SYNERGIC EFFECT OF PREPARATION WITH COORDINATION COMPLEX “TRIMETHYDRAZINIUM PROPIONATE+ETHYMTH METHYLHYDROXYPIRIDINE SUCCINATE” ON ENERGY METABOLISM AND CELL RESPIRATION by M. V. Zhuravleva, M. V. Granovskaya, K. Ya. Zaslavskaya, Yu. G. Kazaishvili, V. S. Scherbakova, A. A. Andreev-Andrievskiy, D. I. Pozdnyakov, M. Yu. Vyssokikh

“…In the study of the mitochondrial respiration stimulated by the substrates of complex I (NADP-coenzyme Q-oxidoreductase), pyruvate and malate, the studied drug led to a more pronounced increase in the oxygen consumption with IC50=75±6 µМ. …”
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Exploring the impact of chronic intermittent EU-GMP certified Cannabis sativa L. therapy and its relevance in a rat model of aging by Ivona-Maria Tudorancea, Gabriela-Dumitrita Stanciu, Carmen Solcan, Mitica Ciorpac, Andrei Szilagyi, Daniela-Carmen Ababei, Raluca-Maria Gogu, Bogdan-Ionel Tamba

“…Abstract Background Aging is a multifaceted process marked by the progressive accumulation of cellular damage in various tissues, resulting in a decline in physiological functions. The primary aim of aging research is to identify compounds that can delay or mitigate these detrimental changes. …”
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Leveraging Large Language Models for Predicting Postoperative Acute Kidney Injury in Elderly Patients by Hanfei Zhu, Ruojiang Wang, Jiajie Qian, Yuhao Wu, Zhuqing Jin, Xishen Shan, Fuhai Ji, Zixuan Yuan, Tingrui Pan

“…Conclusion: The proposed framework showcases the potential of LLMs to enhance generalization and interpretability in postoperative AKI prediction, paving the way for more robust and transparent predictive solutions in clinical settings.…”
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Single-cell sequencing on PBMCs from patients with HA and HB with inhibitors reveals different immune responses to FVIII and FIX by Enhao Li, Zekun Li, Jinzeng Wang, Haoyang Wu, Yilun Xue, Can Lou, Zhenping Chen, Feng Liu, Wenman Wu, Qiulan Ding, Runhui Wu, Xuefeng Wang, Jing Dai

“…HA group exhibited a relatively higher proportion of B cells and more active B cells, whereas HB group demonstrated a higher proportion of T cells, with more active CD4+ T helper cells. …”
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Mechanical feedback mechanisms in a multiscale sliding filament model of lymphatic muscle pumping by Peter Y. Xie, Christopher J. Morris, Christopher D. Bertram, Michael J. Davis, Samira Jamalian, Mohammad Jafarnejad, David C. Zawieja, James E. Moore, Jr

“…Lymph transport is important not only for fluid homeostasis, but also for immune function, as lymph is a carrier for immune cells. Lymphatic muscle cells exhibit both cardiac-like phasic contractions to generate flow and smooth-muscle-like tonic contractions to regulate flow. …”
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Integration of single-cell sequencing and drug sensitivity profiling reveals an 11-gene prognostic model for liver cancer by Qunfang Zhou, Jingqiang Wu, Jiaxin Bei, Zixuan Zhai, Xiuzhen Chen, Wei Liang, Jing Meng, Mingyu Liu

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Levels of physical activity in a large international cohort of patients with systemic lupus erythematosus by Laurent Arnaud, Matteo Piga, Manuel Francisco Ugarte-Gil, Christelle Sordet, Philippe Mertz, Luc Pijnenburg, Marina Rinagel, Lou Kawka, Sophie Geneton, Julien Blaess, Timothée Mischler, Juan C Sarmiento-Monroy

“…Increased fatigue according to the Functional Assessment of Chronic Illness Therapy–Fatigue Scale (p<0.0001), the Multidimensional Fatigue Inventory (p<0.0001), Visual Analogue Scale for fatigue (p=0.02), pain (p=0.009), depression (p=0.02) and stress (p<0.0001) were significantly more prevalent in less active patients, in IPAQ classification.Conclusion In this large international study, more than 40% of patients with SLE were not active enough. …”
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Using selective NIR wavelengths in portable devices to evaluate the chemical composition of cattle feeds by Lorenzo Serva, Luisa Magrin, Giovanni Chillemi, Giorgio Marchesini, Daniele Pietrucci, Francesco Renzi, Riccardo Valentini, Igino Andrighetto, Marco Milanesi

“…Although portable instruments are generally more affordable than benchtop equipment, the current costs of purchasing and maintaining these tools may still be prohibitive for small and medium-sized animal husbandry businesses. …”
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Different methods of estimating riverbed sediment grain size diverge at the basin scale by Peter Regier, Yunxiang Chen, Kyongho Son, Jie Bao, Brieanne Forbes, Amy Goldman, Matt Kaufman, Matt Kaufman, Kenton A. Rod, James Stegen, James Stegen

“…IntroductionThe distribution of sediment grain size in streams and rivers is often quantified by the median grain size (D50), a key metric for understanding and predicting hydrologic and biogeochemical function of streams and rivers. Manual D50 measurements are time-consuming and ignore larger grains, while approaches to model D50 based on catchment characteristics may over-generalize and miss site-scale heterogeneity. …”
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Problems of treatment adherence in patients with rheumatoid arthritis and comorbidity by N. M. Nikitina, E. V. Egorova, I. F. Melehina, S. N. Grigoryeva, A. P. Rebrov

“…Non-adherent patients had higher RA activity index and lower functional capacity.Conclusion. Simultaneous use of several methods to assess treatment adherence is a reasonable way to get more information about the patient and to implement therapy as planned. …”
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Review: Feed efficiency and metabolic flexibility in livestock by W.M. Rauw, L.H. Baumgard, J.C.M. Dekkers

“…Metabolic flexibility for adaptation to disease, and response to regular stress implies that a more reactive immune response and reduced fear response results in higher feed efficiency. …”
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Using hierarchical drift diffusion models to elucidate computational mechanisms of reduced reward sensitivity in adolescent major depressive disorder by Lei Shen, Ya-xin Hu, Qin-yu Lv, Zheng-hui Yi, Jing-bo Gong, Chao Yan

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Blockchain and NFT-Based Solution for Genomic Data Management, Sharing, and Monetization by Ahmad Musamih, Khaled Salah, Raja Jayaraman, Samer Ellaham, Mohammed Omar, Ibrar Yaqoob

“…We present various diagrams and algorithms to illustrate the functionality of our solution. Our testing and validation results demonstrate that smart contracts function as intended. …”
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Quasi-parallel Antisunward-propagating Whistler Waves Associated with the Electron Deficit in the Near-Sun Solar Wind: Particle-in-cell Simulation by Alfredo Micera, Daniel Verscharen, Jesse T. Coburn, Maria Elena Innocenti

“…In situ observations of the solar wind have shown that the electron velocity distribution function (VDF) consists of a quasi-Maxwellian core, comprising most of the electron population, and two sparser components: the halo, which are suprathermal and quasi-isotropic electrons, and an escaping beam population, the strahl. …”
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The Development and Applications of a Dual Optical Imaging System for Studying Glioma Stem Cells by Po-An Tai MD, PhD, Yen-Lin Liu MD, PhD, Ya-Ting Wen MD, Chien-Min Lin MD, PhD, Thanh-Tuan Huynh MD, PhD, Michael Hsiao DVM, PhD, Alexander T. H. Wu PhD, Li Wei MD, PhD

“…Subsequently, Btk inhibitor, ibrutinib, suppressed GSC generation and stemness markers. Finally, we demonstrated real-time evaluation of anti-GSC function of ibrutinib in vivo with TMZ-enriched GSCs. …”
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Efficient and Effective NDVI Time-Series Reconstruction by Combining Deep Learning and Tensor Completion by Ang Li, Menghui Jiang, Dong Chu, Xiaobin Guan, Jie Li, Huanfeng Shen

“…The ST-Tensor method is first used to generate high-quality seamless NDVI data as the label data to construct sample pairs, along with the original degraded observations. …”
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Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapy by Yutao Zou, Junjie Wu, Qiuyun Zhang, Jiayi Chen, Xuanxuan Luo, Yijie Qu, Rui Xia, Weiqi Wang, Xiaohua Zheng

“…Porphyrins-based nanoscale metal-organic frameworks (nMOFs) has been widely utilized to kills tumor cells by generating cytotoxic reactive oxygen species (ROS). …”
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Global Simulations of Gravitational Instability in Protostellar Disks with Full Radiation Transport. I. Stochastic Fragmentation with Optical-depth-dependent Rate and Universal Fra... by Wenrui Xu, Yan-Fei Jiang, Matthew W. Kunz, James M. Stone

“…Applying this result to typical Class 0/I protostellar disks, we find m _frag ∼ 20 M _J , suggesting that fragmentation more likely forms brown dwarfs. Given the finite width of the m _frag distribution, forming massive planets is also possible.…”
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YOLOv8-Scm: an improved model for citrus fruit sunburn identification and classification in complex natural scenes by Guoxun Cong, Guoxun Cong, Xinghong Chen, Xinghong Chen, Zongyu Bing, Zongyu Bing, Wenhuan Liu, Wenhuan Liu, Xiangling Chen, Qun Wu, Zheng Guo, Zheng Guo, Yongqiang Zheng, Yongqiang Zheng

“…Three key enhancements are introduced: (1) DSConv module replaces the standard convolution for a more efficient and lightweight design, (2) Global Attention Mechanism (GAM) improves feature extraction for multi-scale and occluded targets, and (3) EIoU loss function enhances detection precision and generalization. …”
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Integrating the Prior Shape Knowledge Into Deep Model and Feature Fusion for Topologically Effective Brain Tumor Segmentation by Salma Asif, Ahmad Raza Shahid, Kiran Aftab, Syed Ather Enam

“…Deep learning techniques totally rely on the loss function optimization and due to the lack of explicit form of prior knowledge, they may struggle to generate the accurate tumor shapes. …”
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