Fluid balance-adjusted creatinine at initiation of continuous venovenous hemofiltration and mortality. A post-hoc analysis of a multicenter randomized controlled trial. by Susanne Stads, Louise Schilder, S Azam Nurmohamed, Frank H Bosch, Ilse M Purmer, Sylvia S den Boer, Cynthia G Kleppe, Marc G Vervloet, Albertus Beishuizen, Armand R J Girbes, Pieter M Ter Wee, Diederik Gommers, A B Johan Groeneveld, Heleen M Oudemans-van Straaten, CASH study group

“…However, creatinine is not only determined by renal function (excretion), but also by dilution (fluid balance) and creatinine generation (muscle mass). …”
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Longer Drug Retention of Interleukin-12/23 or Interleukin-17 Inhibitors Compared With TNF Inhibitors in Female Patients With TNF Inhibitor-Experienced Psoriatic Arthritis by Godehard A. Scholz, MD, PhD, Eleftherios Papagiannoulis, MSc, Christoph Blapp, MSc, Raphael Micheroli, MD, Adrian Ciurea, MD, Michael J. Nissen, MD, Nikhil Yawalkar, MD, Diana Dan, MD, Jennifer Amsler, MD, Almut Scherer, PhD, Burkhard Möller, MD

“…Objective: To compare the effectiveness of Interleukin (IL)-12/23 or IL-17A inhibitors (summarized to inhibitors of the Th17 cell generation or function, Th17i) with tumor necrosis factor inhibitors (TNFi) in patients with TNFi-experienced psoriatic arthritis (PsA). …”
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Blockchain and NFT-Based Solution for Genomic Data Management, Sharing, and Monetization by Ahmad Musamih, Khaled Salah, Raja Jayaraman, Samer Ellaham, Mohammed Omar, Ibrar Yaqoob

“…We present various diagrams and algorithms to illustrate the functionality of our solution. Our testing and validation results demonstrate that smart contracts function as intended. …”
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Quasi-parallel Antisunward-propagating Whistler Waves Associated with the Electron Deficit in the Near-Sun Solar Wind: Particle-in-cell Simulation by Alfredo Micera, Daniel Verscharen, Jesse T. Coburn, Maria Elena Innocenti

“…In situ observations of the solar wind have shown that the electron velocity distribution function (VDF) consists of a quasi-Maxwellian core, comprising most of the electron population, and two sparser components: the halo, which are suprathermal and quasi-isotropic electrons, and an escaping beam population, the strahl. …”
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The Development and Applications of a Dual Optical Imaging System for Studying Glioma Stem Cells by Po-An Tai MD, PhD, Yen-Lin Liu MD, PhD, Ya-Ting Wen MD, Chien-Min Lin MD, PhD, Thanh-Tuan Huynh MD, PhD, Michael Hsiao DVM, PhD, Alexander T. H. Wu PhD, Li Wei MD, PhD

“…Subsequently, Btk inhibitor, ibrutinib, suppressed GSC generation and stemness markers. Finally, we demonstrated real-time evaluation of anti-GSC function of ibrutinib in vivo with TMZ-enriched GSCs. …”
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Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapy by Yutao Zou, Junjie Wu, Qiuyun Zhang, Jiayi Chen, Xuanxuan Luo, Yijie Qu, Rui Xia, Weiqi Wang, Xiaohua Zheng

“…Porphyrins-based nanoscale metal-organic frameworks (nMOFs) has been widely utilized to kills tumor cells by generating cytotoxic reactive oxygen species (ROS). …”
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Global Simulations of Gravitational Instability in Protostellar Disks with Full Radiation Transport. I. Stochastic Fragmentation with Optical-depth-dependent Rate and Universal Fra... by Wenrui Xu, Yan-Fei Jiang, Matthew W. Kunz, James M. Stone

“…We find that fragmentation is a stochastic process, with the fragment generation rate per disk area p _frag showing an exponential dependence on the parameter β ≡ Ω _K t _cool , where Ω _K is the Keplerian rotation frequency, and t _cool is the average cooling timescale. …”
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A Chimeric Peptide Derived from a Bacterial Effector Protein Attenuates TLR-2/4-Mediated Production of Pro-Inflammatory Cytokines and Enhances the Cellular Availability of Gentamic... by Nandi BR, Patra B, Radhakrishnan GK

“…A chimeric peptide, TB4-BBL2, was then generated and evaluated for cellular uptake, interaction with TLR adaptors, and functional activities. …”
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30 Years of Research in Brand Personality: Mapping Knowledge and Analyzing the Thematic Structure by a Scientometrics Approach by Mohammad Rahim Esfidani, Mohsen Nazari, Shahriar Gharibzadeh, Nakisa Rezaie

“…These roles manifest themselves in functional, symbolic, and emotional domains, sometimes even evolving into emotional bonds between individuals and brands. …”
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Nutrigenomic and Nutritional Analyses Reveal the Effects of Pelleted Feeds on Asian Seabass (Lates calcarifer). by Si Yan Ngoh, Daniel Tan, Xueyan Shen, Purushothaman Kathiresan, Junhui Jiang, Woei Chang Liew, Natascha May Thevasagayam, Hsiao Yuen Kwan, Jolly M Saju, Sridatta R S Prakki, Chin Heng Goh, Hong Ching Wong, Tai Teck Chan, Miklós Mézes, László Orbán

“…Significant enrichment of genes with growth-related function tallied with the morphological data measured. …”
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Gene expression profiling of extraocular muscles in primary inferior oblique overaction by Rui Hao, Yuchuan Wang, Wei Zhang

“…The results indicated that multiply innervated muscle fibers were more abundant in the primary IOOA group, likely enabling slow tension generation, whereas the secondary IOOA group exhibited higher collagen fibril levels that might improve muscle stiffness.…”
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A New Hybrid Machine Learning Method for Stellar Parameter Inference by Sujay Shankar, Michael A. Gully-Santiago, Caroline V. Morley

“…This creates the PHOENIX generator, enabling parallelized spectral synthesis. …”
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Complex Synchronization Dynamics of Electronic Oscillators–Part I: A Time-Domain Approach via Phase-Amplitude Reduced Models by Konstantinos Metaxas, Paul P. Sotiriadis, Yannis Kominis

“…The developed time-domain approach demonstrates that the same limit cycle oscillator can produce periodic output with tunable spectral characteristics, operating as a frequency divider, or function as a chaotic or quasiperiodic signal generator, depending on the driving signal. …”
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Assessing molecular docking tools: understanding drug discovery and design by Harendar Kumar Nivatya, Anjali Singh, Nitin Kumar, Sonam, Lovy Sharma, Vishal Singh, Raghav Mishra, Nishant Gaur, Arun Kumar Mishra

“…Main Body of the Abstract The study of molecular docking with relative components like classifications, models, and different types of approaches and techniques involved, pose generation, scoring function advantages, disadvantages, and comparison with other types of docking tools to conduct the molecular docking with steps involved will be helpful to learn computer-aided drug design and artificial intelligence. …”
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Syphilitic infection: a study on the factors of the innate humoral immune response by N. K. Levchik, N. V. Zilberberg, M. V. Ponomareva, O. A. Belykh

“…For the purpose of studying the immunopathogenesis and the search for novel biomarkers for the assessment of syphilitic infection activity, we analyzed B1 cells, that are responsible for basal protection and primary immune reactivity and for generating broad specificity antibodies, and estimated the frequency of occurrence of different autoantibodies. …”
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Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni. by Kathrin K Geyer, Sabrina E Munshi, Helen L Whiteland, Narcis Fernandez-Fuentes, Dylan W Phillips, Karl F Hoffmann

“…By further elucidating how Schistosoma molecular components cooperate to regulate parasite developmental processes, next generation targets will be identified. Here, we continue our studies on schistosome epigenetic participants and characterise the function of a DNA methylation reader, the Schistosoma mansoni methyl-CpG-binding domain protein (SmMBD2/3). …”
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Synthesis and in silico studies of new thiophene-isoquinolinone hybrids as potential larvicides against Culex pipiens by Mahmoud Kamal, Mohamed H. Hekal, Fatma S. M. Abu El-Azm, Eslam M. Hosni, Yasmeen M. Ali, Abdullah Yahya Abdullah Alzahrani, El-Hady Rafat

“…Overall, these findings highlight thiophene-isoquinolinone hybrids as a promising option for developing next-generation larvicides that target neurophysiological pathways in insect vectors.…”
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The role of long non‐coding RNAs in lung cancer metastasis: Molecular mechanisms, pathogenesis and clinical implications by Musaffe Tuna, Gordon B Mills, Christopher I. Amos

“…The advent of next‐generation sequencing and other high‐throughput technologies guided the discovery of a new class of molecules, non‐coding RNAs (ncRNAs) that play a role in many aspects of cellular physiology. …”
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Intertextuality of the Personosphere as a Factor of Meta-Genre (Clifford Simak “Shakespeare’s Planet”) by Dan Paranyuk, Alyona Tychinina

“…In conclusion, the article claims that the consistent generation of new literary genre formats in the field of the cultural continuum is an immanent feature of the complex literary process, which can be fully realized only with the help of the reader’s rich receptive background. …”
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Complex Synchronization Dynamics of Electronic Oscillators–Part II: Simulations and Validation of Phase-Amplitude Reduced Models by Konstantinos Metaxas, Nikolaos P. Eleftheriou, Yannis Kominis, Paul P. Sotiriadis

“…The developed time-domain approach demonstrates that the same limit cycle oscillator can produce periodic output with tunable spectral characteristics, operating as a frequency divider, or function as a chaotic or quasiperiodic signal generator, depending on the driving signal. …”
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