Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…In the 12 months after fracture, patients are at increased risk of cognitive and functional decline, admission to long-term care institutions and higher mortality. …”
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Induction of tissue resident memory T cells by measles vaccine vector by Heidy Vera-Peralta, Claude Ruffié, Valérie Najburg, Matthias Brione, Chantal Combredet, Phanramphoei Frantz, Jean-Nicolas Tournier, Frédéric Tangy, Marie Mura

“…The intranasal route induced more Trm in the lungs than other routes, confirming the potential of intranasal vaccine administration of replicative viral vectors to generate a strong pulmonary immune response. …”
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Performance and Secrecy Analysis of Cooperative Full-Duplex NOMA System With Fountain Codes and Intelligent Reflective Surface by Phu Tran Tin, Minh-Sang Van Nguyen, Tran Trung Duy, Van Huy Pham, Le Viet Thanh, Byung-Seo Kim

“…Intelligent Reflective Surfaces (IRSs) are recognized as fundamental technology in the context of the forthcoming sixth-generation (6G) communication systems. Non-Orthogonal Multiple Access (NOMA) can augment fifth-generation (5G) wireless networks’ spectral efficiency. …”
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Nuclear mRNA export by Chen Suli, Jiang Qingyi, Fan Jing, Cheng Hong

“…While these mechanisms are generally conserved across eukaryotes, significant differences exist between yeast and higher eukaryotic cells, particularly due to the more genome complexity of the latter. …”
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Multimodal physical therapy intervention based on a biobehavioral approach in a patient with chronic upper limb pain: a case report by Fernando-Balbino Blanco-Fernández, Carlos Forner-Álvarez, Celia Vidal-Quevedo, Ferran Cuenca-Martínez, Mónica Grande-Alonso

“…Chronic upper limb pain is rather common among people in general and is characterized by a complex diagnosis due to the wide variety of factors that are involved in its development. …”
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Revolutionizing pharmacology: AI-powered approaches in molecular modeling and ADMET prediction by Irfan Pathan, Arif Raza, Adarsh Sahu, Mohit Joshi, Yamini Sahu, Yash Patil, Mohammad Adnan Raza, Ajazuddin

“…The convergence of AI with quantum chemistry and density functional theory (DFT) is illustrated through surrogate modeling and reaction mechanism prediction. …”
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Valorization of Andean Native Potatoes Through Chuño Processing: Effects of Potato Variety and Freezing Temperature on Physicochemical, Bioactive, Nutritional, and Technological Pr... by Elmer Robert Torres-Gutiérrez, Grimaldo Wilfredo Quispe-Santivañez, Jimmy Pablo Echevarría-Victorio, David Elí Salazar-Espinoza, Joselin Paucarchuco-Soto, Henry Juan Javier-Ninahuaman, Williams Esteward Castillo-Martinez, Rebeca Salvador-Reyes

“…Color differences were also noted, with P presenting reddish tones and a higher luminosity, whereas C had a more intense yellow hue linked to carotenoids. In general, −10 °C and −20 °C better preserved antioxidant compounds than −30 °C. …”
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Epigenomic and 3D genomic mapping reveals developmental dynamics and subgenomic asymmetry of transcriptional regulatory architecture in allotetraploid cotton by Xianhui Huang, Yuejin Wang, Sainan Zhang, Liuling Pei, Jiaqi You, Yuexuan Long, Jianying Li, Xianlong Zhang, Longfu Zhu, Maojun Wang

“…We systematically identify a subset of genes that are closely associated with specific tissue functions. Interestingly, these genes exhibit not only higher tissue specificity but also a more pronounced homoeologous bias. …”
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Immune-related gene SOX10 affects ferroptosis in pancreatic cancer and facilitates tumor progression by targeting CMTM7-mediated Wnt/β-catenin signaling pathway by Guixing Jiang, Bicheng Wu, Kaikai Wang, Xiaofan Pu, Senhao Zhou, Xin Zhong, Xiaolong Liu, Suihan Wang, Tianyu Lin

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Physical Activity as a Factor to Improve the Quality of Student Life by M. M. Kolokoltsev, S. S. Iermakov, N. V. Tretyakova, V. L. Kraynik, E. V. Romanova

“…The values of indicators such as “role functioning”, “pain intensity”, “mental health”, “emotional state”, “social and life activity” fell substantially. …”
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Descriptive and temporal analysis of the mortality rate and average hospital stay due to burns and corrosion in the elderly in Brazil between 2010 and 2019 by Arthur Antunes Coimbra Pinheiro Pacífico, Ester Saraiva Carvalho Feitosa, Anna Letícia Silveira Parnaíba, Pedro Lucena de Aquino, Amanda de Andrade Cavalcante, Thalia de Souza Bezerra, Leandro Dantas Rolim, Samy Lima Carneiro

“…Introduction: Aging leads to physical and cognitive limitations and decreased functional capacity. Therefore, there is a greater risk, a higher rate of complications and death in elderly patients from burns. …”
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A versatile framework for attitude tuning of beamlines at light source facilities by Peng-Cheng Li, Xiao-Xue Bi, Zhen Zhang, Xiao-Bao Deng, Chun Li, Li-Wen Wang, Gong-Fa Liu, Yi Zhang, Ai-Yu Zhou, Yu Liu

“…It supports flexible input/output ports, easy integration of diverse evaluation functions and free selection of optimization algorithms. …”
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DFT insights into the structural, mechanical, electronic, optical, and thermal properties of Cr2AC (A = Si, Al, Ga, Ge, and P) MAX phases carbides by Md. Nurul Amin, Abdulla Al Faysal, Ahmed Azzouz-Rached, Faisal Islam Chowdhury, Jamal Uddin, Join Uddin, Jahidul Islam, Ali Reza Piyal, Anjan Kumar Chowdhury, A. K. M. Rezaur Rahman

“…This work examines the structural, electronic, mechanical, optical, and thermal properties of Cr2AC (A = Si, Al, Ga, Ge, and P) MAX phases using density functional theory. These properties are investigated through first-principles calculations within the generalized gradient approximation using the CASTEP software package. …”
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Multicomponent one-pot construction of benzo[f]quinoline-linked covalent organic frameworks for H2O2 photosynthesis by Ke-Hui Xie, Guang-Bo Wang, Fang Huang, Fei Zhao, Jing-Lan Kan, Zi-Zheng Chen, Lei Cai, Shu-Lin Han, Yan Geng, Yu-Bin Dong

“…Abstract The exploration of stable and functional linkages by multicomponent reactions to enrich the stability and diversity of covalent organic frameworks (COFs) and to broaden their potential applications is of fundamental significance to the development of COFs. …”
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Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma by Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian

“…Therefore, this study aimed to identify the optimal scFv and investigate its biological functions to further optimize the therapeutic potential of CAR-T cells targeting CEA-positive carcinoma.MethodsWe screened four reported humanized or fully human anti-CEA antibodies (M5A, hMN-14, BW431/26, and C2-45), and inserted them into a 3rd-generation CAR structure. …”
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Pyramidal attention-based T network for brain tumor classification: a comprehensive analysis of transfer learning approaches for clinically reliable and reliable AI hybrid approach... by Tathagat Banerjee, Prachi Chhabra, Manoj Kumar, Abhay Kumar, Kumar Abhishek, Mohd. Asif Shah

“…Abstract Brain tumors are a significant challenge to human health as they impair the proper functioning of the brain and the general quality of life, thus requiring clinical intervention through early and accurate diagnosis. …”
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Microstructural transformation for robust and high-efficiency Zintl thermoelectrics by Meng Jiang, Qinghua Zhang, Siyuan Zhang, Ming Liu, Yuntian Fu, Zhiyuan Zhang, Xin Ai, Bohayra Mortazavi, Lianjun Wang, Qihao Zhang, Denys Makarov, Wan Jiang

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Feasibility and Mechanical Strength Evaluation of New Customized Implants for Tibial Plateau Fractures Fixation by Meng Li, Mengmeng Hu, Xiaomeng Ren, Yi Gao, Longbo Du, Yu Jiang, Wei Zhang

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Computational modelling of immunological mechanisms: From statistical approaches to interpretable machine learning by María Rodríguez Martínez, Matteo Barberis, Anna Niarakis

“…To conclude the workshop, a round table was organized to foster discussions on the existing challenges and chart a roadmap for the development of the next generation of computational models dedicated to investigating the cellular and molecular functions that underlie the immune system.…”
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Novel In Vitro Selection of <i>Trans</i>-Acting <i>BCL-2</i> mRNA-Cleaving Deoxyribozymes for Cancer Therapy by Veera Vijaya Basamshetty, Vijay Kumar Gangipangi, Uppulapu Shravan Kumar, Santhosh Shanthi Bhupathi, Sridhar Reddy Kaulagari, Prashant Giri, Swapnil Sinha, Utpal Mohan, Konstantinos Sdrimas

“…Additionally, investigating the underlying molecular mechanisms in more complex cancer models will further validate the observed effects.…”
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