Acridocarpus smeathmannii root extracts inhibit human prostate and bladder smooth muscle contraction, porcine arterial vasoconstriction, and cytotoxicity of prostate stromal cells by Oluwafemi Ezekiel Kale, Sheng Hu, Claudia Huber, Felix Schierholz, Anna Ciotkowska, Alexander Tamalunas, Christian G. Stief, Wolfgang Eisenreich, Martin Hennenberg

“…In addition, assays were conducted to evaluate cell proliferation and viability, providing complementary insights into functional and cellular-level effects. The bioactive compounds in the extract were characterized using gas chromatography–mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy and were subsequently evaluated in silico for their interaction with the α1-adrenergic receptor.ResultsProstate tissue contractions induced by α1-adrenergic agonists (0.1–100 µM) were reduced by 50% or more with A. smeathmannii at concentrations of 0.25 and 0.50 mg/mL. …”
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Deficiency of T cell CD40L has minor beneficial effects on obesity-induced metabolic dysfunction by Lisa Willemsen, Myrthe den Toom, Myrthe E Reiche, Marion J J Gijbels, Esther Lutgens, Bram van Os, Norbert Gerdes, Suzanne A B M Aarts

“…Our data indicate that other CD40L-expressing cell types are more relevant in the pathogenesis of obesity-associated metabolic dysfunction.…”
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Capturing sexual orientation and gender identity information in electronic medical records to inform the person-centred care of sexual and gender minority people by Simone Schmidt, Timothy Fazio, Aruska N. D’Souza, Stephen Muhi, Kath Feely, Benita Butler, Adam Boulton

“…In November 2022, The Royal Melbourne Hospital (RMH) enabled the SOGI capture EMR functionality. The purpose of this study is to understand how SOGI capture can inform the person-centred care of SGM people by way of interviews with SGM patients and RMH staff. …”
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Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy by Philip D Greenberg, Kristin G Anderson, Shannon K Oda, Breanna M Bates, Madison G Burnett, Magdalia Rodgers Suarez, Susan L Ruskin

“…Background In the USA, more than 50% of patients with ovarian cancer die within 5 years of diagnosis, highlighting the need for therapeutic innovations. …”
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Strong Hsp90α/β Protein Expression in Advanced Primary CRC Indicates Short Survival and Predicts Response to the Hsp90α/β-Specific Inhibitor Pimitespib by Sebastian B. M. Schmitz, Jakob Gülden, Marlene Niederreiter, Cassandra Eichner, Jens Werner, Barbara Mayer

“…The anti-cancer effect and chemosensitization of Pim-based therapy were prospectively confirmed in PDCS directly generated from Hsp90α/β > 40% pCRCs. Protein profiling combined with functional drug testing stratifies Hsp90α/β > 40% pCRC patients diagnosed with UICC IIb-IV for effective Pim-based therapy.…”
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A Monocyte-Driven Prognostic Model for Multiple Myeloma: Multi-Omics and Machine Learning Insights by Xie L, Gao M, Tan S, Zhou Y, Liu J, Wang L, Li X

“…Results indicated that low-risk patients are more likely to benefit from immunotherapy, while a high MGPS score reflects cellular functional impairment.Conclusion: Our findings reveal a complex interplay between immune cells and MM. …”
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Construction and characterization of chimeric FcγR T cells for universal T cell therapy by Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu

“…Methods Chimeric FcγR (CFR) constructs were generated using three distinct forms of FcγR, namely CD16A, CD32A, and CD64. …”
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The sensor histidine kinase PhcS participates in the regulation of quorum sensing-dependent virulence genes in Ralstonia pseudosolanacearum strain OE1-1 by Wakana Senuma, Masayuki Tsuzuki, Chika Takemura, Yuki Terazawa, Akinori Kiba, Kouhei Ohnishi, Kenji Kai, Yasufumi Hikichi

“…It is thus thought that PhcS participates in not only the 3-OH MAME sensing-independently PhcK-mediated regulation of phcA but also the PhcA activation following 3-OH MAME sensing. Both functions of PhcS are significantly influenced by the autophosphorylation of H230-PhcS.IMPORTANCEThe soil-borne Ralstonia solanacearum species complex (RSSC) infects more than 300 plant species in over 50 families, including solanaceous plants, causing the devastating wilt disease that substantially decreases agricultural production worldwide. …”
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A new Maxwell-Log logistic distribution and its applications for mortality rate data by Uthumporn Panitanarak, Aliyu Ismail Ishaq, Alfred Adewole Abiodun, Hanita Daud, Ahmad Abubakar Suleiman

“…We discussed some essential properties of the Max-LL distribution, including moments, moment generating function, probability weighted moments, stress-strength, and order statistics. …”
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A Finite-Interval Uniqueness Theorem for Bilateral Laplace Transforms by Patrick Chareka

“…Two or more bilateral Laplace transforms with a complex argument “s” may be equal in a finite vertical interval when, in fact, the transforms correspond to different functions. …”
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Group Authentication Key Agreement Protocol Based on Certificateless Cryptography in UAV Network by Yuecheng WANG, Youwen ZHU, Zhiqiang ZHANG

“…The central node with high computing power in the group functions as the hub node, undertaking most computing and communication tasks. …”
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Penerapan Algoritma Kunang-Kunang pada Open Vehicle Routing Problem (OVRP) by Ihda Septiyafi, Herry Suprajitno, Asri Bekti Pratiwi

“…The results obtained from the program output indicate that the more the number of iterations and the number of fireflies, then the results of the objective function (total mileage) obtained tend to be better so that these parameters affect the value of the objective function. …”
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A Chimeric Peptide Derived from a Bacterial Effector Protein Attenuates TLR-2/4-Mediated Production of Pro-Inflammatory Cytokines and Enhances the Cellular Availability of Gentamic... by Nandi BR, Patra B, Radhakrishnan GK

“…A chimeric peptide, TB4-BBL2, was then generated and evaluated for cellular uptake, interaction with TLR adaptors, and functional activities. …”
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30 Years of Research in Brand Personality: Mapping Knowledge and Analyzing the Thematic Structure by a Scientometrics Approach by Mohammad Rahim Esfidani, Mohsen Nazari, Shahriar Gharibzadeh, Nakisa Rezaie

“…These roles manifest themselves in functional, symbolic, and emotional domains, sometimes even evolving into emotional bonds between individuals and brands. …”
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Beyond Standard Losses: Redefining Text-to-SQL with Task-Specific Optimization by Iker Azurmendi, Ekaitz Zulueta, Gustavo García, Nekane Uriarte-Arrazola, Jose Manuel Lopez-Guede

“…During the training process, the weights of each component of the loss function are dynamically adjusted to prioritize different aspects of query generation at the appropriate stage. …”
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Long Term Optimal DG Placement Considering Transmission System Reliability and Load Uncertainty by Ali Badri, Mahdy Norouzi

“…This paper presents an optimization method to determine long term optimal DG placement in distribution systems in which system reliability and operational constraints as well as environmental constraints are taken into account. In order to get more realistic results impact of load uncertainty is modeled using normal distribution function. …”
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Energetische upgrading van Nederlandse Wederopbouw flats by Frits Schultheiss

“…The new industrial overcladding repairs defects in the old building envelope. Functionally, this means better wheelchair accessibility, better separation between public and private and more spacious balconies for increased living comfort. …”
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Performance Study on Zn-Doped α-FeOOH in Removing H2S from Blast Furnace Gas by Bin WANG, Xudong LIU, Yuran LI, Li LIU, Wenqing XU, Tingyu ZHU

“…In situ infrared spectroscopy analysis revealed that Zn functions as a catalyst component and also directly interacts with H2S to form ZnS. …”
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Desain Layanan E-Surat untuk Desa Waru Barat, Pamekasan, Madura menggunakan QR-Code by Wahyudi Agustiono, Intan Rofika Putri, Devie Rosa Anamisa

“…Therefore, this research attempted to design and develop e-certificate for Waru Barat Village using QR Code. The functionality testing showed the application successfully generated e-certificate along with the unique QR Code to secure and maintain the validity of the document. …”
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AI in Home Care—Evaluation of Large Language Models for Future Training of Informal Caregivers: Observational Comparative Case Study by Clara Pérez-Esteve, Mercedes Guilabert, Valerie Matarredona, Einav Srulovici, Susanna Tella, Reinhard Strametz, José Joaquín Mira

“… BackgroundThe aging population presents an accomplishment for society but also poses significant challenges for governments, health care systems, and caregivers. Elevated rates of functional limitations among older adults, primarily caused by chronic conditions, necessitate adequate and safe care, including in-home settings. …”
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