Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones. by Erik A Koppes, Marie A Johnson, James J Moresco, Patrizia Luppi, Dale W Lewis, Donna B Stolz, Jolene K Diedrich, John R Yates, Ronald C Wek, Simon C Watkins, Susanne M Gollin, Hyun Jung Park, Peter Drain, Robert D Nicholls

“…Consistent with reduced ER chaperones levels, PWS INS-1 β-cells are more sensitive to ER stress, leading to earlier activation of all three arms of the unfolded protein response. …”
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A Novel Time-Varying P-III Distribution Curve Fitting Model to Estimate Design Floods in Three Gorges Reservoir Operation Period by Yuzuo Xie, Shenglian Guo, Sirui Zhong, Xiaoya Wang, Jing Tian, Zhiming Liang

“…The results indicate that: (1) The modified reservoir index used as a covariate can effectively capture the non-stationary characteristics of the flood series; (2) The Tv-P3/CF model emphasizes the fitness of historical information, yielding superior results compared to time-varying P-III distribution estimated by the maximum likelihood method; (3) Compared to the original design values, the 1000-year design peak discharge <i>Q</i>_m and 3-day and 7-day flood volumes in the TGR operation period are reduced by approximately 20%, while the 15-day and 30-day flood volumes are reduced by about 16%; (4) The flood-limited water level of the TGR can be raised from 145 m to 154 m, which can annually generate 0.32 billion kW h more hydropower (or increase by 6.8%) during flood season without increasing flood prevention risks.…”
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The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. by Les Dethlefsen, Sue Huse, Mitchell L Sogin, David A Relman

“…We investigated the distal gut bacterial communities of three healthy humans before and after treatment with ciprofloxacin, obtaining more than 7,000 full-length rRNA sequences and over 900,000 pyrosequencing reads from two hypervariable regions of the rRNA gene. …”
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Synthesis and in silico studies of new thiophene-isoquinolinone hybrids as potential larvicides against Culex pipiens by Mahmoud Kamal, Mohamed H. Hekal, Fatma S. M. Abu El-Azm, Eslam M. Hosni, Yasmeen M. Ali, Abdullah Yahya Abdullah Alzahrani, El-Hady Rafat

“…Density Functional Theory (DFT) calculations further confirmed the favorable electronic properties and reactivity of the active compounds. …”
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ELTrack: Events-Language Description for Visual Object Tracking by Mohamad Alansari, Khaled Alnuaimi, Sara Alansari, Sajid Javed

“…ELTrack synthesizes event data, filters out noise, and applies imprinting and a step decay function to introduce a novel event image representation called Pseudo-Frames. …”
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The role of long non‐coding RNAs in lung cancer metastasis: Molecular mechanisms, pathogenesis and clinical implications by Musaffe Tuna, Gordon B Mills, Christopher I. Amos

“…Frequent treatment failure due to therapy resistance, highlight the urgent need to identify novel biomarkers for early diagnosis, prognosis, and the development of more effective therapies. This underscores the necessity and urgency of researching lncRNAs. …”
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Intertextuality of the Personosphere as a Factor of Meta-Genre (Clifford Simak “Shakespeare’s Planet”) by Dan Paranyuk, Alyona Tychinina

“…In this case, in Simak’s “Shakespeare’s Planet”, they perform the function of additional (implicit) narratives, and, consequently, as a particular (intertextual) link in the personosphere. …”
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Complex Synchronization Dynamics of Electronic Oscillators&#x2013;Part II: Simulations and Validation of Phase-Amplitude Reduced Models by Konstantinos Metaxas, Nikolaos P. Eleftheriou, Yannis Kominis, Paul P. Sotiriadis

“…The developed time-domain approach demonstrates that the same limit cycle oscillator can produce periodic output with tunable spectral characteristics, operating as a frequency divider, or function as a chaotic or quasiperiodic signal generator, depending on the driving signal. …”
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Optimal Planning of Wind-Based DG: A Two-Stage Approach Linking Penetration Factor, Turbine Type Selection, Capacity, and Power Factors to Minimize Line Losses by Sina Saboktakin, Tarek Medalel Masaud, Ehab F. El-Saadany

“…This is achieved through a novel correlation between DG size, loss reduction, and power factor improvement, ensuring a cost-effective and efficient solution using a single-objective function instead of more complex multi-objective approaches. …”
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Co-Simulation Model for Determination of Optimal Active Power Filters Settings in Low-Voltage Network by Mario Primorac, Zvonimir Klaić, Heidi Adrić, Matej Žnidarec

“…Applying optimization techniques enables the development of more realistic models for applying active power filters. …”
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Biomechanics and Performance of Single-Leg Vertical and Horizontal Hop in Adolescents Post-Anterior Cruciate Ligament Reconstruction by Eva M. Ciccodicola, Alison M. Hanson, Shawn E. Roberts, Mia J. Katzel, Tishya A. L. Wren

“…Adult studies support the use of single-leg vertical hop (SLVH) due to higher power generation from knee extensors compared to single-leg horizontal hop (SLHH). …”
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SYNERGIC EFFECT OF PREPARATION WITH COORDINATION COMPLEX “TRIMETHYDRAZINIUM PROPIONATE+ETHYMTH METHYLHYDROXYPIRIDINE SUCCINATE” ON ENERGY METABOLISM AND CELL RESPIRATION by M. V. Zhuravleva, M. V. Granovskaya, K. Ya. Zaslavskaya, Yu. G. Kazaishvili, V. S. Scherbakova, A. A. Andreev-Andrievskiy, D. I. Pozdnyakov, M. Yu. Vyssokikh

“…In the study of the mitochondrial respiration stimulated by the substrates of complex I (NADP-coenzyme Q-oxidoreductase), pyruvate and malate, the studied drug led to a more pronounced increase in the oxygen consumption with IC50=75±6 µМ. …”
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Social Networks Link Prediction Based on Incremental Learning by Jian SHU, Zhichen CHEN

“…An incremental update strategy is designed for each network layer to generate updated random walk sequences, employing a temporal random walk approach. …”
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Novelle approach to simulating spinal cord stimulation during tSCS using CT images and FEM by Árnason Jón Andri, Guðmundsdóttir-Korchai Ragnhildur, Afework Tesfahunegn Yonatan, Helgason Þórður

“…Later versions of FEM models incorporated more organs and had improved on previous mesh generation flaws, but encountered new mesh generation errors which could not be rectified before the conclusion of the master’s project. …”
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A statistical framework for modelling migration corridors by Tristan A. Nuñez, Mark A. Hurley, Tabitha A. Graves, Anna C. Ortega, Hall Sawyer, Julien Fattebert, Jerod A. Merkle, Matthew J. Kauffman

“…We tested the ability of the approach to recover parameters used to generate simulated movements. We then used GPS data from three migrating mule deer Odocoileus hemionus herds in Idaho and Wyoming to model corridors as a function of elevation, slope, aspect, percent shrub, date of peak green‐up, snow‐off date and human footprint. …”
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HyQ2:&#x2009;A&#x2009;Hybrid&#x2009;Quantum&#x2009;Neural&#x2009;Network for&#x2009;NextG&#x2009;Vulnerability&#x2009;Detection by Yifeng Peng, Xinyi Li, Zhiding Liang, Ying Wang

“…As fifth-generation (5G) and next-generation communication systems advance and find widespread application in critical infrastructures, the importance of vulnerability detection becomes increasingly critical. …”
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Programmable production of bioactive extracellular vesicles in vivo to treat myocardial infarction by Siyuan Fu, Zhiyu Wang, Peihong Huang, Guanjun Li, Jian Niu, Zhiyang Li, Guangyue Zu, Pengcheng Zhou, Lianhui Wang, David Tai Leong, Xianguang Ding

“…The technology, termed electroactive patch for wirelessly and controllable EV generation (ePOWER), leverages wireless bioelectronic patch to stimulate embedded electrosensitive macrophages, actively modulating the biosynthesis of EVs and enabling EV production with high programmability to be delivered directly to the MI area. ~2400% more bioactive EVs were produced per cell under our ePOWER system. …”
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The Use of Autologous Bone Graft vs Allograft Viable Cell Matrix in Forefoot, Midfoot, and Hindfoot Fusion by John O'Keefe MD, Sarah Hall BA, Chase Gauthier MD, Christopher Toussaint MD, Edward Haupt MD, J. Benjamin Jackson MD, MBA, Tyler Gonzalez MD, MBA

“…Allograft may be useful as an alternative to autograft given its high accessibility and lack of harvesting complications. Newer generation allograft mixtures containing osteoconductive, osteoinductive and osteogenic factors which may have similar or even higher rates of success compared to older generations of allograft. …”
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Lysosomal NKG7 restrains mTORC1 activity to promote CD8+ T cell durability and tumor control by Hyoungjun Ham, Jacob B. Hirdler, Daniel T. Bihnam, Zhiming Mao, Joanina K. Gicobi, Bruna Gois Macedo, Maria F. Rodriguez-Quevedo, Destiny F. Schultz, Cristina Correia, Jun Zhong, Kodi E. Martinez, Alma Banuelos, Dallin S. Ashton, Anthony B. Lagnado, Ruifeng Guo, Rodrigo Pessoa, Akhilesh Pandey, Hu Li, Fabrice Lucien, Henrique Borges da Silva, Haidong Dong, Daniel D. Billadeau

“…Human and mouse CD8+ T cells lacking NKG7 show more acidic lysosomes and increased activation of mTORC1 signaling, which could be reversed by inhibition of v-ATPase activity. …”
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Flavones enrich rhizosphere Pseudomonas to enhance nitrogen utilization and secondary root growth in Populus by Jiadong Wu, Sijia Liu, Haoyu Zhang, Sisi Chen, Jingna Si, Lin Liu, Yue Wang, Shuxian Tan, Yuxin Du, Zhelun Jin, Jianbo Xie, Deqiang Zhang

“…Abstract Plant growth behavior is a function of genetic network architecture. The importance of root microbiome variation driving plant functional traits is increasingly recognized, but the genetic mechanisms governing this variation are less studied. …”
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