Presenilin-1 Familial Alzheimer Mutations Impair γ-Secretase Cleavage of APP Through Stabilized Enzyme–Substrate Complex Formation by Sujan Devkota, Masato Maesako, Michael S. Wolfe

“…Familial Alzheimer’s disease (FAD) is caused by dominant missense mutations in amyloid precursor protein (APP) and presenilin-1 (PSEN1), the catalytic component of γ-secretase that generates amyloid β-peptides (Aβ) from the APP C-terminal fragment C99. …”
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Directions and Results of Punctuation Management by Albinas Drukteinis

“…In the recent period, more and more priority is given to the preferences of the author of the text, if it is necessary for the general meaning of the text. …”
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A New Type Iterative Ridge Estimator: Applications and Performance Evaluations by Aydın Karakoca

“…Since the theoretical comparisons among the ridge estimators are not possible, it is general practice to carry out a Monte Carlo study to compare them. …”
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„Dla powszechnego rozwoju, podniesienia i poprawy naszego księstwa”. Lokacje miast mazurskich w Prusach Książęcych (1525-1701) by Grzegorz Białuński

“… The article presents the process of creation of new towns in the Duchy of Prussia (1525-1701), which later became Masuria. More specifically, the paper describes how a hamlet received a location privilege. …”
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Surfactants Adsorption onto Algerian Rock Reservoir for Enhanced Oil Recovery Applications: Prediction and Optimization Using Design of Experiments, Artificial Neural Networks, and... by Kahina Imene Benramdane, Mohamed El Moundhir Hadji, Mohamed Khodja, Nadjib Drouiche, Bruno Grassl, Seif El Islam Lebouachera

“…While DOE showed a slight advantage in relative error (9.10 × 10⁻⁵% vs. 1.88 × 10⁻⁴% for ANN), ANN proved more effective overall. Three optimization approaches—ANN-GA, DOE-GA, and DOE-DF (desirability function)—were compared, all converging to the same optimal conditions (SDS at 200 ppm and 25 °C). …”
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The influence of 6-Benzylaminopurine (BAP) on yield responses and photosynthetic physiological indices of soybean by Xinglong Lian, Shuang Liu, Aatika Sikandar, Zongli Kang, Yaxing Feng, Lanyuwen Jiang, Yuanyuan Wang

“…The expression of genes in leaves exhibited more up-regulation as compared to the stem. In general, this work offers a new and better understanding of how BAP might be employed to boost yield and chlorophyll biosynthesis.…”
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PREVENTION AND TREATMENT OF CARIES AND ITS COMPLICATIONS IN TEMPORARY TEETH IN A DENTAL CLINIC by L.F. Kaskova, O.E. Berezhna, K.A. Lazarieva, P.M. Skrypnykov

“…In such cases, standard crowns were more often used, which made it possible to restore the anatomical shape of temporary molars, their function and achieve a long-term treatment effect until the period of physiological changes in the teeth. …”
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Case Report: Hemodynamic consequences of severe supraventricular arrhythmia assessed by real-time magnetic resonance imaging in combination with electrocardiography by Lena Maria Röwer, Miriam Nathalie Tappel, Mohamed Ali Goundi, Anja Müller-Lutz, Mohamed Abd El Rahman, Jana Rieke, Gerrit Steinhagen, Mathias Emmel, Dirk Klee, Frank Pillekamp

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Case Report: A missed diagnosis of cardiac amyloidosis using echocardiography due to immunoglobulin light chain amyloidosis with normal wall thickness in the early stage by Xiaohui Li, Xiaohui Li, Xiaohui Li, Tongge Mu, Yangxue Deng, Yu Zhang, Yu Zhang, Yu Zhang, Yun Ti, Yun Ti, Yun Ti, Lei Zhang, Lei Zhang, Lei Zhang

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Assessing the Influence of Selected Permeabilization Methods on Lymphocyte Single-Cell Multi-Omics by Shifan Ding, Na Lu, Hassan Abolhassani

“…(1) Background: Single-cell multi-omics is a powerful method for the dissection and detection of complicated immunologic functions and synapses. However, most currently available technologies merge datasets of different omics from separate portions of the same sample to generate combined multi-omics. …”
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Modeling the challenges affecting the internationalization of the Persian Gulf Pro League by Sajad Soroush, Geoff Dickson, Nasrollah Sajjadi, Ebrahim Alidoust Ghahfarokhi

“…During the analysis, we identified 85 codes that generated 49 general concepts. Subsequently, through further reviewing the concepts and their combination with each other, we identified twenty tow final categories that affect the internationalization of PGPL. …”
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Sculpting molecules in text-3D space: a flexible substructure aware framework for text-oriented molecular optimization by Kaiwei Zhang, Yange Lin, Guangcheng Wu, Yuxiang Ren, Xuecang Zhang, Bo Wang, Xiao-Yu Zhang, Weitao Du

“…This work not only holds general significance for the advancement of deep learning methodologies but also paves the way for a transformative shift in molecular design strategies. 3DToMolo creates opportunities for a more nuanced and effective exploration of the vast chemical space, opening new frontiers in the development of molecular entities with tailored properties and functionalities.…”
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Quantifying conformational heterogeneity of 3D genome organization in fruit fly. by Samira Mali, Igor S Tolokh, Erik Cross, Alexey V Onufriev

“…Within our computational approach, depletion of nuclear lamins leads to increased structural heterogeneity at nearly all genomic separations, with the potential implication that cell functions that depend on chromatin structure might be more variable within lamins depleted nuclei compared to the wild type.…”
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A Qualitative Study Examining the Unintended Consequences from Implementing a Case Management Team to Reduce Avoidable Hospital Readmission in Singapore by Shilpa Surendran, Stephen So, Toon Wei Lim, David Bruce Matchar

“…As a result, the intervention team functioned more as a consulting service, providing recommendations to the primary team, which retained decision-making authority. …”
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Role of leisure and sleep in promoting daily physical activity in adults with down syndrome by Melissa R. Jenkins, Victoria L. Fleming, Emily K. Schworer, Yiwen Dong, Dana L. Tudorascu, Benjamin L. Handen, Sigan L. Hartley

“…Although physical activity can mitigate the effects of these conditions, adults with DS spend more time sedentary relative to the adult general population. …”
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Comparative evaluation of artificial intelligence models GPT-4 and GPT-3.5 in clinical decision-making in sports surgery and physiotherapy: a cross-sectional study by Sönmez Saglam, Veysel Uludag, Zekeriya Okan Karaduman, Mehmet Arıcan, Mücahid Osman Yücel, Raşit Emin Dalaslan

“…Paired t-test results (t(55) = 10.45, p < 0.001) demonstrated that GPT-4 provided more accurate diagnoses, superior treatment plans, and more detailed surgical recommendations. …”
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On Convergence Rate of MRetrace by Xingguo Chen, Wangrong Qin, Yu Gong, Shangdong Yang, Wenhao Wang

“…In this paper, we propose an essentially simplified version of a convergence rate to generate general off-policy temporal difference learning algorithms. …”
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Could Some Geriatric Characteristics Hinder the Prescription of Anticoagulants in Atrial Fibrillation in the Elderly? by Paule Denoël, Jacques Vanderstraeten, Pierre Mols, Thierry Pepersack

“…In the group with anticoagulation therapy, the following characteristics were observed more often than in the group without such therapy: a recent (≤6 months) hospitalization and medical treatment including digoxin or based on >3 different drugs. …”
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A New Approach for Free Vibration Analysis of Thin-Walled Box Girder Considering Shear Lag Effect by Zuolong Luo, Haoyun Yuan, Xirong Niu

“…Besides, it is also observed that the natural frequency values considering the SLE have a trend of decreasing markedly in general, and the influence of SLE on higher-order frequency is more significant than on the lower one under the boundary condition of cantilever supported, while a contrary effect under the boundary condition of simple supported.…”
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A review on simulation based training on autonomous ships and protection of Egyptian maritime security by Ashraf Mohamed Elsayed

“…This research study investigates the function that training plays in improving both the general security of autonomous ships that operate in Egyptian seas as well as the cyber security of such ships. …”
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