CDK2 inhibition sensitizes anthracycline-induced immunogenic cell death and enhances the efficacy of anti-PD-1 therapy by Yu Chen, Wancheng Liu, Qiaomei Cai, Chaohu Pan, Zhenghao Yin, Yijiao Tang, Zhixu He, Genhong Cheng, Liping Shu, Liping Shu

“…IntroductionCDK2 (Cyclin-dependent kinase 2) is an oncogenic cyclin-dependent kinase with potent mitogenic and immunosuppressive functions. Despite extensive research on CDK2 inhibitors, the lack of selectivity has made it unclear whether CDK2 inhibition specifically facilitate immunogenic cell death.MethodsWe used CRISPR-Cas9 system to generate Cdk2-/- MCA205 cells. …”
Get full text

Experimental case study for optimizing heat sink performance using ZnO nanocarriers integrated with phase change materials for environmental sustainability by Muhammad Farooq, Imran Zahid, M. Yasar Javaid, Noreen Sher Akbar, Enio Pedone Bandarra Filho, M. Farrukh Shahzad, M. Imran Khan, Mohammad Ilyas Khan, Mohammad Rehan, Fahid Riaz

“…Electronic equipment generates heat during prolonged operation, making efficient heat dissipation essential to ensure continuous functionality and prevent premature device failure. …”
Get full text

Patellar motion and dysfunction of its stabilizers in a biomechanical model of the knee joint by A. S. Yurova, A. I. Tyagunova, F. B.  Loginov, Yu. V. Vassilevski, A. V. Lychagin, E. B. Kalinsky, E. V. Larina, N.  V. Gorohova, K. A. Devyatyarov, O. N. Bogdanov, I. B. Kovalenko, K. V. Chesnokova, M. A.  Dergachev, E. Yu. Mychka, O. N. Kosukhin

“…Additionally, deactivation of LR components 1 and 2 induces more medial tilt and translation. Deactivating LR components 3 and 4 leads to further lateral translation and slight additional medial tilt.Conclusion. …”
Get full text

VALUE OF BONE REMODELLING MARKERS IN MANDIBULAR FRACTURE PATIENTS BY GENDER AND BONE MINERAL DENSITY by D.I. Matsyuk, N.B. Kuzniak

“…Thus, analysis of bone remodeling marker levels showed that in patients with mandibular fractures due to destruction of the bone matrix as a result of trauma, there was an increase in osteoresorption activity that depended on the structural-functional state of the patients' bone tissue and was more pronounced in women. …”
Get full text

Long‐Term Prognosis of Ischemic Stroke in Young Adults—A Single‐Center Chinese Cohort Study by Yuhui Sha, Qiqi Wang, Mingyu Tang, Ming Yao, Yicheng Zhu, Lixin Zhou, Jun Ni

Get full text

STAT1β modulates the tumor immune microenvironment to improve prognosis in ovarian cancer: a comprehensive study of transcriptional and protein expression differences by Ning Lan, Xintong Li, Yifan Qiao, Siyi Zhang, Min Chen, Xiaofeng Yang, Yuliang Zou, Juan Ren, Meili Pei

“…Abstract Objectives As a central regulator of the JAK/STAT signaling pathway, STAT1 generates functionally distinct α and β protein isoforms through alternative splicing. …”
Get full text

Common variable immunodeficiency disorder: a clinical case by E. A. Sobko, I. V. Demko, I. A. Soloveva, A. Yu. Kraposhina, N. V. Gordeeva, D. A. Anikin, N. S. Pronkina, O. P. Ischenko

“…Primary immunodeficiency is a rare congenital pathology associated with failure of immune system, manifested by disturbances of its functions. These defects lead to increased susceptibility of patients to various infectious agents, as well as the development of autoimmune, malignant and other diseases. …”
Get full text

Comprehensive sieve analysis of breakthrough HIV-1 sequences in the RV144 vaccine efficacy trial. by Paul T Edlefsen, Morgane Rolland, Tomer Hertz, Sodsai Tovanabutra, Andrew J Gartland, Allan C deCamp, Craig A Magaret, Hasan Ahmed, Raphael Gottardo, Michal Juraska, Connor McCoy, Brendan B Larsen, Eric Sanders-Buell, Chris Carrico, Sergey Menis, Gustavo H Kijak, Meera Bose, RV144 Sequencing Team, Miguel A Arroyo, Robert J O'Connell, Sorachai Nitayaphan, Punnee Pitisuttithum, Jaranit Kaewkungwal, Supachai Rerks-Ngarm, Merlin L Robb, Tatsiana Kirys, Ivelin S Georgiev, Peter D Kwong, Konrad Scheffler, Sergei L Kosakovsky Pond, Jonathan M Carlson, Nelson L Michael, William R Schief, James I Mullins, Jerome H Kim, Peter B Gilbert

“…The identified signature sites significantly covaried with other sites across the genome (mean = 32.1) more than did non-signature sites (mean = 0.9) (p < 0.0001), suggesting functional and/or structural relevance of the signature sites. …”
Get full text

Breakfast skipping and depressive symptoms in an epidemiological youth sample in Hong Kong: the mediating role of reduced attentional control by Stephanie Ming Yin Wong, Olivia Choi, Yi Nam Suen, Christy Lai Ming Hui, Edwin Ho Ming Lee, Sherry Kit Wa Chan, Sherry Kit Wa Chan, Eric Yu Hai Chen, Eric Yu Hai Chen, Eric Yu Hai Chen

“…Participants were asked about their general breakfast consumption habits, impulsivity (overall and its subdomains, using the Barratt Impulsiveness Scale–11), depressive symptoms (Patient Health Questionnaire–9), anxiety symptoms (Generalized Anxiety Disorder Scale–7), and functioning (reduced and lost productivity due to mental health problems, and the observer-rated Social and Occupational Functioning Assessment Scale). …”
Get full text

Investigating Measurement Equivalence of Smartphone Sensor–Based Assessments: Remote, Digital, Bring-Your-Own-Device Study by Lito Kriara, Frank Dondelinger, Luca Capezzuto, Corrado Bernasconi, Florian Lipsmeier, Adriano Galati, Michael Lindemann

“…The study used the Floodlight Open app, a “bring-your-own-device” (BYOD) solution that remotely measured MS-related functional ability via smartphone sensor–based active tests. …”
Get full text

Genealogy of the Arab tribes living in Syria during the Caliphate of Imam Ali (AS)Typology of the Arab Tribes Living in the Levant during the Caliphate of Imam Ali (AS) Typology... by Akram sadat Hoseini, Yahya Mirhoseini

“…However, in the analysis of the eighty Arab tribes inhabiting the Levant, a more nuanced picture emerged through a review of individual and tribal behaviors and functions. 4 distinct currents were identified: "Companions", "Semi-Companions", "Neutrals", and "Non-Companions". …”
Get full text

Risk Assessment of Community-Scale High-Temperature and Rainstorm Waterlogging Disasters: A Case Study of the Dongsi Community in Beijing by Pei Xing, Ruozi Yang, Wupeng Du, Ya Gao, Chunyi Xuan, Jiayi Zhang, Jun Wang, Mengxin Bai, Bing Dang, Feilin Xiong

“…In this study, the Dongsi Community in the functional core area of Beijing was explored, and the risk assessment of high temperatures and rainstorm waterlogging was implemented at the community scale. …”
Get full text

A secure and energy-efficient routing using coupled ensemble selection approach and optimal type-2 fuzzy logic in WSN by S. Ambareesh, Pundalik Chavan, S. Supreeth, Rajesh Nandalike, P. Dayananda, S. Rohith

“…Conventional strategies generally goal particular troubles, like strength optimization or improving QoS, frequently failing to provide a holistic answer that effectively balances more than one crucial elements concurrently. …”
Get full text

THE EFFECT OF NUTRITIONAL THERAPY ON QUALITY OF LIFE INDICATORS FOR PATIENTS WITH GASTRIC CANCER AT THE STAGE OF SURGICAL TREATMENT by A. D. Sergienko, V. E. Khoronenko, E. V. Gameeva, A. B. Ryabov, V. M. Khomyakov

“…Improving appetite in patients of the main group led to an improvement in the functioning of the gastrointestinal tract as a whole. …”
Get full text

Laparoscopic completion gastrectomy in elderly patients with remnant gastric cancer: a case series by Masaki Kaihara, Satoru Matsuda, Eisuke Booka, Fumitaka Saida, Jumpei Takashima, Hanako Kasai, Koki Mihara, Atsushi Nagashima, Tomohisa Egawa

“…Moreover, elderly patients (EPs) often have multiple complicating factors (i.e., frailty and comorbidities), leading to more postoperative complications after abdominal surgery. …”
Get full text

Microglia in the aged brain develop a hypoactive molecular phenotype after surgery by Zhuoran Yin, Anna K. Leonard, Carl M. Porto, Zhongcong Xie, Sebastian Silveira, Deborah J. Culley, Oleg Butovsky, Gregory Crosby

Get full text

The relevance of creating a new combined ophthalmic drug with anti-inflammatory and antibacterial effects by L. I. Kucherenko, D. V. Okolzin

“…The surface of the eye, constituting only 0.3 % of the total body surface, is extremely sensitive, and it accounts for more than 13 % of all injuries during hostilities. …”
Get full text

The association between eight complete blood count-derived inflammatory markers and muscle health by Jingyuan Zhang, Yuqi Wang, Heng Liu, Zhuolin Lei, Shouquan Cheng, Hong Cao

“…., PIV and dNLR), the SII demonstrated a more robust predictive ability, was less influence by covariates, and exhibited high generalization performance in internal and external validation. …”
Get full text

Quality Evaluation of Muffins Enriched With Blueberry and Cranberry Powders by Njomza Gashi, Endrit Hasani, Salih Salihu

“…This factor is crucial to fulfill consumers’ requests for more attractive attributes of such products not only in taste but also in their physical appearance. …”
Get full text

Risk of myocardial infarction and heart failure in gout patients: a systematic review and meta-analysis by Panpan Wang, Huanhuan Yang

Get full text