Identification of potential drug targets for achalasia from genetic insights: a Mendelian randomization study by Kai Xiong, Hao Fang, Caihong Song, Dilihumaer Tuerxun, Peng Zhang

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Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model. by Jun-Yi Zhu, Natalia Vereshchagina, Vrinda Sreekumar, Lena F Burbulla, Ana C Costa, Katharina J Daub, Dirk Woitalla, L Miguel Martins, Rejko Krüger, Tobias M Rasse

“…We generated the first loss-of-Hsc70-5/mortalin-function Drosophila model. …”
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Identification of Ecological Security Pattern and Ecological Restoration Zoning Strategy in the Shandong Section of the Beijing-Hangzhou Grand Canal by Chizhou Xu, Yande Jing, Yiwen Zhang, Yingchun Liu, Wenyang Yin, Shiping Zhao

“…Additionally, 40 ecological corridors, 48 ecological pinch points, and 75 ecological barrier points were generated, densely distributed in the east. The area was divided into five core functional zones. (4) Conclusions: Establishing ecological function zones and considering landscape changes from high-frequency human activities in spatial planning can lead to a more reasonable division of ecological restoration areas. …”
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TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres by Tomáš Janovič, Gloria I. Perez, Greta Boelting, Jens C. Schmidt

“…To quantitatively analyze shelterin function, we generated a panel of human cancer cell lines expressing HaloTagged shelterin proteins from their endogenous loci. …”
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Successful Management Strategies for Lupus Nephritis in the Intensive Care Unit: A Case Series by Achmad Marwan, Bambang Pujo Semedi, Maulydia Maulydia

“…Patients with SLE undergoing immunosuppressive therapy are also at risk of developing infections, which can progress to sepsis and require more intensive care. Treatment of lupus nephritis in ICU generally necessitates intensive care, which includes hemodialysis and sepsis control. …”
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Advances in the study of the role of high-frequency mutant subunits of the SWI/SNF complex in tumors by Jiumei Zhao, Jing Zhu, Yu Tang, Kepu Zheng, Ziwei Li

“…As a catalytic subunit of the SWI/SNF complex, SMARCA4 has ATPase activity that catalyzes the hydrolysis of ATP to produce energy and power the chromatin remodeling complex, which is critical to the function of the SWI/SNF complex. The study data indicate that approximately 25% of cancers have one or more SWI/SNF subunit genetic abnormalities, and at least nine different SWI/SNF subunits have been identified as having repeated mutations multiple times in various cancers, suggesting that mutations affecting SWI/SNF subunits may introduce vulnerabilities to these cancers. …”
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Public security patrol path planning recommendation method based on wolf-pack optimization algorithm using DAF and BRS by Dongxing Wang, Gaomin Zhang, Fangbo Wu, Zhiyang Huang, Yiping Chen

“…Firstly, an optimization objective function regarding the public security patrol path planning (S3P-Function) was abstracted from the actual situation; Moreover, this paper proposed an improved wolf-pack optimization algorithm named DAF-BRS-CWOA using Dynamic-Adjustment-Factor(DAF) and Balanced-Raid-Strategy (BRS), and DAF devoted to adjust the overall wolf-pack running strategy by dynamically adjusting the number of airdropped wolves during the stage of Summon-Raid while BRS with symmetric property was to improve both the algorithm’s global exploration as well as the local development capabilities by increasing the number of checking locations, that means not only checking the reverse position of the current wolf, but also the positions generated according to certain rules between the reverse position of the current wolf and the current optimal wolf during the stage of Summon-Raid; Finally, DAF-BRS-CWOA was adopted to optimize S3P-Function, forming a public security patrol path planning recommendation method based on DAF-BRS-CWOA (S3PRM-DAF-BRS-CWOA). 30 independent numerical experiments were conducted on 20 public classical datasets by DAF-BRS-CWOA compared with GA, PSO, WDX-WPOA. …”
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Large Language Model-Guided SARSA Algorithm for Dynamic Task Scheduling in Cloud Computing by Bhargavi Krishnamurthy, Sajjan G. Shiva

“…Nowadays, more enterprises are rapidly transitioning to cloud computing as it has become an ideal platform to perform the development and deployment of software systems. …”
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A New Approach to Concavity Fuzzification by Ibtesam Alshammari, Azza M. Alghamdi, A. Ghareeb

“…In this paper, we introduce a more general approach to the fuzzification of fuzzy concavity. …”
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PI16 attenuates response to sorafenib and represents a predictive biomarker in hepatocellular carcinoma by Pusen Wang, Zhongyi Jiang, Xueni Liu, Kanru Yu, Chunguang Wang, Hao Li, Lin Zhong

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Comprehensive Peri-Operative Risk Assessment and Management of Geriatric Patients by Nikolaos Theodorakis, Maria Nikolaou, Christos Hitas, Dimitrios Anagnostou, Magdalini Kreouzi, Sofia Kalantzi, Aikaterini Spyridaki, Gesthimani Triantafylli, Panagiota Metheniti, Ioannis Papaconstantinou

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ON THE CHANGE OF VALUES OF POSTNOMINATIVE APPENDICES IN THE PROCESS OF TRANSFORMATION IN THE MODERN ENGLISH by Sevil M. Radjabova

“…In the English language the adjectives can perform the function of predicative. For the semantics of the adjectives which have the predicative function, these adjectives are characterized by inner qualitative diversity. …”
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AN INVESTIGATION INTO FIRM PERFORMANCE DURING THE COVID-19 PANDEMIC IN THE BALTIC STATES by Derick Blaauw, Anmar Pretorius

“…From a macro perspective, Lithuania’s economic climate during a growth phase provided more support to firms as well as government support in terms of wage subsidies. position the business cycle the general. …”
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Hearing analysis in heterozygous and homozygous klotho gene deficient mice by Na Yuan, Shiwei Qiu, Qian Wang, Wei Zhuang, Guoping Li, Tiantian Sun, Shiming Yang, Yuehua Qiao, Xi Shi

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Characteristics Associated with the Differential Activity of Nondominant and Dominant Affected Hands in Patients with Poststroke Right Hemiparesis by Jen-Pei Lee, Shuya Chen, Chien-Tsung Tsai, Hsu-Chih Chung, Wen-Dien Chang

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Sucla2 Knock‐Out in Skeletal Muscle Yields Mouse Model of Mitochondrial Myopathy With Muscle Type–Specific Phenotypes by Makayla S. Lancaster, Paul Hafen, Andrew S. Law, Catalina Matias, Timothy Meyer, Kathryn Fischer, Marcus Miller, Chunhai Hao, Patrick Gillespie, David McKinzie, Jeffrey J. Brault, Brett H. Graham

“…Physiological and morphological analyses of hindlimb muscles showed remarkable differences in ex vivo function and cellular consequences between the EDL and SOL muscles, with SOL muscles significantly more impacted by Sucla2 inactivation. …”
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Effectiveness and Safety of DLBS3233 in Newly Diagnosed Type 2 Diabetes Mellitus: A 12-week Clinical Trial by Heri Nugroho, Nurmilawati Nurmilawati, Diana Novitasari, Lidia Rombeallo, Rambu Farah Effendi, Reski Reski, Intan Surayya, Nugroho Agung Daryanto, Solomon Putera, Raymond Rubianto Tjandrawinata

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Effectiveness and Safety of DLBS3233 in Newly Diagnosed Type 2 Diabetes Mellitus: A 12-week Clinical Trial by Heri Nugroho, Nurmilawati Nurmilawati, Diana Novitasari, Lidia Rombeallo, Rambu Farah Effendi, Reski Reski, Intan Surayya, Nugroho Agung Daryanto, Solomon Putera, Raymond Rubianto Tjandrawinata

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Posterior Indirect Adhesive Restorations and Preparation Designs by Arife Doğan, Zeynep Söylemez

“…As a result, posterior indirect adhesive restorations are a much more minimally invasive treatment option compared to conventional treatments to achieve aesthetic, functional and biological results.The purpose of this article is to give general information about posterior indirect adhesive restorations and preparation designs.…”
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Neural Mechanisms of Circadian Regulation of Natural and Drug Reward by Lauren M. DePoy, Colleen A. McClung, Ryan W. Logan

“…Circadian rhythms are endogenously generated near 24-hour variations of physiological and behavioral functions. …”
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