Fluid balance-adjusted creatinine at initiation of continuous venovenous hemofiltration and mortality. A post-hoc analysis of a multicenter randomized controlled trial. by Susanne Stads, Louise Schilder, S Azam Nurmohamed, Frank H Bosch, Ilse M Purmer, Sylvia S den Boer, Cynthia G Kleppe, Marc G Vervloet, Albertus Beishuizen, Armand R J Girbes, Pieter M Ter Wee, Diederik Gommers, A B Johan Groeneveld, Heleen M Oudemans-van Straaten, CASH study group

“…However, creatinine is not only determined by renal function (excretion), but also by dilution (fluid balance) and creatinine generation (muscle mass). …”
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Prostruc: an open-source tool for 3D structure prediction using homology modeling by Shivani V. Pawar, Wilson Sena Kwaku Banini, Musa Muhammad Shamsuddeen, Toheeb A. Jumah, Nigel N. O. Dolling, Abdulwasiu Tiamiyu, Olaitan I. Awe

“…IntroductionHomology modeling is a widely used computational technique for predicting the three-dimensional (3D) structures of proteins based on known templates,evolutionary relationships to provide structural insights critical for understanding protein function, interactions, and potential therapeutic targets. …”
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Longer Drug Retention of Interleukin-12/23 or Interleukin-17 Inhibitors Compared With TNF Inhibitors in Female Patients With TNF Inhibitor-Experienced Psoriatic Arthritis by Godehard A. Scholz, MD, PhD, Eleftherios Papagiannoulis, MSc, Christoph Blapp, MSc, Raphael Micheroli, MD, Adrian Ciurea, MD, Michael J. Nissen, MD, Nikhil Yawalkar, MD, Diana Dan, MD, Jennifer Amsler, MD, Almut Scherer, PhD, Burkhard Möller, MD

“…Objective: To compare the effectiveness of Interleukin (IL)-12/23 or IL-17A inhibitors (summarized to inhibitors of the Th17 cell generation or function, Th17i) with tumor necrosis factor inhibitors (TNFi) in patients with TNFi-experienced psoriatic arthritis (PsA). …”
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Blockchain and NFT-Based Solution for Genomic Data Management, Sharing, and Monetization by Ahmad Musamih, Khaled Salah, Raja Jayaraman, Samer Ellaham, Mohammed Omar, Ibrar Yaqoob

“…We present various diagrams and algorithms to illustrate the functionality of our solution. Our testing and validation results demonstrate that smart contracts function as intended. …”
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Quasi-parallel Antisunward-propagating Whistler Waves Associated with the Electron Deficit in the Near-Sun Solar Wind: Particle-in-cell Simulation by Alfredo Micera, Daniel Verscharen, Jesse T. Coburn, Maria Elena Innocenti

“…In situ observations of the solar wind have shown that the electron velocity distribution function (VDF) consists of a quasi-Maxwellian core, comprising most of the electron population, and two sparser components: the halo, which are suprathermal and quasi-isotropic electrons, and an escaping beam population, the strahl. …”
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The Development and Applications of a Dual Optical Imaging System for Studying Glioma Stem Cells by Po-An Tai MD, PhD, Yen-Lin Liu MD, PhD, Ya-Ting Wen MD, Chien-Min Lin MD, PhD, Thanh-Tuan Huynh MD, PhD, Michael Hsiao DVM, PhD, Alexander T. H. Wu PhD, Li Wei MD, PhD

“…Subsequently, Btk inhibitor, ibrutinib, suppressed GSC generation and stemness markers. Finally, we demonstrated real-time evaluation of anti-GSC function of ibrutinib in vivo with TMZ-enriched GSCs. …”
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Efficient and Effective NDVI Time-Series Reconstruction by Combining Deep Learning and Tensor Completion by Ang Li, Menghui Jiang, Dong Chu, Xiaobin Guan, Jie Li, Huanfeng Shen

“…The ST-Tensor method is first used to generate high-quality seamless NDVI data as the label data to construct sample pairs, along with the original degraded observations. …”
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Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapy by Yutao Zou, Junjie Wu, Qiuyun Zhang, Jiayi Chen, Xuanxuan Luo, Yijie Qu, Rui Xia, Weiqi Wang, Xiaohua Zheng

“…Porphyrins-based nanoscale metal-organic frameworks (nMOFs) has been widely utilized to kills tumor cells by generating cytotoxic reactive oxygen species (ROS). …”
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Global Simulations of Gravitational Instability in Protostellar Disks with Full Radiation Transport. I. Stochastic Fragmentation with Optical-depth-dependent Rate and Universal Fra... by Wenrui Xu, Yan-Fei Jiang, Matthew W. Kunz, James M. Stone

“…Applying this result to typical Class 0/I protostellar disks, we find m _frag ∼ 20 M _J , suggesting that fragmentation more likely forms brown dwarfs. Given the finite width of the m _frag distribution, forming massive planets is also possible.…”
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Integrating the Prior Shape Knowledge Into Deep Model and Feature Fusion for Topologically Effective Brain Tumor Segmentation by Salma Asif, Ahmad Raza Shahid, Kiran Aftab, Syed Ather Enam

“…Deep learning techniques totally rely on the loss function optimization and due to the lack of explicit form of prior knowledge, they may struggle to generate the accurate tumor shapes. …”
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An IoT intrusion detection framework based on feature selection and large language models fine-tuning by Huan Ma, Wan Zhang, Dalong Zhang, Baozhan Chen

“…This algorithm utilizes the CMA-ES algorithm for feature search while also taking into account the mutual information and collinearity among features, thereby more effectively reducing redundancy features. Subsequently, we employ the selected representative features to fine-tune LLMs and generate additional attack samples. …”
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Nutrigenomic and Nutritional Analyses Reveal the Effects of Pelleted Feeds on Asian Seabass (Lates calcarifer). by Si Yan Ngoh, Daniel Tan, Xueyan Shen, Purushothaman Kathiresan, Junhui Jiang, Woei Chang Liew, Natascha May Thevasagayam, Hsiao Yuen Kwan, Jolly M Saju, Sridatta R S Prakki, Chin Heng Goh, Hong Ching Wong, Tai Teck Chan, Miklós Mézes, László Orbán

“…Significant enrichment of genes with growth-related function tallied with the morphological data measured. …”
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Few-Shot Unsupervised Domain Adaptation Based on Refined Bi-Directional Prototypical Contrastive Learning for Cross-Scene Hyperspectral Image Classification by Xuebin Tang, Hanyi Shi, Chunchao Li, Cheng Jiang, Xiaoxiong Zhang, Lingbin Zeng, Xiaolei Zhou

“…Furthermore, our framework introduces the class-balanced multicentric dynamic prototype strategy to generate more robust and representative prototypes. …”
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Gene expression profiling of extraocular muscles in primary inferior oblique overaction by Rui Hao, Yuchuan Wang, Wei Zhang

“…The results indicated that multiply innervated muscle fibers were more abundant in the primary IOOA group, likely enabling slow tension generation, whereas the secondary IOOA group exhibited higher collagen fibril levels that might improve muscle stiffness.…”
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A New Hybrid Machine Learning Method for Stellar Parameter Inference by Sujay Shankar, Michael A. Gully-Santiago, Caroline V. Morley

“…This creates the PHOENIX generator, enabling parallelized spectral synthesis. …”
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Statistical Analysis of Inverse Weibull based on Step-Stress Partially Accelerated Life Tests with Unified Hybrid Censoring Data by Amal Soliman Hassan, Abd ELwahab Hagag, Nader Metwally, Omar Hussein Sery

“…For the purpose of estimating the model parameters and acceleration factor, the maximum likelihood approach is applied along with the maximum product of the spacing procedure to generate point and interval estimates. The squared error loss function is used to calculate the Bayes point estimates based on the assumption of independent gamma priors. …”
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Complex Synchronization Dynamics of Electronic Oscillators–Part I: A Time-Domain Approach via Phase-Amplitude Reduced Models by Konstantinos Metaxas, Paul P. Sotiriadis, Yannis Kominis

“…The developed time-domain approach demonstrates that the same limit cycle oscillator can produce periodic output with tunable spectral characteristics, operating as a frequency divider, or function as a chaotic or quasiperiodic signal generator, depending on the driving signal. …”
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Assessing molecular docking tools: understanding drug discovery and design by Harendar Kumar Nivatya, Anjali Singh, Nitin Kumar, Sonam, Lovy Sharma, Vishal Singh, Raghav Mishra, Nishant Gaur, Arun Kumar Mishra

“…Main Body of the Abstract The study of molecular docking with relative components like classifications, models, and different types of approaches and techniques involved, pose generation, scoring function advantages, disadvantages, and comparison with other types of docking tools to conduct the molecular docking with steps involved will be helpful to learn computer-aided drug design and artificial intelligence. …”
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Syphilitic infection: a study on the factors of the innate humoral immune response by N. K. Levchik, N. V. Zilberberg, M. V. Ponomareva, O. A. Belykh

“…Antibodies against oxidized low-density lipoprotein and cardiolipin were detected more frequently than antibodies against mitochondrial antigen M2, modified citrullinated vimentin, cyclic citrullinated peptide, nuclear antigens, myeloperoxidase, proteinase 3, Fc portion of immunoglobulin G. …”
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Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni. by Kathrin K Geyer, Sabrina E Munshi, Helen L Whiteland, Narcis Fernandez-Fuentes, Dylan W Phillips, Karl F Hoffmann

“…By further elucidating how Schistosoma molecular components cooperate to regulate parasite developmental processes, next generation targets will be identified. Here, we continue our studies on schistosome epigenetic participants and characterise the function of a DNA methylation reader, the Schistosoma mansoni methyl-CpG-binding domain protein (SmMBD2/3). …”
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