Depletion of conventional CD4+ T cells is required for robust priming and dissemination of tumor antigen-specific CD8+ T cells in the setting of anti-CD4 therapy by Keisuke Shirai, Tiffany Chen, Mary Jo Turk, Delaney E Ramirez, Christo P C Dragnev, Tyler G Searles, Nathaniel Spicer, J Louise Lines, Aaron R Hawkes, Wilson L Davis, Asmaa Mohamed, Joseph D Phillips, Pamela C Rosato, Yina H Huang

“…However, the underlying basis for treatment efficacy, more specifically the implications of codepleting other CD4-expressing cell compartments in tumor-bearing hosts, is not well understood.Methods Tumor-bearing mice were treated with anti-CD4 versus other therapies that preserve helper T cell function, and the priming, tissue distribution, and maintenance of tumor antigen-specific CD8 T cells were assessed. …”
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The Role of Landscape Metrics and Spatial Processes in Performance Evaluation of GEOMOD (Case Study: Neka River Basin) by Shrif Joorabian Shooshtari, Kamran Shayesteh, Mehdi Gholamalifard, Mahmood Azari, Juan Ignacio López-Moreno

“…In this study, a multi-criteria evaluation procedure was used to generate the transition suitability map from forest to non-forest. …”
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A Reflection on the Visual Representation of Nationalism Discourse in Iran During the Qajar Period (A Case Study of Qajar Newspaper Images as Cultural Texts of the Modernization Pe... by Shadi Taki, Sedaghat Jabbari Kalkhoran, Yaghoub Azhand

“…The serious connection between Iran and Europe, and consequently the Iranian quest for modernity, began during the Qajar era and resulted in numerous outcomes and cultural productions such as various texts aimed at generating meaning in verbal, written, and visual forms. …”
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Contribution of entropy analysis on three-dimensional Prandtl model under Hall and ion slip effects with generalized mass and heat fluxes via OHAM by Sana Akbar, Muhammad Sohail, Syed Tehseen Abbas, Abha Singh

“…The influence of distinct parameters associated with this current study like Brownian and diffusion constraint, temperature and also concentration difference, Eckert number, Hall as well as ion slip parameters, Brinkman number, magnetic constraint, radiation and Prandtl fluid constraint are sketched for temperature, velocity field along xy-axes, concentration and entropy generation rate. It is noticed that velocity distribution along x-axes is an increasing function of magnetic constraint, Prandtl fluid and also elastic constraint whilst contrast impact is seen along y-axes. …”
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Early epileptic encephalopathy associated with SCN2A mutations: clinical and genetic description of eight novel patients by E. L. Dadali, F. A. Konovalov, I. A. Akimova, A. A. Sharkov, G. E. Rudenskaya, S. V. Mikhaylova, S. A. Korostelev

“…All patients received more than 2 therapy regimens (including hormonal therapy and ketogenic diet) but full remission wasn’t obtained. …”
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Sepsis beyond bundles: contextualising paediatric care in resource-limited settings through situational analysis by John Adabie Appiah, Leah Ratner, Sheila Agyeiwaa Owusu, Ahmet Uluer, Gustav Nettey, Allysa Warling, Charles Martyn-Dickens, Emma Otchere, R. Elaine Cagnina, Maame Fremah Kotoh- Mortty, Eugene Martey

“…Future qualitative research will explore pre- and peri-hospital barriers to care and inform more effective, contextually appropriate interventions.…”
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SOX7: Autism associated gene identified by analysis of multi-Omics data. by Samantha Gonzales, Jane Zizhen Zhao, Na Young Choi, Prabha Acharya, Sehoon Jeong, Xuexia Wang, Moo-Yeal Lee

“…Genome-wide association studies and next generation sequencing data analyses based on DNA information have identified thousands of mutations associated with autism spectrum disorder (ASD). …”
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Biomarkers for neurodegenerative diseases in regulatory decision‐making by the European Medicines Agency by Audrey M. M. Hermans, Elisabeth Bakker, Viktoriia Starokozhko, Loes den Otter, André J. A. Elferink, Angela Bradshaw, Lorenzo Guizzaro, Peter G. M. Mol, Anna M. G. Pasmooij

“…Collaboration and data‐sharing among stakeholders is vital in generating this evidence and enhancing the understanding and management of NDDs. …”
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PDGF-BB overexpressing dental pulp stem cells improve angiogenesis in dental pulp regeneration by Wentao Jiang, Wentao Jiang, Wentao Jiang, Wentao Jiang, Shuhan Duan, Shuhan Duan, Shuhan Duan, Shuhan Duan, Weiping Li, Huijiao Yan, Huijiao Yan, Huijiao Yan, Huijiao Yan, Chenli Si, Chenli Si, Chenli Si, Ningwei Xu, Ningwei Xu, Ningwei Xu, Ningwei Xu, Yishuai Li, Yishuai Li, Yishuai Li, Yishuai Li, Wenjie Zhang, Wenjie Zhang, Wenjie Zhang, Wenjie Zhang, Shensheng Gu, Shensheng Gu, Shensheng Gu, Shensheng Gu

“…In vivo transplants generated more vascular structures containing CD31 (+) endothelia. …”
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Mental Health in the Age of Hyperconnectivity: A Crisis Hidden in Plain Sight by Sitara Ejaz, Hafiz Muhammad Haseeb Khaliq

“…Data indicates that individuals who spend more than three hours daily on social media face a 60% higher likelihood of developing anxiety or depressive symptoms 5. …”
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Unlocking data: Decision-maker perspectives on cross-sectoral data sharing and linkage as part of a whole-systems approach to public health policy and practice by Emily Tweed, Kristina Cimova, Peter Craig, Mirjam Allik, Denise Brown, Mhairi Campbell, David Henderson, Charlie Mayor, Petra Meier, Nick Watson

“…Plain language summary A lot of information is generated every day by services such as health care, education, housing and social care, as part of their day-to-day work. …”
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Prediction of dam deformation using adaptive noise CEEMDAN and BiGRU time series modeling by WANG Zixuan, OU Bin, CHEN Dehui, YANG Shiyong, ZHAO Dingzhu, FU Shuyan

“…【Method】The model uses sample entropy reconstruction and the K-means clustering algorithm to optimize the adaptive noise complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) process, generating multiple intrinsic mode functions (IMF). …”
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Anisotropic flexible stress sensors based on Loofah/CN/MWCNTs by 刘璐, 贾晓丽, 黄书童, 张景龙, 李守宝, 柯燎亮

“…Consequently, the loofah skeleton and conductive coating were compressed and released simultaneously, effectively functioning as a variable resistor. As applied stress increased, the loofah framework became more compact, gradually increasing the contact area between carbon-based materials of different sizes, thereby generating new current pathways. …”
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Sensing of Liver‐Derived Nicotinamide by Intestinal Group 2 Innate Lymphoid Cells Links Liver Cirrhosis and Ulcerative Colitis Susceptibility by Jing Shen, Zhen Li, Xiaoyu Liu, Mengqi Zheng, Peng Zhang, Yatai Chen, Qiuheng Tian, Wenyu Tian, Guanjun Kou, Yanyan Cui, Bowen Xu, Yunjiao Zhai, Weijia Li, Xiaohuan Guo, Ju Qiu, Chunyang Li, Ran He, Lixiang Li, Chunhong Ma, Yanqing Li, Xiuli Zuo, Detian Yuan, Shiyang Li

“…Mechanistically, the NAD+ salvage pathway regulates gut ILC2s in a cell‐intrinsic manner by supporting the generation of succinate, which fuels the electron transport chain to sustaining ILC2s function. …”
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Global disparities in access to hepatitis C medicines before and during the early phase of the COVID-19 pandemic: an ARIMA-based interrupted time series analysis by Nick Bansback, Mina Tadrous, Marie Paul Nisingizwe, Michael R Law, Bethany Hedt-Gauthier, Naveed Z Janjua, Katie J Suda

“…High-income countries purchased more units than other groups. In terms of geographic location, North America (124 144 per 100 000 HCV cases) and Europe (81 001 per 100 000 HCV cases) had the highest DAA sales over time; the newer generation of combination DAAs was mainly used in high-income countries. …”
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LcIMT1, a litchi inositol methyl transferase gene, is responsible for d-bornesitol biosynthesis and confers drought tolerance by Liang-Liang Huang, Xin-Ying Li, Fang-Fang Liu, Xu-Ming Huang, Ren-Fang Zeng, Farhat Abbas, Hui-Cong Wang

“…l-quebrachitol, also known as 2-O-methyl-l-chiro-inositol, is a common form of methylated cyclitol found in Litchi chinensis, accounting for more than half of the soluble sugars. Nonetheless, the biological function of l-quebrachitol is somewhat restricted. …”
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Experimental Study on Hydraulic Characteristics of Fish-friendly Culverts with Baffles by MAO Jing-qiao, LU Peng, GONG Yi-qing, GAO Huan, DAI Jie

“…The baffles significantly enhanced turbulence intensity in the region near the baffle-side sidewall, generating clockwise vortices and positive horizontal Reynolds stress that play an important role in maintaining swimming stability. …”
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Proses Kreatif Komposisi Karawitan “Gesang” Sebagai Wujud Representasi Sosial by Vivi Euis Susanti, Tri Suhatmini

“…The primary research question focuses on how the creative process of this composition generates innovation within the framework of Javanese karawitan tradition, without losing its aesthetic identity. …”
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HEMOPHILIA: ADVANCES IN TREATMENTS by Nurgül Karakaya

“…Another method is PEGylation, where one or more PEG chains are covalently linked to rFVIII or rFIX. …”
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Optimization design of liquid crystal-based reconfigurable intelligent surface-assisted indoor visible light communication systems by Lisu YU, Xinxin LÜ, Run ZHONG, Mingli ZHANG, Zhenghai WANG, Yuhao WANG

“…Owing to the nonconvexity of the objective function, it is first transformed into a multinomial fractional planning problem using the Lagrangian dual transform, making it more tractable. …”
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