Normal stress on surface of mesenchymal stem cells boosts extracellular vesicle secretion and regenerative bioactivity by Chengmeng Bai, Huifang Ren, Feng Zhang, Dandan Li, Qingyu Feng, Ying Li, Ting Chen, Chengxu Li, Xuan Xiao, Hengrui Zhang, Liang Hu

“…Here, we present a user-friendly method to manipulate the extracellular mechanical microenvironment of umbilical cord-derived mesenchymal stem cells (MSCs), a promising cell type for generating sEVs with therapeutic benefits, to boost sEV secretion and regenerative bioactivity. …”
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Constructing a knee osteoarthritis transplant via the neutrality aggregation operators under spherical fuzzy Z-numbers framework by Shahzaib Ashraf, Maria Akram, Subrata Jana, Jungeun Kim, Ibrahim M. Hezam, Chiranjibe Jana

“…Next, we create a method for generating decisions for MAGDM situations by using SFZˆN information. …”
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Improved Translational Relevance of In Vitro Fibrosis Models by Integrating IOX2-Mediated Hypoxia-Mimicking Pathways by Manuel A. González Hernández, Jennifer Venhorst, Lars Verschuren, Karin Toet, Martien P. M. Caspers, Martine C. Morrison, Beatrice Coornaert, Gerard J. P. van Westen, Roeland Hanemaaijer

“…Here, the ability of a hypoxia-mimicking compound (IOX2) to more accurately reflect the human fibrotic phenotype on a functional level was investigated. …”
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Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial by Jess Kerr-Gaffney, Zohra Zenasni, Kimberley Goldsmith, Nahel Yaziji, Huajie Jin, Alessandro Colasanti, John Geddes, David Kessler, R Hamish McAllister-Williams, Allan H Young, Alvaro Barrera, Lindsey Marwood, Rachael W Taylor, Helena Tee, Anthony J Cleare

“…Conclusions As well as being more cost-effective, quetiapine may be a more clinically effective augmentation option for treatment-resistant depression. …”
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A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging by Cheng Yao, Ruwei Wei, Xiao Luo, Jie Zhou, Xiaodong Zhang, Xicun Lu, Yan Dong, Ruofan Chu, Yuxin Sun, Yu Wang, Wencheng Xia, Dahui Qu, Cong Liu, Jun Ren, Guangbo Ge, Jinquan Chen, Xuhong Qian, Youjun Yang

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Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effec... by Sofia Cividini, Ian Sinha, Giovanna Culeddu, Sarah Donegan, Michelle Maden, Katie Rose, Olivia Fulton, Dyfrig Hughes, Stephen Turner, Catrin Tudur Smith

“…A cost-effectiveness curve was generated to depict the probability of each intervention being cost-effective at different willingness-to-pay thresholds. …”
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Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma by Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian

“…Therefore, this study aimed to identify the optimal scFv and investigate its biological functions to further optimize the therapeutic potential of CAR-T cells targeting CEA-positive carcinoma.MethodsWe screened four reported humanized or fully human anti-CEA antibodies (M5A, hMN-14, BW431/26, and C2-45), and inserted them into a 3rd-generation CAR structure. …”
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Glycerol-assisted grain modulation in femtosecond-laser-induced photochemical synthesis of patterned ZnO nanomaterials by Yingchen Wang, Songyan Xue, Yinuo Xu, Jing Long, Binzhang Jiao, Hui Gao, Xuhao Fan, Yuncheng Liu, Leimin Deng, Wei Xiong

“…ZnO nanomaterials have become appealing for next-generation micro/nanodevices owing to their remarkable functionality and outstanding performance. …”
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Association Aamong Ppolymorphisms in the Aapoptosis‐Rrelated NKX3‐1, Caspase‐3, Caspase‐9, and BCL‐2 Genes and Prostate Cancer Susceptibility From 9706 Cases and 12,567 Controls... by Yanyan Feng, Zhenting Feng, Dan Li, Jiandong Gui, Zhihong Song, Xiaohua Xie, Lijie Zhu, Yuanyuan Mi

“…Aims This meta‐analysis was thus developed with the goal of generating more precise estimates of the relationships between polymorphisms in four apoptosis‐associated genes (NKX3‐1, caspase‐3, caspase‐9, and BCL‐2) and the risk of PCa. …”
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Chromosome-level genome assembly, reannotation and decoding of a Trichomonas vaginalis clinical isolate from Shiyan, Central China by Yanqing Zhao, Yinjie Lian, Wei Guan, Peng Wu, Shuguo Yang, Jian Li

“…Methods: Clinical T. vaginalis isolates were collected, cultured and sequenced via the next-generation Illumina, SMRT DNA sequencing platform and chromosome conformation capture (Hi-C) technologies. …”
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Artificial Intelligence as Assessment Tool in Occupational Therapy: A Scoping Review by Christos Kokkotis, Ioannis Kansizoglou, Theodoros Stampoulis, Erasmia Giannakou, Panagiotis Siaperas, Stavros Kallidis, Maria Koutra, Christina Koutra, Anastasia Beneka, Evangelos Bebetsos

“…Occupational therapy (OT) is vital in improving functional outcomes and aiding recovery for individuals with long-term disabilities, particularly those resulting from neurological diseases. …”
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Sugarcane Straw Hemicellulose Extraction by Autohydrolysis for Cosmetic Applications by Maria João Pereira, Sílvia S. Pedrosa, Joana R. Costa, Maria João Carvalho, Tânia Neto, Ana L. Oliveira, Manuela Pintado, Ana Raquel Madureira

“…Sugarcane is a popular crop whose cultivation generates a wide range of by-products. The aim was to optimize the hydrothermal extraction of hemicellulose from sugarcane straw using response-surface methods with a two-factor composite design and to assess its functional qualities. …”
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Regulatory role of MicroRNA164 in heat and salinity stress responses via candidate target genes during seed germination in petunia by Tao Jiang, Keila Rodriguez, Sameena Ejaz Tanwir, Fangchen Liu, Fida Hussain, Jaideep Chandranshu Cherukula, Heqiang Huo

“…This study explores its role in regulating stress responses in petunia by generating MIR164 overexpression (MIR164-ox) and miR164 suppression (miR164-STTM) lines. …”
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Advances in enhancing hydrodeoxygenation selectivity of lignin-derived oxygenates: From synthetic strategies to fundamental techniques by Xinru Wu, Hongwei Zhang, Cejun Hu, Xiaojun Bao, Pei Yuan

“…Considering hydrogen consumption and lignin properties, the preference is directed towards generating aromatic hydrocarbons rather than saturated components. …”
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Design, Fabrication, and Performance Evaluation of a Food Solar Dryer by Md. Suman Rana, A. N. M. Arifur Rahman, Rakib Ahmed, Md. Pallob Hossain, Md. Salim Shadman, Pranta Kumar Majumdar, Kh. Shafiqul Islam, Jonathan Colton

“…With a one-year payback period, an economic attribute of 3.26, and a life cycle benefit of BDT 310,651 (USD 2597.68), economics show the dryer’s feasibility. The solar dryer functioned faster than direct sun drying due to its significantly higher heat generation. …”
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DNA metabarcoding of benthic algae and associated eukaryotes from Lake Baikal in the face of rapid environmental changes by Yu. S. Bukin, L. S. Kravtsova, T. E. Peretolchina, A. P. Fedotov, A. E. Tupikin, M. R. Kabilov, D. Yu. Sherbakov, E. V. Mincheva

“…About 15 thousand reads of the 18S rRNA marker were obtained by applying NGS (next-generation sequencing). The species of algae dominating in the number of reads, as well as the difficult-to-identify taxa (Stramenopiles, Alveolata, Euglenozoa, Chromista, Rhizaria, Amoebozoa, etc.), which play an important role in the functioning and formation of the structure of algal communities, were revealed. …”
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Deciphering the role of dietary modifications and gut dysbiosis in Non-Alcoholic Fatty Liver Disease by Meenakshi Vachher, Kohinoor Kaur, Manisha Marothia, Archana Burman, Deepanjana, Savita Bansal

“…Approximately one-third of the total population is affected by NAFLD. The more aggressive form of NAFLD, non-alcoholic steatohepatitis (NASH) could progress to liver failure, fibrosis, cirrhosis, hepatocellular carcinoma and even death. …”
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Carbonation heat recovery via dry reforming to improve the techno-economic performance of the Ca-Cu looping post-combustion CO2 capture by Song He, Lifan Gao, Yawen Zheng, Junyao Wang, Shenghui Lin, Zhi Yang, Xuelan Zeng

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Antibody–Drug Conjugates (ADCs): current and future biopharmaceuticals by Ruili Wang, Baohui Hu, Ziyu Pan, Chongxia Mo, Xin Zhao, Guojia Liu, Ping Hou, Qi Cui, Zhao Xu, Wenjia Wang, Zhaojin Yu, Lin Zhao, Miao He, Yan Wang, Chen Fu, Minjie Wei, Lifeng Yu

“…We hope that this work will provide valuable insights into the design and optimization of next-generation ADCs for wider clinical applications.…”
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TGFβ-specific T cells induced by a TGFβ-derived immune modulatory vaccine both directly and indirectly modulate the phenotype of tumor-associated macrophages and fibroblasts by Mads Hald Andersen, Inés Lecoq, Evelina Martinenaite, Maria Perez-Penco, Lucia Lara de la Torre

“…Reducing immunosuppression and immune exclusion in pancreatic tumors by targeting TAMs and CAFs with the TGFβ-based immune modulatory vaccine emerges as an innovative strategy for the generation of a more favorable environment for immune-based therapies, such as immune checkpoint inhibitors.…”
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