CDK2 inhibition sensitizes anthracycline-induced immunogenic cell death and enhances the efficacy of anti-PD-1 therapy by Yu Chen, Wancheng Liu, Qiaomei Cai, Chaohu Pan, Zhenghao Yin, Yijiao Tang, Zhixu He, Genhong Cheng, Liping Shu, Liping Shu

“…IntroductionCDK2 (Cyclin-dependent kinase 2) is an oncogenic cyclin-dependent kinase with potent mitogenic and immunosuppressive functions. Despite extensive research on CDK2 inhibitors, the lack of selectivity has made it unclear whether CDK2 inhibition specifically facilitate immunogenic cell death.MethodsWe used CRISPR-Cas9 system to generate Cdk2-/- MCA205 cells. …”
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Experimental case study for optimizing heat sink performance using ZnO nanocarriers integrated with phase change materials for environmental sustainability by Muhammad Farooq, Imran Zahid, M. Yasar Javaid, Noreen Sher Akbar, Enio Pedone Bandarra Filho, M. Farrukh Shahzad, M. Imran Khan, Mohammad Ilyas Khan, Mohammad Rehan, Fahid Riaz

“…Electronic equipment generates heat during prolonged operation, making efficient heat dissipation essential to ensure continuous functionality and prevent premature device failure. …”
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Patellar motion and dysfunction of its stabilizers in a biomechanical model of the knee joint by A. S. Yurova, A. I. Tyagunova, F. B.  Loginov, Yu. V. Vassilevski, A. V. Lychagin, E. B. Kalinsky, E. V. Larina, N.  V. Gorohova, K. A. Devyatyarov, O. N. Bogdanov, I. B. Kovalenko, K. V. Chesnokova, M. A.  Dergachev, E. Yu. Mychka, O. N. Kosukhin

“…Additionally, deactivation of LR components 1 and 2 induces more medial tilt and translation. Deactivating LR components 3 and 4 leads to further lateral translation and slight additional medial tilt.Conclusion. …”
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In Situ Synthesis of CoMoO₄ Microsphere@rGO as a Matrix for High-Performance Li-S Batteries at Room and Low Temperatures by Ronggang Zhang, Haiji Xiong, Jia Liang, Jinwei Yan, Dingrong Deng, Yi Li, Qihui Wu

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Patient education for people with multiple sclerosis-associated fatigue: A systematic review. by Maria Janina Wendebourg, Christoph Heesen, Marcia Finlayson, Björn Meyer, Jana Pöttgen, Sascha Köpke

“…CBT-based approaches seem to generate better results in reducing patient-reported fatigue severity. …”
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An AI-Based Telerehabilitation Solution to Improve Mobility in People With Multiple Sclerosis (the PLATINUMS Project): Protocol for an Implementation and Evaluation Study by Lars Hvid, Susan Coote, Massimiliano Pau, Alon Kalron

“… BackgroundMultiple sclerosis (MS) is a chronic, progressive, and neurodegenerative disease affecting more than 2.8 million people globally. Mobility impairments are among the most significant challenges faced by people with MS, leading to physical inactivity, deconditioning, and disability progression (for some, even irreversible disability). …”
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Application of 3D Printing Technology in Minimally Invasive Pelvic Surgery by Sergey V. Donchenko, Karen A. Egiazaryan, Andrey A. Prokhorov, Aleksey V. Shabunin, Alexander D. Rubtsov, Alexander M. Nemnonov

“…Due to the technological progress in traumatology, there are more opportunities to apply MIPO (minimally invasive plate osteosynthesis) techniques for treating pelvic ring injuries. …”
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Influences of Gait Training with Knee–Ankle–Foot Orthosis on Gait Ability and Independence in Severe Hemiplegia and Pusher Behavior with Unilateral Spatial Neglect Following Stroke... by Kota Sawa, Miko Tamura, Saori Arai

“…Outcomes comprised the following: procedure A, comparing ambulation at admission and discharge (functional ambulation category [FAC]) and gait independence (FIM‐gait) between groups;and procedure B, investigating factors affecting gait ability, and determinants of pusher behavior with USN presence, derived from demographics. …”
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AI in Medical Questionnaires: Innovations, Diagnosis, and Implications by Xuexing Luo, Yiyuan Li, Jing Xu, Zhong Zheng, Fangtian Ying, Guanghui Huang

“… This systematic review aimed to explore the current applications, potential benefits, and issues of artificial intelligence (AI) in medical questionnaires, focusing on its role in 3 main functions: assessment, development, and prediction. …”
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Role of Fcγ receptors in HER2-targeted breast cancer therapy by Hope S Rugo, Antonino Musolino, William J Gradishar, Jeffrey L Nordstrom, Edwin P Rock, Fernanda Arnaldez, Mark D Pegram

“…Polymorphisms in FcγRIIIa and FcγRIIa generate variants that bind to the Fc portion of antibodies with different affinities. …”
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Emotion Perception and Service Optimization in ChatGPT-Driven Smart Libraries by ZHANG Mingjie, ZHAO Ruixue

“…As smart libraries continue to develop, traditional service models focused only on functionality are no longer enough to meet users' diverse and personalized needs. …”
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Physical Activity as a Factor to Improve the Quality of Student Life by M. M. Kolokoltsev, S. S. Iermakov, N. V. Tretyakova, V. L. Kraynik, E. V. Romanova

“…The values of indicators such as “role functioning”, “pain intensity”, “mental health”, “emotional state”, “social and life activity” fell substantially. …”
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Biochar Is Superior to Organic Substitution for Vegetable Production—A Revised Approach for Net Ecosystem Economic Benefit by Ruiyu Bi, Bingxue Wang, Xintong Xu, Yubing Dong, Ying Jiao, Zhengqin Xiong

“…One kilogram of harvested vegetables for carbon/Nr footprints and one hectare of cultivated land per crop for cost and benefit were adopted as functional units considering the multi-cropping characteristics for intensive vegetable production. …”
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Health effects and mediating mechanisms of smart wearable devices on older people: evidence from China by Enkai Guo, Enkai Guo, Enkai Guo, Shiyi He, Shiyi He, Shiyi He, Lan Zheng, Lan Zheng, Lan Zheng

“…To maximize benefits, we propose a dual-path optimization strategy: (1) Develop age-appropriate functions and use methods to improve device accessibility among older adult people, and (2) Generate a personalized exercise prescription for the older people to promote regular physical activity and exercise habits to improve their health level.…”
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On the problem of linguistic interpretation of the patterns яжемать, онжеребёнок by Fedor Albrekht

“…This article studies patterns of the type яжемать in Russian and shows the insufficiency of the so-called “word-dependent” (system-oriented) approach to the description of semantics and derivational structure of speech units (Russ. яжемать is originally the phrase я же мать, approximately ‘I’m a mother, in fact’, functioning as a single word in the sentence). According to this approach, words and morphemes are self-sufficient sense-generating entities, and the linguist needs to determine their structural properties correctly defi ning their meaning on the base of these properties. …”
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SOCIAL COMPETENCE FORMATION AMONG TEENAGERS FROM HUMANIST TREND MULTIPLE-AGED GROUPS by Larisa A. Krapivina

“…Based on the Children and Youth Public Centre «Carabela» that has been working in Yekaterinburg for more than fifty years, the author discloses how to use the technology of inter-age communication and interaction to provide the continuity of traditions, to preserve historical memory, to transfer humanistic ideas in the chain of generations, and to create personality with sound emotional and moral compass. …”
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Retalho supramaleolar de fluxo reverso: aplicações clínicas Supramalleolous flap of reverse flow: clinical applications by Juliano Candido Batista

“…In the past, with intermediate transfer flaps were used, as the leg cross, are still with major drawbacks: they rely on more than one occasion, generate a lot of discomfort to the patient and are not always effective. …”
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JAUNOSIOS KARTOS KATALIKŲ INTELEKTUALŲ POŽIŪRIS Į FAŠIZMĄ IR NACIONALSOCIALIZMĄ TARPUKARIO LIETUVOJE by Valdas Pruskus

“…Exactly here the new standpoint on democracy, a state and its functioning was being formed. Trying to understand more deeply the origin and character of this phenomenon, the intellectual Catholic youth singled out two expressions of it - fascism and national-socialism. …”
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JAUNOSIOS KARTOS KATALIKŲ INTELEKTUALŲ POŽIŪRIS Į FAŠIZMĄ IR NACIONALSOCIALIZMĄ TARPUKARIO LIETUVOJE by Valdas Pruskus

“…Exactly here the new standpoint on democracy, a state and its functioning was being formed. Trying to understand more deeply the origin and character of this phenomenon, the intellectual Catholic youth singled out two expressions of it - fascism and national-socialism. …”
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JAUNOSIOS KARTOS KATALIKŲ INTELEKTUALŲ POŽIŪRIS Į FAŠIZMĄ IR NACIONALSOCIALIZMĄ TARPUKARIO LIETUVOJE by Valdas Pruskus

“…Exactly here the new standpoint on democracy, a state and its functioning was being formed. Trying to understand more deeply the origin and character of this phenomenon, the intellectual Catholic youth singled out two expressions of it - fascism and national-socialism. …”
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