Research Progress of DNA Methylation in Fish by Hai HUANG, Yan LU, Liu CAO

“…Differential methylation—cytosine-phosphate-guanine sites—is involved in apoptosis, epigenetic regulation, autophagy, collagen metabolism, cell membrane function, and homeobox protein generation through gene expression regulation. …”
Get full text

Direct conversion of urine-derived cells into functional motor neuron-like cells by defined transcription factors by Hiroaki Nagai, Masayo Saito, Hidehisa Iwata

“…Herein, induced motor neuron-like cells (iMNs) were generated from UDCs by transducing transcription factors involved in motor neuron (MN) differentiation. iMNs exhibited neuronal morphology, upregulation of pan-neuron and MN markers, and MN functionality, including spontaneous calcium oscillation and bungarotoxin-positive neuromuscular junction formation, when co-cultured with myotubes. …”
Get full text

Hyperspectral Data Can Classify Plant Functional Groups Within New Zealand Hill Farm Pasture by Thomas A. Cushnahan, Miles C. E. Grafton, Diane Pearson, Thiagarajah Ramilan

“…This study used hyperspectral imagery to map hill country pasture into plant functional groups (PFGs) as a proxy for pasture quality. …”
Get full text

Combined transcriptome and proteome profiling reveal cell-type-specific functions of Drosophila garland and pericardial nephrocytes by Heiko Meyer, Judith Bossen, Maren Janz, Xenia Müller, Sven Künzel, Thomas Roeder, Achim Paululat

“…Factor-specific comparisons identified novel candidate proteins either expressed and secreted by the nephrocytes or sequestered by them. The data generated in this study represent a valuable basis for a more specific application of the Drosophila model in analysing renal cell function in health and disease.…”
Get full text

Large-scale urban building function mapping by integrating multi-source web-based geospatial data by Wei Chen, Yuyu Zhou, Eleanor C. Stokes, Xuesong Zhang

“…Due to the limited availability of socio-economic geospatial data, it is more challenging to map building functions than building morphological information, especially over large areas. …”
Get full text

Narrowing the gap between machine learning scoring functions and free energy perturbation using augmented data by Ísak Valsson, Matthew T. Warren, Charlotte M. Deane, Aniket Magarkar, Garrett M. Morris, Philip C. Biggin

Get full text

Intra-abdominal pressure and residual renal function decline in peritoneal dialysis: a threshold-based investigation by Jingjing Zhang, Lei Song, Zhongwei Ma, Lina Sun, Xiaoqing Wang, Duanyan Liu, Feng Huang, Yulin Man

“…Receiver operating characteristic (ROC) curves were generated to determine the optimal threshold value. …”
Get full text

Investigating the causal pathways among psychopathological variables, cognitive impairment, and real-life functioning in people with schizophrenia by Luigi Giuliani, Francesco Sanmarchi, Armida Mucci, Paola Rucci, Edoardo Caporusso, Paola Bucci, Giulia M. Giordano, Mario Amore, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Silvana Galderisi, Mario Maj

“…State-of-the-art instruments were used to assess the study variables. Two PAGs were generated at baseline and after 4 years of follow-up to model the nature of the causal relationships linking psychopathology, cognition, and functioning. …”
Get full text

Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs) by Emma Keltsch, Jennifer Greiner, Lena Wahl, Ingrid Knape, Daniel Tews, Michael Denkinger, Klaus-Michael Debatin, Gudrun Strauss

“…Myeloid-derived suppressor cells (MDSCs) are potent inhibitors of T cell activation and function, whose induction requires chronic inflammation. …”
Get full text

Functional properties and toxicological analysis of nanocellulose-based aerogels loaded with polyphenols from Hyeronima macrocarpa berries by Andrés Felipe Alzate-Arbeláez, Farid B. Cortés, Benjamín A. Rojano

“…The differences found in samples for the different functional assays can be explained by the various types of interactions generated between the antioxidant molecules and aerogels, in the various media where the analyses are carried out. …”
Get full text

Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice by Jie Li, Yuanjie Guo, Liyuan Ma, Yixiang Liu, Chao Zou, Huiying Kuang, Bing Han, Yingliang Xiao, Yanbo Wang

Get full text

Electrogeneration of non-electroactive and non-conducting materials: a counterintuitive concept for the functionalization and nanostructuration of electrode surfaces by Walcarius, Alain

“…It is mainly based on electrochemically induced redox reactions involving electroactive precursors, which are intended to form solid deposits onto the electrode surface. More recently, a rather counterintuitive approach has emerged by exploiting electrochemistry to generate non-electroactive and non-conductive thin films (e.g., sol–gel derived materials), based on the electrogeneration of a catalyst that is likely to induce indirectly the formation of a thin film (i.e., without direct electron transfer with the precursors). …”
Get full text

FUNCTIONAL ACTIVITY OF IFNα- AND IL-4-INDUCED HUMAN DENDRITIC CELLS: A COMPARATIVE STUDY by O. Yu. Leplina, M. A. Tikhonova, T. V. Tyrinova, E. A. Alyamkina, S. S. Bogachev, A. A, Ostanin, E. R. Chernykh

“…It was shown that IL-4-DCs and IFN-DCs didnot differ in their key functional characteristics, i.e., in their ability to stimulate proliferation of T-cells inresponse to alloantigens, and to induce generation of T-regulatory cells in mixed leukocyte culture. …”
Get full text

Recent advances on biogenesis, functions and therapeutic potential of long noncoding RNAs in T cell acute lymphoblastic leukemia by Parminder Kaur, Pankaj Sharma, Prateek Bhatia, Minu Singh

Get full text

Reference Function Based Spatiotemporal Fuzzy Logic Control Design Using Support Vector Regression Learning by Xian-Xia Zhang, Ye Jiang, Shiwei Ma, Bing Wang

“…The concept of reference function is introduced to 3D FLC for the generation of 3D membership functions (MF), which enhance the capability of the 3D FLC to cope with more kinds of MFs. …”
Get full text

Effects of Mesenchymal Stem Cells on Functions of Chimeric Antigen Receptor-Expressing T Lymphocytes and Natural Killer Cells by Vladislav Volarevic, Carl Randall Harrell, Aleksandar Arsenijevic, Valentin Djonov, Ana Volarevic

“…Additionally, MSCs may serve as vehicles for targeted delivery of immunomodulatory agents, and should be considered as active components in the design of next-generation CAR-based immunotherapies. Accordingly, in this review article we emphasize molecular and cellular mechanisms involved in MSC-dependent modulation of CAR-expressing immune cells, paving the way for more efficient CAR-based immunotherapy for malignant diseases.…”
Get full text

Increased functional potency of multi-edited CAR-T cells manufactured by a non-viral transfection system by Aine O’Sullivan, Sarah Case, Aisling McCrudden, Emer Hackett, Louise Gallagher, Darren Martin, Gillian P. Johnson, Kirti Mahadik, Thomas Kienzle, Jude Kevin Lim, Aya Nashat, Kartik Srinivasan, Mark W. Lowdell, Lisa O’Flynn, Jamie Frankish

“…Improving manufacturing processes to preserve cell health and function of edited T cells is equally critical. Here, we report that Solupore, a Good Manufacturing Practice-aligned, non-viral physicochemical transfection system, can be used to manufacture multi-edited CAR-T cells using CRISPR-Cas9 ribonucleoproteins while maintaining robust cell functionality. …”
Get full text

Metagenomic and physicochemical profiling reveal microbial functions in pit mud for Jiang-Nong Jianxiang Baijiu fermentation by Lianbin Cao, Hongmei Sun, Ziyi Xu, Xiaoxiao Xu, Guangchuan Shi, Jianqiang Zhang, Changli Liang, Tongbiao Li, Chaoying Liu, Mingcheng Wang, Shilin Tian, Enzhong Li

Get full text

Transplantation of decellularized porcine kidney grafts repopulated with primary human cells demonstrates filtration function in pigs by David Y. Lo, Boyukkhanim Ahmadzada, MacKenna A. Stachel, Melia Schaefer, Usman Ashraf, John I. Wagner, Ethan J. Vanderslice, Madie Tornquist, Kendra Mariakis, Peggy Halsten, Christopher D. Lindsay, Emily C. Beck, Scott L. Nyberg, Jeffrey J. Ross

“…Conclusions Our results showcase a human-scale, transplantable bioengineered kidney capable of performing requisite filtration function. This study reinforces the possibility for the bioengineering of transplantable human kidneys, which could someday provide increased and more equitable access to kidney grafts for the treatment of end-stage renal disease.…”
Get full text

PhyloFunc: phylogeny-informed functional distance as a new ecological metric for metaproteomic data analysis by Luman Wang, Caitlin M. A. Simopoulos, Joeselle M. Serrana, Zhibin Ning, Yutong Li, Boyan Sun, Jinhui Yuan, Daniel Figeys, Leyuan Li

“…A more informative functional distance metric that incorporates evolutionary relatedness is needed to better understand microbiome functional dissimilarities. …”
Get full text