“…In addition, given the likelihood that multiple underlying mechanisms support cognitive function, research is currently focusing on how to combine lifestyle factors into multi-component interventions to generate greater and more meaningful effects. …”
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The association between gestational selective serotonin reuptake inhibitor (SSRI) treatment and newborn thyroid screen: a large-scale cohort study by Orian Raviv, Yael Lebenthal, Michal Yackobovitch-Gavan, Eyal Cohen-Sela, Shlomo Almashanu, Ronella Marom, Jacky Herzlich, Liran Hiersch, Avivit Brener

“…However, the impact of gestational SSRI treatment on newborn thyroid function is lacking. We explored the impact of gestational SSRI treatment on newborn thyroid function as measured by the National Newborn Screening (NBS) Program and identified contributory factors. …”
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Incorporation of liver chemistry score in predicting survival of liver‐involved advanced gastric cancer patients who received palliative chemotherapy by Ying Feng, Cheng Zhang, Zhijun Wu, Hui Xu, Xiaopeng Zhang, Chong Feng, Jingyi Shao, Minmin Xie, Yahui Yang, Yi Zhang, Tai Ma

“…Abstract Background Gastric cancer liver metastasis (GCLM) patients usually accompany by abnormal serum liver function tests (LFTs) more or less; however, the prognostic value of LFTs is not fully understood. …”
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The financial basis for the functioning of Western Siberian departments of the Imperial Orthodox Palestine Society at the end of XIX - beginning of XX century by Tsys' Valerii, Tsys' Olga

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Effects of Cacna1d D307G Mutation on Blood Pressure and Kidney Function in Rats with Salt Loading by Lan Cheng, Hui Chen, R. Nfornah Maboh, Huan Wang

“…Methods: We used the CRISPR/Cas9 technique to generate the Cacna1d D307G mutation rat model and investigated the effects of Cacna1d D307G mutation on blood pressure (BP) and renal function. …”
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Neospora caninum infection specifically suppresses the expression of a host lncRNA XR_001919077.1 to facilitate parasite propagation by modulating host cell mitochondrial function... by Shan-Shan Zhao, De-Liang Tao, Jin-Ming Chen, Ming-Yi Zhang, Xin Yang, Jun-Ke Song, Qun Liu, Guang-Hui Zhao

“…Rapid amplification of cDNA ends analysis generated six splice variants of XR_001919077.1, with lengths ranging from 592 to 694 nt. …”
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Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expression by Efrat Oron, Tamir Tuller, Ling Li, Nina Rozovsky, Daniel Yekutieli, Sigal Rencus‐Lazar, Daniel Segal, Benny Chor, Bruce A Edgar, Daniel A Chamovitz

“…We are using Drosophila as a model system to elucidate the function of this important complex. Transcriptome data were generated for four csn mutants, sampled at three developmental time points. …”
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Structure–function relationships in unspecific peroxygenases revealed by a comparative study of their action on the phenolic lignin monomer 4-propylguaiacol by Marta Barros-Reguera, Esteban Lopez-Tavera, Gabriela C. Schröder, Greta Nardini, Kenneth A. Kristoffersen, Iván Ayuso-Fernández, Vincent G. H. Eijsink, Morten Sørlie

“…In this study, UPOs were evaluated for their potential in the selective oxyfunctionalization of the phenolic lignin monomer 4-propylguaiacol (4-PG) to generate versatile scaffolds for the synthesis of high-value compounds. …”
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PromarkerD Versus Standard of Care Biochemical Measures for Assessing Future Renal Function Decline in Type 2 Diabetes by Kirsten E. Peters, Isabella A. Joubert, Scott D. Bringans, Wendy A. Davis, Richard J. Lipscombe, Timothy M. E. Davis

“…<b>Conclusions:</b> PromarkerD more accurately identifies adults with T2D at risk of kidney function decline than current usual care biochemical tests.…”
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Functional and Taxonomic Insights into Root Endophytic Bacterial Communities in Hybrid Tomato and Finger Millet: Implications for Crop Resilience and Growth by Surendirakumar Kannaiah, Ramganesh Selvarajan, Salam Nirmalashachi Chanu, Radha Raman Pandey, Akebe Luther King Abia

“…A total of 165,772 and 181,327 16S rRNA gene sequences were generated from tomato and finger millet roots, respectively. …”
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Phenotype and functions of human dendritic cells derived from CD14+ monocyte subsets opposed to CD16 expression by E. R. Chernykh, T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, Yu. D. Kurochkina, E. A. Oleynik, L. V. Sakhno, A. A. Ostanin

“…The presence of CD16+ cells in whole blood monocyte pool is associated with generation of DCs showed a more mature phenotype and higher allostimulatory activity. …”
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HLA antibodies and their value during renal transplantation by M. Sh. Khubutia, N. V. Borovkova, R. V. Storozhev, N. V. Doronina, M. V. Storozheva, A. S. Pertsev, A. V. Pinchuk

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Development of channel transmission loss function for WRF_HYDRO modeling of semi-arid regions: The case of wadi Faria, Palestine by Abdelhaleem Khader, Anan Jayyousi, Sameer Shadeed, Joel Arnault, Harald Kunstmann, Christian Chwala, Benjamin Fersch

“…To address these challenges, hydrological modeling has been used to gain understanding of the hydro-logical systems and to provide the required inputs needed for sustainable water resources management. Further-more, coupling hydrological models with climatic models provides even more understanding of the influence of the climatic parameters on hydrological processes and systems, and hence on runoff generation mechanism. …”
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Selective metabolic regulations by p53 mutant variants in pancreatic cancer by Sabrina Caporali, Alessio Butera, Alessia Ruzza, Carlotta Zampieri, Marina Bantula’, Sandra Scharsich, Anna-Katerina Ückert, Ivana Celardo, Ian U. Kouzel, Luigi Leanza, Andreas Gruber, Joan Montero, Angelo D’Alessandro, Thomas Brunner, Marcel Leist, Ivano Amelio

“…Abstract Background Approximately half of all human cancers harbour mutations in the p53 gene, leading to the generation of neomorphic p53 mutant proteins. These mutants can exert gain-of-function (GOF) effects, potentially promoting tumour progression. …”
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Response of organic matter pore development to functional groups in overmature marine shale: Insights from AFM-IR spectroscopy by Jianhua ZHAO, Keyu LIU, Shenghui ZHAO, Qinhong HU, Wei WU, Yang CHEN, Guoheng LIU, Junqian LI, Lingjie YU, Zuhui YOU, Ye WANG

“…Pyrobitumen-clay mineral composites generally exhibit superior pore development, likely attributable to clay mineral dehydration participating in hydrocarbon generation reactions that promote the removal of more functional groups. …”
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Dynamics of Clinical Manifestations and Social Functioning in Schizophrenia: A Non-interventional Observational Study of Paliperidone Palmitat Dosage Forms by Aleksandr M. Reznik, Olga A. Karpenko, Elena A. Shumakova, Aleksandr V. Mudrak, Andrey V. Sokolov, Svetlana V. Nazimova, Alina M. Saifulina, Anton M. Eliseenko, Tatjana K. Matvievskaya, Angelina N. Khannanova, Vladimir I. Revenko, Dmitriy V. Scherbakov, Yuriy L. Martynyuk, Aleksandr L. Arbuzov, Oleg A. Yacenko, Polina N. Alekseeva, Aleksandr B. Berdalin, Larisa A. Burygina

“…Hallucinations proved more susceptible to therapy (p 0.001), while persistent delusions showed greater treatment resistance. …”
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Billion‐Scale Expansion of Functional hiPSC‐Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation by Pedro Vicente, Lara R. Inocêncio, Asier Ullate‐Agote, Ana F. Louro, João Jacinto, Beatriz Gamelas, Olalla Iglesias‐García, Patxi San Martin‐Uriz, Paula Aguirre‐Ruiz, Gonzalo R. Ríos‐Muñoz, María Eugenia Fernández‐Santos, Alain vanMil, Joost P. G. Sluijter, Felipe Prósper, Manuel M Mazo Vega, Paula M. Alves, Margarida Serra

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Genetic manipulation of porcine deltacoronavirus reveals insights into NS6 and NS7 functions: a novel strategy for vaccine design by Mengjia Zhang, Wan Li, Peng Zhou, Dejian Liu, Rui Luo, Anan Jongkaewwattana, Qigai He

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Cross-Architecture Vulnerability Detection Combining Semantic and Attribute Feature by LI Kun, LI Bin, ZHU Wenjing, ZHOU Qinglei

“…The assembly code and attribute control flow diagram of binary function are used as input to extract the semantic information of all assembly code in basic block, and the basic block-level semantic information and attribute feature information are fused to generate a 139-dimensional basic block-level vector representation, in order to represent the semantic and attribute information of the function more comprehensively. …”
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