Tocilizumab in combination with corticosteroids: potential for managing cancer cachexia with systemic hyperinflammation by Ping Chen, Dingyi Wang, Zhouwei Zhan, Ling Chen, Yu Chen

“…Weight, body mass index, liver metastasis, Eastern Cooperative Oncology Group score, patient-generated subjective global assessments, the Anorexia/Cachexia Subscale of the Functional Assessment of Anorexia/Cachexia Therapy, handgrip strength, neutrophil-to-lymphocyte ratio, and the C-reactive protein, hemoglobin, prealbumin, and albumin levels were recorded in both groups.ResultsTocilizumab treatment favorably influenced the levels of patient biomarkers (p<0.05), ameliorated systemic inflammation, and demonstrated enhanced clinical short-term efficacy compared to the control group, including rates of symptomatic relief (60% vs. 20%, p = 0.024), improvement of serum PAB and ALB (70% vs. 25%, p = 0.004), weight gain >2% (45% vs. 15%, p = 0.038), and improvement of grip strength and 6-m walk speed (p<0.05). …”
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The Impact of Test Number on the Mechanical Properties of Dracaena Draco Cellulose Fibers for Composite Structures: Weibull Statistic by Abdelwaheb Hadou, Ahmed Belaadi, Messaouda Boumaaza, Boon Xian Chai, Mahmood M. S. Abdullah, Ibrahim M. H. Alshaikh, Amar Al-Khawlani, Djamel Ghernaout

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Analysis of Visitor Perceptions of Malang City Thematic Parks using a Text Mining Approach by Nur Izza Vania, Aisyah Larasati, Yuh-Wen Chen, Nikmatus Sholikha

“…City parks, as representations of GOS, can be enhanced through thematic development and place branding to improve user engagement and functional value. This study aims to analyze visitor perceptions of thematic parks by identifying high-frequency keywords extracted from user-generated reviews. …”
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Development of biometric systems for passenger identification based on noise-resistant coding means by A. A. Gladkikh, A. K. Volkov, T. G. Ulasyuk

“…The basic elements and the principle of the classical biometric system functioning are presented. On the basis of the International Civil Aviation Organization (ICAO) recommendations, the procedure features of pattern recognition are presented. …”
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Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome. by Susan M Gribble, Frances K Wiseman, Stephen Clayton, Elena Prigmore, Elizabeth Langley, Fengtang Yang, Sean Maguire, Beiyuan Fu, Diana Rajan, Olivia Sheppard, Carol Scott, Heidi Hauser, Philip J Stephens, Lucy A Stebbings, Bee Ling Ng, Tomas Fitzgerald, Michael A Quail, Ruby Banerjee, Kai Rothkamm, Victor L J Tybulewicz, Elizabeth M C Fisher, Nigel P Carter

“…Here, the combination of next generation sequencing, array-CGH and fluorescence in situ hybridization technologies has enabled us to identify unsuspected rearrangements of Hsa21 in this mouse model; revealing one deletion, six duplications and more than 25 de novo structural rearrangements. …”
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A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples. by Diana Pauly, Benedikt M Nagel, Jörg Reinders, Tobias Killian, Matthias Wulf, Susanne Ackermann, Boris Ehrenstein, Peter F Zipfel, Christine Skerka, Bernhard H F Weber

“…Thus, in vitro anti-properdin mAb 1340 was up to fifteen times more efficient in blocking the complement system as compared to anti-C5 or anti-Ba antibodies. …”
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Assessing the Influence of Selected Permeabilization Methods on Lymphocyte Single-Cell Multi-Omics by Shifan Ding, Na Lu, Hassan Abolhassani

“…(1) Background: Single-cell multi-omics is a powerful method for the dissection and detection of complicated immunologic functions and synapses. However, most currently available technologies merge datasets of different omics from separate portions of the same sample to generate combined multi-omics. …”
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The Effectiveness of Transcranial Magnetic Stimulation (TMS) Paradigms as Treatment Options for Recovery of Language Deficits in Chronic Poststroke Aphasia by Anastasios M. Georgiou, Maria Kambanaros

“…Language assessment, with standardized and functional measures, and cognitive evaluations were carried out at four time points: twice prior to treatment (baseline), one day immediately posttreatment, and at follow-up two months after treatment was terminated. …”
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Effect of Steam Explosion Pretreatment on Nutritional and Antioxidant Properties of Rapeseed Oil by HUANG Ying, ZHENG Chang, ZHOU Qi, LIU Changsheng, LI Wenlin

“…As the explosion pressure increased, the moisture content gradually declined from 42.17% to 92.24%, and the oil yield initially increased and then decreased, and the contents of oleic acid, linoleic acid, and α-linolenic acid significantly changed. The energy generated during steam explosion pretreatment could effectively destroy active substance complexes, resulting in the release of more free polyphenols, so that the average content of total phenols in the treatment group was increased by 9.56 folds on average when compared with the control group. …”
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Advanced Microfluidic Biofuel Cells Using Gold and Silver Leaf on Paper and PDMS Substrates: Toward Implantable Energy Solution by S. Vanmathi, Sanket Goel

“…Microfluidic biofuel cells with nanostructured gold and silver leaf devices harvest ultra-low power energy, making them more practical for real-world applications. The gold and silver leaf enzymatic biofuel cell (LEBFC) operates using glucose as fuel, with glucose oxidase functioning at the anode and laccase at the cathode, both coating the GL and SL bioelectrodes. …”
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Modeling the challenges affecting the internationalization of the Persian Gulf Pro League by Sajad Soroush, Geoff Dickson, Nasrollah Sajjadi, Ebrahim Alidoust Ghahfarokhi

“…Overall, the internationalization of a sports league can help it grow, become more competitive, and reach a wider audience, leading to benefits for both the league and its fans. …”
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Two-stream spatio-temporal GCN-transformer networks for skeleton-based action recognition by Dong Chen, Mingdong Chen, Peisong Wu, Mengtao Wu, Tao Zhang, Chuanqi Li

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Nonlinear behavior of dispersive solitary wave solutions for the propagation of shock waves in the nonlinear coupled system of equations by Mujahid Iqbal, Waqas Ali Faridi, Huda Daefallh Alrashdi, Abeer Aljohani, Muhammad Amin S. Murad, Nazar Mohammad, Abdullah S. Alsubaie

“…Consequently, various solutions in solitons and solitary waves are generated in rational, trigonometric, and hyperbolic functions and displayed within contour, two–dimension and three–dimension plotting by using the numerical simulation. …”
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Sculpting molecules in text-3D space: a flexible substructure aware framework for text-oriented molecular optimization by Kaiwei Zhang, Yange Lin, Guangcheng Wu, Yuxiang Ren, Xuecang Zhang, Bo Wang, Xiao-Yu Zhang, Weitao Du

“…This work not only holds general significance for the advancement of deep learning methodologies but also paves the way for a transformative shift in molecular design strategies. 3DToMolo creates opportunities for a more nuanced and effective exploration of the vast chemical space, opening new frontiers in the development of molecular entities with tailored properties and functionalities.…”
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Quantifying conformational heterogeneity of 3D genome organization in fruit fly. by Samira Mali, Igor S Tolokh, Erik Cross, Alexey V Onufriev

“…Within our computational approach, depletion of nuclear lamins leads to increased structural heterogeneity at nearly all genomic separations, with the potential implication that cell functions that depend on chromatin structure might be more variable within lamins depleted nuclei compared to the wild type.…”
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Novel resistance to Cydia pomonella granulovirus (CpGV) in codling moth shows autosomal and dominant inheritance and confers cross-resistance to different CpGV genome groups. by Annette J Sauer, Eva Fritsch, Karin Undorf-Spahn, Petr Nguyen, Frantisek Marec, David G Heckel, Johannes A Jehle

“…Commercial Cydia pomonella granulovirus (CpGV) products have been successfully applied to control codling moth (CM) in organic and integrated fruit production for more than 30 years. Since 2005, resistance against the widely used isolate CpGV-M has been reported from different countries in Europe. …”
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A Qualitative Study Examining the Unintended Consequences from Implementing a Case Management Team to Reduce Avoidable Hospital Readmission in Singapore by Shilpa Surendran, Stephen So, Toon Wei Lim, David Bruce Matchar

“…As a result, the intervention team functioned more as a consulting service, providing recommendations to the primary team, which retained decision-making authority. …”
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Prediction and design of thermostable proteins with a desired melting temperature by Purva Tijare, Nishant Kumar, Gajendra P. S. Raghava

“…Abstract The stability of proteins at higher temperatures is crucial for their functionality, which is measured by their melting temperature (Tm). …”
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Cost-effectiveness of percutaneous mitral repair for patients with severe secondary mitral regurgitation: an updated evaluation using a modelling approach based on COAPT final data... by Xavier Armoiry, Peter Auguste, Martin Connock, Jean-Francois Obadia

“…After discounting, the model generated life-years of 3.843 years and 3.055 years for PR+GDMT and GDMT, respectively. …”
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Assessment of test-retest reproducibility by [18F]Bavarostat for PET imaging of HDAC6 by Mika Naganawa, Ming-Qiang Zheng, Jean-Dominique Gallezot, Robin Bonomi, Jiwei Gu, Hong Gao, Swanee Jacutin-Porte, Nabeel B. Nabulsi, Michel Koole, Koen Van Laere, David Matuskey, Yiyun Huang, Richard E. Carson

“…Arterial blood sampling and metabolite analysis were performed to derive the input function. The two scans were 28 ± 12 days apart (14–43 days, n = 6). …”
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