Mechanistic insights into effects of the cardiac myosin activator omecamtiv mecarbil from mechanokinetic modelling by Alf Månsson

“…Repeated tests lead to at a set of parameter values that allow faithful reproduction of range of functional variables of cardiac myocytes. We then apply the model to studies of OM.Results and discussionThe results suggest that major effects of OM such as large reduction of the maximum velocity with more limited effects on maximum isometric force and slowed actin-activated ATPase can be accounted for by two key molecular effects. …”
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Avian lungs: A novel scaffold for lung bioengineering. by Sean M Wrenn, Ethan D Griswold, Franziska E Uhl, Juan J Uriarte, Heon E Park, Amy L Coffey, Jacob S Dearborn, Bethany A Ahlers, Bin Deng, Ying-Wai Lam, Dryver R Huston, Patrick C Lee, Darcy E Wagner, Daniel J Weiss

“…These initial studies demonstrate that decellularized avian lungs may be a feasible approach for generating functional lung tissue for clinical therapeutics.…”
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Ruthenium Thrifting – Computation Insights in NH3 Decomposition Onto Ru Single Atom Catalyst CeO2  by Nomcebo P. Motsa, Daniel A. Oduma, Cecil N.M. Ouma, Eni Oko, Michael O. Daramola

“…NH3 is crucial for the hydrogen economy because it generates hydrogen, a versatile energy source and carrier. …”
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Driver Clustering Based on Individual Curve Path Selection Preference by Gergo Igneczi, Tamas Dobay, Erno Horvath, Krisztian Nyilas

“…The development of Advanced Driver Assistance Systems (ADASs) has reached a stage where, in addition to the traditional challenges of path planning and control, there is an increasing focus on the behavior of these systems. Assistance functions shall be personalized to deliver a full user experience. …”
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Design and Development of a Customer Management System in the Food Industry by Zhekova Mariya, Katrandzhiev Nedyalko, Petkov Mario

“…It stores information about customers, materials and suppliers, generates reports and provides business process management. …”
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Immunotargets and Therapy for Systemic Lupus Erythematosus by Mok CC

“…Impaired clearance of apoptotic bodies and self-antigens, dysregulated cytokine network and aberrated functions of the immune cells lead to overproduction of autoantibodies, activation of complements, immune complex deposition and tissue injury. …”
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Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure. by Marco Maccarana, René B Svensson, Anki Knutsson, Antonis Giannopoulos, Mea Pelkonen, MaryAnn Weis, David Eyre, Matthew Warman, Sebastian Kalamajski

“…Functionally, Aspn-/- mice had an increased skin mechanical toughness, although there were no structural changes present on histology or immunohistochemistry. …”
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Integrating Intrinsic and Eccentric Seismic Vulnerability Indices to Prioritize Road Network Accessibility by Ahmad Mohamad El Maissi, Sotirios A. Argyroudis, Moustafa Moufid Kassem, Lee Vien Leong, Fadzli Mohamed Nazri

“…Subsequently, the variation between the accessibility rates is investigated and the integrated seismic risk assessment for a road system is developed with a focus on the integration between asset damage and functionality by generating integrated heat maps that take into consideration the correlation between all the developed vulnerability indices.…”
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Consultative dimension in the European Union's multilevel governance process: a lever for regulatory and institutional resilience by TECLEAN Cezar, DRĂGAN Gabriela

“…The specified phenomenon feeds an imperfect subsidiarity and a deficient proximity within the EU, for the remedy of which the feasible solution consists in improving the administrative-legal cohesion in the EU through a potential reconsolidation of the Union treaties, which would generate a more homogeneous distribution of the administrative-territorial devolution.…”
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Efficient structure learning of gene regulatory networks with Bayesian active learning by Dániel Sándor, Péter Antal

“…Results We introduce novel acquisition functions for experiment design in gene expression data, leveraging active learning in both Essential Graph and Graphical Model spaces. …”
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Machine Learning Approaches for Data-Driven Self-Diagnosis and Fault Detection in Spacecraft Systems by Enrico Crotti, Andrea Colagrossi

“…This study explores data-driven alternatives for self-diagnosis and fault detection using Machine Learning techniques, focusing on spacecraft Guidance, Navigation, and Control (GNC) subsystems. A high-fidelity functional engineering simulator is employed to generate realistic datasets from typical onboard signals, including sensor and actuator outputs. …”
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Quantifying avian wing shapes: Evaluating indices, their relationships, and ecological correlates by Jiahui Li, Canwei Xia

“…Avian wings are central to their remarkable flight ability and diverse life history strategies, including behaviors such as fighting and mating. These multifaceted functions are intricately tied to wing shape, which varies significantly across species because of the complex interplay of evolutionary and ecological pressures. …”
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PI(4,5)P2 Imaging Using a GFP Reporter in Living Cells by Mariam Alkandari, Christopher McMaster, Mahtab Tavasoli

“…Altered metabolism or mislocalization of PI(4,5)P2 can perturb one or more of its functions and contribute to disease states. …”
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Growth and Characterizations of Organic NLO Imidazolium L-Tartrate (IMLT) Single Crystal by Hiral Raval, B. B. Parekh, K. D. Parikh, M. J. Joshi

“…The presence of various functional groups has been identified by ATR-FTIR. UV-Vis-NIR spectroscopy has shown more than 60% of optical transparency with the lower UV cutoff at 245nm. …”
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Rolling Bearing Fault Diagnosis via Temporal-Graph Convolutional Fusion by Fan Li, Yunfeng Li, Dongfeng Wang

“…A shared Multi-Layer Perceptron (MLP) then established inter-channel dependencies to generate attention weights, enhancing critical features for more complete fault information extraction. …”
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Venüs Heykelciklerinden İdollere Kadın Temsilleri by Tülin CENGİZ

“…These artifacts, which have been discovered in a wide area from Europe to Siberian context, are generally depictions of women with exaggerated female organs. …”
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The Main Directions of Improving the Methodology for the Application of Advanced Information and Communication Technologies in the Statistical Activities of the Republic of Uzbekis... by I. E. Zhukovskaya

“…The scientific article presents the main directions of improving the methodology for the application of advanced information and communication technologies in the statistical activities of the Republic of Uzbekistan in the context of the formation of a digital economy, in particular with the aim of achieving maximum reliability and efficiency in collecting and processing statistical data, as well as the openness and quality of information when receiving consolidated indicators for various user requests, an analysis of the functionality of information systems and technologies used in the statistical field was carried out, a methodology for the provision of modern state interactive services to end users was developed on the basis of the implementation of a digital analytical platform, mechanisms for improving the quality of state statistical reporting based on the use of web service technologies were proposed, scientific approaches to the integration of statistical activities with other ministries and departments in the in the context of the digitalization of the economy are expressed.The author concludes that the digital economy changes all spheres of life in modern society, contributes to the formation of a new management paradigm, methods and means based on the strengthening of the role of science as a leading productive force generating more and more new knowledge, leading to new trends in the improvement of managerial processes, solving problems of information compatibility of various software and technological complexes, which, in turn, contributes to the processes of globalization and improvement of the social sphere of the national economy, which are manifested not only in the growth of production indicators, but also in the improvement of the quality of life of the country's population.The article shows that a comprehensive analysis, statistical data on the development of innovative processes in the economy allow us to note that innovations based on the use of the advanced ICT contribute to improving the technical and technological basis of production processes, optimizing management processes, and developing human capital. …”
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Chain entanglement enhanced strong and tough wool keratin/albumin fibers for bioabsorbable and immunocompatible surgical sutures by Haonan He, Xianchi Zhou, Yuxian Lai, Rouye Wang, Hongye Hao, Xintian Shen, Peng Zhang, Jian Ji

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Advances and challenges in the treatment of myelodysplastic syndromes by Rohit Thalla, Ryan Mack, Jorgena Kosti-Schwartz, Peter Breslin, Jiwang Zhang

“…MDS develop from genetically mutant clonal hematopoietic stem and progenitor cells (HSPCs) which have defects in generating mature functional blood cells due to impaired differentiation and/or survival activities. …”
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Faba bean and oat as ingredients in fermented plant-based foods: opportunities and challenges by Laura Alejandra Fernandez Castaneda, Maud Langton, Galia Zamaratskaia

“…There is an urgent need for the development of more plant-based foods alternatives with high nutritional and sensory qualities. …”
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