The Impact of Hotspot-Targeted Interventions on Malaria Transmission in Rachuonyo South District in the Western Kenyan Highlands: A Cluster-Randomized Controlled Trial. by Teun Bousema, Gillian Stresman, Amrish Y Baidjoe, John Bradley, Philip Knight, William Stone, Victor Osoti, Euniah Makori, Chrispin Owaga, Wycliffe Odongo, Pauline China, Shehu Shagari, Ogobara K Doumbo, Robert W Sauerwein, Simon Kariuki, Chris Drakeley, Jennifer Stevenson, Jonathan Cox

“…<h4>Background</h4>Malaria transmission is highly heterogeneous, generating malaria hotspots that can fuel malaria transmission across a wider area. …”
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Diseño de un Software de Intermediación de Comunicación para Sistemas Distribuidos de Tiempo Real Críticos en Java by Daniel Tejera, Alejandro Alonso, Miguel A. de Miguel

“…This work proposes a predictable serialization that introduces a new compiler to generate optimized code according to the computational model. …”
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AlphaBind, a domain-specific model to predict and optimize antibody–antigen binding affinity by Aditya A. Agarwal, James Harrang, David Noble, Kerry L. McGowan, Adrian W. Lange, Emily Engelhart, Miranda C. Lahman, Jeffrey Adamo, Xin Yu, Oliver Serang, Kyle J. Minch, Kimberly Y. Wellman, David A. Younger, Randolph M. Lopez, Ryan O. Emerson

“…Recent advances in deep learning provide opportunities to address this challenge by learning sequence–function relationships to accurately predict fitness landscapes. …”
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Leveraging Large Language Models for Predicting Postoperative Acute Kidney Injury in Elderly Patients by Hanfei Zhu, Ruojiang Wang, Jiajie Qian, Yuhao Wu, Zhuqing Jin, Xishen Shan, Fuhai Ji, Zixuan Yuan, Tingrui Pan

“…LLMs, with extensive pretraining and text generation capabilities, offer a new solution. Methods: We applied prompt engineering and knowledge distillation based on instruction fine-tuning to optimize LLMs for AKI prediction. …”
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Original Personalized Reconstruction Method for Certain Large Tumors of the Lower Lip (Not Including Oral Commissures) by Ovidiu Dan Grigorescu, Marius Irimie, Nadinne Roman, Roxana Steliana Miclaus, Maria-Cristina Cîmpeanu, Bogdan-Radu Necula, Christian-Gabriel Strempel, Simona Grigorescu, Marius Alexandru Moga, Dana Gabriela Festila

“…<i>Background/Objective</i>: Surgical treatment of extensive tumors of the lower lip generates important defects in its structure and functions. …”
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A 30 m Global Flood Inundation Model for Any Climate Scenario by Oliver E. J. Wing, Paul D. Bates, Niall D. Quinn, James T. S. Savage, Peter F. Uhe, Anthony Cooper, Thomas P. Collings, Nans Addor, Natalie S. Lord, Simbi Hatchard, Jannis M. Hoch, Joe Bates, Izzy Probyn, Sam Himsworth, Josué Rodríguez González, Malcolm P. Brine, Hamish Wilkinson, Christopher C. Sampson, Andrew M. Smith, Jeffrey C. Neal, Ivan D. Haigh

“…Abstract Global flood mapping has developed rapidly over the past decade, but previous approaches have limited scope, function, and accuracy. These limitations restrict the applicability and fundamental science questions that can be answered with existing model frameworks. …”
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Transcriptional profiles of Microcystis reveal gene expression shifts that promote bloom persistence in in situ mesocosms by Lauren E. Krausfeldt, Paisley S. Samuel, Robert P. Smith, Hidetoshi Urakawa, Barry H. Rosen, Rita R. Colwell, Jose V. Lopez

“…At later times in the bloom, upregulation of genes involved in biomass generation, phage protection, genomic rearrangement, and toxin production was observed. …”
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State Estimation in Power Systems Under Random Data Attack Using Correlation Matching, Semidefinite Relaxation, and Truncated Eigenvalue Decomposition by Bamrung Tausiesakul, Krissada Asavaskulkiet, Chuttchaval Jeraputra, Ittiphong Leevongwat, Thamvarit Singhavilai, Supun Tiptipakorn

“…Such kind of perturbation could be targeted at any domain of a smart grid from household customers to bulk generation, leading to network failures and power disruption. …”
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Sequence-based GWAS in 180,000 German Holstein cattle reveals new candidate variants for milk production traits by Ana-Marija Križanac, Christian Reimer, Johannes Heise, Zengting Liu, Jennie E. Pryce, Jörn Bennewitz, Georg Thaller, Clemens Falker-Gieske, Jens Tetens

“…Genome-wide significant signals were fine-mapped with the Bayesian approach that determines the credible variant sets and generates the probability of causality for each signal. …”
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Random Finite Element Analysis and Random Factor response Mechanism for Geocell-reinforced Soil Retaining Walls by ZHANG Bingbing, SONG Fei

“…For this reason, a finite element analysis method based on random field theory is proposed in this paper, which can more realistically reflect the non-homogeneous characteristics of the reinforced soil retaining wall system by introducing a spatial random distribution model of the soil parameters and the mechanical properties of the geocells, so as to more accurately assess the influence of the spatial variability of the material parameters on the deformation behavior and stability of the retaining wall.MethodsFirstly, in parameter random field modeling, an innovative combination of Latin Hypercube Sampling (LHS) and exponential autocorrelation function is used to construct parameter random fields. …”
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Systematic metabolic engineering enables highly efficient production of vitamin A in Saccharomyces cerevisiae by Yi Shi, Shuhuan Lu, Xiao Zhou, Xinhui Wang, Chenglong Zhang, Nan Wu, Tianyu Dong, Shilong Xing, Ying Wang, Wenhai Xiao, Mingdong Yao

“…Vitamin A is a micronutrient critical for versatile biological functions and has been widely used in the food, cosmetics, pharmaceutical, and nutraceutical industries. …”
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A highly conserved sRNA downregulates multiple genes, including a σ54 transcriptional activator, in the virulence mode of Bordetella pertussis by Minji Sim, Jeffers Nguyen, Karolína Škopová, Kyungyoon Yoo, Chin-Hsien Tai, Leslie Knipling, Qing Chen, David Kim, Summer Nolan, Rawan Elaksher, Nadim Majdalani, Hernan Lorenzi, Scott Stibitz, Kyung Moon, Deborah M. Hinton

“…We show that transcription from a σA-dependent promoter yields a long form of 190 nucleotides (nt) that is processed by RNase E to generate a shorter, more stable form (BpsA-S) of 67 nt. …”
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New insights of cerium oxide nanoparticles in head and neck cancer treatment by Elif Tarakci, Sahra Esmkhani, Jamila Bayramova, Feride Melisa Bilgin, Kubra Kidik, Sevin Adiguzel, Yigithan Tufan, Ahsen Morva Yilmaz, Hulya Yilmaz, Ozgur Duygulu, Serpil Harbeck, Batur Ercan, Filiz Kaya, Digdem Aktoprakligil Aksu, Hulya Yazici, Hilal Yazici

“…The effectivity of the SD1 and SD2 on the HNC cell lines (A253, SCC-25, FaDu) were investigated by analyzing their cytotoxicity, genotoxicity, reactive oxygen species (ROS) generation properties. Low IC50 value, high ROS generation and stability profiling of SD2 compared to SD1 indicates the distinct function of dextran type on Dex-CeNPs effectivity on HNC. …”
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Impact of Endocrine Disrupting Pesticide Use on Obesity: A Systematic Review by Marcelino Pérez-Bermejo, Cristian Barrezueta-Aguilar, Javier Pérez-Murillo, Ignacio Ventura, María Ester Legidos-García, Francisco Tomás-Aguirre, Manuel Tejeda-Adell, Miriam Martínez-Peris, Belén Marí-Beltrán, María Teresa Murillo-Llorente

“…<b>Background/Objectives:</b> Endocrine disruptors are substances capable of altering the functions of the endocrine system. There is evidence that some pesticides can be endocrine disruptors and, among some of their effects, we find alterations in pubertal development and in the function of the thyroid gland, which could be related to a greater tendency of obesity. …”
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Sustainable and cost-efficient hydrogen production using platinum clusters at minimal loading by Hongliang Zeng, Zheng Chen, Qiu Jiang, Qingtian Zhong, Yuan Ji, Yizhen Chen, Jiawei Li, Chunxiao Liu, Runhao Zhang, Jialin Tang, Xiaoxia Xiong, Zhongyue Zhang, Zhaoyang Chen, Yizhou Dai, Chengbo Li, Yinfang Chen, Donghao Zhao, Xu Li, Tingting Zheng, Xin Xu, Chuan Xia

“…We herein present a Mo2TiC2 MXene-supported Pt nanocluster catalyst (Mo2TiC2-PtNC) that requires a minimal Pt content (36 μg cm−2) to function, yet remains highly active and stable. Operando spectroscopy and theoretical simulation provide evidence for anomalous charge transfer from the MXene substrate to PtNC, thus generating highly efficient electron-rich Pt sites for robust hydrogen evolution. …”
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TODAY'S CONSUMERS ON THE MARKET IN CSÍKSZEREDA (MIERCUREA CIUC) by Emőke Katalin Péter, László Illyés

“… Due to the geographical situation of Harghita County, farming mostly in small agricultural areas encourages farmers to engage in more integrated agricultural activities. As a result, more and more farmers who are open to development are starting to appear on local markets with processed products. …”
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Female Adolescent Soccer Players Utilize Different Neuromuscular Strategies Between Limbs During the Propulsion Phase of a Lateral Vertical Jump by Matthew D DeLang, Joseph P Hannon, Shiho Goto, James M Bothwell, J Craig Garrison

“…These findings are important to research on functional performance measures related to attaining between-limb symmetry, as measures of energy generation contribution open the door for a more thorough understanding of joint-by-joint intra-limb contributions during a functional task.…”
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Sources of uncertainty in DNA metabarcoding of whole communities: Implications for its use in biomonitoring by J. Iwan Jones, Amanda Arnold, Dominik Buchner, John F. Murphy, Jasmine N. Childress, Pedro Beja, Florian Altermatt, Kristian Meissner, Ian Adams, Meri Anderson, Yaisel J. Borrell, Andrew G. Briscoe, Kat Bruce, Cátia Chaves, Chris Conyers, Kristy Deiner, Vasco Elbrecht, Álvaro Fueyo, Tim Goodall, Javier Granero‐Castro, Cristina Hartmann‐Fatu, Eleanor Jones, Elvira Mächler, Filipa M. S. Martins, Sam McGreig, Lyndall Pereira‐da‐Conceicoa, James L. Pretty, Daniel S. Read, Ben Price, Florian Leese, Rosetta C. Blackman

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CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models by Hong Jiang, Sandra Hervás-Stubbs, Sara Labiano, Candelaria Gomez-Manzano, Juan Fueyo, Marta Alonso, Zhihong Chen, Montserrat Puigdelloses, Marc Garcia-Moure, Virginia Laspidea, Marisol Gonzalez-Huarriz, Marta Zalacain, Lucia Marrodan, Naiara Martinez-Velez, Daniel De la Nava, Iker Ausejo, Guillermo Herrador, Dolores Hambardzumyan, Ana Patino Garcia, Jaime Gállego Pérez-Larraya

“…Moreover, Delta-24-ACT expressed functional 4-1BBL that was able to costimulate T lymphocytes in vitro and in vivo. …”
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Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress... by Ágnes Szabó, Zsolt Galla, Eleonóra Spekker, Mónika Szűcs, Diána Martos, Keiko Takeda, Kinuyo Ozaki, Hiromi Inoue, Sayo Yamamoto, József Toldi, Etsuro Ono, László Vécsei, Masaru Tanaka

“…Over 90% of the 5-HT precursor tryptophan (Trp) is metabolized via the Trp-kynurenine (KYN) metabolic pathway, which generates a variety of bioactive molecules. Dysregulation of KYN metabolism, particularly low levels of kynurenic acid (KYNA), appears to be linked to neuropsychiatric disorders. …”
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